Abstract: The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of Formula (I) as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.

Abstract: A system and method for calculating, across one or more objects or portfolios, a probability distribution of values of a first parameter for one or more values of a second parameter (e.g., time). Probability distributions are assigned to each object at two or more different values of the second parameter. Each probability distribution defines a first parameter value distribution for that object at that particular value of the second parameter. Probability distributions of the first parameter across two or more objects or across a portfolio are calculated over changing values of the second parameter as a function of the probability distributions assigned to each object involved.

Abstract: A method including authorizing a user to access a dispensing unit upon receipt of a medication request, is provided. The dispensing unit comprises a storage location with one or more door enclosure storing at least one container. The method also includes providing a visual indicator to the user for a selected container in the storage location with one or more door enclosure, the selected container comprising a medication associated with the medication request, and unlocking the selected container for the user by wirelessly actuating a latch for a lid in the selected container from a mat that is communicatively coupled with the dispensing unit. The method also includes locking the selected container when the user verifies a transaction comprising the medication request, and updating a record and a medication inventory in a remote server based on the transaction. A storage location with one or more door enclosure and a container used in the above method are also provided.

Abstract: A smart carrier has a housing comprising one or more docking locations configured to accept a secure receptacle, a wireless interface module disposed within the housing, and a processor disposed within the housing and operatively coupled to the one or more docking locations and the wireless interface module. The processor is configured to communicate with an external device through the wireless interface module and with a secure receptacle that is mated with one of the one or more docking locations. The smart carrier also has a battery disposed within the housing and configured to provide all operational power to the processor, the wireless interface module, and the one or more docking locations.

Abstract: The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations.

Abstract: A medical device may be a loading tool including a tubular member having a lumen extending therethrough. The tubular member may include a distal portion and a proximal portion. The proximal portion of the tubular member may include a flexible member. The flexible member may be axially and radially adjustable between a first configuration and a second configuration. The distal portion of the tubular member may be configured to engage a valve, and the valve may be in communication with a lumen of an elongated medical device.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: A packaging is disclosed for a powdered material comprising a tub for receiving the material, the tub having a base and a peripheral wall with a top edge; an outer sleeve around at least the peripheral wall of the tub, thereby supporting the tub; a removable membrane for separating the powdered material in the tub from the environment; and a lid assembly comprising a peripheral rim for connection over the top edge of the peripheral wall of the tub and defining a wide access opening and a lid, hingedly attached to the rim for reclosing the access opening. Furthermore, a method of manufacturing a package for a powdered material is disclosed, comprising sliding the tub in the sleeve, such that at least the peripheral wall of the tub is enclosed by the sleeve, whereby the sleeve supports the tub and the tub and sleeve form a container for the powdered material.

Abstract: The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

Abstract: Embolic material delivery devices and methods of using them are disclosed. An example embolic material delivery assembly includes an outer member having a lumen extending therein and a distal end region, an inner member disposed within the lumen of the outer member, wherein the inner member includes a first lumen extending therein. The embolic material delivery assembly also includes a first embolic material extending within the first lumen of the inner member, the embolic material having a first distal end region. The embolic material delivery assembly also includes an anchor disposed within the lumen of the outer member, the anchor having a first attachment region. Further, the first distal end region of the first embolic material is coupled to the first attachment region of the anchor.

Abstract: A packaging for a powdered material includes a tub for receiving the material, the tub having a base and a peripheral wall with a top edge; an outer sleeve around at least the peripheral wall of the tub, thereby supporting the tub; a removable membrane for separating the powdered material in the tub from the environment; and a lid assembly having a peripheral rim for connection over the top edge of the peripheral wall of the tub and defining a wide access opening and a lid, hingedly attached to the rim for reclosing the access opening. A method of manufacturing such a package for a powdered material includes sliding the tub in the sleeve, such that at least the peripheral wall of the tub is enclosed by the sleeve, whereby sleeve supports the tub and the tub and sleeve form a container for the powdered material.

Abstract: A completion running tool includes a body that defines a central flow passage and one or more radial flow ports. A piston is coupled to the body at a releasable coupling and positioned for longitudinal movement within a piston chamber defined radially between the body and an outer shroud. A prop sleeve is positioned in the central passage and defines one or more apertures that facilitate fluid communication between the central passage and a piston setting chamber via the one or more radial flow ports. The prop sleeve is movable within the central flow passage between a first position, where the prop sleeve radially supports the releasable coupling and thereby prevents disengagement of the piston, and a second position, where the piston is able to disengage from the releasable coupling and move within the piston chamber.

Abstract: Presented is a closure assembly and a method for opening. The closure assembly includes a body, the body defining an opening and a body locking portion, and a lid, the lid moveably affixed to the body and comprising a lid locking portion, the lid locking portion configured to engage the body locking portion to releasably lock the lid in the closed position. The closure assembly also includes a hinge, the hinge being affixed to the lid and the body, the hinge configured to move the lid from a closed position occluding the opening of the body to an open position permitting passage through the opening, the hinge further configured to urge the lid into the open position, and at least one spring member.

Abstract: A smart carrier has a housing comprising one or more docking locations configured to accept a secure receptacle, a wireless interface module disposed within the housing, and a processor disposed within the housing and operatively coupled to the one or more docking locations and the wireless interface module. The processor is configured to communicate with an external device through the wireless interface module and with a secure receptacle that is mated with one of the one or more docking locations. The smart carrier also has a battery disposed within the housing and configured to provide all operational power to the processor, the wireless interface module, and the one or more docking locations.

Abstract: A sample analysis and medical data acquisition system for patient management includes a first user interface (UI) display module for displaying a medical chart page that includes selectable items associated with patient management. The first UI display module displays a set of medical delivery systems associated with a selectable medical delivery selection item, from which a medical delivery system is chosen. The system includes a second UI display module, in communication with the first UI display module, for displaying parameter fields for entry of operation data associated with the chosen medical delivery system. Medical data is captured from a patient by an analyzer configured to perform analysis of samples from the patient. The medical data is analyzed in accordance with entered operation data. The system includes an analysis display module, in communication with at least the first UI display module, for displaying sample analysis results.

Abstract: A fuel cell system and corresponding methods are provided. The fuel cell system includes a fuel cell stack configured for in-block reforming, as well as a pre-reformer. The fuel cell stack may include a plurality of fuel cells. The fuel cell stack may also include a fuel supply manifold, a fuel exhaust manifold, an oxidant supply manifold, and an oxidant exhaust manifold. The fuel supply manifold may be configured to receive fuel, and to supply the fuel to the fuel cell stack for in-block reforming. The fuel exhaust manifold may be configured to expel fuel exhaust from the fuel cell stack. The oxidant supply manifold may be configured to receive an oxidant and to supply the oxidant to the fuel cell stack for in-block reforming. The oxidant exhaust manifold may be configured to expel oxidant exhaust from the fuel cell stack.

Abstract: A fuel cell system and corresponding methods are provided. The fuel cell system includes a fuel cell stack configured for in-block reforming, as well as a pre-reformer. The fuel cell stack may include a plurality of fuel cells. The fuel cell stack may also include a fuel supply manifold, a fuel exhaust manifold, an oxidant supply manifold, and an oxidant exhaust manifold. The fuel supply manifold may be configured to receive fuel, and to supply the fuel to the fuel cell stack for in-block reforming. The fuel exhaust manifold may be configured to expel fuel exhaust from the fuel cell stack. The oxidant supply manifold may be configured to receive an oxidant and to supply the oxidant to the fuel cell stack for in-block reforming. The oxidant exhaust manifold may be configured to expel oxidant exhaust from the fuel cell stack.

Abstract: A completion string can have an outer surface and an inner surface, a first fluid passageway being defined between the outer surface and the inner surface. The inner surface can define an inner region of the completion string and can have a recess that is sized to receive a sleeve that is moveable between an open position and a closed position. The inner region can be sized to receive a work string at a position at which a surface of the work string cooperates with the sleeve and the inner surface of the completion string to define a first chamber on a side of the sleeve, the first chamber being hydraulically sealed by a plurality of sealing elements. The work string can define a second fluid passageway to provide fluid communication with the first chamber.

Abstract: A wagering game system and its operations are described herein. In some embodiments, the operations can include detecting that one or more wearable computers are within a proximity range to a wagering game machine. In some examples, the operations further include determining one or more characteristics associated with the one or more wearable computers in response to the detecting that the one or more wearable computers are within the proximity range to the wagering game machine. In some examples, the operations further include providing a feature associated with a wagering game based on the one or more characteristics of the one or more wearable computers.

Abstract: An aqueous fluid, possibly a wellbore fracturing fluid, comprises an aqueous solution or dispersion of a first polymer, which may be polysaccharide, as a thickener and a cross linking agent to enhance the viscosity of the fluid by crosslinking the first polymer, wherein the crosslinking agent is a second polymer comprising at least one polymer chain with phenyl boronate groups distributed along the polymer chain and the phenyl boronic acid groups have nitrogen attached to the phenyl group at a position which is meta relative to the boronate group.