Abstract: The present invention provides a total reflection prism that can be used in multiple reflection method and that can make the contact area with the sample small. A total reflection prism is made of a plate-shaped optical member, has a leading-in part and a leading-out part of a measurement light provided at positions deviated from the center of either of the front and back surfaces, and has a plurality of plane parts that are formed perpendicularly to the front and back surfaces respectively on an outer periphery of the prism excluding the front and back surfaces of the prism. The leading-in part is provided to irradiate the measurement light that is guided inside at an angle of incidence of total reflection toward either of the front and back surfaces. The front and back surfaces are provided so that the measurement light travels while totally reflected alternately.

Abstract: The present disclosure relates to a composition for analysis of DNA sequences and a method for analysis of DNA sequences by using the same and, more particularly, to a composition comprising the compound represented by Chemical Formula 1 and a method for analysis of DNA sequences, the method comprising a step of treating a sample with the same. The compound represented by Chemical Formula 1 in which TAMRA is linked to polypyrrole specifically binds an A/T base pair (W) to fluoresce alone without causing DNA photocleavage. Therefore, the compound is useful for DNA analysis particularly at the single DNA molecule level.

Abstract: To provide a total reflection measurement device that can improve a light utilization rate more than a Cassegrain type objective mirror, is capable of total reflection measurement at low magnification, and can maintain compatibility with a conventional objective mirror. The device (1) includes: a pair of plane mirrors (2a, 2b) disposed on a central axis (P1); a pair of intermediate mirrors (4a, 4b) opposing to the plane mirrors (2a, 2b), respectively; a pair of ellipsoidal mirrors (6a, 6b) opposing to the intermediate mirrors (4a, 4b), respectively; and an ATR crystal (8) provided at a position nearer to the sample side than the pair of plane mirrors (2a, 2b) on the central axis (P1).

Abstract: A high-frequency transistor includes a source electrode, a drain electrode, a gate electrode, and a gate drive line that applies a voltage to the gate electrode. An impedance adjustment circuit is connected between the gate electrode and the gate drive line. A characteristic impedance of the gate electrode is Z1, when a connecting point between the impedance adjustment circuit and the gate electrode is viewed from the impedance adjustment circuit. A characteristic impedance of the gate drive line is Z2, when a connecting point between the impedance adjustment circuit and the gate drive line is viewed from the impedance adjustment circuit. X that denotes a characteristic impedance of the impedance adjustment circuit is a value between Z1 and Z2.

Abstract: A conjugate comprising a pyrrole-imidazole polyamide that recognizes a specific DNA sequence and a bromodomain inhibitor, a composition for regulating biochemical activity, specifically for regulating histone modification, e.g., for inducing histone acetylation, which comprises the conjugate, a composition for recruiting a bromodomain-containing protein which comprises the conjugate, a method for nucleosome acetylation which comprises using the conjugate, and a method for bromodomain-containing protein recruitment which comprises using the conjugate are provided.

Abstract: The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.

Abstract: An ATR optical instrument condensing an infrared light to a sample-side surface of a ATR crystal to measure a total reflection absorption spectrum includes: an incident-side ellipsoidal mirror condensing the infrared light to the sample-side surface at an incident angle equal to or larger than a critical angle ?c inside; an exiting-side ellipsoidal mirror condensing a total reflection light from the sample-side surface; dichroic mirrors guiding an illumination light coaxially to the ellipsoidal mirrors; and a ZnS lens condensing a visible light from the sample-side surface to observe a contact state of the sample. The dichroic mirrors are configured to guide the illumination light to the ellipsoidal mirrors such that the illumination light is condensed to the sample-side surface at an angle less that a critical angle ?c? of the visible light. Accordingly, the ATR optical instrument becomes compact, and can visually observe the contact state of the sample surface.

Abstract: The present invention provides: a histone modification control agent for activating expression of a specific gene, i.e., a complex including a histone acetylation enzyme activator useful as an agent for activating a specific gene, and a polyamide for recognizing a regulatory region of a target gene; and a method for manufacturing the same. This complex specifically activates a group of genes relating to maintenance and/or differentiation of stem cells or precursor cells.

Abstract: Provided are a RUNX inhibitor which binds to a RUNX-binding sequence on DNA and thus inhibits the binding of a RUNX family member to the sequence; an antitumor agent comprising the RUNX inhibitor; and an antiallergic agent comprising the RUNX inhibitor.

Abstract: The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.

Abstract: An ATR optical instrument condensing an infrared light to a sample-side surface of a ATR crystal to measure a total reflection absorption spectrum includes: an incident-side ellipsoidal mirror condensing the infrared light to the sample-side surface at an incident angle equal to or larger than a critical angle ?c inside; an exiting-side ellipsoidal mirror condensing a total reflection light from the sample-side surface; dichroic mirrors guiding an illumination light coaxially to the ellipsoidal mirrors; and a ZnS lens condensing a visible light from the sample-side surface to observe a contact state of the sample. The dichroic mirrors are configured to guide the illumination light to the ellipsoidal mirrors such that the illumination light is condensed to the sample-side surface at an angle less that a critical angle ?c? of the visible light. Accordingly, the ATR optical instrument becomes compact, and can visually observe the contact state of the sample surface.

Abstract: The problem to be solved by the present invention is to provide an infrared microscope with good measuring accuracy and less crosstalk. The infrared microscope 10 comprises a light source 12, an irradiating unit 14 for irradiating the infrared light from the light source to a sample 16, a focusing unit 18 for focusing the infrared light transmitted through or reflected by the sample 16, and a detector 20 for detecting the focused infrared light. The irradiating unit 14 comprises a first aperture 24, and the first aperture is disposed at a position where the infrared light from the light source passes therethrough. The focusing unit 18 comprises a second aperture 30, and the second aperture is disposed at an imaging position of the infrared light at the first aperture 24. The first aperture has a plurality of holes, and the holes are disposed at intervals corresponding to the arrangement of the light-receiving elements provided in the detector 20 to detect the infrared light as a detecting light.

Abstract: To provide a total reflection measurement device that can improve a light utilization rate more than a Cassegrain type objective mirror, is capable of total reflection measurement at low magnification, and can maintain compatibility with a conventional objective mirror. The device (1) includes: a pair of plane mirrors (2a, 2b) disposed on a central axis (P1); a pair of intermediate mirrors (4a, 4b) opposing to the plane mirrors (2a, 2b), respectively; a pair of ellipsoidal mirrors (6a, 6b) opposing to the intermediate mirrors (4a, 4b), respectively; and an ATR crystal (8) provided at a position nearer to the sample side than the pair of plane mirrors (2a, 2b) on the central axis (P1).

Abstract: The problem to be solved by the present invention is to provide an infrared microscope with good measuring accuracy and less crosstalk. The infrared microscope 10 comprises a light source 12, an irradiating unit 14 for irradiating the infrared light from the light source to a sample 16, a focusing unit 18 for focusing the infrared light transmitted through or reflected by the sample 16, and a detector 20 for detecting the focused infrared light. The irradiating unit 14 comprises a first aperture 24, and the first aperture is disposed at a position where the infrared light from the light source passes therethrough. The focusing unit 18 comprises a second aperture 30, and the second aperture is disposed at an imaging position of the infrared light at the first aperture 24. The first aperture has a plurality of holes, and the holes are disposed at intervals corresponding to the arrangement of the light-receiving elements provided in the detector 20 to detect the infrared light as a detecting light.

Abstract: The present invention provides an end-face cleaner for cleaning an end face having a pin projected thereon, comprising an adhesive layer configured to be pierced with a pin, and a support configured to support the adhesive layer and expose a partial surface of the adhesive layer.

Abstract: A high zirconia electrically fused cast refractory having long time durability with less cracking during production and in the course of temperature rising, excellent in productivity, less forming zircon crystals in the refractory itself and even in contact with molten glass, excellent in bubble foamability to molten glass, less generating cracks even undergoing heat cycles during operation of a glass melting furnace. A high zirconia electrically fused cast refractory comprises, as chemical component, 85 to 95% by weight of ZrO2, 0.4 to 2.5% by weight of Al2O3, 3.5 to 10.0% by weight of SiO2, 0.05% by weight or more of Na2O, 0.05 to 0.7% by weight of Na2O and K2O in total, 0.01 to 0.04% by weight of B2O3, 0.1 to 3.0% by weight of SrO or BaO when one of BaO and SrO is contained, 0.1% by weight or more of SrO and 0.1 to 3.0% by weight of SrO and BaO in total when both of BaO and SrO are contained, 0.01 to 0.2% by weight of CaO, 0.1% by weight or less of MgO, 0.01 to 0.7% by weight of SnO2, 0.

Abstract: A high zirconia electrically fused cast refractory of high electric resistance having long time durability, less suffering from cracking during production and upon temperature rising, excellent in productivity, less forming zircon crystals even upon heating the refractory in itself and when the refractory is in contact with molten glass, generating less cracks even when undergoing heat cycles during operation of a glass melting furnace is provided. A high zirconia electrically fused cast refractory has, as chemical components, 85 to 95% by weight of ZrO2, 0.1 to less than 0.8% by weight of Al2O3, 3.5 to 10.0% by weight of SiO2, less than 0.05% by weight of Na2O and K2O in total, 0.1 to 1.5% by weight of B2O3, 0.1% by weight or less of MgO, 0.01 to 0.2% by weight of CaO, in the case where any one of BaO and SrO is contained, from 0.05 to 3.0% by weight of BaO or 0.01 to 3.0% by weight of SrO, or in the case where both of them are contained, 0.01% by weight or more of SrO and from 0.01% to 3.

Abstract: A biosensing platform capable of high throughput mechanochemical biosensing comprising a DNA origami nanostructure having a plurality of slots into which recognition elements are strategically placed and apparatus that senses a change in the origami nanostructure in response to the introduction of a target where the apparatus includes a signal transduction unit and signal sensor which exploits mechanical signals in a recognition element which signal includes one or more mechanical tension or mechanochemical rearrangement event. The nanostructure is preferably a 2-dimensional or 3-dimensional arrangement of tiles linked by locking elements, such as aptamers that will open in response to an event such as exposure to a drug molecule, DNA, RNA or protein target.

Abstract: A high zirconia electrically fused cast refractory having long time durability with less cracking during production and in the course of temperature rising, excellent in productivity, less forming zircon crystals in the refractory itself and even in contact with molten glass, excellent in bubble foamability to molten glass, less generating cracks even undergoing heat cycles during operation of a glass melting furnace. A high zirconia electrically fused cast refractory comprises, as chemical component, 85 to 95% by weight of ZrO2, 0.4 to 2.5% by weight of Al2O3, 3.5 to 10.0% by weight of SiO2, 0.05% by weight or more of Na2O, 0.05 to 0.7% by weight of Na2O and K2O in total, 0.01 to 0.04% by weight of B2O3, 0.1 to 3.0% by weight of SrO or BaO when one of BaO and SrO is contained, 0.1% by weight or more of SrO and 0.1 to 3.0% by weight of SrO and BaO in total when both of BaO and SrO are contained, 0.01 to 0.2% by weight of CaO, 0.1% by weight or less of MgO, 0.01 to 0.7% by weight of SnO2, 0.

Abstract: According to one embodiment, there is provided a magnetic disk device including a magnetic disk, a magnetic head, and a controller. The magnetic head is opposite the magnetic disk. The magnetic head includes a first read head and a second read head. The controller determines a track pitch in the vicinity of a first track or a second track adjacent to the first track of the magnetic disk based on first position information and second position information. The first position information depends on a servo signal read by the first read head and corresponds to the first track. The second position information depends on a servo signal read by the second read head and corresponds to the second track.