Abstract: It is intended to provide a novel monomer unit by which Z type DNA can be more effectively stabilized, a reagent for integrating this monomer unit into an oligonucleotide, and a method of stabilizing Z type DNA by using the reagent. Namely, a guanosine derivative represented by the following general formula [1]: wherein R1 represents acyl; R2 represents lower alkyl; R3 represents tri-substituted silyloxy or tetrahedropyranyloxy; and R4 represents cyanoethyl or allyl; a reagent for stabilizing Z type DNA which contains the guanosine derivative; and a method of stabilizing Z type DNA by using the guanosine derivative. It is also intended to provide a method of transferring guanosine having lower alkyl at the 8-position into an oligonucleotide by using the guanosine derivative; and an oligonucleotide carrying guanosine having lower alkyl at the 8-position transferred thereinto.

Abstract: A bias current to be supplied to an amplification circuit 60 is drawn out of a collector of a transistor Q11 of a bias circuit 10. The drawn-out bias current is input to a base of a transistor Q13 via an attenuation filter F2 and is output from an emitter of the transistor Q13 in the state where the voltage thereof is reduced by a level corresponding to Vbe. The attenuation filter F2 is conducted in a DC manner, and attenuates a component of a frequency fH(=2ft?fr) defined by a transmission frequency ft and a receiving frequency fr of a radio frequency signal. The bias current output from the emitter of the transistor Q13 is supplied to the amplification circuit 60 via an attenuation filter attenuates a component of a frequency fL(=|fr?ft|).

Abstract: The object of the present invention is to provide an active substance which has an anti-obesity effect such as a triglyceride lowering activity, a cholesterol lowering activity and the like. The present invention provides a blood triglyceride lowering agent, a cholesterol lowering agent, a body fat storage suppressive agent, an anti-obesity agent and an antilipemic agent, characterized in that each of said agents comprises a cycloartane-type triterpene or glycoside thereof. Moreover, the present invention provides the use of a Black cohosh plant in order to prepare said agents. Further, the present invention provides a beverage, food and quasi-drug comprising said agents.

Abstract: It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

Abstract: A control apparatus for controlling first devices existing in an arbitrary place includes a first memory to store a plurality of device lists corresponding to a plurality of places respectively and each including device information items which indicate devices existing in corresponding one of the places, and a second memory to store a plurality of control information lists corresponding to the places respectively and each including control information items which indicate control operations for the devices existing in corresponding one of the places, and acquires first device information items indicating the first devices, detects an existence place of the first devices by comparing the first device information items with the device lists, and controls the first devices, based on one of the control information lists which corresponds to the existence place of the first devices.

Abstract: A guidance information providing apparatus comprises a first memory to store network data including line segment data representing a passage in a target area of route guidance in an information map and point data representing a connecting point of a passage, a second memory store three-dimensional shape data representing a three-dimensional shape of the target area, a route search unit which searches for a guiding route connecting an input departure place and destination, a setting unit which sets viewpoint position candidates, an evaluation unit which obtains an evaluation value, from each viewpoint position candidate, an generating unit which determines a viewpoint position, on the basis of the evaluation value of visibility from each viewpoint position candidate, and generates the information map by projecting the three-dimensional shape data, and a presentation unit which presents the generated information map to a user.

Abstract: There is disclosed an information exchange apparatus in which apparatus name information and address information of a display/headphone are transferred to a DVD reproduction apparatus from the display/headphone via a path of an infrared ray or the like different from a radio path for exchanging information. The information are registered in the DVD reproduction apparatus. The DVD reproduction apparatus on a transmission side transmits video and audio information based on information concerning the display/headphone as a reception side registered in the reproduction apparatus, and the display/headphone on the reception side receives the video and audio information transmitted to the display/headphone.

Abstract: A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting or identifying the function of a chemical species A on a substance containing DNA or RNA by using one or more chemical species represented by the following general formula (I) which are capable of recognizing a DNA base sequence; a kit therefor; and a plate to be used therein: B-L-A (I) wherein B represents a chemical structure containing an non-natural base capable of recognizing a DNA base sequence; A represents a chemical structure having an interaction with DNA; and L represents a linker whereby the chemical structures A and B can be linked together.

Abstract: Compounds represented by the general formula (I): which two DNA strands can be interstrand-crossliked: A-L-B-X-B-L-A??(I) wherein B represents a chemical structure capable of recognizing the nucleotide sequence of DNA; A represents a chemical structure capable of binding to one of the bases of DNA; L represents a linker by which the chemical structures of A and B can be linked to each other; X represents a spacer by which the A-L-B components can be linked to each other. A method of interstrand-crosslinking DNA by using these compounds; and medicinal compositions containing interstarand-crosslinking agents of DNA.

Abstract: It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional molecules of this type, for a specific base sequence occurring on DNA. A hairpin polyamide having an alkylation site via a vinyl linker at the end of a pyrrole-imidazole polyamide. Drugs for inhibiting the expression of a specific gene and anticancer agents containing the above hairpin polyamide.

Abstract: This invention is directed to a destination guidance system for providing presentation information that contains guidance pertaining to movement from a place of departure to a destination on the basis of structure information and guidance information on the premises of a building or construction. The presentation information contains both information of the entire three-dimensional structure, and detailed information, and a three-dimensional movement and normal two-dimensional movement in the presentation information are presented by different methods. Also, this invention is directed to a destination guidance data acquisition system for acquiring structure information and guidance information on the premises of a building, which are used by the destination guidance system. The destination guidance data acquisition system inputs and compiles information of a three-dimensional structure on the basis of a plan view of the building to support acquisition of the detailed information.

Abstract: A guidance information providing apparatus comprises a first memory to store network data including line segment data representing a passage in a target area of route guidance in an information map and point data representing a connecting point of a passage, a second memory store three-dimensional shape data representing a three-dimensional shape of the target area, a route search unit which searches for a guiding route connecting, an input departure, place and destination, a setting unit which sets viewpoint position candidates, an evaluation unit which obtains an evaluation value, from each viewpoint position candidate, an generating unit which determines a viewpoint position, on the basis of the evaluation value of visibility from each viewpoint position candidate, and generates the information map by projecting the three-dimensional shape data, and a presentation unit which presents the generated information map to a user.

Abstract: It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

Abstract: This service system includes a portable terminal for acquiring a game character to be distributed, and then, executing a game in collaboration with a processor main body, an external station for making communication with the portable terminal via a short distance wireless equipment, and a service server for distributing the game character to the external station. The portable terminal transmits to the external station the contents of a history information storage section for storing history information concerning a game and a game character depending on a user that possesses the portable terminal. The external station receives the history information transmitted from the portable terminal, and then transmits to the portable terminal the game character information transmitted by referring to the history.

Abstract: Compounds represented by the general formula (I): which two DNA strands can be interstrand-crossliked:

Abstract: An ink jet recording apparatus comprises a carriage movable in a given direction with a recording head which is detachably mountable on it and provided with discharge ports for discharging liquid. The apparatus is arranged to include a sensor for detecting the presence or absence of the carriage, the recording head, and at least one of the ink containers. This sensor is provided for the main body of the apparatus and positioned within the movable range of the carriage. With this arrangement, it is possible to simplify the structure required for detecting whether or not these vital elements for recording are installed without any auxiliary power-supply or memory means.

Abstract: This service system includes a portable terminal for acquiring a game character to be distributed, and then, executing a game in collaboration with a processor main body, an external station for making communication with the portable terminal via a short distance wireless equipment, and a service server for distributing the game character to the external station. The portable terminal transmits to the external station the contents of a history information storage section for storing history information concerning a game and a game character depending on a user that possesses the portable terminal. The external station receives the history information transmitted from the portable terminal, and then transmits to the portable terminal the game character information transmitted by referring to the history.

Abstract: This invention is directed to a destination guidance system for providing presentation information that contains guidance pertaining to movement from a place of departure to a destination on the basis of structure information and guidance information on the premises of a building or construction. The presentation information contains both information of the entire three-dimensional structure, and detailed information, and a three-dimensional movement and normal two-dimensional movement in the presentation information are presented by different methods. Also, this invention is directed to a destination guidance data acquisition system for acquiring structure information and guidance information on the premises of a building, which are used by the destination guidance system. The destination guidance data acquisition system inputs and compiles information of a three-dimensional structure on the basis of a plan view of the building to support acquisition of the detailed information.

Abstract: Novel chemical species capable of simultaneously alkylating double-stranded DNA and cleaving the same; methods for alkylating and cleaving DNA by using these species; and anticancer agents with the use of these compounds. Compounds represented by the following general formula (I) which are capable of simultaneously alkylating double-stranded DNA and cleaving the same; a method for alkylating DNA and a method for cleaving double stranded DNA by using these compounds; and medicinal compositions with the use of these compounds: B—L—A(I) wherein B represents a chemical structure capable of recognizing the base sequence of DNA, for example, optionally substituted pyrrole-imidazole polyamide; A represents a chemical structure capable of binding to one base of DNA, for example, the alkylation moiety of duocarmycin A; and L represents a linker capable of binding the chemical structures A and B, for example, vinyl.

Abstract: An output apparatus which produces the print output by saving in a first memory print data input via a two-way interface, and converting the print data into the print out information, comprising a second memory different from the first memory for saving the print data with a print ID number added which is input via the interface, a retrieving unit for retrieving corresponding print data of the second memory based on a print ID number input from the outside, and an output unit for outputting the retrieved print data converted into the print out information.