Abstract: A new treatment schedule for administration of N-?2-(dimethylamino)ethyl!acridine-4-carboxamide and other related carboxamide anticancer drugs in which the drug is administered in a divided-dose schedule comprising two or more administrations at frequent intervals, for example every hour. Schedules to produce cyclic peaks/troughs in plasma levels are mentioned. The compounds can be used for circumventing multidrug resistance in cancers and may, for example, be used in combination with other cytotoxic drugs, especially non-topo II inhibitors. Treatment of melanoma and advanced colon cancer is included.

Abstract: Novel 4-substituted amino benzothieno?3,2-d!pyrimidine and 4-substituted amino?2,3-d!pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Abstract: A motor coach designed generally for highway travel has a passenger compartment between sides of the coach and forwardly of the rear wall of the coach and defined above a raised floor of the coach. Underneath the floor is provided an engine compartment behind the rear wheels of the coach and luggage compartment forward of the rear wheels. A lavatory compartment is located at the junction between the rear wall and one side wall and immediately forwardly of the lavatory compartment is provided a floor area on which the rear seats at that side of the coach can be moved forwardly to a stored position to form an open area of the coach aligned with a wheel chair lift mounted in the engine compartment and arranged to lift a passenger from the ground onto the floor of the coach into the area forwardly of the lavatory compartment.

Abstract: A method for treating patients having erectile dysfunction is described. The method involves treating patients with a renin-angiotensin system inhibitor. A method for treating a subject to improve erectile function is also described. The method involves treating patients with a renin-angiotensin system inhibitor. Preferably the inhibitor is an angiotensin II antagonist, an ACE inhibitor, or a renin inhibitor.

Abstract: Novel 4-substituted amino pyrido pyrimidine and 4-substituted amino pyrido pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinase are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Abstract: A programmable workstation for collaborative working in a network comprises a conventional operating system and a network control program layer. Additionally, the workstation includes a collaborative application support subsystem for interfacing with application programs. The subsystem is responsive to predetermined application program calls to create a logical network model of a collaborative environment. The model comprises sharing sets of application programs, which share data and resources across nodes and logical dedicated data channels connecting members of the sharing set. The subsystem cooperates with the network layer to establish the physical links necessary to implement the model in a physical network, transparently to the application program.

Abstract: A garden arrangement including a conveyor assembly with a plurality of longitudinally spaced mounting means supporting containers utilizing growth material, the conveyor being arranged along a predetermined path whereby the containers may be successively advanced to an accessible location for tending by a gardener.

Abstract: Location apparatus for making saw cuts in workpieces has a saw guide and support means for a workpiece to set a side face of the workpiece at predetermined positions to the saw guide. In various forms of the apparatus, said positions are angularly adjustable in horizontal and/or vertical planes. Means are also described for setting the workpiece to a predetermined location transversely of the sawing plane defined by said saw guide.

Abstract: A novel exhaust gas recirculation (EGR) control system comprises an EGR valve having an inlet control port connected through a normally closed solenoid-actuated valve to venturi vacuum tap of the caburetor. The solenoid-actuated valve is controllably energized via an electrical control circuit which monitors a number of engine operational characteristics. In the preferred embodiment, these monitored characteristics include: the amount of throttle blade opening; the magnitude of intake manifold vacuum; the relative durations of idle and non-idle operation during a immediately past time period; and the engine temperature. Individual electrical control signals are derived for each of the monitored characteristics and the value of each signal indicates whether the correspondingoperating characteristic is commanding the solenoid-actuated valve to be energized.

Abstract: A deep-hole boring head comprising a body member arranged to support a boring tool at one end and to be attached to a boring bar at the other end, the body member being provided with a number of guidance members in strip form adjustably mounted thereon and arranged during use of the boring head to contact the surface of the hole bored by the boring tool so as to guide the tool during the boring of a deep hole, and adjustment means connected with the guidance members and arranged, on movement of the guidance members in directions substantially parallel to their longitudinal axes, to adjust the radial distances of the guidance members from the center line of the hole to be bored.

Abstract: The method comprises introducing a mixture of uncured epoxy resin and curing agent in a coolant passage adjacent an exhaust passage and curing the resin into a solid insulating layer against the walls of the coolant passage.

Abstract: A road vehicle battery charging system includes an alternator and a rectifier assembly connected to apply d.c. to the battery. A further rectifier provides d.c. to a separate line from which current is drawn for the field coil under the control of a voltage regulator. The line is connected via a series circuit including a resistor and the vehicle ignition switch to one side of the battery, this resistor forming part of a switching circuit which operates a warning lamp whenever the voltage on the separate line is substantially less than voltage on said one side of the battery.

Abstract: 3. Automatic target following apparatus comprisingA. sensing means for deriving a video signal representing a target,B. means for storing signal elements from a frame of said video signal,C. means for comparing signal elements from a subsequent frame of said video signal with the stored signal elements with different relative phase shifts to detect deviation from a desired point of view of the target,D. said comparing means including means for deriving a plurality of correlation signals dependent on the correlations of the signal elements from said subsequent frame and said stored signal elements with different relative phase shifts,E. means for deriving a guidance signal for the apparatus responsive to the largest of said correlation signals,F. means for detecting a decline in the correlation of signal elements from said subsequent frame with said stored signal elements, andG.

Abstract: A road vehicle battery charging system includes an alternator, and a rectifier connecting the alternator across a battery. A further rectifier provides an additional d.c. output for energising the field winding of the alternator and this additional output is connected to the appropriate battery terminal via an ignition switch. A voltage sensing circuit operates to illuminate a warning lamp should the voltage on the line exceed a predetermined level.

Abstract: A sawing location apparatus adapted to be placed on a workpiece has a bearing engagement for the workpiece to one side of a saw guide device and a location device on the other side of the saw guide device for setting the workpiece to a desired position in a direction transverse to the cutting plane defined by the saw guide device. Arrangements are described for making right-angled and oblique transverse cuts in an elongate workpiece as well as longitudinally directed cuts in an end face of such a workpiece.