Abstract: The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

Abstract: A smart carrier has a housing comprising one or more docking locations configured to accept a secure receptacle, a wireless interface module disposed within the housing, and a processor disposed within the housing and operatively coupled to the one or more docking locations and the wireless interface module. The processor is configured to communicate with an external device through the wireless interface module and with a secure receptacle that is mated with one of the one or more docking locations. The smart carrier also has a battery disposed within the housing and configured to provide all operational power to the processor, the wireless interface module, and the one or more docking locations.

Abstract: A system is described and includes a first track assembly for connecting a top surface of a pallet supporting payload to an upper interior surface of a payload bay of an aircraft; a second track assembly for connecting a side surface of the pallet to a side interior surface of the payload bay; and a pallet actuator system for selectively moving the pallet along the first and second track assemblies between a first position in which the pallet is fully extended from the payload bay and a second position in which the pallet is fully retracted into the payload bay.

Abstract: Computer-implemented methods, computer-readable storage media, and computer systems for associating received medical imaging data with stored medical imaging data. Medical imaging data associated with a patient is received from a client device. The medical imaging data includes an image object, one or more data objects related to the image object, and metadata associated with the patient encoded in Digital Imaging and Communication in Medicine (DICOM) format. The metadata includes personal information about the patient, and time and location at which the DICOM image file was captured. The received metadata is compared with existing metadata associated with multiple existing patients to identify a subset of the existing patients who may be a potential match to the patient. Selection of an existing patient from among the subset is requested. When received, the medical imaging data is associated with the existing patient.

Abstract: In an aspect, there is provided a temperature scanner for measuring a temperature of a selected area on a human subject having a first eye and a second eye. The temperature scanner includes an infra-red sensor, a first reflective surface region, a second reflective surface region, and a controller. The infra-red sensor has a selected field of view so as to detect a temperature of the selected area of the human subject when the selected area is positioned to completely fill the field of view. The first reflective surface region is concave, has a first principal axis, and has a first focal point along the first principal axis. The first reflective surface region and the second reflective surface region are positioned relative to the infra-red sensor such that positioning the first eye of the human subject at a selected first eye position and positioning the second eye of the human subject at a selected second eye position positions the selected area of the human subject to completely fill the field of view.

Abstract: Loading tools for use with medical devices are disclosed. An example loading tool may be suitable for use with a drug-coated expandable medical device. The loading tool may include a tubular sleeve having a distal end region, a proximal end region, and a lumen extending therethrough. The distal end region may include a reduced distal tip designed to interact with a hemostasis valve having a resilient seal member.

Abstract: This disclosure may generally relate to subterranean operations and, more particularly, to systems and methods for setting a packer. Specifically, embodiments of the present disclosure may provide real-time verification of setting a packer in order to form a seal within a wellbore. A system for packer setting may comprise a packer, a telemetry module operable to wirelessly receive one or more control signals from a surface location, and a control module coupled to the telemetry module and the packer, wherein the control module is operable to actuate the packer in response to the one or more control signals from the surface location.

Abstract: A method for improving designs of electronic message templates based on identified variations includes importing, by a capture engine executing on a first computing device, an email template into an email client. The method includes rendering the email template in the email client. The method includes generating a screen shot of a portion of the rendered email template. The method includes comparing, by a comparison engine, the generated screen shot with an archived screen shot of the rendered portion. The method includes determining that a first level of variation between the generated screen shot and the archived screen shot exceeds a first threshold level of variation. The method includes transmitting, by an alert engine executed by the first computing device, to a second computing device, a notification of the first level of variation and a recommendation to modify the email template to minimize the first level of variation.

Abstract: An apparatus for controlling fluid flow into a well includes an outer tubular member and an inner tubular member. The outer tubular member includes a screen configured to enable fluid flow therethrough between an exterior and an interior of the outer tubular member. The inner tubular member is configured to be positionable within the outer tubular member. The inner tubular member is a remotely activated flow control device configured to control fluid flow between an exterior and an interior of the inner tubular member.

Abstract: Methods and systems for a remote control flow path system in a wellbore. In one embodiment, the system comprises a plurality of transceivers spaced in the wellbore; a telemetry module operable to wirelessly receive control signals from a surface location by way of the plurality of transceivers and to wireless transmit signals to the surface location by way of the plurality of transceivers; a control module comprising a controller, a pump, and a reservoir of hydraulic fluid; a plurality of valves; and a plurality of control lines for the hydraulic fluid, wherein the plurality of control lines are disposed between the pump and the plurality of valves; wherein the control module is operable to hydraulically actuate one or more of the valves to open or closed positions in response to the control signals from the surface location to create one or more flow paths in the wellbore.

Abstract: The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

Abstract: A method for improving designs of electronic message templates based on identified variations includes importing, by a capture engine executing on a first computing device, an email template into an email client. The method includes rendering the email template in the email client. The method includes generating a screen shot of a portion of the rendered email template. The method includes comparing, by a comparison engine, the generated screen shot with an archived screen shot of the rendered portion. The method includes determining that a first level of variation between the generated screen shot and the archived screen shot exceeds a first threshold level of variation. The method includes transmitting, by an alert engine executed by the first computing device, to a second computing device, a notification of the first level of variation and a recommendation to modify the email template to minimize the first level of variation.

Abstract: Systems are disclosed for a communication system optimized for low data volume communications. In embodiments of the invention, a terminal in the communication system is configured to send and a receiver in the network infrastructure is configured to receive bursts containing pilot waveforms that include time spacing and/or phase changes between short sequences. The time spacing and/or phase changes can be selected to reduce out-of-phase autocorrelation and achieve robust performance.

Abstract: The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations.

Abstract: Methods and systems for a remote control flow path system in a wellbore. In one embodiment, the system comprises a plurality of transceivers spaced in the wellbore; a telemetry module operable to wirelessly receive control signals from a surface location by way of the plurality of transceivers and to wireless transmit signals to the surface location by way of the plurality of transceivers; a control module comprising a controller, a pump, and a reservoir of hydraulic fluid; a plurality of valves; and a plurality of control lines for the hydraulic fluid, wherein the plurality of control lines are disposed between the pump and the plurality of valves; wherein the control module is operable to hydraulically actuate one or more of the valves to open or closed positions in response to the control signals from the surface location to create one or more flow paths in the wellbore.

Abstract: Embodiments herein relate generally to the field of footwear, and more particularly to components of performance footwear, such as midsoles, and in particular related to a high performance composite foam for a midsole, the composite foam comprising: a pelletized expanded thermoplastic elastomer; and a polyurethane (PU) matrix, wherein the pelletized expanded thermoplastic elastomer is mixed within the PU matrix. Midsoles made from a high performance composite foam and footwear including such midsoles. A method of making a high performance midsole is also provided.

Abstract: A sleeve on a downhole work string or a completion string may be actuated without movement of the work string, by positioning the work string within the completion string such that a sleeve positioned in a recess on a surface the work string or the completion string, in combination with surfaces of the work string and the completion string define a chamber on a side of the sleeve. A fluid may be pumped from a fluid source through a fluid passageway in the work string to the chamber for forcing the sleeve to actuate from an open position to a closed position or vice versa. In some aspects, multiple sleeves may be actuated concurrently via additional fluid passageways that are in fluid communication with one another. In some aspects, multiple sleeves may be actuated independently via additional fluid passageways that are fluidly isolated from one another.

Abstract: The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

Abstract: A completion running tool includes a body that defines a central flow passage and one or more radial flow ports. A piston is coupled to the body at a releasable coupling and positioned for longitudinal movement within a piston chamber defined radially between the body and an outer shroud. A prop sleeve is positioned in the central passage and defines one or more apertures that facilitate fluid communication between the central passage and a piston setting chamber via the one or more radial flow ports. The prop sleeve is movable within the central flow passage between a first position, where the prop sleeve radially supports the releasable coupling and thereby prevents disengagement of the piston, and a second position, where the piston is able to disengage from the releasable coupling and move within the piston chamber.

Abstract: The invention relates to methods for CC bond formation using organolithium compounds under continuous flow conditions in a micro or mesoreactor system, wherein an organic substrate is reacted with an alkyl lithium compound in the presence of a donor solvent to form a Li intermediate, which can be reacted in situ or subsequently in a second reaction step with an electrophile to form an organic secondary product, the organolithium compound RLi being used as a solution in a hydrocarbon or hydrocarbon mixture and the RLi concentration being at least 3 M, preferably at least 4 M.