Abstract: A hand tool includes a first and a second handles, a rotating locking set, a fastening set, and a spring. The first and second handles include chamfered planes respectively. The rotating locking set includes a rotating block and a locking block. The fastening set includes a stud and a nut. The spring is mounted around the stud and elastically abuts against the rotating block. The first handle or the second handle drives the rotating block to disengage from the locking block when being pulled by an external force. The first handle and the rotating block rotate with respect to the second handle by the stud as the center point. The rotating block and the locking block are locked with each other after rotating a specific angle, so as to position the first handle and the second handle.

Abstract: A hand tool includes a first handle, a second handle, a rotating locking set and a button set. The first and second handles include oblique faces respectively. The rotating locking set includes an annular seat arranged in the first handle, a locking barrel passing the annular seat and rotatable relative to the annular seat, and a locking block. The locking barrel includes an insertion hole and at least one locking groove communicating with each other. One end of the locking block is fixed on the second handle, and the other end of the locking block is combined with the locking barrel. The button set is disposed on the first handle and includes a button exposed from the first handle, a locking lever, and a spring. The locking lever is connected with the button and extends into the insertion hole. The spring is arranged in the first handle.

Abstract: The invention relates to an antimicrobial knitted fabric, comprising at least one first knitted layer comprises one or more first yarns comprising a metallic material, wherein the first yarns are arranged to provide a plurality of free-floating loop structures at a surface of the first knitted layer thereby increasing surface area of the metallic material-comprising first yarns to enhance antimicrobial effect of the fabric.

Abstract: Disclosed herein are binding moieties that comprise non-CDR loops for masking the binding of a binding molecule to its target and CDRs for binding bulk serum proteins. Conditionally active target binding proteins that contain the binding moieties are also provided. Cleavable linkers used in the conditionally active target binding proteins are also disclosed.

Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Provided herein are EpCAM binding proteins, pharmaceutical compositions comprising such proteins or fragments thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such EpCAM binding proteins. Also disclosed are methods of using the disclosed EpCAM binding proteins in the prevention, and/or treatment diseases, conditions and disorders.

Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2: wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

Abstract: Provided herein are descriptions of extended-release immune cell binding protein comprising a masking peptide and cleavable linker, and the methods of using thereof. Also described is a pharmaceutical composition comprising a protein with a masking peptide and a cleavable linker, and the method of using thereof.

Abstract: The present disclosure is a screwdriver. A rotating seat includes a turntable and a plurality of locking blocks. A driving rod set includes a driving rod and a ratchet gear, and the ratchet gear is located in the turntable. A retaining set includes a tooth block and an elastic piece. The tooth block includes a plurality of teeth, and the elastic piece abuts a driving plate and the tooth block. A driving seat set includes a driving seat and a positioning set, and the positioning set includes a spring and a positioning piece. A locking block is inserted between the tooth block and the ratchet gear, so that the locking tooth is locked or separated from the ratchet gear.

Abstract: The present disclosure is a combined screwdriver. A handle includes a cavity. A rod is arranged in the cavity, and the rod includes a positioning part. A storage assembly includes a storage seat and a stopper seat, and the storage assembly is sleeved on the rod. The storage seat includes a sleeve and a plurality of elastic clips, the sleeve may move out of the cavity. An abutting piece is fixed on the positioning part, and the abutting piece includes a plurality of elastic pieces. The plurality of elastic pieces elastically abuts the sleeve, and a cap covers the cavity.

Abstract: A multifunctional hand tool has a grip and a metal working rod. The grip has an assembly hole. A polygonal coupling part is disposed on the assembly hole has. The metal working rod has two action sections, each action section has a polygonal portion, and each polygonal portion has an insertion hole. When one of the two action sections is inserted in the assembly hole, one of the two polygonal portions is engaged with the polygonal coupling part, the other action section is assembled to a suitable tool head, and a torque exerting element may be used to exert torque to the other polygonal portion or the insertion hole thereof. Accordingly, it is possible to provide versatility by having interchangeable tool heads on a top end and a bottom end of the metal working rod, and increasing torque on the top end and the bottom end.

Abstract: A ratchet wrench for rotating a workpiece with a top side includes a wrench body and a ratchet. The wrench body has a working end. The working end has a first end face and a second end face opposite to each other. The working end is disposed with a through hole. The ratchet is disposed in the through hole and formed with a first tool trough and a second tool trough communicating with each other. The first tool trough is arranged corresponding to the first end face and has a first blocking face. The second tool trough is arranged corresponding to the second end face and has a second blocking face. The workpiece is optionally received in the first tool trough or the second tool trough to make the top side abut against the first blocking face or the second blocking face.

Abstract: A hand tool includes a first and a second handles, a rotating locking set, a fastening set, and a spring. The first and second handles include chamfered planes respectively. The rotating locking set includes a rotating block and a locking block. The fastening set includes a stud and a nut. The spring is mounted around the stud and elastically abuts against the rotating block. The first handle or the second handle drives the rotating block to disengage from the locking block when being pulled by an external force. The first handle and the rotating block rotate with respect to the second handle by the stud as the center point. The rotating block and the locking block are locked with each other after rotating a specific angle, so as to position the first handle and the second handle.

Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2: wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

Abstract: The present disclosure is a screwdriver. A rotating seat includes a turntable and a plurality of locking blocks. A driving rod set includes a driving rod and a ratchet gear, and the ratchet gear is located in the turntable. A retaining set includes a tooth block and an elastic piece. The tooth block includes a plurality of teeth, and the elastic piece abuts a driving plate and the tooth block. A driving seat set includes a driving seat and a positioning set, and the positioning set includes a spring and a positioning piece. A locking block is inserted between the tooth block and the ratchet gear, so that the locking tooth is locked or separated from the ratchet gear.

Abstract: The present disclosure is a combined screwdriver. A handle includes a cavity. A rod is arranged in the cavity, and the rod includes a positioning part. A storage assembly includes a storage seat and a stopper seat, and the storage assembly is sleeved on the rod. The storage seat includes a sleeve and a plurality of elastic clips, the sleeve may move out of the cavity. An abutting piece is fixed on the positioning part, and the abutting piece includes a plurality of elastic pieces. The plurality of elastic pieces elastically abuts the sleeve, and a cap covers the cavity.

Abstract: A hand tool with insulation handle. The handle is made of an insulation material and is formed with a hollow portion (11) and an embedding groove (12). The embedding groove (12) is communicated with the hollow portion (11) and located on a front end (101) of the handle. The tool rod (20) includes a shaft (21) having a rear end (211) and a front end (212). The end plug (30) is made of the insulation material and includes a clamping section (31) and an abutting section (32). The rear end (211) of the shaft is positioned in the end plug through snapping the clamping section. The tool rod (20) is replaceablely inserted in the hollow portion (11) of the handle and protrudes from the handle.

Abstract: The present invention relates to devices for carrying firearms, including rifles, and methods for making and using devices of the present invention.

Abstract: A hand tool with insulation handle. The handle is made of an insulation material and is formed with a hollow portion (11) and an embedding groove (12). The embedding groove (12) is communicated with the hollow portion (11) and located on a front end (101) of the handle. The tool rod (20) includes a shaft (21) having a rear end (211) and a front end (212). The end plug (30) is made of the insulation material and includes a clamping section (31) and an abutting section (32). The rear end (211) of the shaft is positioned in the end plug through snapping the clamping section. The tool rod (20) is replaceablely inserted in the hollow portion (11) of the handle and protrudes from the handle.