Patents by Inventor Georg Thierbach

Georg Thierbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7666634
    Abstract: The present invention relates to a fermentation process for the preparation of L-amino acids in which the following steps are carried out: (a) fermentation of the microorganisms of the family Enterobacteriaceae producing the desired L-amino acid, in which microorganisms' open reading frames of yjfA and ytfP are individually or jointly inactivated by one or more methods of mutagenesis selected from the group consisting of deletion, insertional mutagenesis due to homologous recombination, and transition or tranversion mutagenesis with incorporation of a non-sense mutation in the yjfA and ytfP gene region; (b) concentration of the fermentation broth to eliminate water and increase the concentration of said L-amino acids; and (c) isolation of the L-amino acids.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: February 23, 2010
    Assignee: Evonik Degussa GmbH
    Inventors: Mechthild Rieping, Christine Bastuck, Thomas Hermann, Georg Thierbach
  • Publication number: 20100009035
    Abstract: The invention relates to sulfur-containing animal-feed additives produced from fermentation liquors, and to processes for their production.
    Type: Application
    Filed: December 14, 2007
    Publication date: January 14, 2010
    Applicant: DEGUSSA AG
    Inventors: Michael BUCHHOLZ, Michael Binder, Thomas Hermann, Walter Pfefferle, Georg Thierbach
  • Publication number: 20090325242
    Abstract: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Application
    Filed: July 28, 2009
    Publication date: December 31, 2009
    Applicant: Degussa AG
    Inventors: Brigitte Bathe, Natalie Schischka, Georg Thierbach
  • Patent number: 7618798
    Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: November 17, 2009
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Stephan Hans, Natalie Schischka, Georg Thierbach
  • Patent number: 7585650
    Abstract: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: September 8, 2009
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Natalie Schischka, Georg Thierbach
  • Publication number: 20090221043
    Abstract: The invention relates to mutated variants of the proB gene from coryneform bacteria, which encode ?-glutamyl kinase, and to processes for fermentative production of L-proline using bacteria which contain this mutation.
    Type: Application
    Filed: December 13, 2005
    Publication date: September 3, 2009
    Applicant: DEGUSSA GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Georg Thierbach
  • Patent number: 7563602
    Abstract: The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: July 21, 2009
    Assignee: Degussa AG, Intellectural Property Management
    Inventors: Georg Thierbach, Brigitte Bathe, Natalie Schischka
  • Publication number: 20090117624
    Abstract: The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
    Type: Application
    Filed: September 19, 2008
    Publication date: May 7, 2009
    Applicants: Evonik Degussa GmbH, Forschungszentrum Julich GmbH
    Inventors: Brigitte Bathe, Bastian Blombach, Bernhard Eikmanns, Verena Engels, Georg Thierbach, Volker Wendisch
  • Publication number: 20090053794
    Abstract: An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
    Type: Application
    Filed: October 16, 2007
    Publication date: February 26, 2009
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Brigitte Bathe, Caroline Kreutzer, Georg Thierbach
  • Publication number: 20080274265
    Abstract: An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described.
    Type: Application
    Filed: October 25, 2007
    Publication date: November 6, 2008
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Brigitte BATHE, Caroline Kreutzer, Georg Thierbach
  • Publication number: 20080261269
    Abstract: The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
    Type: Application
    Filed: November 9, 2007
    Publication date: October 23, 2008
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: Brigitte Bathe, Wilfried Claes, Silke Jerrentrup, Caroline Kreutzer, Georg Thierbach
  • Publication number: 20080131903
    Abstract: The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
    Type: Application
    Filed: January 18, 2008
    Publication date: June 5, 2008
    Applicant: EVONIK DEGUSSA Gmbh
    Inventors: Georg THIERBACH, Brigitte Bathe, Natalie Schischka
  • Publication number: 20080131927
    Abstract: The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Application
    Filed: May 15, 2006
    Publication date: June 5, 2008
    Inventors: Natalie Schischka, Brigitte Bathe, Georg Thierbach
  • Patent number: 7348037
    Abstract: The invention relates to sulfur-containing animal-feed additives produced from fermentation liquors, and to processes for their production.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: March 25, 2008
    Assignee: Evonik Degussa GmbH
    Inventors: Michael Buchholz, Michael Binder, Thomas Hermann, Walter Pfefferle, Georg Thierbach
  • Patent number: 7338792
    Abstract: The invention provides a process for the preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the Bacillus group, in particular those which already produce D-pantothenic acid, which comprises enhancing, in particular over-expressing, in the microorganisms one or more of the nucleotide sequence(s) which code(s) for the gene or ORF ybbT, ywkA, yjmC, ytsJ, mdh, cysK, iolJ, pdhD, yuiE, dhaS, adk, yusH, yqhJ, yqjK and yqhI.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: March 4, 2008
    Assignee: Degussa AG
    Inventors: Daniela Kruse, Georg Thierbach
  • Patent number: 7338790
    Abstract: The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: March 4, 2008
    Assignee: Degussa AG, Intellectual Property Management
    Inventors: Georg Thierbach, Brigitte Bathe, Natalie Schischka
  • Publication number: 20070224666
    Abstract: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Application
    Filed: April 23, 2007
    Publication date: September 27, 2007
    Applicant: Degussa AG
    Inventors: Brigitte Bathe, Natalie Schischka, Georg Thierbach
  • Patent number: 7262034
    Abstract: The invention provides a process for the fermentative preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the Bacillus group, in particular those which already produce D-pantothenic acid, which comprises enhancing, in particular over-expressing, in the microorganisms one or more of the nucleotide sequence(s) which code(s) for the gene or ORF serA, serC, ywpJ or glyA.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: August 28, 2007
    Assignee: Degussa AG
    Inventors: Daniela Kruse, Georg Thierbach
  • Publication number: 20070141680
    Abstract: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
    Type: Application
    Filed: February 14, 2007
    Publication date: June 21, 2007
    Applicant: Degussa AG
    Inventors: Brigitte Bathe, Stephan Hans, Natalie Schischka, Georg Thierbach
  • Publication number: 20070111291
    Abstract: The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
    Type: Application
    Filed: December 18, 2006
    Publication date: May 17, 2007
    Inventors: Brigitte Bathe, Caroline Kreutzer, Bettina Mockel, Georg Thierbach