Patents by Inventor Gregory S. Hamilton

Gregory S. Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
    Patent number: 7078424
    Abstract: This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: July 18, 2006
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
  • Rotamase enzyme activity inhibitors
    Patent number: 7056935
    Abstract: This invention relates to methods of using neurotrophic compounds having an affinity for FKBP-type immunophilins to stimulate or promote neuronal growth or regeneration and to prevent neuronal degeneration.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: June 6, 2006
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Heterocyclic ketone and thioester compounds and uses
    Patent number: 6984639
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: January 10, 2006
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
    Patent number: 6974823
    Abstract: The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; for treating alopecia and promoting hair growth; for treating vision disorders and/or improving vision; for treating memory impairment and/or enhancing memory performance; and for treating sensorineural hearing loss by administering such compounds.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: December 13, 2005
    Assignee: GPI NIL Holdindgs, Inc.
    Inventor: Gregory S. Hamilton
  • Pyrrolidine derivative hair growth compositions and uses
    Patent number: 6943187
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: September 13, 2005
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
    Publication number: 20040242648
    Abstract: The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.
    Type: Application
    Filed: October 7, 2003
    Publication date: December 2, 2004
    Applicant: ARTESIAN THERAPEUTICS, INC.
    Inventors: Gregory S. Hamilton, Harry Jefferson Leighton
  • Polyprolyl inhibitors of cyclophilin
    Publication number: 20040204340
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule peptidic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Application
    Filed: April 11, 2003
    Publication date: October 14, 2004
    Applicant: Guilford Pharmaceuticals, Inc.
    Inventors: Gregory S. Hamilton, Ling Wei, Joseph P. Steiner
  • Trisubstituted carbocyclic cyclophilin binding compounds and their use
    Publication number: 20040157919
    Abstract: The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.
    Type: Application
    Filed: November 14, 2003
    Publication date: August 12, 2004
    Inventors: Yong-Qian Wu, Sergei Belyakov, Gregory S. Hamilton, David Limburg, Joseph P. Steiner, Mark Vaal, Ling Wei, Douglas Wilkinson
  • Heterocyclic ketone and thioester compounds and uses
    Publication number: 20040106652
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Application
    Filed: July 10, 2003
    Publication date: June 3, 2004
    Applicant: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
    Publication number: 20040082622
    Abstract: This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.
    Type: Application
    Filed: June 24, 2003
    Publication date: April 29, 2004
    Applicant: Guilford Pharmaceuticals Inc.
    Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
  • Small molecule inhibitors of rotamase enzyme activity
    Publication number: 20040049046
    Abstract: This invention relates to neurotrophic N-glyoxylprolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Application
    Filed: August 16, 2002
    Publication date: March 11, 2004
    Applicant: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Non-peptidic cyclophilin binding compounds and their use
    Patent number: 6677376
    Abstract: The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: January 13, 2004
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner, Mark J. Vaal, Chi Choi, Ling Wei
  • Non-peptidic cyclophilin binding compounds and their use
    Publication number: 20030232815
    Abstract: The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.
    Type: Application
    Filed: June 11, 2003
    Publication date: December 18, 2003
    Inventors: Gregory S. Hamilton, Joseph P. Steiner, Mark Vaal, Chi Choi, Ling Wei
  • Trisubstituted carbocyclic cyclophilin binding compounds and their use
    Patent number: 6656971
    Abstract: The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: December 2, 2003
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Yong-Qian Wu, Sergei Belyakov, Gregory S. Hamilton, David Limburg, Joseph P. Steiner, Mark Vaal, Ling Wei, Douglas Wilkinson
  • Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
    Publication number: 20030186961
    Abstract: This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.
    Type: Application
    Filed: August 2, 2001
    Publication date: October 2, 2003
    Applicant: Guilford Pharmaceuticals
    Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
  • Non-peptidic cyclophilin binding compounds and their use
    Patent number: 6593362
    Abstract: This invention relates to pharmaceutical compositions and methods of using non-peptidic cyclophilin-binding compounds in medical conditions involving breakdown of mitochondrial energy metabolism induced by calcium overload, in treating alopecia and promoting hair growth, in treating infections with filarial and helmintic parasites, and in treating and preventing infections with the human immunodeficiency virus.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: July 15, 2003
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Inhibitors of rotamase enzyme activity
    Publication number: 20030114365
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Application
    Filed: August 27, 2002
    Publication date: June 19, 2003
    Applicant: GPI NIL Holding, Inc.
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Method of using neurotrophic sulfonamide compounds
    Publication number: 20030114492
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Application
    Filed: March 23, 2001
    Publication date: June 19, 2003
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Methods of effecting neuronal activity
    Publication number: 20030068321
    Abstract: This invention is related to methods of effecting neuronal activity with non-immunosuppressive neurotrophic low molecular weight, small molecule cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins. The methods of this invention are useful in the stimulation of damaged neurons, promotion of neuronal regeneration, prevention of neurodegeneration, and treatment of neurological disorders.
    Type: Application
    Filed: September 7, 2001
    Publication date: April 10, 2003
    Applicant: Guilford Pharmaceuticals, Inc.
    Inventors: Gregory S. Hamilton, Ling Wei, Joseph P. Steiner
  • Non-peptidic cyclophilin binding compounds and their use
    Publication number: 20030055009
    Abstract: This invention relates to pharmaceutical compositions and methods of using non-peptidic cyclophilin-binding compounds in medical conditions involving breakdown of mitochondrial energy metabolism induced by calcium overload, in treating alopecia and promoting hair growth, in treating infections with filarial and helmintic parasites, and in treating and preventing infections with the human immunodeficiency virus.
    Type: Application
    Filed: May 21, 2001
    Publication date: March 20, 2003
    Inventors: Joseph P. Steiner, Gregory S. Hamilton