Abstract: The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as starting materials via a series of reactions, namely etherification, condensation, substitution, and asymmetric reduction. The preparation method provided in the present invention has a novel route of synthesis, allows an intermediate compound to be introduced conveniently into the chiral center of a glycol via enzyme reduction, and not only is low in costs, but also is reliable in quality. The route of synthesis provided in the present invention uses raw materials of low costs, has an easy to operate process, and provides a final product of great purity and high yield.

Abstract: The present invention is to provide a slow-start photocuring device, comprising: a housing, one or a plurality of UV LED modules, and a switch control module connected to the one or the plurality of UV LED modules. The housing has an inner side provided with an internal cavity, wherein the inner side of the housing is further provided with one or a plurality of openings in one or two sides of the internal cavity. The one or the plurality of UV LED modules provided around the internal cavity, wherein each of the one or the plurality of UV LED modules has a light-emitting side facing the internal cavity. The switch control module comprises a signal modulator, and the signal modulator activates a power buffer mode when receiving a trigger signal, in order to modulate an irradiation power of the one or the plurality of UV LED modules gradually from a first level to a second level.

Abstract: A ball screw with a dustproof member includes: a screw, a nut and the dustproof member. The dustproof member is inserted along the axis into the annular receiving groove and sleeved onto the screw, and includes an annular first dustproof portion and an arc-shaped second dustproof portion. The annular first dustproof portion includes a dustproof hole for insertion of the screw, the dustproof hole has a dustproof inner surface defining an clearance relative to the circumferential surface of the screw, the arc-shaped second dustproof portion protrudes from the dustproof inner surface, and includes an arc-shaped dustproof section contacting the outer helical groove. Such arrangements provide a dustproof effect and prevent overstress on the screw, consequently decreasing friction resistance, thus making the assembly easier and reducing the required starting torque.

Abstract: A method of using a polishing system includes securing a wafer to a support, wherein the wafer has a first diameter. The method further includes polishing the wafer using a first polishing pad rotating about a first axis, wherein the first polishing pad has a second diameter greater than the first diameter. The method further includes rotating the support about a second axis perpendicular to the first axis after polishing the wafer using the first polishing pad. The method further includes polishing the wafer using a second polishing pad after rotating the support, wherein the second polishing pad has a third diameter less than the first diameter. The method further includes releasing the wafer from the support following polishing the wafer using the second polishing pad.

Abstract: Provided is a gene encoding alanyl-glutamine dipeptide biosynthetic enzyme and the application thereof. The nucleotide sequence of said gene is shown in SEQ ID NO: 1. Further, provided is an amino acid sequence encoded by the gene, and provided recombinant vector, recombinant E. coli, recombinant S. cerevisiae, and a self-flocculating recombinant S. cerevisiae containing the gene. Furthermore, provided is a method for carrying out bioconversion to synthesize alanyl-glutamine dipeptide by using said recombinant microorganisms. The application of the gene and recombinant batteries has the characteristics of high molar conversion rate, fast production rate and repeated recycling of the bacteria. It is a good choice for efficient, environmentally friendly and economical production of alanyl-glutamine dipeptide. In addition, through the recycling process, it is expected to reduce the cost of industrial production, solve the problems of difficult enzyme recovery, low utilization rate and unstable enzyme activity.

Abstract: A ball screw with a cooling passage includes a ball screw, a nut and a sealing unit. The nut is provided with the input and output cooling holes parallel to the axis, and the flat surface is provided with the guide groove. A first hole and a second hole are disposed between the guide groove and the input cooling hole and the output cooling hole, respectively, and then a sealing unit seals the guide groove, so as to form the cooling passage. The guide groove, the first hole and the second hole all extend along the axial direction of the nut, and the cooling passage can be formed simply by sealing the guide groove with the sealing unit, which effectively reduces the assembling steps and time, consequently decreasing the assembling cost.

Abstract: A polymer containing a carboxyl group, a preparation method and an application thereof, a supported catalyst and a preparation method thereof and preparation methods of penem antibiotic intermediate are disclosed. The polymer has high rigidity and hardness, thus the mechanical properties of the polymer is effectively improved. Meanwhile, in the polymer, the carboxyl group is used as a main functional group, and is used as a carrier to prepare, by means of a coordination reaction between the carboxyl group and a heavy metal, a supported metal catalyst which has better connection stability between the metal and the polymer. The above two factors can improve the stability of the supported metal catalyst, such that the catalyst can be recycled without losing the catalytic activity. Meanwhile, loss of a heavy metal active ingredient and production cost can be reduced.

Abstract: A polishing system includes a wafer support that holds a wafer, the wafer having a first diameter. The polishing system further includes a first polishing pad that polishes a first region of the wafer, the first polishing pad having a second diameter greater than the first diameter. The polishing system further includes an auxiliary polishing system comprising at least one second polishing pad that polishes a second region of the wafer, wherein the second polishing pad has a third diameter less than the first diameter, and the wafer support is configured to support the wafer during use of the first polishing pad and the auxiliary polishing system.

Abstract: A method includes delivering a wafer into a process chamber, applying a thermal energy to the wafer by a heat source, and moving the heat source substantially along a longitudinal direction of the heat source with respect to the wafer. An apparatus that performs the method is also disclosed.

Abstract: The present invention provides a mobile charging device capable of battery replacement, comprising a demountable casing, a control module, and a replaceable battery pack. The demountable casing is demounted or mounted by a demountable means. The control module is disposed in the demountable casing. The replaceable battery pack is disposed in the demountable casing, electrically connected to the control module, controlled by the control module to perform charging or discharging, and is changeable when the demountable casing is demounted. The mobile charging device of the present invention can be directly replaced the battery when the mobile power source is exhausted or insufficient, which enhances practicability.

Abstract: A ball screw with a cooling passage includes a ball screw, a nut and a sealing unit. The nut is provided with the input and output cooling holes parallel to the axis, and the axial flat surface is provided with the guide groove. A first radial hole and a second radial hole are disposed between the guide groove and the input cooling hole and the output cooling hole, respectively, and then a sealing unit seals the guide groove, so as to form the cooling passage. The guide groove, the first radial hole and the second radial hole all extend along the axial direction of the nut, and the cooling passage can be formed simply by sealing the guide groove with the sealing unit, which effectively reduces the assembling steps and time, consequently decreasing the assembling cost.

Abstract: A method for preparing sulfobutyl ether-?-cyclodextrin. ?-cyclodextrin and 1,4-sulfobutyrolactone are used as raw materials, and a proper amount of an organic solvent is introduced into an alkaline aqueous solution, so that the solubility of the 1,4-sulfobutyrolactone is increased, and the synthesis yield of the sulfobutyl ether-?-cyclodextrin is improved. Operations including ultrasonic dialysis, active carbon decoloration, freeze-drying and so on are performed on the obtained product solution, so as to obtain a powder product of the sulfobutyl ether-beta-cyclodextrin.

Abstract: An apparatus for processing a wafer includes a process chamber, a wafer support, a heat source, and a movable device. The wafer support is in the process chamber. The heat source is in the process chamber. The movable device contacts the heat source, in which the movable device is movable with respect to the wafer support.

Abstract: A ball screw with a dustproof member includes: a screw, a nut and the dustproof member. The dustproof member is inserted along the axis into the annular receiving groove and sleeved onto the screw, and includes an annular first dustproof portion and an arc-shaped second dustproof portion. The annular first dustproof portion includes a dustproof hole for insertion of the screw, the dustproof hole has a dustproof inner surface defining an clearance relative to the circumferential surface of the screw, the arc-shaped second dustproof portion protrudes from the dustproof inner surface, and includes an arc-shaped dustproof section contacting the outer helical groove. Such arrangements provide a dustproof effect and prevent overstress on the screw, consequently decreasing friction resistance, thus making the assembly easier and reducing the required starting torque.

Abstract: A pre-processing circuit is used for pre-processing a data-line voltage representative of a data output of a memory device. The pre-processing circuit includes a pre-charging circuit and a clamping circuit. The pre-charging circuit pre-charges a data line to adjust the data-line voltage at the data line that is coupled to the memory device. The clamping circuit clamps the data-line voltage to generate a clamped data-line voltage when the data-line voltage is pre-charged to a level that enables a clamping function of the clamping circuit, wherein the clamped data-line voltage is lower than a supply voltage of the pre-processing circuit. The clamping circuit includes a feedback circuit that feeds back a control voltage according to the data-line voltage at the data line, and further reduces its direct current (DC) leakage when the data-line voltage is clamped, wherein the clamping function of the clamping circuit is controlled by the control voltage.

Abstract: A transaminase and a use thereof are provided. The transaminase has the amino acid sequences as shown in SEQ ID NO: 2 or 4, or has at least 80% identity to the amino acid sequences as shown in SEQ ID NO: 2 or 4, or has amino acid sequences which are obtained by the substitution, deletion or addition of one or more amino acids and have an the activity of an omega-transaminase with high stereoselective R-configuration catalytic activity, wherein the high stereoselective refers to the content of one of the stereoisomers being at least about 1.1 times that of the other.

Abstract: The application provides a Diketoreductase (DKR) mutant, its nucleotide coding sequence, and an expression cassette, recombinant vector and host cell containing the sequence, as well as a method for application of the mutant to the preparation of 3R,5S-dicarbonyl compound. An ee value of the obtained 3R,5S-dicarbonyl compound is higher than 99%, and a de value is about 90%. The DKR mutant is a key pharmaceutical intermediate, and particularly provides an efficient catalyst for synthesis of a chiral dicarbonyl hexanoic acid chain of a statin drug.

Abstract: The present invention is to provide a spring-based capacitive touch-sensing structure, comprising: a substrate and a touch panel provided on one side of the substrate. The substrate provided thereon with an electrode unit and one or a plurality of conductive springs electrically connected to the electrode unit. The touch panel has a bottom side in contact with the one or the plurality of conductive springs such that a surface of an opposite side of the touch panel is coupled with the one or the plurality of conductive spring to enable touch-based input. Thanks to the compressibility of the conductive springs in the present invention, tolerances for dimensional errors are ensured once the conductive springs are installed. In other words, the resulting product will not have dimensional errors even if the unmolding or manufacturing process is carried out with limited precision.

Abstract: An apparatus for processing a wafer includes a process chamber, a wafer support, a heat source, and a movable device. The wafer support is in the process chamber. The heat source is in the process chamber. The movable device contacts the heat source, in which the movable device is movable with respect to the wafer support.

Abstract: The present invention is to provide a slow-start photocuring device, comprising: a housing, one or a plurality of UV LED modules, and a switch control module connected to the one or the plurality of UV LED modules. The housing has an inner side provided with an internal cavity, wherein the inner side of the housing is further provided with one or a plurality of openings in one or two sides of the internal cavity. The one or the plurality of UV LED modules provided around the internal cavity, wherein each of the one or the plurality of UV LED modules has a light-emitting side facing the internal cavity. The switch control module comprises a signal modulator, and the signal modulator activates a power buffer mode when receiving a trigger signal, in order to modulate an irradiation power of the one or the plurality of UV LED modules gradually from a first level to a second level.