Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The present invention relates to a polymer-drug conjugate wherein the polymer is hyaluronic acid and the drug is an anticancer compound. The anticancer compound is covalently linked to the hyaluronic acid by a pH-labile boronic acid-containing linkage. These conjugates can be used for the treatment of cancer.

Abstract: An open-cavity, reduced-pressure treatment device and system for treating a cavity in a patient's body, such as an abdominal cavity, is presented. In one instance, an open-cavity, reduced-pressure treatment device includes a plurality of encapsulated leg members, each having an interior portion with a leg manifold member and formed with fenestrations operable to allow fluid flow into the interior portion, and a central connection member fluidly coupled to the plurality of encapsulated leg members. The central connection member has a connection manifold member. The open-cavity, reduced-pressure treatment devices, systems, and methods allow for, among other things, removal of fluids.

Abstract: Apparatuses, systems, and methods for applying reduced pressure to a tissue site on a foot are provided. An apparatus may include an insole and a tissue contacting surface covering at least a portion of the insole. At least one portion of the tissue contacting surface is removable to form a void. The apparatus may also include a reduced-pressure interface for receiving reduced pressure from a reduced-pressure source, and at least one flow channel fluidly coupled to the reduced-pressure interface and the void.

Abstract: A manually-activated reduced pressure treatment system includes a substantially rigid housing, and an end cap slidingly received by the housing. An inner chamber is disposed between the end cap and housing, and a volume of the inner chamber is variable in amount depending on the position of the end cap within the housing. The end cap is slidingly movable between an uncompressed position at which the volume of the inner chamber is at a maximum value and a compressed position at which the volume of the inner chamber is at a minimum value. A position indicating member is associated with the end cap and housing to indicate the position of the end cap relative to the housing at predetermined positions between the uncompressed position and the compressed position.

Abstract: In one embodiment, a server generates expected levels of capability associated with possible combinations of settings for first and second adjustable parameters for an aspect of a software image feature. The server receives an indication of a desired level of capability for the aspect of the software image feature and, based on the indication, identifies a particular expected level of capability associated with a particular possible combination of the settings for the first and second adjustable parameters. The particular expected level of capability is closer to a desired level of capability for an aspect of a software image feature than the other expected levels of capability associated with the possible combinations of the settings for the first and second adjustable parameters. The server produces a software image that includes the particular possible combination of the settings for the first and second adjustable parameters.

Abstract: In an embodiment, an antenna is disclosed. The antenna comprises: a substrate of dielectric material, the substrate being substantially planar and defining a first surface and a second surface opposed to the first surface; an electrically conductive ground plane on the first surface, the ground plane defining a slot; a first feed line configured to receive a first input signal having a frequency within an operating frequency range, the first feed line extending over the slot on the second surface in a first direction by a length of between 0.3 and 0.

Abstract: A computer device performs operations for managing registry access, including monitoring a user process on the computer device and, in response, establishing a set of registry access rules relevant to the user process. Each registry operation requested by the user process is evaluated and, in response, an appropriate action determined. Such action suitably includes at least one of: blocking the registry operation in relation to a particular key in a registry of the operating system, and enabling access to a particular key in the registry of the operating system to perform the requested registry operation. In particular, the operations may be performed using a registry filter driver in a kernel mode of an operating system of the computer device.

Abstract: A dental charting system and method of generating a dental chart are provided. The dental charting system comprises a display unit, an input unit and an output unit. The display unit is configured to display a quadrant view of a set of teeth. The quadrant view comprises a quadrant subset of the set of teeth, and at least one of a diagnosis field and a procedure field for each tooth in the quadrant subset. Each tooth in the quadrant subset displayed having a crown, a root and an outline. The input unit is configured to receive an input for at least one of the diagnosis field and the procedure field for at least one tooth in the quadrant set of teeth. The output unit is configured to generate a dental chart displaying the set of teeth. Each tooth in the set of teeth displayed in a color associated with the received input for at least one of the diagnosis field and the procedure field.

Abstract: An extensible single point orchestration system receives service requests from applications. In dependence upon the service request a single third party provider service or multiple third party provider services is identified. When the single third party provider service is identified, the system dynamically adapts a core capability service, using a stored configuration entity, so as to set an appropriate message format and transmit a service call message to an external API of the identified single third party provider service. When multiple third party provider services are identified, the system dynamically adapts the core capability service, using another stored configuration entity, so as to set a respective appropriate message format for parallel data transmission of service call messages to each of the respective identified third party provider services and transmits the service call messages to respective external APIs of each of the third party provider services.

Abstract: Anonymous containers are discussed herein. An operating system running on a computing device, also referred to herein as a host operating system running on a host device, prevents an application from accessing personal information (e.g., user information or corporate information) by activating an anonymous container that is isolated from the host operating system. In order to create and activate the anonymous container, a container manager anonymizes the configuration and settings data of the host operating system, and injects the anonymous configuration and settings data into the anonymous container. Such anonymous configuration and settings data may include, by way of example and not limitation, application data, machine configuration data, and user settings data. The host operating system then allows the application to run in the anonymous container.

Abstract: There is provided apparatus and a method for assessing the integrity of a bonded joint and a bonded joint assembly. The assembly has a bonded joint monitored for bond integrity and comprises first (1) and second (2) components each defining a bonding surface (3,4); the joint (5) is formed between the bonding surfaces (3,4) and the first component (1) defines a passage (15) therethrough from the bonding surface to an exterior of the component. The joint (5) includes an optical fiber (11) extending along the joint (5) between the bonding surfaces, through the passage (15) and emerging from the passage (15) to the exterior of the component. The method of constructing the assembly includes the steps of passing the optical fiber (11) through the passage (15) and adhering the optical fiber (11) to the bonding surface (3) of the first component (1), thus bringing the two bonding surfaces (3,4) together and forming the bond (5).

Abstract: There is disclosed a system and method for processing requests over an architecture. The architecture may utilize logical partitioning to distribute work load across multiple logical servers in an efficient manager. The system may comprise a router, a directory, at least one logical server, and a wallet server. The router may receive a request from a consumer via the consumer's device and extract a value from the request that identifies the consumer. The router may access the directory, which may contain a map that matches consumers with logical servers, to determine which logical server to forward the request to. The router may then pass the request to the determined logical server. The logical server may process the request by utilizing both generic and network or market specific plug-in processing.

Abstract: An open-cavity, reduced-pressure treatment device and system for treating a cavity in a patient's body, such as an abdominal cavity, is presented. In one instance, an open-cavity, reduced-pressure treatment device includes a plurality of encapsulated leg members, each having an interior portion with a leg manifold member and formed with fenestrations operable to allow fluid flow into the interior portion, and a central connection member fluidly coupled to the plurality of encapsulated leg members. The central connection member has a connection manifold member. The open-cavity, reduced-pressure treatment devices, systems, and methods allow for, among other things, removal of fluids.

Abstract: Selection of content selection criteria based on entities related by relationship dimensions. In one aspect, a method receives a selection of a seed entity described in entity relation data, the entity relation data defining instances of entities, and for each entity one or more relationship dimensions; generating a set of selected entities; iteratively updating the set of selected entities, each iteration comprising: determining a set of relationship dimensions from the entities in the set of selected entities, each relationship dimension in the set being selected from the one or more relationship dimensions of the entities in the set of selected entities, receiving a selection of one of the relationship dimensions and in response: determining a set of candidate entities from the relationship dimensions and in response to receiving a selection of one or more candidate entities, updating the set of selected entities to include the one or more candidate entities.

Abstract: Pseudorandom bit sequences are recorded to a heat-assisted recording medium at a laser power that is stepped while recording the pseudorandom bit sequences. The pseudorandom bit sequences are read from the heat-assisted recording medium to determine timing differences between bits written before and after the laser power is stepped. A thermal gradient of bits written to the heat-assisted recording medium is determined based on the timing differences.

Abstract: Selection of content selection criteria based on entities related by relationship dimensions. In one aspect, a method receives a selection of a seed entity described in entity relation data, the entity relation data defining instances of entities, and for each entity one or more relationship dimensions; generating a set of selected entities; iteratively updating the set of selected entities, each iteration comprising: determining a set of relationship dimensions from the entities in the set of selected entities, each relationship dimension in the set being selected from the one or more relationship dimensions of the entities in the set of selected entities, receiving a selection of one of the relationship dimensions and in response: determining a set of candidate entities from the relationship dimensions and in response to receiving a selection of one or more candidate entities, updating the set of selected entities to include the one or more candidate entities.

Abstract: A novel disposable cartridge for use in an electronic nicotine delivery system having an electric heater includes a reservoir containing a nicotine-containing liquid, a port in liquid communication with the reservoir, a liquid barrier disposed proximate the port to prevent undesired leakage of the nicotine-containing liquid from the reservoir, and a durable, elongate wick arranged and configured to be slideable in the port and to contact the nicotine-containing liquid in the reservoir.