Abstract: Disclosed herein is a dual binding moiety that comprises non-CDR loops for masking the binding of a domain, such as a target antigen binding domain to its target, by steric occlusion and specific masking, and CDRs for binding bulk serum proteins. Pharmaceutical compositions comprising the dual binding moiety disclosed herein and methods of using such compositions are further provided.

Abstract: The present invention relates to devices for carrying firearms, including rifles, and methods for making and using devices of the present invention.

Abstract: Disclosed herein is a conditionally active target binding protein that contains a first binding domain that binds to a bulk serum protein and sterically occludes binding of a second binding domain to its target. Pharmaceutical compositions comprising the conditionally active binding proteins disclosed herein and methods of using such compositions are further provided.

Abstract: A locking nut includes a first nut, including a nut base and a screwing portion protruding outward from a face of the nut base, where the screwing portion is provided with a plurality of longitudinal sectional grooves in a spaced manner, such that the screwing portion is formed with a plurality of screwing claw bodies, and a first inner threaded wall is provided on each of inner walls of the screwing claw bodies, and is used for threadedly connecting to a bolt; and a pressing ring, mounted and located outside the screwing portion of the first nut, where an inner wall of the pressing ring includes a pressing inner-wall for pressing outer walls of the screwing claw bodies of the screwing portion.

Abstract: A multifunctional hand tool has a grip and a metal working rod. The grip has an assembly hole. A polygonal coupling part is disposed on the assembly hole has. The metal working rod has two action sections, each action section has a polygonal portion, and each polygonal portion has an insertion hole. When one of the two action sections is inserted in the assembly hole, one of the two polygonal portions is engaged with the polygonal coupling part, the other action section is assembled to a suitable tool head, and a torque exerting element may be used to exert torque to the other polygonal portion or the insertion hole thereof. Accordingly, it is possible to provide versatility by having interchangeable tool heads on a top end and a bottom end of the metal working rod, and increasing torque on the top end and the bottom end.

Abstract: Provided herein is a strap with increased pull strength and footwear comprising such a strap. In particular, provided herein are straps with texture features that increase pull strength.

Abstract: Forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I.

Abstract: A hand tool for improving torque is provided. The handle tool includes a metal rod, a handle and a polygonal portion. The metal rod includes a first head, a first end and an operation section between the first head and the first end. The operation section includes a uniform outside diameter. The handle partially receives the metal rod and has a second head and a second end. The polygonal portion is formed on the operation section and exposed from the second head. The polygonal portion has a largest outside diameter. The largest outside diameter is equal to the uniform outside diameter. Accordingly, the metal rod has improved structural strength, does not break easily and facilitates ergonomic operations.

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

Abstract: The invention provides NSP4 inhibitors (such as anti-NSP4 antibodies) and methods of using the same.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.

Abstract: The invention provides NSP4 inhibitors (such as anti-NSP4 antibodies) and methods of using the same.

Abstract: Disclosed are compounds of Formula I(b): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Ring A, Ring HD, J, each T, R3, R4, R5, each R7, and m are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

Abstract: Compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R1, R2, Q1, Q2, and Q3, are described in this disclosure, compositions thereof, and methods and uses thereof.

Abstract: The invention relates generally to antibodies that bind CD147, activatable antibodies that bind to CD147 and methods of making and using these antibodies and activatable antibodies in a variety of therapeutic, prophylactic, and diagnostic contexts. In some embodiments, the CD147 antibodies and CD147 activatable antibodies bind human and cynomolgus monkey CD147.

Abstract: Forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I.

Abstract: The present invention provides a filter device having a water inlet and a water outlet. The filter device comprises a filter cabin (10) and a filter core (11). The water inlet and the water outlet are disposed on one end of the filter cabin (10). The filter cabin (10) comprises a cabin body, a cabin door and a gear driving assembly. The cabin body disposes a gear-mounting slot for receiving and holding the gear driving assembly. The filter core has an end portion, which is fluidly connected with the water inlet and the water outlet. The filter core disposes a driving rack on an outside surface thereof. The driving rack is engaged with the gear driving assembly. The filter device of the present invention can quickly replace the filter core (11) by the special design of the filter core, the filter cabin (10) and the gear driving assembly.

Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Q, P1 and P2 are as defined in this disclosure.