Abstract: In one aspect, embodiments disclosed herein are directed to engineered CRISPRCas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type II effector protein. In certain other example embodiments, the Type V effector protein is Cas9 or an orthologs or engineered variant thereof. Example Cas9 proteins suitable for use in the embodiments disclosed herein are discussed in further detail below.

Abstract: Embodiments of the present application provide a method and a device for controlling train formation tracking, the method comprising: obtaining a current distance between a first train and a second train in a train formation, wherein the first train is adjacent to the second train and located behind the second train; determining a target tracking mode of the first train based on the current distance, wherein the target tracking mode is one of a speed tracking mode, a distance tracking mode and a braking mode; and tracking the second train, by the first train based on the target tracking mode. Tracking efficiency is improved according to the method of the embodiments of the present application.

Abstract: A display driving device configured to control a display panel including pixel units to display, includes: an over driver compensation module configured to, when a first polarity frame image is displayed, perform line over driver compensation on the pixel units based on line over driver compensation data corresponding to the first polarity frame image, to determine a target over driver grayscale of the pixel units; and to, when a second polarity frame image is displayed, perform line over driver compensation on the pixel units based on line over driver compensation data corresponding to the second polarity frame image, to determine a target over driver grayscale of the pixel units. The first and second polarity are opposite to each other, and the line over driver compensation data corresponding to the first polarity frame image is different from the line over driver compensation data corresponding to the second polarity frame image.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: The present disclosure provides a driving method for a liquid crystal display panel and a non-transitory computer storage medium. The driving method includes: for the plurality of sub-pixels, adopting a first gray-level table for displaying a picture in other frame pictures other than a first frame picture in each of the plurality of predetermined periods, the first gray-level table including a plurality of first gray-level values; and adopting a second gray-level table for displaying a picture in the first frame picture in each of the plurality of predetermined periods, the second gray-level table including a plurality of second gray-level values.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: The present application discloses an ultra-micro defect detection apparatus and a detection method thereof. The apparatus includes an imaging module, a light source module, a filtering module, and a mounting platform; the imaging module further includes a camera, an imaging lens, and an objective lens; the camera, the imaging lens, and the objective lens are sequentially and vertically arranged from top to bottom; the light source module further includes a collimator, a light source generator, and a beam splitting mirror; the light source generator is connected to the beam splitting mirror, and the collimator is mounted between the light source generator and the beam splitting mirror; the filtering module further includes a spatial filter, and the spatial filter is mounted between the imaging lens and the objective lens.

Abstract: The present specification discloses video matching. In a computer-implemented method, a plurality of feature vectors of a target video is obtained. A candidate video similar to the target video is retrieved from a video database based on the plurality of feature vectors of the target video. A time domain similarity matrix feature map is constructed between the target video and the candidate video based on the target video and the candidate video. Using the time domain similarity matrix feature map as an input into a deep learning detection model, a video segment matching the target video in the candidate video and a corresponding similarity is output.

Abstract: Provided are a mutant HPPD polypeptide having high resistance to a herbicide and an encoding gene thereof, and an application thereof in an improved plant. The amino acid at position 282 of the mutant HPPD polypeptide is mutated from arginine to serine at a wild-type HPPD polypeptide. In addition, the mutant HPPD polypeptide further comprises an amino acid at position 349 that is mutated from glutamic acid to lysine, and/or an amino acid at position 156 that is mutated from alanine to valine. The mutated HPPD polypeptide can be used for cultivating plants having resistance to a herbicide having HPPD inhibition.

Abstract: The present disclosure relates to a backlight module, a method for designing the same, and a display device. The backlight module includes: a first substrate; a plurality of LED chips on the first substrate; and a light control structure on the first substrate. The backlight module includes a plurality of light control region groups in one-to-one correspondence with the plurality of light-emitting diode chips, each light control region group includes at least a first light control region and a second light control region. The light control structure includes a plurality of light control substructure groups respectively located in the plurality of light control region groups. Each light control substructure group includes at least a first light control substructure in the first light control region and a second light control substructure in the second light control region.

Abstract: This disclosure relates to a see-through display device, including: a collimated light source assembly, configured to form collimated light and control a light emitting direction; a first light extraction layer, configured to extract, in a collimated manner, the light ray transmitted inside the light guide plate through a light extraction outlet; an extinction layer and a second light extraction layer, wherein the extinction layer includes a light guide region and a light absorption region which are arranged alternately, and the second light extraction layer includes multiple light extraction inlets; a reflecting layer, arranged on a side, close to the light guide plate, of the second light extraction layer and configured to reflect the collimated light extracted from the light extraction outlet to the light guide plate; and a liquid crystal dimming layer. This disclosure further relates to a manufacturing method of the see-through display device.

Abstract: A method and an apparatus for three-dimensional reconstruction. Images of the reconstruction space captured by N cameras are acquired as N current images in response to an object entering the reconstruction space. Foreground-background differences of all position points in the N current images are obtained according to the N current images and N corresponding initial background images captured by the N cameras when the reconstruction space is empty. Corresponding foreground-background differences of position points in the N current images are fused according to a corresponding relationship between all position points in the N current images and all position points in the reconstruction space, to obtain a foreground-background difference of each position point in the reconstruction space.

Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements. Specifically, the disclosure provides an engineered composition comprising: a programmable DNA-binding protein and two or more Tn7-like transposition proteins, wherein at least one of the Tn7-like transposition proteins is connected to the DNA-binding protein or otherwise capable of forming a complex with the DNA-binding protein, wherein the DNA-binding protein comprising a Cas protein including a Cas12k protein, and wherein two or more Tn7-like transposition proteins consisting of TnsB, TnsC, and TniQ.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Embodiments are generally directed to a system and method for adapting executable object to a processing unit. An embodiment of a method to adapt an executable object from a first processing unit to a second processing unit, comprises: adapting the executable object optimized for the first processing unit of a first architecture, to the second processing unit of a second architecture, wherein the second architecture is different from the first architecture, wherein the executable object is adapted to perform on the second processing unit based on a plurality of performance metrics collected while the executable object is performed on the first processing unit and the second processing unit.

Abstract: A multi-axis turntable includes a base, a rocker arm and a first driving device capable of driving the rocker arm to rock around the first rotation axis on the base. A swing arm and a second driving device, which is capable of driving the swing arm to swing around the second rotation axis on the rocker arm, are provided on the rocker arm. A workbench and a third driving device for driving the workbench to rotate around the third rotation axis are provided on the swing arm. The second rotation axis and the third rotation axis are parallel to each other or on different planes. Compared with the existing double rotating shaft turntable, the multi-axis turntable of the present invention has a cutting tool system of good and stable rigidity.

Abstract: The embodiments of the present application provide a method and apparatus for tracking and controlling virtual marshalling trains, an electronic device, and a readable storage medium, which is intended to balance the running safety and the utilization of the railway resources. In the present application, the running state data of the target train is obtained, the target control operation corresponding to the running state data is determined from the plurality of preset control operations based on the preset reinforcement learning model, and the control of the target train is implemented according to the target control operation. In addition, the reward value corresponding to the previous control operation of the target control operation is determined according to the distance contained in the running state data, and the reinforcement learning model is updated according to the reward value.

Abstract: Methods and systems are provided for improving user authentication and access control by a network file system service in a multi-tenant public cloud environment by receiving a request for a connection to a file system from a file system client (client), sending an identification request for identification authentication of the client to a control system, receiving a response from the control system, establishing the connection to the file system upon determining that the connection to the file system is allowed based on cloud tenant information associated with the client, receiving an attempt to access the file system from the client by a sub-user, authenticating the sub-user based on the cloud tenant information, issuing a security token including a globally unique sub-user identifier of the sub-user, and using the security token to determine access rights of the sub-user to the file system for a subsequent request.