Abstract: The disclosure is directed to an expression vector or a combination of at least two expression vectors for producing a polypeptide of interest, the vector or vectors comprising a polynucleotide encoding a mutated folate receptor as a selectable marker. The disclosure also relates to host cells, selection methods and methods for producing polypeptides with high yield.

Abstract: The invention relates to an automated method for providing local computing capacity for at least one local computing unit (1.1) for a less required computing task (3) of a demander, wherein the local computing unit (1.1) is used at least partially for controlling a local power generation unit (5.2), wherein the local computing unit (1.1) is provided as part of a local Edge Cloud (1), wherein the electrical energy generated by the local power generation unit (5.2) is used for supplying power to the Edge Cloud (1), and wherein the local computing capacity is provided to the demander by the Edge Cloud (1) in the event of an over-production of power. The invention also relates to an associated device for providing local computing capacity of at least one local computing unit (101) for a less required computing task (3) of a demander.

Abstract: In a winding device for wrapping an elongated bundled item and method for wrapping a bundled item with an adhesive tape in a winding device for wrapping an elongated bundled item with an adhesive tape, a roll for a predetermined length of adhesive tape is held in the winding head. The predetermined length is dimensioned for one portion of the item to be wrapped. A cutting of the adhesive tape on the bundled item can be avoided hereby.

Abstract: A rotor assembly may be used in a gas turbine. The rotor assembly includes rotor segments arranged in succession in an axial direction and interconnected in the axial direction by a tie-rod, and a rotor segment disposed forwardly in the axial direction having a first contact surface and a rotor segment disposed rearwardly in the axial direction having a second contact surface. The first and second contact surfaces are at least partially in contact with each other, are substantially annular in shape, and extend in a radial direction and in a circumferential direction. The first contact surface and/or the second contact surface extend at least partially obliquely relative to the radial direction. An angle is formed between the first contact surface and the second contact surface when viewed in a sectional plane defined by the axial direction and the radial direction.

Abstract: The invention relates to relates to a pressure cell configured for working according to the piezo-resistive principle and for use under high-energy radiation, particularly for use in space, i.e. to work under cosmic radiation. In order to reduce radiation drift effects during operation of the pressure cell, the pressure cell is treated with a radiation hardening procedure comprising an exposing of the cell with a radiation dose up to a saturation range of a radiation drift curve or above.

Abstract: The invention relates to the in vivo transduction of hematopoietic stem and progenitor cells (HSPCs) in a subject, such as a human subject, and to the treatment of subjects suffering from various pathologies, such as blood diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: The present disclosure describes techniques for detecting foreign objects. In some aspects, an apparatus for detecting objects is provided. The apparatus includes a plurality of sense circuits, each of the plurality of sense circuits including a primary sense coil having a first terminal and a second terminal, a secondary sense coil having a first terminal and a second terminal, and a capacitor having a first terminal and a second terminal. The first terminal of the capacitor is electrically connected to the second terminals of each of the primary sense coil and the secondary sense coil. The apparatus further includes a driver circuit electrically connected to the first terminal of the primary sense coil of each of the plurality of sense circuits. The apparatus further includes a measurement circuit electrically connected to the first terminal of the secondary sense coil of each of the plurality of sense circuits.

Abstract: The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.

Abstract: A frame device for a vehicle, including a subframe which can be attached to a structure of the vehicle and which has two side members spaced apart from one another in the transverse direction of the subframe and at least one cross member via which the side members are interconnected. The frame device also includes at least one support element, which is formed separately from the subframe and has at least one attachment element by which at least one component of the vehicle can be attached to the support element, and a steering gear which is formed separately from the subframe and separately from the support element for a steering system of the vehicle. Both the steering gear and the support element are attached to the subframe by one and the same fastening element.

Abstract: A ball includes a bladder that has a majority weight component of a material of a first material class. The ball includes at least one intermediate layer that is arranged exterior to the bladder and that has a majority weight component of the material of the first material class. The ball includes at least one exterior layer that is arranged exterior to the at least one intermediate layer and that has a majority weight component of the material of the first material class.

Abstract: Multi-spectral imaging systems include an excitation light source that produces an excitation beam having an excitation light spectrum. A programmable light source sequentially selects three or more excitation wavelength ranges from a plurality of excitation wavelength ranges based on code words defined by a selected code. Based on the code words, a sequence of encoded excitation beams is produced which are sequentially directed to a sample location. An imaging system such as a hyperspectral camera is situated to produce spectral images of a sample associated with a plurality of emission wavelength ranges in response to each of the encoded excitation beams. The spectral images are decoded to produce a spectral emission image corresponding to emitted intensity at the plurality of emission wavelengths as a function of excitation wavelength.

Abstract: The current disclosure provides recombinant adenoviral vectors and adenoviral genomes that can accommodate or that contain a large transposon payload, for instance a transposon payload of up to 40 kb. The adenoviral vectors and genomes can deliver the large transposon payload into a target genome, for instance for gene therapy.

Abstract: The invention relates to a device including a nanoaerosol nozzle for releasing an aerosol with very fine particles.

Abstract: The present invention provides a coating comprising hyaluronic acid (HA), for application on the surface of a medical sampling device, wherein the HA is end-point attached to the surface of the medical device. It also provides a process for applying a coating comprising HA onto the surface of a medical sampling device, wherein the HA is end-point attached to the surface of the device, comprising a step (A) of aminating the surface, followed by a step (B) of end-point attaching the HA to the surface, preferably followed by a step (C) of blocking any residual amine groups on the surface. The invention also provides a medical diagnostic device comprising the coating.

Abstract: A method for implementing deep reinforcement learning with T-cell receptor (TCR) mutation policies to generate binding TCRs for immunotherapy includes extracting peptides to identify a virus or tumor cells, collecting a library of TCRs from patients, predicting interaction scores between the extracted peptides and the TCRs from the patients, developing a deep reinforcement learning framework with TCR mutation policies to generate TCRs with maximum binding scores, defining reward functions, outputting mutated TCRs, ranking the outputted TCRs to utilize top-ranked TCR candidates to target the virus or the tumor cells, and for each top-ranked TCR candidate, repeatedly identifying a set of self-peptides that the top-ranked TCR candidate binds to and further optimizing it greedily by maximizing a sum of its interaction scores with a given set of peptide antigens while minimizing a sum of its interaction scores with the set of self-peptides until stopping criteria of efficacy and safety are met.

Abstract: Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate oligonucleotides can have advantageous properties, for example in the form of defined multi-conjugate siRNA (i.e., including two, three or more siRNA) having enhanced intracellular delivery and/or multi-gene silencing effects. In various embodiment, the defined multi-conjugate oligonucleotides can be synthesized via new synthetic intermediates and methods. The defined multi-conjugate oligonucleotides can be used, for example, in reducing gene expression, biological research, treating or preventing medical conditions, or to produce new or altered phenotypes in cells or organisms.

Abstract: The invention relates to a hybrid gas generator (10) which comprises a compressed gas chamber (20) and an igniting unit (30), wherein the compressed gas chamber (20) is closed by a first igniter-side bursting membrane (21) and a second bursting membrane (22). According to the invention, a first, rapidly burning-off pyrotechnic agent (51) and a second pyrotechnic agent (52) burning off slowly in comparison to the first pyrotechnic agent (51) are located in the hybrid gas generator (10), wherein the second bursting membrane (22) is openable by positive pressure which can be generated in the compressed gas chamber (20) and the first pyrotechnic agent (51) is separated from the second pyrotechnic agent (52) in such a manner that the positive pressure in the compressed gas chamber (20) for opening the second bursting membrane (22) can be generated by the first pyrotechnic agent (51).

Abstract: Systems and methods are provided for measuring and identifying real-world tremors in order to calculate and display an anti-tremor in a virtual reality world. A system may identify a tremor in a body part, such as hands, and measure the tremor movement from, e.g., body sensors, to calculate an opposite movement and animate virtual hands performing the reverse tremor motion. Depicting inverse motions, such as an anti-tremor, may be used in a few ways to therapeutically train and exercise patients to better control their tremors. Providing a visual cue may help a patient interrupt the movement, as well as provide possibilities for therapy or training muscle memory and stimulating nerve and neuron recovery. By displaying an anti-tremor with virtual hands, a VR system may be used to help train or exercise body parts experiencing tremors.

Abstract: Examples relate to a behavioral and biometric testing system for animals that includes an electronic biometric testing device and a behavioral test management system. The electronic biometric testing device is attached to the animal and comprises a battery, a biometric recording component, a memory to store biometric data, and a wireless transmitter to transmit the biometric data. The behavioral test management system receives the biometric data and determines that a set of testing conditions has been satisfied and automatically administers a test in response to the satisfaction of those testing conditions.

Abstract: A secure, reliable and simplified control mechanism for operating an inverter is provided. In particular, a mechanical switch is used for connecting a local grid with a public grid and for disconnecting the local grid from the public grid. The mechanical switch comprises an intermediate position. Each time when the switch is in this intermediate position, the inverter is immediately shut down in a fast shutdown operation.