Abstract: The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Abstract: An array substrate includes gate lines, data lines and an insulating layer. The data lines all extend in a first direction, and the gate lines all extend in a second direction, the first direction intersecting the second direction. A data line includes first line segments and second line segments that all extend in the first direction and are arranged alternately. The second line segments are disposed at a side of the gate lines proximate to the base, and the first line segments are disposed at a side of the gate lines away from the base. There is no overlap among orthographic projections of the first line segments on the base and orthographic projections of the gate lines on the base. The insulating layer includes first vias. In the first direction, any two adjacent first line segments are electrically connected to a second fine segment through at least two first vias.

Abstract: Traffic proxy-based Internet of Things terminal key information leakage monitoring methods and systems, electronic devices, storage media, and computer programs. An example method includes: receiving a proxy request sent by an Internet of Things terminal, the proxy request including protocol related information of the Internet of Things terminal, and the protocol related information including part or all of device model information, service type information, and data packet information; according to the protocol related information of the Internet of Things terminal, determining a target protocol corresponding to the Internet of Things terminal; and allocating a target proxy service to the Internet of Things terminal according to the target protocol, and a usage state and an online state of each proxy service in a full traffic proxy pool, and performing key information monitoring on the traffic of the Internet of Things terminal by the target proxy service.

Abstract: A liquid crystal phase shifter includes: a first substrate; a second substrate, provided opposite to the first substrate; a liquid crystal layer, provided between the first substrate and the second substrate; and a phase shift region, including a first electrode, a second electrode and a control circuit, where the first electrode is provided on a side of the first substrate close to the second substrate, the second electrode is provided on a side of the second substrate close to the first substrate, an orthographic projection of the second electrode on the first substrate partially overlaps with an orthographic projection of the first electrode on the first substrate, and the second electrode is grounded.

Abstract: A radar ranging method, device, electronic device, and computer-readable storage medium are provided. The radar ranging method includes: obtaining a plurality of measurement data sets by sampling at least one echo signal based on a plurality of thresholds in a measurement period, wherein the echo signal is sampled based on one threshold to obtain one measurement data set, and each measurement data set includes at least one measurement data; determining M backup data and N auxiliary data in the plurality of measurement data sets, and obtaining a total composite degree of each backup data; determining target data from the M backup data, based on the total composite degree; and determining a measurement distance based on the target data. The radar ranging method enhances the dynamic range of a LiDAR system, improves the measurement accuracy of the LiDAR and reduces the short-distance detection blind zone of the LiDAR.

Abstract: The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered RNA-targeting system comprising an RNA-targeting Cas protein and at least one RNA-targeting guide RNA, wherein said RNA-targeting guide RNA is capable of hybridizing with a target RNA in a cell.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The present disclosure generally relates to methods and user interfaces for authentication, including providing authentication at a computer system in accordance with some embodiments.

Abstract: Provided is a method for removing arsenic from copper smelting soot and comprehensive recovery of valuable metals. According to the method, a metal leaching synergist is prepared through thiol-ene click chemical reaction, which is capable of reacting more effectively with arsenic and metal impurities in the copper smelting soot due to its special chemical structure, thereby improving leaching efficiency; and the cage-like structure of the polysilsesquioxane provides excellent chemical stability, the removal rate of harmful substances in the copper smelting soot can be increased by using the synergist, environmental pollution is reduced, meanwhile, the recovery rate of metal resources is increased, and the requirements of green chemistry and sustainable development are met. The present disclosure realizes the centralized management of As and also realizes the step-by-step recovery of valuable metals such as Cu, Zn, Pb, Bi, and In.

Abstract: Engineered or non-naturally occurring systems and compositions comprising novel Type V Cas polypeptides and orthologs thereof are disclosed herein. Also provided are methods of use for the novel Type V Cas polypeptide systems and compositions for reprogrammable targeting of nucleic acid and polynucleotide components.

Abstract: A powertrain system includes a conversion device, a first motor, a second motor, and an engine. At least one of the first motor and the engine is configured to selectively output power to a first traveling end by means of the conversion device; the engine is configured to selectively output the power to the first motor by means of the conversion device, to drive the first motor to generate electricity; and the second motor is in driving connection with the engine, so that the powertrain system has a first simultaneous driving and electricity-generating mode. In the first simultaneous driving and electricity-generating mode, the first motor outputs the power to the first traveling end by means of the conversion device; and the second motor, driven by the engine, generates electricity.

Abstract: A loudspeaker module and an electronic apparatus are disclosed, the loudspeaker module comprises a housing, a loudspeaker unit and a barrier rib body; the loudspeaker unit is provided in an inner cavity of the housing and divides the inner cavity of the housing into a front acoustic cavity and a rear acoustic cavity, the rear acoustic cavity is filled with sound-absorbing particles, and a cavity wall of the rear acoustic cavity is provided with a leakage hole. The barrier rib body is provided in the rear acoustic cavity, at least a part of the barrier rib body faces the leakage hole, and the distance between the leakage hole and the part of the barrier rib body facing the leakage hole is less than the size of the sound-absorbing particles. The technical solution can reduce the occurrence of the situation where the sound-absorbing particles block the leakage hole.

Abstract: Provided herein is a nucleic acid detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind to corresponding target molecules; an RNA-based masking construct; and optionally, nucleic acid amplification reagents to amplify target RNA molecules in a sample. In another aspect, the embodiments provide a polypeptide detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind a trigger RNA, an RNA-based masking construct; and one or more detection aptamers comprising a masked RNA polymerase promoter binding site or a masked primer binding site. In some embodiments, the system may be used to detect viruses in samples.

Abstract: Provided are a display substrate, a method for manufacturing a display substrate and a display apparatus. The display substrate includes a base, a drive structure layer disposed on the base, a light emitting element disposed on the drive structure layer, an encapsulation layer disposed on the light emitting element, a circular polarizer layer disposed on the encapsulation layer, and a lens definition layer and a lens structure layer disposed on the circular polarizer layer. The light emitting element includes a pixel definition layer provided with a plurality of sub-pixel openings; the lens structure layer includes a plurality of lenses disposed at intervals, the lens definition layer is disposed in a gap region between adjacent lenses, and an orthographic projection of each lens on the base contains an orthographic projection of a sub-pixel opening on the base.

Abstract: A tunable phase shifter and a method for manufacturing the same, and a tunable phase shifting device. The phase shifter includes a first substrate, a second substrate, and a tunable dielectric layer between the first substrate and the second substrate; the first substrate includes a first base substrate and a first electrode on the first base substrate; the second substrate includes a second base substrate and a second electrode on the second base substrate; an orthographic projection of the first electrode on the first base substrate is at least partially overlapped with an orthographic projection of the second electrode on the first base substrate, and sheet resistances of materials of the first electrode and the second electrode are both less than or equal to 0.024?/?.

Abstract: Provided is a pressure sensor, including a first pedestal (1) and an electrode member (4), the first pedestal (1) is provided with a supporting portion (11) for supporting the electrode member (4), and a plurality of adjusting members (51, 52) are stacked in sequence between two opposite surfaces of the electrode member (4) and the supporting portion (11); and thermal expansion coefficients of the electrode member (4), the plurality of adjusting members (51, 52), and the first pedestal (1) gradually increase in a direction from the electrode member (4) to the supporting portion (11). The pressure sensor can solve the problem of relative displacement of parts caused by a temperature change.

Abstract: Provided is a display substrate, which includes a base substrate, a circuit structure layer disposed on the base substrate, multiple ultrasonic sensing elements and multiple micro light-emitting elements. The multiple ultrasonic sensing elements are disposed on a side of the circuit structure layer away from the base substrate, and are electrically connected to the circuit structure layer, and the multiple light-emitting elements are disposed on the side of the circuit structure layer away from the base substrate, and are electrically connected to the circuit structure layer. An orthographic projection of the multiple ultrasonic sensing elements on the base substrate does not overlap with an orthographic projection of the multiple micro light-emitting elements on the base substrate.

Abstract: Described herein are engineered antigen presenting cells that can be capable of modulating a target T-cell in a T-cell antigen specific manner. In some embodiments, the engineered APCs can include a modified antigen presentation pathway. Also described herein are methods of making and using the engineered antigen presenting cells.

Abstract: An embodiment of the present disclosure provides a display substrate. The display substrate includes a driver backplane, and a reflective structure and a pixel electrode on the driver backplane. Reflective structure and the pixel electrode are disposed sequentially away from the driver backplane along a thickness direction of the driver backplane. The pixel electrode is connected to the driver backplane through the reflective structure. A surface of the reflective structure away from the driver backplane is a reflective surface comprising a plurality of arc surfaces, and each of the plurality of arc surfaces is convex protruding towards a direction away from the driver backplane. The plurality of the arc surfaces are continuously arranged, and any two adjacent arc surfaces of the plurality of the arc surfaces are connected to each other.

Abstract: A microlens substrate, a display device and a method for manufacturing a microlens substrate are provided. The microlens substrate includes: a base; a first lens pattern disposed on a side of the base and including a plurality of first microlenses distributed at intervals; a second lens pattern disposed on a side of the first lens pattern and including a plurality of second microlenses distributed at intervals, where an orthographic projection of at least one of the plurality of second microlens on the base is located between two orthographic projections of two adjacent first microlenses on the base.