Abstract: A method of performing a microfracture procedure includes creating fractures in subchondral bone and administering a Wnt pathway inhibitor.

Abstract: A wavelength conversion module includes a driving element, a wavelength conversion wheel, and at least one flow guide. The wavelength conversion wheel includes a rotary disc and at least one wavelength conversion layer. The driving element is connected to the rotary disc to drive the wavelength conversion wheel to rotate along an axis of the driving element as a central axis. The flow guide is disposed beside the wavelength conversion wheel at intervals along the axis, and at least one airflow channel is formed between the flow guide and the wavelength conversion wheel. The flow guide and the driving element are disposed at intervals, and the flow guide does not contact the rotary disc and the driving element. An orthographic projection of the flow guide on the rotary disc overlaps the wavelength conversion layer. When the wavelength conversion wheel rotates, the wavelength conversion wheel and the flow guide move relatively.

Abstract: A package structure is provided. The package structure includes a first die and a second die, a dielectric layer, a bridge, an encapsulant, and a redistribution layer structure. The dielectric layer is disposed on the first die and the second die. The bridge is electrically connected to the first die and the second die, wherein the dielectric layer is spaced apart from the bridge. The encapsulant is disposed on the dielectric layer and laterally encapsulating the bridge. The redistribution layer structure is disposed over the encapsulant and the bridge. A top surface of the bridge is in contact with the RDL structure.

Abstract: A fan structure including a center portion, multiple fan blades, and a fixing ring is provided. The center portion includes a bottom surface and a center shaft. The center shaft is perpendicular to the bottom surface, and the direction in which the center shaft extends is an axial direction. The fan blades are mutually separated and connected to the bottom surface of the center portion and are disposed around the axial direction. Each of the fan blades has a height which is parallel to the axial direction. The fixing ring simultaneously contacts the side of the fan blades which is away from the center shaft. Along the axial direction, with the bottom surface of the center portion as a reference surface, the fixing ring is disposed at a range of 40% to 80% of the height of each of the fan blades.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: A method for predicting clinical severity of a neurological disorder includes steps of: a) identifying, according to a magnetic resonance imaging (MRI) image of a brain, brain image regions each of which contains a respective portion of diffusion index values of a diffusion index, which results from image processing performed on the MRI image; b) for one of the brain image regions, calculating a characteristic parameter based on the respective portion of the diffusion index values; and c) calculating a severity score that represents the clinical severity of the neurological disorder of the brain based on the characteristic parameter of the one of the brain image regions via a prediction model associated with the neurological disorder.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: An apparatus for 5G security management of a malicious device based on an open-radio access network (O-RAN) architecture includes a service management orchestration (SMO) unit, an O-RAN element unit and an artificial intelligence (AI) processing unit. The SMO unit includes a non-real time radio access network intelligent controller (non-RT RIC). The non-RT RIC collects a non-real time traffic data of a user. The O-RAN element unit includes a near-real time radio access network intelligent controller (near-RT RIC). The near-RT RIC collects a near-real time traffic data of the user. The AI processing unit is configuring to classify the user into one of a plurality of categories, predict at least one traffic index of the user, and determine whether the user is the malicious device.

Abstract: A method for forming a chip package structure is provided. The method includes disposing a first chip structure and a second chip structure over a wiring substrate. The first chip structure is spaced apart from the second chip structure by a gap. The method includes disposing a ring structure over the wiring substrate. The ring structure has a first opening, the first chip structure and the second chip structure are in the first opening, the first opening has a first inner wall, the first inner wall has a first recess, and the gap extends toward the first recess.

Abstract: A chip package structure is provided. The chip package structure includes a wiring substrate. The chip package structure includes a first chip structure and a second chip structure over the wiring substrate. The first chip structure is spaced apart from the second chip structure by a gap. The chip package structure includes a ring structure over the wiring substrate. The ring structure has a first opening, the first chip structure and the second chip structure are in the first opening, the first opening has a first inner wall, the first inner wall has a first recess, and the gap extends toward the first recess.

Abstract: A wavelength conversion element, including a turntable, is provided. The turntable is configured to rotate along a central axis. The turntable has a first surface and a plurality of first turbulence portions and a plurality of second turbulence portions located on the first surface, wherein the first turbulence portions and the second turbulence portions are arranged by surrounding the central axis, a shape of each of the first turbulence portions is different from a shape of each of the second turbulence portions, and at least one of the second turbulence portions is arranged between two adjacent first turbulence portions of the first turbulence portions. A projector, including the wavelength conversion element, is further provided. The wavelength conversion element and the projector effectively improve the heat dissipation effect.

Abstract: A fan structure including a center portion, multiple fan blades, and a fixing ring is provided. The center portion includes a bottom surface and a center shaft. The center shaft is perpendicular to the bottom surface, and the direction in which the center shaft extends is an axial direction. The fan blades are mutually separated and connected to the bottom surface of the center portion and are disposed around the axial direction. Each of the fan blades has a height which is parallel to the axial direction. The fixing ring simultaneously contacts the side of the fan blades which is away from the center shaft. Along the axial direction, with the bottom surface of the center portion as a reference surface, the fixing ring is disposed at a range of 40% to 80% of the height of each of the fan blades.

Abstract: A wavelength conversion module includes a driving element, a wavelength conversion wheel, and at least one flow guide. The wavelength conversion wheel includes a rotary disc and at least one wavelength conversion layer. The driving element is connected to the rotary disc to drive the wavelength conversion wheel to rotate along an axis of the driving element as a central axis. The flow guide is disposed beside the wavelength conversion wheel at intervals along the axis, and at least one airflow channel is formed between the flow guide and the wavelength conversion wheel. The flow guide and the driving element are disposed at intervals, and the flow guide does not contact the rotary disc and the driving element. An orthographic projection of the flow guide on the rotary disc overlaps the wavelength conversion layer. When the wavelength conversion wheel rotates, the wavelength conversion wheel and the flow guide move relatively.

Abstract: A method is provided for producing a live cartilaginous material useful for implantation into a patient. A method of treating a patient comprising implanting a cartilaginous material prepared according to the provided method in an anatomical site in a patient also is provided.

Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.

Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.

Abstract: A wavelength conversion element, including a turntable, is provided. The turntable is configured to rotate along a central axis. The turntable has a first surface and a plurality of first turbulence portions and a plurality of second turbulence portions located on the first surface, wherein the first turbulence portions and the second turbulence portions are arranged by surrounding the central axis, a shape of each of the first turbulence portions is different from a shape of each of the second turbulence portions, and at least one of the second turbulence portions is arranged between two adjacent first turbulence portions of the first turbulence portions. A projector, including the wavelength conversion element, is further provided. The wavelength conversion element and the projector effectively improve the heat dissipation effect.

Abstract: The disclosure provides a smart liquor cabinet and a management method for the liquor cabinet. In the management method, a voice command is received and an intent of the voice command is determined. If the intent of the voice command is related to a remaining space of the liquor cabinet, then the remaining space with no liquor in the liquor cabinet is determined. If the intent of the voice command is related to an inventory situation of the liquor cabinet, then the inventory situation of stored liquor in the liquor cabinet is determined. The response of the intent is outputted. The response is related to the remaining space or the inventory situation. In this way, the liquor and space in the liquor cabinet may be counted easily and quickly.

Abstract: A method for forming a chip package structure is provided. The method includes disposing a first chip structure and a second chip structure over a wiring substrate. The first chip structure is spaced apart from the second chip structure by a gap. The method includes disposing a ring structure over the wiring substrate. The ring structure has a first opening, the first chip structure and the second chip structure are in the first opening, the first opening has a first inner wall, the first inner wall has a first recess, and the gap extends toward the first recess.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.