Abstract: Gate-all-around structures having devices with source/drain-to-substrate electrical contact are described. An integrated circuit structure includes a first vertical arrangement of horizontal nanowires above a first fin. A first gate stack is over the first vertical arrangement of horizontal nanowires. A first pair of epitaxial source or drain structures is at first and second ends of the first vertical arrangement of horizontal nanowires. One or both of the first pair of epitaxial source or drain structures is directly electrically coupled to the first fin. A second vertical arrangement of horizontal nanowires is above a second fin. A second gate stack is over the second vertical arrangement of horizontal nanowires. A second pair of epitaxial source or drain structures is at first and second ends of the second vertical arrangement of horizontal nanowires. Both of the second pair of epitaxial source or drain structures is electrically isolated from the second fin.

Abstract: A multifunctional hand tool has a grip and a metal working rod. The grip has an assembly hole. A polygonal coupling part is disposed on the assembly hole has. The metal working rod has two action sections, each action section has a polygonal portion, and each polygonal portion has an insertion hole. When one of the two action sections is inserted in the assembly hole, one of the two polygonal portions is engaged with the polygonal coupling part, the other action section is assembled to a suitable tool head, and a torque exerting element may be used to exert torque to the other polygonal portion or the insertion hole thereof. Accordingly, it is possible to provide versatility by having interchangeable tool heads on a top end and a bottom end of the metal working rod, and increasing torque on the top end and the bottom end.

Abstract: A ratchet wrench for rotating a workpiece with a top side includes a wrench body and a ratchet. The wrench body has a working end. The working end has a first end face and a second end face opposite to each other. The working end is disposed with a through hole. The ratchet is disposed in the through hole and formed with a first tool trough and a second tool trough communicating with each other. The first tool trough is arranged corresponding to the first end face and has a first blocking face. The second tool trough is arranged corresponding to the second end face and has a second blocking face. The workpiece is optionally received in the first tool trough or the second tool trough to make the top side abut against the first blocking face or the second blocking face.

Abstract: A video acquisition method, an electronic device, and a storage medium are disclosed. The video acquisition method is applicable to a virtual scene including at least one virtual object and at least one virtual camera. The terminal determines a target virtual object from the at least one virtual object in response to a camera capturing instruction triggered by a user on a virtual scene interface, controls the at least one virtual camera to capture the target virtual object to acquire capturing data of the target virtual object, and acquires the video of the target virtual object based on the capturing data.

Abstract: A hand tool includes a first and a second handles, a rotating locking set, a fastening set, and a spring. The first and second handles include chamfered planes respectively. The rotating locking set includes a rotating block and a locking block. The fastening set includes a stud and a nut. The spring is mounted around the stud and elastically abuts against the rotating block. The first handle or the second handle drives the rotating block to disengage from the locking block when being pulled by an external force. The first handle and the rotating block rotate with respect to the second handle by the stud as the center point. The rotating block and the locking block are locked with each other after rotating a specific angle, so as to position the first handle and the second handle.

Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2: wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

Abstract: The present disclosure is a screwdriver. A rotating seat includes a turntable and a plurality of locking blocks. A driving rod set includes a driving rod and a ratchet gear, and the ratchet gear is located in the turntable. A retaining set includes a tooth block and an elastic piece. The tooth block includes a plurality of teeth, and the elastic piece abuts a driving plate and the tooth block. A driving seat set includes a driving seat and a positioning set, and the positioning set includes a spring and a positioning piece. A locking block is inserted between the tooth block and the ratchet gear, so that the locking tooth is locked or separated from the ratchet gear.

Abstract: The present disclosure is a combined screwdriver. A handle includes a cavity. A rod is arranged in the cavity, and the rod includes a positioning part. A storage assembly includes a storage seat and a stopper seat, and the storage assembly is sleeved on the rod. The storage seat includes a sleeve and a plurality of elastic clips, the sleeve may move out of the cavity. An abutting piece is fixed on the positioning part, and the abutting piece includes a plurality of elastic pieces. The plurality of elastic pieces elastically abuts the sleeve, and a cap covers the cavity.

Abstract: A hand tool with insulation handle. The handle is made of an insulation material and is formed with a hollow portion (11) and an embedding groove (12). The embedding groove (12) is communicated with the hollow portion (11) and located on a front end (101) of the handle. The tool rod (20) includes a shaft (21) having a rear end (211) and a front end (212). The end plug (30) is made of the insulation material and includes a clamping section (31) and an abutting section (32). The rear end (211) of the shaft is positioned in the end plug through snapping the clamping section. The tool rod (20) is replaceablely inserted in the hollow portion (11) of the handle and protrudes from the handle.

Abstract: The present invention relates to devices for carrying firearms, including rifles, and methods for making and using devices of the present invention.

Abstract: A hand tool with insulation handle. The handle is made of an insulation material and is formed with a hollow portion (11) and an embedding groove (12). The embedding groove (12) is communicated with the hollow portion (11) and located on a front end (101) of the handle. The tool rod (20) includes a shaft (21) having a rear end (211) and a front end (212). The end plug (30) is made of the insulation material and includes a clamping section (31) and an abutting section (32). The rear end (211) of the shaft is positioned in the end plug through snapping the clamping section. The tool rod (20) is replaceablely inserted in the hollow portion (11) of the handle and protrudes from the handle.

Abstract: Provided herein are EpCAM binding proteins, pharmaceutical compositions comprising such proteins or fragments thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such EpCAM binding proteins. Also disclosed are methods of using the disclosed EpCAM binding proteins in the prevention, and/or treatment diseases, conditions and disorders.

Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Disclosed herein are conditionally active receptors which comprise a target antigen binding domain and a binding moiety. Each binding moiety comprises non-CDR loops for masking the binding of a target antigen binding domain to its target. The receptors are activated upon cleavage of the cleavable linkers. Pharmaceutical compositions comprising cells comprising the conditionally active receptors disclosed herein and methods of using such formulations are further provided.

Abstract: Disclosed herein are conditionally active multivalent target-binding proteins which comprise two binding moieties, two linkers, two target antigen binding domains, and a constant domain. Each binding moiety comprises non-CDR loops for masking the binding of a target antigen binding domain to its target and CDRs for binding a further target. The multivalent target-binding proteins are activated upon cleavage of the cleavable linkers. Also disclosed are pro immune modulating molecules comprising dual binding moieties comprising non-CDR loops and cleavable linkers, that prohibit the binding of a target binding domain to their targets (e.g., binding of an antibody to an immune modulatory target is masked by the dual binding moieties). The dual binding moieties further have specificity for a bulk serum protein or a dual binding moiety target (e.g., a tumor antigen, an immune modulatory protein).

Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2: wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.

Abstract: A torque screwdriver includes a sleeve (10), an escape element (20), an elastic body (30) and a shaft (40). The sleeve (10) has a first trough (11), a second trough (12) and a third trough (13). The escape element (20) is disposed in the third trough (13) and rotated with the sleeve (10). The sleeve (10) has driving teeth (22). Each driving tooth (22) has a buffer surface (222). The elastic body (30) is disposed in the sleeve (10) and formed beside the escape element (20). The shaft (40) includes a teeth seat (41) and a rod (43). The teeth seat (41) is disposed in the third trough (13) and has driven teeth (411). Each driven tooth (411) engages or disengages with one of the driving teeth (22). Thereby, the structural strength of each driving tooth can be enhanced to increase durability, and the operational feel also becomes better.

Abstract: Disclosed herein are binding moieties that comprise non-CDR loops for masking the binding of a binding molecule to its target and CDRs for binding bulk serum proteins. Conditionally active target binding proteins that contain the binding moieties are also provided. Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of using such formulations are further provided.

Abstract: Disclosed herein is a dual binding moiety that comprises non-CDR loops for masking the binding of a domain, such as a target antigen binding domain to its target, by steric occlusion and specific masking, and CDRs for binding bulk serum proteins. Pharmaceutical compositions comprising the dual binding moiety disclosed herein and methods of using such compositions are further provided.