Abstract: The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

Abstract: A fuel filter for removing fuel impurities, particularly thiophenes, includes a hollow housing having a filter element therein. The filter element includes a substrate, which may include a nonwoven fiber web, a plurality of particles, or both of these. Where particles are used, the substrate may be homogeneous or may be a mixture of different particles. The substrate may include a sorbent selected from the group consisting of metals, metal oxides, metallic salts, organometallic compounds, catalysts, and oxidizing agents. Optionally, a sulfur-treating reactant may be operatively associated with the substrate to reduce the concentration of thiophenes in fuel passing through the filter.

Abstract: Disclosed are compounds of the Formula I 1

Abstract: An improved oil conditioning filter, for use with an internal combustion engine, includes a mechanically active filter element and a chemically active filter element having a reactive basic conditioner therein. The reactive basic conditioner is provided to counteract acidic combustion products in lubricating oil in an internal combustion engine. In a preferred embodiment of the invention, the chemically active conditioning agent is provided in a plurality of pellets disposed within the oil filter housing. The pellets may be bonded together to form an integral porous filter element having spaces defined between the pellets thereof. The pellets are made of a mixture including a polymeric binder and the chemically active conditioning agent, in a defined weight ratio and in a narrow range of particle sizes. The chemically active filter element reacts with acids present in the oil to form a product which may be filtered out of the oil. The pellets are made either by a hot extrusion process or by a solvent process.

Abstract: The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.

Abstract: Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula: where: at least two of A-E are nitrogen, with the remaining atom(s) carbon; X=NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms); n=0, 1, 2. The remaining substituents are described in detail in the specification.

Abstract: The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.

Abstract: The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

Abstract: The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.

Abstract: The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.

Abstract: A unique filtration device (10) which removes metal ions from a contaminated aqueous stream through the use of partially hollow wicking fibers (20) impregnated with a selected liquid (18) which can capture the metal ions in the aqueous stream. The wicking fibers (20) are formed into a filter element (12) which extends from a chamber (16) through which the aqueous stream is directed into a chamber (18) wherein the unwanted metal ions are removed from the extracting liquid (18). The wicking fibers (20) include internal longitudinal cavities (22) each with a relatively small longitudinal extending opening (24). The wicking fibers (20) are filled with the selected liquid extraction (18) which remains within the fiber through capillary action by which capillary action the individual wicking fibers (20) rapidly draw the selected liquid,(18) with which they comes into contact, through the internal cavities (22).

Abstract: Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula: 1

Abstract: An oil-conditioning filter, for use with an internal combustion engine, includes a mechanically active filter element and a chemically active filter element. The chemically active filter element has a beneficial oil conditioning agent contained in a plurality of porous additive-dispensing modules. Each of the additive-dispensing modules includes a hollow housing having a plurality of holes formed therein, and a beneficial oil additive disposed within the housing. Optionally, each additive-dispensing module may also include a porous or semi-porous polymeric membrane covering the housing, to control the rate at which the additive material diffuses outwardly therefrom.

Abstract: Described are compounds of the following formula and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula: wherein the formula terms are described in the specification and wherein the members in the aforementioned structure are defined in the specification.

Abstract: Disclosed are compounds of Formulae (Ia), (Ib), (Ic), (Id) wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.

Abstract: A fuel filter for removing fuel impurities, particularly thiophenes, includes a hollow housing having a filter element therein. The filter element includes a substrate, which may include a nonwoven fiber web, a plurality of particles, or both of these. Where particles are used, the substrate may be homogeneous or may be a mixture of different particles. The substrate may include a sorbent selected from the group consisting of metals, metal oxides, metallic salts, organometallic compounds, catalysts, and oxidizing agents. Optionally, a sulfur-treating reactant may be operatively associated with the substrate to reduce the concentration of thiophenes in fuel passing through the filter.

Abstract: A multiple lift position rocker arm 307 is provided which includes a body 10 and a pivotally mounted lost motion arm 44. A latch 120 is connected on one end of the body to prevent pivotal movement of the arm 344 with respect to the body 10 in a first given angular direction. The latch 120 has a second position to allow the arm 344 to pivot relative to the body to activate a valve stem 18 in a second state of activation. Preferably a roller 356 is connected with the arm 344 and rollers 162 are connected with the body 10. Roller 356 makes contact with a cam lobe in the first state of activation of the rocker arm assembly 307. The rollers 162 make contact with a cam lobe when the rocker arm assembly is in a second state of activation.

Abstract: Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula: where: at least two of A-E are nitrogen, with the remaining atom(s) carbon; X=NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms); n=0, 1, 2. The remaining substituents are described in detail in the specification.

Abstract: A fibrous element is described. The fibrous element includes a container member and an anti-microbial agent, wherein the anti-microbial agent is disposed within the container member. The container member can include structures such as an elongated fiber having multiple lobes with a longitudinally extending internal cavity including an opening from the internal cavity to the outer fiber formed between adjacent lobes, an elongated fiber having an internal longitudinally extending cavity having a longitudinally extending opening, and a particulate. The anti-microbial agent is capable of diffusing out of the container member and throughout the fibrous element in response to elevated relative humidity levels in order to contact and kill a microbial population.

Abstract: An oil-conditioning filter, for use with an internal combustion engine, includes a mechanically active filter element and a chemically active filter element. The chemically active filter element has a beneficial oil conditioning agent contained in a plurality of porous additive-dispensing modules. Each of the additive-dispensing modules includes a hollow housing having a plurality of holes formed therein, and a beneficial oil additive disposed within the housing. Optionally, each additive-dispensing module may also include a porous or semi-porous polymeric membrane covering the housing, to control the rate at which the additive material diffuses outwardly therefrom.