Abstract: The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasome production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Abstract: Embodiments herein relate generally to the field of footwear, and more particularly to components of performance footwear, such as midsoles, and in particular related to a high performance composite foam for a midsole, the composite foam comprising: a pelletized expanded thermoplastic elastomer; and a polyurethane (PU) matrix, wherein the pelletized expanded thermoplastic elastomer is mixed within the PU matrix. Midsoles made from a high performance composite foam and footwear including such midsoles. A method of making a high performance midsole is also provided.

Abstract: Certain aspects of the present disclosure provide techniques for identifying a minimal, or at least reduced, set of representative calibration paths in radio frequency (RF) circuits and calibrating other calibration paths based on calibration codes used for the representative calibration paths. An example method generally includes receiving a calibration data set including measurements associated with each calibration path of a plurality of calibration paths in an RF circuit. Based on a clustering model and the calibration data set, a plurality of calibration clusters is generated. From each respective calibration cluster of the plurality of calibration clusters, a respective representative calibration path for is selected for the respective calibration cluster. Generally, calibration codes generated for the representative calibration path are applicable to other calibration paths in the calibration cluster.

Abstract: The invention relates to novel compounds for use as inhibitors of NL-RP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Abstract: The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Abstract: Disclosed herein are a non-invasive alcohol detection, identity management, access control, remote screening, and reporting systems.

Abstract: Systems and methods for interaction of satellite and Internet protocol features in content delivery systems are presented. Using such systems and methods, the delivery of some content to the same product by Satellite delivery, other content by IP delivery, and still other content by both Satellite and IP delivery can enhance the utility of both the content and the product for an end user and can further optimize the costs and quality of service associated with delivering the content.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: Expandable occlusive plugs and methods of using them are disclosed. The devices generally include a tubular body bearing multiple slits defining leaves, which expand radially outward when the ends of the device are brought toward one another.

Abstract: A patient ventilation interface has a throat body defining a venturi throat that is open to ambient air, a nasal pillow disposed around the venturi throat to define a plenum between the venturi throat and the nasal pillow, a jet nozzle arranged to output ventilation gas into the venturi throat, and a pressure sensing tube having a pressure sensing port positioned to be in fluid communication with the plenum. The nasal pillow may be an integral part of the throat body. An expected error in the sensed patient airway pressure Psense may be corrected by applying a correction factor Pdelta indexed by the sensed patient airway pressure Psense and a jet nozzle flow V?n of the jet nozzle. Delivery of the ventilation gas output by the jet nozzle may be controlled in response to the corrected patient airway pressure.

Abstract: Computer-implemented methods, computer-readable storage media, and computer systems for associating received medical imaging data with stored medical imaging data. Medical imaging data associated with a patient is received from a client device. The medical imaging data includes an image object, one or more data objects related to the image object, and metadata associated with the patient encoded in Digital Imaging and Communication in Medicine (DICOM) format. The metadata includes personal information about the patient, and time and location at which the DICOM image file was captured. The received metadata is compared with existing metadata associated with multiple existing patients to identify a subset of the existing patients who may be a potential match to the patient. Selection of an existing patient from among the subset is requested. When received, the medical imaging data is associated with the existing patient.

Abstract: Embolic material delivery devices and methods of using them are disclosed. An example embolic material delivery assembly includes an outer member having a lumen extending therein and a distal end region, an inner member disposed within the lumen of the outer member, wherein the inner member includes a first lumen extending therein. The embolic material delivery assembly also includes a first embolic material extending within the first lumen of the inner member, the embolic material having a first distal end region. The embolic material delivery assembly also includes an anchor disposed within the lumen of the outer member, the anchor having a first attachment region. Further, the first distal end region of the first embolic material is coupled to the first attachment region of the anchor.

Abstract: The disclosed electronic smart mat includes a planar surface configured to receive a mobile electronic container configured to store one or more medications, an antenna configured to wirelessly communicate with the mobile electronic container when the mobile electronic container is received over the surface, a communication module configured to communicate with a server, and a processor. The processor is configured to determine a medication content of the mobile electronic container responsive to the mobile electronic container being received over the surface, receive patient data associated with a patient responsive to placement of a mobile computing device associated with the patient over the surface of the electronic mat, and provide, to the server using the communication module, the patient data, and updated medication inventory based on the determined medication content of the mobile electronic container. The electronic mat may form a bottom surface of an enclosure within a dispensing machine.

Abstract: A compact muffler (40) for an engine exhaust system, which is particularly applicable for use with small, reciprocating piston two-stroke engines of the type used on unmanned aerial vehicles (UAVs). The compact muffler (40) comprises an exhaust gas flow path (67) between an inlet (61) and an outlet (63). The exhaust gas flow path (67) comprises a plurality of adjacent flow passages (65), wherein at least two of the adjacent flow passages (65) are fluidly connected in series to enable the flow of exhaust gas from one to the other along the flow path (67). The adjacent flow passages (65) are configured for fluid flow therealong in opposed directions. A bypass passage (70) is provided between the two adjacent flow passages (65) for further communication between the two flow passages and to promote an equalisation of fluid pressure within the two adjacent passages (65). A UAV having an internal combustion engine (31) fitted with an exhaust system comprising the compact muffler (40) is also disclosed.

Abstract: A variable throat jet venturi for delivering ventilation gas to a patient includes a jet nozzle, a deformable throat body arranged to receive ventilation gas output by the jet nozzle and defining a gas inlet and a gas outlet, and a housing containing the deformable throat body. The housing may define an entrainment opening which is open to ambient air and a pilot pressure port for pressurizing a plenum between an outer wall of the deformable throat body and an inner wall of the housing. A pilot pressure line may be fluidly coupled to the pilot pressure port. A controller may be programmed to energize the pilot pressure line to constrict the deformable throat body during an exhalation phase of positive end-expiratory pressure (PEEP) therapy.

Abstract: The invention relates to methods for CC bond formation using organolithium compounds under continuous flow conditions in a micro or mesoreactor system, wherein an organic substrate is reacted with an alkyl lithium compound in the presence of a donor solvent to form a Li intermediate, which can be reacted in situ or subsequently in a second reaction step with an electrophile to form an organic secondary product, the organolithium compound RLi being used as a solution in a hydrocarbon or hydrocarbon mixture and the RLi concentration being at least 3 M, preferably at least 4 M.

Abstract: A system is described and includes a first track assembly for connecting a top surface of a pallet supporting payload to an upper interior surface of a payload bay of an aircraft; a second track assembly for connecting a side surface of the pallet to a side interior surface of the payload bay; and a pallet actuator system for selectively moving the pallet along the first and second track assemblies between a first position in which the pallet is fully extended from the payload bay and a second position in which the pallet is fully retracted into the payload bay.

Abstract: Systems and methods for interaction of satellite and Internet protocol features in content delivery systems are presented. Using such systems and methods, the delivery of some content to the same product by Satellite delivery, other content by IP delivery, and still other content by both Satellite and IP delivery can enhance the utility of both the content and the product for an end user and can further optimize the costs and quality of service associated with delivering the content.

Abstract: A method including authorizing a user to access a dispensing unit upon receipt of a medication request, is provided. The dispensing unit comprises a storage location with one or more door enclosure storing at least one container. The method also includes providing a visual indicator to the user for a selected container in the storage location with one or more door enclosure, the selected container comprising a medication associated with the medication request, and unlocking the selected container for the user by wirelessly actuating a latch for a lid in the selected container from a mat that is communicatively coupled with the dispensing unit. The method also includes locking the selected container when the user verifies a transaction comprising the medication request, and updating a record and a medication inventory in a remote server based on the transaction. A storage location with one or more door enclosure and a container used in the above method are also provided.

Abstract: Systems are disclosed for a communication system optimized for low data volume communications. In embodiments of the invention, a terminal in the communication system is configured to send and a receiver in the network infrastructure is configured to receive bursts containing pilot waveforms that include time spacing and/or phase changes between short sequences. The time spacing and/or phase changes can be selected to reduce out-of-phase autocorrelation and achieve robust performance.