Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.

Abstract: A hose or cable protector has a pair of articulating guides, each with rollers for creating an arcuate hose path around the sharp corner of a tunnel mouth which would otherwise cause abrasion to the hose. A stop imposes a guide to guide angle of eighty (80) degrees but the usual angle is greater and up to one hundred and twenty (120) degrees. Arches span the guides and retain the protector on the hose or cable. In a variant, the arches are spring loaded and adjustable to retain or release the hose. A control line positions the protector at the selected site.

Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

Abstract: The present invention is directed to a bitumen bale capsule, capsule dispenser and bale strip former for viscous bitumen products comprising a bitumen bale capsule; a capsule dispenser (L) in order to position the said PE encapsulating capsule inline with a plurality of dispensing valves (F) and a plurality of forming nozzles (M); a bitumen bale strip former for converting the said round PE encapsulated tubes into flat strips suitable for baling. The overall function of the said bitumen bale capsule is to encapsulate viscous bituminous products forcing through the internal core of the said capsule. The said products exiting the said encapsulation process in the form of a PE round tube are converted into a flat strip suitable for baling utilizing both of the said capsule dispenser and the said bale strip former.

Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

Abstract: A fuel filter for removing fuel impurities, particularly thiophenes, includes a hollow housing having a filter element therein. The filter element includes a substrate, which may include a nonwoven fiber web, a plurality of particles, or both of these. Where particles are used, the substrate may be homogeneous or may be a mixture of different particles. The substrate may include a sorbent selected from the group consisting of metals, metal oxides, metallic salts, organometallic compounds, catalysts, and oxidizing agents. Optionally, a sulfur-treating reactant may be operatively associated with the substrate to reduce the concentration of thiophenes in fuel passing through the filter.

Abstract: An apparatus for communicating using multiple channels. The apparatus includes a first radio receiver and a controller. The first radio receiver is configured to produce a first receive signal in response to a first radio frequency signal in a first frequency band. The controller has a first receive input for receiving the first receive signal, an audio input for receiving an audio in signal, a selector input for receiving a selector signal, an audio output for producing an audio out signal and a first transmitter output for producing a first transmitter signal. The first transmit output is configured for communication with a radio transmitter operable to transmit a second radio frequency signal in a second frequency band different from the first frequency band.

Abstract: A process for preparing bitumen bale for clean, safe, eco-friendly and cost-effective packing, storing and transporting of viscous bitumen products and the products thereof is delineated in the present disclosure. The said bituminous products being introduced into a baling process line. The cooling efficiency is enhanced by utilizing the process of the present invention. Viscous bitumen products are made in the form of spiral bitumen bale. “BituBale Film capsules” are produced by the process of the present invention. Polymer additives are added to bitumen/asphalt, by the said process, to enhance the durability and to get good gripping surfaces. The said process enhances the homogenous nature of the said products. The process for preparing bitumen bale for clean, safe, eco-friendly and cost-effective packing, storing and transporting of viscous bitumen products is a clean, safe, environmentally friendly and cost effective method.

Abstract: A fuel filter for removing fuel impurities, particularly thiophenes, includes a hollow housing having a filter element therein. The filter element includes a substrate, which may include a nonwoven fiber web, a plurality of particles, or both of these. Where particles are used, the substrate may be homogeneous or may be a mixture of different particles. The substrate may include a sorbent selected from the group consisting of metals, metal oxides, metallic salts, organometallic compounds, catalysts, and oxidizing agents. Optionally, a sulfur-treating reactant may be operatively associated with the substrate to reduce the concentration of thiophenes in fuel passing through the filter.

Abstract: An improved oil conditioning filter, for use with an internal combustion engine, includes a mechanically active filter element and a chemically active filter element containing a beneficial additive therein. The beneficial additive is provided to extend the useful life of lubricating oil in an internal combustion engine. The beneficial additive may include an antioxidant, an anti-wear agent, and/or a basic salt. In a preferred embodiment of the invention, the chemically active conditioning agent is provided in a plurality of particles disposed within the oil filter housing. The particles may be bonded together to form an integral porous filter element having spaces defined between the particles thereof. The particles are made either by a hot extrusion process or by a solvent process.

Abstract: A case (1), such as a suitcase or trolley case, with a seat (6) is disclosed. The case has a channel (7A, 7B) provided near or along a surface (such as the rear surface 4B) of the case, and the seat is movable between a first stowed position in which the seat is held within the channel and a second seating position in which at least part of the seat lies substantially flat along the top surface (4C) of the case. The seat may be stowed within a pocket (5) along the surface of the case, with the channel being housed inside the pocket. Alternatively, the surface of the seat may also act as the case surface when the seat is in the stowed position.

Abstract: A fuel filter for removing fuel impurities, particularly thiophenes, includes a hollow housing having a filter element therein. The filter element includes a substrate, which may include a nonwoven fiber web, a plurality of particles, or both of these. Where particles are used, the substrate may be homogeneous or may be a mixture of different particles. The substrate may include a sorbent selected from the group consisting of metals, metal oxides, metallic salts, organometallic compounds, catalysts, and oxidizing agents. Optionally, a sulfur-treating reactant may be operatively associated with the substrate to reduce the concentration of thiophenes in fuel passing through the filter.

Abstract: An improved oil conditioning filter, for use with an internal combustion engine, includes a mechanically active filter element and a chemically active filter element having a reactive basic conditioner therein. The reactive basic conditioner is provided to counteract acidic combustion products in lubricating oil in an internal combustion engine. In a preferred embodiment of the invention, the chemically active conditioning agent is provided in a plurality of pellets disposed within the oil filter housing. The pellets may be bonded together to form an integral porous filter element having spaces defined between the pellets thereof. The pellets are made of a mixture including a polymeric binder and the chemically active conditioning agent, in a defined weight ratio and in a narrow range of particle sizes. The chemically active filter element reacts with acids present in the oil to form a product which may be filtered out of the oil. The pellets are made either by a hot extrusion process or by a solvent process.

Abstract: An improved oil conditioning filter, for use with an internal combustion engine, includes a mechanically active filter element and a chemically active filter element containing a beneficial additive therein. The beneficial additive is provided to extend the useful life of lubricating oil in an internal combustion engine. The beneficial additive may include an antioxidant, an anti-wear agent, and/or a basic salt. In a preferred embodiment of the invention, the chemically active conditioning agent is provided in a plurality of particles disposed within the oil filter housing. The particles may be bonded together to form an integral porous filter element having spaces defined between the particles thereof. The particles are made either by a hot extrusion process or by a solvent process.

Abstract: The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.

Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

Abstract: The present invention provides methods for the treatment or prophylaxis of one or more aldosterone-mediated pathogenic effects in a subject suffering from or susceptible to the pathogenic effect or effects wherein the subject has one or more conditions selected from the group consisting of a sub-normal endogenous aldosterone level, salt sensitivity and an elevated dietary sodium intake. The methods comprise administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds that are aldosterone antagonists.

Abstract: Disclosed are compounds of Formulae (Ia), (Ib), (Ic), (Id) wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3–7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.

Abstract: The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

Abstract: The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis.