Patents by Inventor Georg Thierbach

Georg Thierbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7214526
    Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: May 8, 2007
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Stephan Hans, Natalie Schischka, Georg Thierbach
  • Publication number: 20070092951
    Abstract: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Application
    Filed: November 22, 2005
    Publication date: April 26, 2007
    Applicant: Degussa AG
    Inventors: Brigitte Bathe, Natalie Schischka, Georg Thierbach
  • Publication number: 20070092950
    Abstract: The invention provides an improved process for the fermentative preparation of L-threonine using L-threonine-producing bacteria from the family Enterobacteriaceae.
    Type: Application
    Filed: July 29, 2004
    Publication date: April 26, 2007
    Applicant: Degussa AG
    Inventors: Daniela Kruse, Thomas Hermann, Georg Thierbach, Mechthild Rieping
  • Patent number: 7160711
    Abstract: The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: January 9, 2007
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Caroline Kreutzer, Bettina Mockel, Georg Thierbach
  • Publication number: 20060252133
    Abstract: The invention relates to an improved process for the fermentative preparation of L-threonine using bacteria of the Enterobacteriaceae family which produce L-threonine.
    Type: Application
    Filed: July 27, 2004
    Publication date: November 9, 2006
    Applicant: Degussa AG
    Inventors: Daniela Kruse, Thomas Hermann, Georg Thierbach, Mechthild Rieping
  • Publication number: 20060246554
    Abstract: The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
    Type: Application
    Filed: September 16, 2005
    Publication date: November 2, 2006
    Applicant: Degussa AG
    Inventors: Georg Thierbach, Brigitte Bathe, Natalie Schischka
  • Publication number: 20060166338
    Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
    Type: Application
    Filed: January 18, 2006
    Publication date: July 27, 2006
    Applicant: Degussa AG
    Inventors: Brigitte Bathe, Stephan Hans, Natalie Schischka, Georg Thierbach
  • Publication number: 20060014259
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an amplified gene encoding the Zwischenferment protein.
    Type: Application
    Filed: March 6, 2002
    Publication date: January 19, 2006
    Inventors: Kevin Burke, Hermann Sahm, Lothar Eggeling, Bernd Moritz, L. Dunican, Ashling McCormack, Cliona Stapelton, Bettina Mockel, Georg Thierbach, Rita Dunican
  • Publication number: 20050271768
    Abstract: The invention relates to sulfur-containing animal-feed additives produced from fermentation liquors, and to processes for their production.
    Type: Application
    Filed: August 11, 2003
    Publication date: December 8, 2005
    Applicant: DEGUSSA AG
    Inventors: Michael Buchholz, Michael Binder, Thomas Hermann, Walter Pfefferle, Georg Thierbach
  • Publication number: 20050266535
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metE gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.
    Type: Application
    Filed: June 29, 2005
    Publication date: December 1, 2005
    Applicant: DEGUSSA AG
    Inventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Michael Binder, Dieter Greissinger, Georg Thierbach, Alfred Puehler
  • Patent number: 6958228
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metH gene is present in enhanced form, and use of the polynucleotide sequences as hybridization probes.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: October 25, 2005
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Publication number: 20050233373
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metH gene is present in enhanced form, and use of the polynucleotide sequences as hybridization probes.
    Type: Application
    Filed: June 20, 2005
    Publication date: October 20, 2005
    Applicant: DEGUSSA AG
    Inventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Publication number: 20050233424
    Abstract: Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
    Type: Application
    Filed: July 26, 2004
    Publication date: October 20, 2005
    Applicant: DEGUSSA AG
    Inventors: Mike Farwick, Klaus Huthmacher, Natalie Schischka, Brigitte Bathe, Walter Pfefferle, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Publication number: 20050221451
    Abstract: The present invention relates to a fermentation process for the preparation of L-amino acids in which the following steps are carried out (a) fermentation of the microorganisms of the family Enterobacteriaceae producing the desired L-amino acid, in which microorganisms' pckA gene, and/or the open reading frames of yjfA and ytfP are individually or jointed inactivated by one or methods of mutagenesis selected from the group consisting of deletion, insertional mutagenesis due to homologous recombination, and transition or tranversion mutagenesis with incorporation of a non-sense mutation in the ytfP and ytfA gene, concentration of the fermentation broth to eliminate water and increase the concentration of said L-amino acids in the broth and E. coli, and isolation of the L-amino acids.
    Type: Application
    Filed: May 27, 2005
    Publication date: October 6, 2005
    Applicant: Degussa AG
    Inventors: Mechthild Rieping, Christine Bastuck, Thomas Hermann, Georg Thierbach
  • Patent number: 6942996
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID. No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and p1 d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metE gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: September 13, 2005
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Patent number: 6916637
    Abstract: The invention relates to a fermentation process for the preparation of L-amino acids, especially L-threonine, in which the following steps are carried out: a) fermentation of the microorganisms of the family Enterobacteriaceae producing the desired L-amino acid, in which microorganisms at least the pckA gene and/or the open reading frames yjfA and ytfP are, individually or jointly, attenuated and, in particular, switched off, b) enrichment of the L-amino acid in the medium or in the bacterial cells, and c) isolation of the L-amino acid.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: July 12, 2005
    Assignee: Degussa AG
    Inventors: Mechthild Rieping, Christine Bastuck, Thomas Hermann, Georg Thierbach
  • Patent number: 6913909
    Abstract: The invention relates to preferably recombinant DNA derived from Corynebacterium and replicable in coryneform microorganisms, which contains at least one nucleotide sequence that codes for the thrE gene, and a process for the production of L-threonine, which is characterised in that the following steps are carried out: a) Fermentation of microorganisms in which at least the thrE gene is amplified (overexpressed), optionally in combination with further genes, b) Enrichment of the L-threonine in the medium or in the cells of the microorganisms, and c) Isolation of the L-threonine.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: July 5, 2005
    Assignee: Degussa AG
    Inventors: Petra Ziegler, Lothar Eggeling, Hermann Sahm, Georg Thierbach
  • Patent number: 6911329
    Abstract: The invention relates to a process for preparing D-pantothenic acid using Coryneform bacteria in which the poxB gene is attenuated.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: June 28, 2005
    Assignee: Degussa AG
    Inventors: Nicole Dusch, Hermann Thomas, Georg Thierbach
  • Publication number: 20050112733
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an amplified gene encoding the Zwischenferment protein.
    Type: Application
    Filed: December 30, 2004
    Publication date: May 26, 2005
    Inventors: Kevin Burke, Hermann Sahm, Lothar Eggeling, Bernd Moritz, L. Dunican, Ashling McCormack, Cliona Stapleton, Bettina Mockel, Georg Thierbach, Rita Dunican
  • Publication number: 20050064551
    Abstract: The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 24, 2005
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach