Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.

Abstract: A LED filament comprises a frame, a metal electrode, a fasten member, a second fasten member, at least one LED chip. The frame is a bottomless frame and the metal electrode is disposed on one side of the frame. The first fasten member is formed on the frame and the second fasten member formed on the metal electrode. The metal electrode having the second fasten member is placed on the first fasten member of the frame, thereby fastening the metal electrode on the frame; wherein one of the first fasten member and the second fasten member is a protrusion while the other one is a hole. The at least one LED chip disposed inside the frame and electrically connecting to the metal electrode.

Abstract: An electronic paper apparatus including a communication module and a control module is provided. The communication module receives an electrical signal and generates a power voltage according to the electric signal. The communication module wakes up a controller during a first period of a work period by using the power voltage. The control module is electrically connected to the communication module, and includes the controller and an electronic paper display. The control module establishes a communication connection with the communication module during a second period of the work period. The power circuit module generates a driving voltage according to the power voltage to drive the electronic paper display to display image information according to the driving voltage during a display period. The first period and the second period are two continuous time intervals forming the work period. Furthermore, a driving method of the electronic paper apparatus is also provided.

Abstract: A computer-implemented method for automatically registering an application with an enterprise system. The method includes, obtaining the application associated with the enterprise system, wherein the application is pre-configured for subsequent registration with the enterprise system such that the registration establishes a trust relationship between the application and the enterprise system. The method further includes installing the application on a host device, and in conjunction with installing the application, automatically requesting the registration of the application with the enterprise system.

Abstract: Various examples of detecting whether a device meets an enrollment level are disclosed. A request to authenticate a user based upon user credentials is obtained. Applications for which the user is authorized are identified. An enrollment level associated with each of the plurality of applications is also identified. A user interface including the plurality of applications and the enrollment level associated with each of the plurality of applications is generated.

Abstract: Various examples of detecting whether a device meets an enrollment level are disclosed. A request to authenticate a user based upon user credentials is obtained. Applications for which the user is authorized are identified. An enrollment level associated with each of the plurality of applications is also identified. A user interface including the plurality of applications and the enrollment level associated with each of the plurality of applications is generated.

Abstract: Prepregs, composites and articles are described that comprise a porous core layer and a surface layer comprising bi-component fibers which can enhance formability of the article without breakthrough. The enhanced formability can permit forming or drawing of the article to increased depths without breakthrough. Interior and exterior automotive components including the articles are described.

Abstract: An intelligent authentication system including an electronic lock and an electronic key is provided. The electronic key includes an electronic paper display apparatus. The electronic key is adapted to perform a two-step authentication with the electronic lock. The two-step authentication includes the first authentication step and the second authentication step. The electronic paper display apparatus is driven after the first authentication step is passed. And during the second authentication step, the electronic key performs an authentication operation with the electronic lock by using the driven electronic paper display apparatus. Furthermore, an electronic key for the foregoing intelligent authentication system is also provided.

Abstract: A LED filament includes a frame; two metal electrodes, respectively disposed on two sides of the frame; a LED chip assembly, comprising a plurality of LED chips disposed inside the frame and electrically connecting to the two metal electrodes respectively; and a gel comprising phosphor, wrapping the LED chip assembly and parts of the metal electrodes inside the frame.

Abstract: An LED tube lamp includes a lamp tube, which includes a light transmissive portion, a reinforcing portion and an end cap, and an LED light assembly, which includes an LED light source and an LED light strip. The light transmissive portion is fixedly connected to the reinforcing portion. The reinforcing portion includes a platform and a bracing structure fixedly connected to the platform and holds the platform in place. The bracing structure is made from a material having a greater stiffness than the material from which the lamp tube is made. The LED light source is thermally and electrically connected to the LED light strip, which is in turn thermally connected to the reinforcing portion. The end cap is attached to an end of the lamp tube. The light transmissive portion and the reinforcing portion define a first line between them on a cross section of the lamp tube.

Abstract: Disclosed are various examples for providing a single sign-on experience for managed mobile devices. A management application executed in a computing device receives a single sign-on request from a managed client application executed by the same computing device. The management application determines that the client application is permitted to access a management credential for single sign-on use. The management application provides the management credential to the client application in response to the single sign-on request.

Abstract: An LED tube lamp includes a glass tube, a plurality of LED light sources, two end caps respectively sleeving two end portions of the glass tube, a power supply in one of the end caps or separately in both of the end caps, and an LED light strip in the glass tube. The plurality of LED light sources is on the LED light strip. Each of the end caps comprises a plurality of openings formed thereon. The plurality of openings dissipating heat resulted from the power supply are divided into two sets. The two sets of the plurality of openings are symmetric to each other with respect to a virtual central axis of the end cap.

Abstract: Various examples of detecting whether a device meets an enrollment level are disclosed. A request to authenticate a user based upon user credentials is obtained. Applications for which the user is authorized are identified. An enrollment level associated with each of the plurality of applications is also identified. A user interface including the plurality of applications and the enrollment level associated with each of the plurality of applications is generated.

Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.

Abstract: Disclosed are various examples for providing a single sign-on experience for managed mobile devices. A management application executed in a computing device receives a single sign-on request from a managed client application executed by the same computing device. The management application determines that the client application is permitted to access a management credential for single sign-on use. The management application provides the management credential to the client application in response to the single sign-on request.

Abstract: A test substrate for detecting a LAL-reactive substance, wherein at least a portion of said test substrate has been preloaded with at least one LAL reagent and/or at least one LAL-reactive standard. Methods of use of the test substrate are disclosed. Methods of depositing test reagents on a test substrate are also disclosed.

Abstract: Composite articles comprising a porous prepreg or core layer and a powder coated layer thereon are described. In some instances, a thermoplastic composite article comprises a porous core layer comprising a web of reinforcing fibers held together by a thermoplastic material, and a powder coated layer disposed on the porous core layer, in which a particle size of the powder coated layer is selected to provide an interface between the powder coated layer and the porous core layer, wherein at least 50% by weight of the disposed powder coated layer is present above the interface.

Abstract: The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1 R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.

Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.