Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same bitter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.

Abstract: The present invention discloses an application instance staging method and apparatus. The method comprising: obtaining a list of functional services bound to an application program; determining a buildpack corresponding to the bound functional service; and performing, by the determined buildpack, application instance staging of the application program. With the technical solution according to embodiments of the invention, an application program can be automatically extended during application instance staging, such that it can interact with the bound service.

Abstract: In this application are described chimeric, humanized, affinity matured, stability enhanced, and bispecific Anti-GD2 antibodies and fragments thereof. Also provided are methods of using individual antibodies or compositions thereof for the detection, prevention, and/or therapeutical treatment of GD2-related diseases, in particular, neuroblastoma.

Abstract: A radiation-sensitive composition includes particles including a metal oxide as a principal component, and an organic solvent. A metal atom constituting the metal oxide includes a first metal atom that is a zinc atom, a boron atom, an aluminum atom, a gallium atom, a thallium atom, a germanium atom, an antimony atom, a bismuth atom, a tellurium atom, or a combination thereof. A percentage content of the first metal atom with respect to total metal atoms in the radiation-sensitive composition is no less than 50 atomic %. A pattern-forming method includes applying the radiation-sensitive composition to form a film on a substrate, exposing the film, and developing the film exposed.

Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.

Abstract: Disclosed are various examples for determining whether a client device complies with compliance rules while authenticating a user account. A client certificate can include an identifier corresponding to a client device. An identity provider can extract the identifier while authenticating the user account. The identity provider can determine whether the client device complies with compliance rules prior to authenticating the user account on the client device.

Abstract: A computer-implemented method for automatically registering an application with an enterprise system. The method includes, obtaining the application associated with the enterprise system, wherein the application is pre-configured for subsequent registration with the enterprise system such that the registration establishes a trust relationship between the application and the enterprise system. The method further includes installing the application on a host device, and in conjunction with installing the application, automatically requesting the registration of the application with the enterprise system.

Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.

Abstract: An LED tube lamp includes a glass tube, a plurality of LED light sources, two end caps respectively sleeving two end portions of the glass tube, a power supply in one of the end caps or separately in both of the end caps, and an LED light strip in the glass tube. The plurality of LED light sources is on the LED light strip. Each of the end caps comprises a plurality of openings formed thereon. The plurality of openings dissipating heat resulted from the power supply are divided into two sets. The two sets of the plurality of openings are symmetric to each other with respect to a virtual central axis of the end cap.

Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.

Abstract: In this application are described chimeric, humanized, affinity matured, stability enhanced, and bispecific Anti-GD2 antibodies and fragments thereof. Also provided are methods of using individual antibodies or compositions thereof for the detection, prevention, and/or therapeutical treatment of GD2-related diseases, in particular, neuroblastoma.

Abstract: A method for authenticating a user seeking access to first and second resources that have different authentication levels. The method includes receiving a primary token that is associated with a first authentication event of the user and authenticates the user to access the first resource, and receiving a first request to access the second resource. The method further includes receiving first credentials of the user. The method further includes, responsive to validating the first credentials, generating a second authentication event, associating the second authentication event with the primary token, and issuing a first secondary token that authenticates the user to access the second resource.

Abstract: A microfluidic testing cartridge for testing LAL-reactive substances in fluid samples is provided. The cartridge may include at least two (2) testing modules, wherein each testing module includes at least one inlet port for receiving one of the fluid samples, and at least four (4) testing channels in fluid communication with the inlet port. Each of the testing channels may include a metering portion for metering an aliquot of the fluid sample, an analyzing portion, and a mixing portion, wherein a valve is positioned between the metering portion and the analyzing portion to selectively fluidly separate the metering portion from the analyzing portion. The cartridge is insertable into an optical reader which performs optical measurements of the fluid sample within each testing channel during a testing process.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.

Abstract: Disclosed is a carrier particle, comprising a sphere and a sub-sphere on the surface of the sphere; the sphere and/or at least one sub-sphere comprise at least one type of quantum dots. Also disclosed is a method for preparing the carrier particle, mainly by connecting at least one nanosphere to a microsphere, and the microsphere and/or the nanosphere are loaded with at least one type of quantum dots.

Abstract: The disclosure provides an LED tube lamp, comprising a tube, a terminal adapter circuit, a first rectifying circuit, a filtering circuit, an LED lighting module and an anti-flickering circuit. The tube has a first pin and a second pin for receiving an external driving signal. The terminal adapter circuit has two fuses respectively coupled to the first and second pins. The first rectifying circuit is coupled to the first and second pins for rectifying the external driving signal to generate a rectified signal. The filtering circuit is coupled to the first rectifying circuit for filtering the rectified signal to generate a filtered signal. The LED lighting module is coupled to the filtering circuit and the LED lighting module having a LED module, wherein the LED lighting module is configured to receive the filtered signal and generate a driving signal, and the LED module receives the driving signal and lights.

Abstract: An LED tube lamp includes a glass tube, two end caps, a power supply, and an LED light strip. The glass tube includes a main body region, two rear end regions, and two transition regions connecting the main body region and the rear end regions. The end cap is disposed at one end of the glass tube and the power supply is provided inside the end cap. The LED light strip is disposed inside the glass tube and has LED light sources disposed thereon. The LED light strip includes a bendable circuit sheet mounted on inner surface of the glass tube. The bendable circuit sheet of the LED light strip is formed with a freely extending end portion at one end, and the freely extending end portion is electrically connected to the power supply. The glass tube and the end cap are secured by a hot melt adhesive.

Abstract: Handling locale information on a computing platform, a computer obtains, in response to an event that an application is pushed to a computing platform, locale information corresponding to the application. The computer determines the type of the application, configures a runtime executable file required by the application according to the locale information corresponding to the application and the type of the application, creates a script for configuring a locale of an operating system on the computing platform consistent with the locale information corresponding to the application, and creates a droplet for the application that includes the configured runtime executable file required by the application and is associated with the created script.

Abstract: Various examples of detecting whether a device meets an enrollment level are disclosed. A request to authenticate a user based upon user credentials is obtained. Applications for which the user is authorized are identified. An enrollment level associated with each of the plurality of applications is also identified. A user interface including the plurality of applications and the enrollment level associated with each of the plurality of applications is generated.

Abstract: Various examples of detecting whether a device meets an enrollment level are disclosed. A request to authenticate a user based upon user credentials is obtained. Applications for which the user is authorized are identified. An enrollment level associated with each of the plurality of applications is also identified. A user interface including the plurality of applications and the enrollment level associated with each of the plurality of applications is generated.