Abstract: A decision tool models emissions for a sustainable aircraft fuel (SAF) for the lifecycle of the fuel. The decision tool includes a controller module configured to receive data related to at least one fuel pathway for the fuel wherein the fuel pathway considers emissions from initial feedstock production to fuel burn during flight and arrival. The decision tool determines at least one fuel pathway for the fuel used to fuel the aircraft during a flight, models an emission score for the at least one fuel pathway, and then outputs the emission score where a user can purchase the fuel or make other decisions based upon the fuel pathway provided by the decision tool.

Abstract: Recent advances in the understanding of two CRISPR-Cas systems, namely, Type VI (Cas13a-d) and Type III (Type III-A-B), have shown both of them to have the ability to efficiently target RNA. Provided herein are compositions and methods for trans-splicing precursor mRNA using a catalytically-inactive Cas protein (dCas) and a trans-splicing construct comprising a guide RNA, an intron, a splice acceptor, donor RNA, and a poly A tail. The dCas is capable of forming a complex with the guide RNA and directing sequence-specific binding of the complex to a target precursor mRNA for genetic modification and any polypeptides derived thereof. The technology has important potential therapeutic applications such as correcting genetic mutations through exon replacement, insertion of transgenes, and increasing gene expression, and in non-therapeutic applications such as cell- and tissue-specific diagnostics.

Abstract: Embodiments of the present disclosure provide a microlens structure and a manufacturing method therefor, and a display apparatus. The microlens structure comprises: a base substrate; and a plurality of microlenses, located at one side of the base substrate, wherein the material of each microlenses comprises a product generated after crosslinking a non-photosensitive resin monomer.

Abstract: A button assembly is adapted to be installed at a conductive casing. Two opposite sides of the conductive casing respectively have first and second openings, and the first opening is communicated with the second opening. The button assembly includes a conductive button, a first insulating sleeve, and a second insulating sleeve. The conductive button includes a button part corresponding to the first opening and a shaft part connected to the button part and passing through the second opening from the first opening. The first insulating sleeve includes a first shaft hole and a first lateral slit. The second insulating sleeve includes a second shaft hole and a second lateral slit. The first insulating sleeve is sleeved on the shaft part and located at the first opening. The second insulating sleeve is sleeved on the shaft part and located at the second opening. An electronic device is also provided.

Abstract: This disclosure provides an anti-interference method for a new radio network, to reduce intra-frequency interference caused by a long term evolution (LTE) cell to a neighboring new radio (NR) cell. In the method, a base station obtains network configuration information of at least one LTE cell neighboring to an NR cell, based thereon determines anti-interference configuration information that includes an anti-interference pattern having a plurality of strip areas, in which at least one first area and at least one second area are distributed in spacing, the first area is used to carry a service signal of the NR cell, and the second area is used to carry an interference signal of the at least one LTE cell. The base station sends the anti-interference configuration information to a target user equipment for selecting the at least one first area to carry the service signal of the NR cell.

Abstract: A microlens array substrate (200) and a preparation method therefor, and a display device. The microlens array substrate (200) comprises: a base; a microlens film layer disposed on a side of the base and comprising at least one microlens array, the microlens array comprises a plurality of microlenses and a spacer portion between adjacent microlenses; a barrier layer disposed on a side of the microlens film layer away from the base, an orthographic projection of at least part of the barrier layer on the base is overlapped with an orthographic projection of the microlenses on the base; a light shielding layer disposed on a side of the microlens film layer away from the base and comprising at least one light shielding pattern, an orthographic projection of the at least one light shielding pattern on the base is overlapped with an orthographic projection of the spacer portion on the base.

Abstract: The disclosure belongs to the field of monitoring equipment and provides an automobile dual-camera monitor system, including a first camera, a second camera, a transmission line and a display, the first camera and the second camera being fixed in an automobile through a first fixing assembly and a second fixing assembly respectively, and a camera end of each of the first camera and the second camera facing a front end of a safety seat.

Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

Abstract: A production line for producing components to a high standard of cleanliness and sealed and protected in that state includes a loading device, a cleaning device, a detecting device, a pasting device, a heat-sealing device, a packing device, and transfer devices of the production line. The production line automatically processes the components for obtaining components with the high cleanliness. By the processes of protective film pasting, heat-sealing, and packing, the components may be further protected from subsequent pollution. A method for producing components with a high cleanliness applied to the production line is also disclosed.

Abstract: Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

Abstract: A wearable device includes: a main structure, two straps, a connecting piece and a driving structure. The two straps are respectively connected to two ends of the main structure; the connecting piece is provided with a mounting cavity, a slide cavity in communication with the mounting cavity, and two communicating ports, each of the two straps having one end thereof distal to the main structure movably passing through one of the communicating ports to extend into the slide cavity, and the main structure, the two straps and the connecting piece enclosing a wearable space: the driving assembly is provided in the mounting cavity, the two transmission parts being provided spaced apart in the slide cavity and in transmission connection with the driving assembly, each of the two transmission parts being in respective transmission connection with the two straps.

Abstract: A timed gas cut-off device, which comprises a device body, comprising an inlet gas channel, an outlet gas channel and a valve rod channel; the inlet and outlet gas channels are respectively in communication with the valve rod channel, an accommodation chamber with a through hole communicating the accommodation chamber with the valve rod channel; a valve rod device, comprising a rod body slidably cooperating in the valve rod channel, a shim connected to the rod body and moves in synchronization with the rod body to open or close the valve rod channel; a free end of the rod body extends through the through hole and disposed inside the accommodation chamber; an elastic soft sealing piece, sealingly connected to the through hole, sleeved on the free end of the rod body; a timer with a drive piece connected inside the accommodation chamber for timed gas use and improves the safety.

Abstract: The present invention relates to in vivo methods for modeling tumor formation and/or tumor evolution comprising the use of eukaryotic cells in which one or more genetic target locus has been altered by the CRISPR/Cas system, and which cells are transplanted in non-human eukaryote as a model system for tumor formation and tumor evolution. In particular in vivo genetic screening methods for identifying genes involved in tumorigenesis and metastasis are disclosed. The invention further relates to kits and components for practicing the methods, as well as materials obtainable by the methods, in particular tumor and metastasis samples and cells or cell lines derived therefrom. The invention also relates to diagnostic and therapeutic methods derived from the information obtained in the modeling methods.

Abstract: An interactive system includes a terminal, a display screen and a server, the server determines a current position of a target object on the display screen; generates an object identifier of the target object according to the current position thereof object, and associates the object identifier with the current position; receives adjustment information of the target object, generates an indication pattern according to the current position and the adjustment information, and transmits the indication pattern to the display screen; the terminal displays a frame image configured for the display screen, displays the object identifier according to an association relationship between the object identifier and the current position; generates adjustment information of the target object in response to an arrangement operation of a user on the object identifier; the display screen displays the indication pattern to instruct the target object to adjust according to an indication of the indication pattern.

Abstract: Disclosed is a fast self-adaptive rotary plug-in underwater force-bearing connector, which comprises a plug part and a socket part, wherein the plug part comprises a plug housing, a pin arranged in the plug housing, and a push-pull sleeve, a rotary sleeve, a front retaining ring, a ratchet lock nut and a rear retaining ring arranged outside the plug housing; the socket part comprises a socket housing and a jack arranged in the socket housing; the pin and the jack cooperate to connect the plug part and the socket part. The fast self-adaptive rotary plug-in underwater force-bearing connector of the present application can work under the working condition of a large tensile force and has a high reliability.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Systems and methods for rapid diagnostics related to the use of combinations of CRISPR effector systems with optimized guide sequences, OSD probes, RNA probes and/or RNase H for detection of nucleic acid sequences, such as sequences from coronavirus, as well as multiplex lateral flow diagnostic devices and methods of use, are provided.

Abstract: The present invention is directed to compositions having chair-side handling properties comprising polymers for dental, soft tissue and combination products applications.