Abstract: A computer-based system and process are disclosed for reconstructing the internal electrical behavior of a patient's heart based partly or wholly on the patient's electrocardiogram (ECG). The output of the process may include, for example, a cardiac activation map, and/or a representation of transmembrane potentials over time. The process advantageously does not require any medical imaging of the patient, and does not require any special medical equipment. For example, the patient's activation map and transmembrane potentials may be reconstructed based solely on a preexisting or newly-obtained 12-lead cardiac ECG of the patient. The process makes use of a machine learning model, such as a neural network based model, trained with actual and/or simulated ECGs and intracardiac electrical data (typically transmembrane potentials) of many thousands of patients.

Abstract: The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for adversarially generated communication. In some implementations, first information is used as input for a generator machine-learning network. Information is taken from both the generator machine-learning network and target information that includes sample signals or other data. The information is sent to a discriminator machine-learning network which produces decision information including whether the information originated from the generator machine-learning network or the target information. An optimizer takes the decision information and performs one or more iterative optimization techniques which help determine updates to the generator machine-learning network or the discriminator machine-learning network.

Abstract: A peritoneal dialysis system for detecting peritonitis is disclosed herein. In one example, an impedance measurement system includes an impedance monitor configured to sense an impedance of peritoneal dialysis (“PD”) fluid residing within a fluid line. The impedance monitor includes a first conductive lead disposed within a first port along the fluid line and a second conductive lead disposed within a second port along the fluid line. The impedance measurement system also includes a control unit electrically coupled to the impedance monitor. The control unit uses the sensed impedance from the impedance monitor to detect white blood cells to form a patient peritonitis determination. The control unit may communicate the peritonitis determination to alert a clinician.

Abstract: The present invention relates to a cell of the human immune system transduced or transfected with a T cell receptor (TCR) or chimeric antigen receptor (CAR), said cell being further modified to render its MALT1 protease activity constitutive active. The present invention further relates a said cell of the human immune system for use as a medicament. In particular, the present invention relates to said cell for use in adoptive T cell therapy. The invention also comprises a cell of the human immune system transduced or transfected with a T cell receptor (TCR) or chimeric antigen receptor (CAR), and further modified to render its MALT1 protease activity constitutive active for use in a method of treating cancer. The invention also relates to a method for generating a cell of the human immune system, comprising modifying a cell to render MALT1 protease activity constitutive active.

Abstract: A computer-based system and process are disclosed for reconstructing the internal electrical behavior of a patient's heart based partly or wholly on the patient's electrocardiogram (ECG). The output of the process may include, for example, a cardiac activation map, and/or a representation of transmembrane potentials over time. The process advantageously does not require any medical imaging of the patient, and does not require any special medical equipment. For example, the patient's activation map and transmembrane potentials may be reconstructed based solely on a preexisting or newly-obtained 12-lead cardiac ECG of the patient. The process makes use of a machine learning model, such as a neural network based model, trained with actual and/or simulated ECGs and intracardiac electrical data (typically transmembrane potentials) of many thousands of patients.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for characterizing radio propagation channels. One method includes receiving, at a first modem, a first unit of communication over a radio frequency (RF) communication path from a second modem, wherein the first modem and the second modem process information for RF communications. The first modem identifies fields in the first unit of communication, the fields used to analyze the RF communication path. The first modem extracts data from the fields. The first modem accesses a channel model for approximating a channel representative of the RF communication path from the first modem to the second modem, wherein the channel model includes machine learning models. The first modem trains the channel model using the extracted data. The first modem applies the trained channel model to simulate a set of channel effects associated with the communication path.

Abstract: An electrified vehicle winch includes, among other things, a winch and a charge port connector that connects to a charge port of an electrified vehicle. The winch is powered through the charge port connector. A winch operating method includes, among other things, operating a winch to move a load and, during the operating, powering the winch through a charge port of the electrified vehicle.

Abstract: A medical waste fluid collection cart may include a container assembly and a suction tube having a lumen extending through the suction tube. The suction tube may communicate with the container to deposit waste fluid from a surgical site in the container. The container assembly may include a container, a base forming a bottom of the container, and a lid assembly. The base may include an interior surface defining a draining opening. The interior surface may extend along a ramped path toward the drain opening. The lid assembly may include a lid ring and a lid capable of engaging each other with a twist lock mechanism. The lid ring may engage the container and the lid may cover at least part of a central opening to the container. The container may have a window and a tinting assembly. The container assembly may have a vacuum level detection system.

Abstract: Adhesive seals include an elastic sealing sheet, an adhesive layer, and a release sheet on the adhesive layer.

Abstract: A laser ablation system, and method, facilitates the execution of user-defined scans (i.e., in which a laser beam is scanned across a sample along a beam trajectory to ablate or dissociate a portion of the sample) and enables the user define additional scans while a scan is being executed.

Abstract: Viral filtration media, an article comprising the viral filtration media, and a method of filtering a virus-containing sample using the viral filtration media, wherein the viral filtration media comprises: a porous substrate comprising a surface having a polymer grafted thereto, wherein the grafted polymer comprises interpolymerized monomers comprising: a (meth)acrylic acid monomer: and, optionally, a poly (alkylene oxide) monomer.

Abstract: Aspects of this disclosure relate to one or more particles that move within a container in response to a magnetic field. A measurement circuit is configured to output an indication of the magnetic field based on position of the one or more particles.

Abstract: The present disclosure relates generally to detection of molecular biomarkers in a sample or diagnosis of a subject based upon detection or quantification of molecular biomarkers in a sample, specifically to the identification and use of biomarkers for pancreatic cysts.

Abstract: A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided.

Abstract: Provided is an Active Electronically Scanned Array (AESA) including at least one planar Printed Circuit Board (PCB), a first set of first notch antenna elements arranged on the PCB, and a second set of second antenna elements; wherein the first and second antenna elements are interleaved, wherein each first antenna element is configured to transmit and/or receive, a signal having a first direction of polarization, and wherein each second antenna element is configured to transmit and/or receive, a signal having a second direction of polarization, which is different from the first direction of polarization, characterized in that each second antenna element is a notch antenna element which is included in a surface mounted element on the PCB, and wherein the first direction of polarization and the second direction of polarization is separated by at least 45°.

Abstract: A mobile robot is configured for operation in a commercial or industrial setting, such as an office building or retail store. The robot can patrol one or more routes within a building, and can detect violations of security policies by objects, building infrastructure and security systems, or individuals. In response to the detected violations, the robot can perform one or more security operations. The robot can include a removable fabric panel, enabling sensors within the robot body to capture signals that propagate through the fabric. In addition, the robot can scan RFID tags of objects within an area, for instance coupled to store inventory. Likewise, the robot can generate or update one or more semantic maps for use by the robot in navigating an area and for measuring compliance with security policies.

Abstract: A method of forming a microfluidic device is disclosed. The method includes forming a first dielectric layer on a substrate, forming electrodes partially into the first dielectric layer, and forming a second dielectric layer on the electrodes. The method includes filling, with a metal material, two wells formed in the second dielectric layer such that the metal material is in direct contact with the electrodes. The method includes forming a third dielectric layer on the metal material and second dielectric layer. The method includes filling, with a structural material, a channel formed between the wells such that the structural material does not directly contact the electrodes. The method includes forming a fourth dielectric layer on the third dielectric layer and the structural material, extracting the structural material through at least one vent hole in the fourth dielectric layer, and forming a fifth dielectric layer on the fourth dielectric layer.

Abstract: The present invention is directed to coated articles. A substrate is coated with an underlayer having at a first underlayer film made of a first high refractive index material. A transparent conductive oxide layer over at least a portion of the underlayer. An embedded film is embedded within the transparent conductive oxide layer wherein the embedded film comprises a second high refractive index material.

Abstract: A combustor includes an outer tube having an interior space extending between first and second openings. An inner tube within the interior space extends along a centerline from a first end to a second end and defines a central passage. The first end is closed by an end wall in a fluid-tight manner. The interior space is supplied with a mixture of air and combustible fuel pre-mixed upstream of the inner tube. The inner tube has fluid directing structures for directing the pre-mixed mixture radially inward from the interior space to the central passage such that the pre-mixed mixture converges towards the central axis in a direction extending towards the second end of the inner tube.