Patents by Inventor Georg Thierbach

Georg Thierbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10829746
    Abstract: A bacterium of the species Corynebacterium glutamicum has the ability to excrete L-lysine, and contains in its chromosome a polynucleotide encoding a mutated polypeptide having the assumed function of an acyltransferase, hydrolase, alpha/beta hydrolase or of a pimeloyl-ACP methyl ester esterase. Also, a method is used for producing L-lysine using such bacterium.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: November 10, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Frank Schneider, Georg Thierbach, Kornelia Voß, Thomas Bekel
  • Publication number: 20200231946
    Abstract: A bacterium of the species Corynebacterium glutamicum has the ability to excrete L-lysine, and contains in its chromosome a polynucleotide encoding a mutated polypeptide having the assumed function of an acyltransferase, hydrolase, alpha/beta hydrolase or of a pimeloyl-ACP methyl ester esterase. Also, a method is used for producing L-lysine using such bacterium.
    Type: Application
    Filed: December 18, 2019
    Publication date: July 23, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Frank Schneider, Georg Thierbach, Kornelia Voss, Thomas Bekel
  • Patent number: 10717999
    Abstract: A method is useful for the fermentative production of L-lysine using a C. glutamicum strain having a mutated Kup transporter.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: July 21, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Thomas Bekel, Kornelia Voss, Georg Thierbach, Frank Schneider
  • Patent number: 10689677
    Abstract: A method is used for the fermentative production of L-lysine using bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine and containing in their chromosome a mutated NCgl2816 polynucleotide. Further, the method is used for cultivating the bacteria in a suitable medium under suitable conditions, and accumulating said L-lysine in the suitable medium to form an L-lysine containing fermentation broth.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: June 23, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Frank Schneider, Georg Thierbach, Thomas Bekel, Kornelia Voβ
  • Publication number: 20200190546
    Abstract: A method is useful for the fermentative production of L-lysine using a C. glutamicum strain having a mutated Kup transporter.
    Type: Application
    Filed: December 3, 2019
    Publication date: June 18, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Thomas Bekel, Kornelia Voss, Georg Thierbach, Frank Schneider
  • Patent number: 10683511
    Abstract: The present invention provides a bacterium of the genus Corynebacterium, in particular of the species Corynebacterium glutamicum, having the ability to excrete an L-amino acid selected from proteinogenic L-amino acids and L-omithine and new measures for the fermentative production of proteinogenic L-amino acids and L-ornithine by such bacteria.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: June 16, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Georg Thierbach, Thomas Bekel, Kornelia Voss
  • Publication number: 20200095622
    Abstract: A method is used for the fermentative production of L-lysine using bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine and containing in their chromosome a mutated NCgl2816 polynucleotide. Further, the method is used for cultivating the bacteria in a suitable medium under suitable conditions, and accumulating said L-lysine in the suitable medium to form an L-lysine containing fermentation broth.
    Type: Application
    Filed: September 18, 2019
    Publication date: March 26, 2020
    Applicant: Evonik Operations GmbH
    Inventors: Frank SCHNEIDER, Georg Thierbach, Thomas Bekel, Kornelia Voss
  • Publication number: 20200032306
    Abstract: A novel method is used for the fermentative production of L-lysine using bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine, containing in their chromosome a variant of a polynucleotide encoding a polypeptide having hydrolase activity. The bacteria are cultivated in a suitable medium under suitable conditions, and then L-lysine is accumulated in the medium to form an L-lysine containing fermentation broth.
    Type: Application
    Filed: July 19, 2019
    Publication date: January 30, 2020
    Applicant: Evonik Degussa GmbH
    Inventors: Frank SCHNEIDER, Georg Thierbach, Kornelia Voss, Thomas Bekel
  • Publication number: 20200017893
    Abstract: A novel method is for the fermentative production of L-lysine using bacteria of the species Corynebacterium glulamicum. The bacteria have the ability to excrete L-lysine and contain in their chromosome a polynucleotide, which encodes a polypeptide having the activity of a transcriptional factor. An amino acid at a particular position of the amino acid sequence of the polypeptide has been substituted by a different proteinogenic amino acid.
    Type: Application
    Filed: July 10, 2019
    Publication date: January 16, 2020
    Applicant: Evonik Degussa GmbH
    Inventors: Thomas BEKEL, Frank Schneider, Georg Thierbach, Kornelia Voß
  • Patent number: 10533200
    Abstract: The present invention relates to polynucleotides encoding novel fusion polypeptides essentially composed of a signal peptide for membrane translocation and a polypeptide providing ?-1,6-glucosidase activity and to bacteria containing said polynucleotides. The invention further relates to methods for producing fine chemicals using media containing isomaltose and/or panose as carbon source.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: January 14, 2020
    Assignee: Evonik Degussa GmbH
    Inventors: Kornelia Voss, Michaela Voss, Georg Thierbach
  • Publication number: 20190185890
    Abstract: The present invention makes available novel L-lysine excreting bacteria of the species Corynebacterium glutamicum, having the ability to excrete L-lysine, containing in their chromosome a polynucleotide encoding a polypeptide having the activity of a malate:quinone reductase wherein the amino acid at position 228 of the amino acid sequence of the polypeptide contains any proteinogenic amino acid different from valine and a method for producing L-lysine using such bacteria.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 20, 2019
    Inventors: Kornelia VOSS, Georg THIERBACH, Thomas BEKEL
  • Publication number: 20190106721
    Abstract: A method for the fermentative production of an L-amino acid, selected from L-lysine, L-threonine and L-isoleucine, includes cultivating a bacterium of the genus Corynebacterium having the ability to excrete said L-amino acid in a suitable medium under suitable conditions. The method also includes accumulating said L-amino acid in the medium to form an L-amino acid containing fermentation broth. Said bacterium comprises a polynucleotide coding for a polypeptide conferring a resistance to lincosamides which has been modified by deleting or replacing at least parts of said polynucleotide and at least one copy of a gene coding for a feedback resistant aspartokinase.
    Type: Application
    Filed: October 2, 2018
    Publication date: April 11, 2019
    Applicant: Evonik Degussa GmbH
    Inventors: Thomas BEKEL, Georg Thierbach, Kornelia Voß
  • Publication number: 20190085340
    Abstract: The present invention provides a bacterium of the genus Corynebacterium, in particular of the species Corynebacterium glutamicum, having the ability to excrete an L-amino acid selected from proteinogenic L-amino acids and L-omithine and new measures for the fermentative production of proteinogenic L-amino acids and L-ornithine by such bacteria.
    Type: Application
    Filed: September 17, 2018
    Publication date: March 21, 2019
    Inventors: Georg Thierbach, Thomas Bekel, Kornelia Voss
  • Publication number: 20180363014
    Abstract: The present invention relates to polynucleotides encoding novel fusion polypeptides essentially composed of a signal peptide for membrane translocation and a polypeptide providing ?-1,6-glucosidase activity and to bacteria containing said polynucleotides. The invention further relates to methods for producing fine chemicals using media containing isomaltose and/or panose as carbon source.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 20, 2018
    Inventors: Kornelia VOSS, Michaela VOSS, Georg THIERBACH
  • Patent number: 8592187
    Abstract: The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: November 26, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Wilfried Claes, Silke Jerrentrup, Caroline Kreutzer, Georg Thierbach
  • Patent number: 8592177
    Abstract: The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
    Type: Grant
    Filed: January 21, 2012
    Date of Patent: November 26, 2013
    Assignees: Evonik Degussa GmbH, Forschungszentrum Jülich GmbH
    Inventors: Brigitte Bathe, Georg Thierbach, Volker Wendisch, Verena Engels, Bernhard Eikmanns, Bastian Blombach
  • Publication number: 20130142937
    Abstract: The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
    Type: Application
    Filed: February 15, 2011
    Publication date: June 6, 2013
    Inventors: Brigitte Bathe, Wilfried Claes, Silke Jerrentrup, Caroline Kreutzer, Georg Thierbach
  • Patent number: 8343734
    Abstract: The invention relates to processes for fermentative production of L-proline using bacteria which contain mutated variants of the proB gene.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: January 1, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Georg Thierbach
  • Patent number: 8334126
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: December 18, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Andreas Tauch, Michael Binder, Walter Pfefferle, Georg Thierbach, Jörn Kalinowski, Alfred Pühler
  • Patent number: 8293514
    Abstract: An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: October 23, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Caroline Kreutzer, Georg Thierbach