Abstract: A ratchet driving mechanism for a hand tool includes: a drive unit, including a drive shaft, a position member and a plurality of latch members, wherein each of the latch members includes a latch plate and an elastic piece; an adjustment ring, sleeved on the drive shaft and formed with a plurality of cavities allowing the position member to be selectively latched and positioned and an accommodation slot allowing each of the latch plates to inwardly/outwardly move; and a ratchet unit, sleeved on the drive shaft and formed with a plurality of ratchet teeth allowing each of the latch plates to be engaged. Accordingly, during the drive shaft driving the ratchet unit for generating rotation, the position member is able to precisely position the ratchet unit on drive shaft.

Abstract: The present disclosure provides methods of treating a subject suffering from or at risk of a BRAF V600 mutation or BRAF fusion mutation related disease or condition, without activating the MAPK pathway or inducing expression of MAPK pathway genes in cells harboring wild-type BRAF.

Abstract: The present invention disclosed a filter having an automatic control of flow, which contains a housing having a water inlet and a water outlet on one end, a bottom cover connecting to the other end of the housing and a filter material provided in the housing, comprising an outlet end fluidly connecting with the water outlet through a flow control unit. Based on the structure designs of the flow control unit, the filter of the present invention can remind users to replace the filter materials in an easy and visible way at the time when the filter materials reach the end of working period.

Abstract: The present invention disclosed a filter with an automatic control of flow, which contains a housing having a water inlet and a water outlet on one end, a bottom cover connecting to the other end of the housing and a filter material provided in the housing, comprising an outlet end fluidly connecting with the water outlet through a flow control unit. Based on the structure design of the flow control unit, the filter of the present invention can remind users to replace the filter materials in an easy and visible way at the time when the filter materials reach the end of working period.

Abstract: Compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R1, R2, Q1, Q2, and Q3, are described in this disclosure, compositions thereof, and methods and uses thereof.

Abstract: The present invention provides a filter device having a water inlet and a water outlet. The filter device comprises a filter cabin (10) and a filter core (11). The water inlet and the water outlet are disposed on one end of the filter cabin (10). The filter cabin (10) comprises a cabin body, a cabin door and a gear driving assembly. The cabin body disposes a gear-mounting slot for receiving and holding the gear driving assembly. The filter core has an end portion, which is fluidly connected with the water inlet and the water outlet. The filter core disposes a driving rack on an outside surface thereof. The driving rack is engaged with the gear driving assembly. The filter device of the present invention can quickly replace the filter core (11) by the special design of the filter core, the filter cabin (10) and the gear driving assembly.

Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line.

Abstract: The invention provides NSP4 inhibitors (such as anti-NSP4 antibodies) and methods of using the same.

Abstract: A hand tool with a latch structure includes a main body (10) and a latch unit (20) coupled to the main body (10), and the latch unit (20) includes a rod body (21) and an elastic element (22). The rod body (21) has a center hole (211) formed in an axial direction parallel to the rod body (21) and a through hole (213) formed in an axial direction perpendicular to the rod body (21) and communicated with the center hole (211). The elastic element (22) has a circular plate (221) and a tongue (222) formed by bending from an end of circular plate (221), and the circular plate (221) is clamped outside the rod body (21), and the tongue (222) passes through the through hole (213) into the center hole (211) to achieve the effects of an easy installation and a secured latch.

Abstract: A filter cartridge having double threads is provided, and has a housing and a cap. The housing is opaque and provided with a connecting portion, a filter containing portion and a bottom portion. The housing and the cap are tightly connected to each other by a connector. When the housing and the cap are assembled via the connector, various types of threads and shapes of the bottom portion of the housing can be selected. Additionally, users can conveniently observe the using condition of a filter media through an opened window formed on an outer circumference surface of the bottom portion of the housing and a transparent base, so that the user can then directly decide whether the filter media should be changed or not.

Abstract: A system includes a sound processor included in an electro-acoustic stimulation (“EAS”) device and that directs a cochlear implant to apply electrical stimulation to a patient and a receiver to apply acoustic stimulation to the patient. The system further includes a volume control facility and a selection facility that selectively associates the volume control facility with the electrical stimulation in response to a first user input, selectively associates the volume control facility with the acoustic stimulation in response to a second user input, and selectively associates the volume control facility with both the electrical stimulation and the acoustic stimulation in response to a third user input.

Abstract: A hand tool with a latch structure includes a main body (10) and a latch unit (20) coupled to the main body (10), and the latch unit (20) includes a rod body (21) and an elastic element (22). The rod body (21) has a center hole (211) formed in an axial direction parallel to the rod body (21) and a through hole (213) formed in an axial direction perpendicular to the rod body (21) and communicated with the center hole (211). The elastic element (22) has a circular plate (221) and a tongue (222) formed by bending from an end of circular plate (221), and the circular plate (221) is clamped outside the rod body (21), and the tongue (222) passes through the through hole (213) into the center hole (211) to achieve the effects of an easy installation and a secured latch.

Abstract: A system includes a sound processor included in an electro-acoustic stimulation (“EAS”) device and that directs a cochlear implant to apply electrical stimulation to a patient and a receiver to apply acoustic stimulation to the patient. The system further includes a volume control facility and a selection facility that selectively associates the volume control facility with the electrical stimulation in response to a first user input, selectively associates the volume control facility with the acoustic stimulation in response to a second user input, and selectively associates the volume control facility with both the electrical stimulation and the acoustic stimulation in response to a third user input.

Abstract: A ratchet driving mechanism for a hand tool includes: a drive unit, including a drive shaft, a position member and a plurality of latch members, wherein each of the latch members includes a latch plate and an elastic piece; an adjustment ring, sleeved on the drive shaft and formed with a plurality of cavities allowing the position member to be selectively latched and positioned and an accommodation slot allowing each of the latch plates to inwardly/outwardly move; and a ratchet unit, sleeved on the drive shaft and formed with a plurality of ratchet teeth allowing each of the latch plates to be engaged. Accordingly, during the drive shaft driving the ratchet unit for generating rotation, the position member is able to precisely position the ratchet unit on drive shaft.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line.

Abstract: An impact driver includes a sleeve, a striking unit and a chuck. The sleeve includes a bore with an open end and a polygonal section near the open end. The striking unit can strike a bit partially inserted in the sleeve through the open end. The chuck includes a ring, a tube, a spring and a ball. The tube includes a polygonal section movably inserted in the polygonal section of the bore of the sleeve, a circular section extended through the ring, an annular rib formed thereon, a polygonal bore for receiving the bit, and at least one aperture in communication with the polygonal bore. The spring is compressed between the annular rib and the sleeve. The ball includes a portion placed in the aperture and another portion movable into the polygonal bore.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.