Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.

Abstract: An impact driver includes a sleeve, a striking unit and a chuck. The sleeve includes a bore with an open end and a polygonal section near the open end. The striking unit can strike a bit partially inserted in the sleeve through the open end. The chuck includes a ring, a tube, a spring and a ball. The tube includes a polygonal section movably inserted in the polygonal section of the bore of the sleeve, a circular section extended through the ring, an annular rib formed thereon, a polygonal bore for receiving the bit, and at least one aperture in communication with the polygonal bore. The spring is compressed between the annular rib and the sleeve. The ball includes a portion placed in the aperture and another portion movable into the polygonal bore.

Abstract: A toolbox includes two shells and at least one shelf. The shells are pivotally connected to each other. At least one of the shells includes two racks formed thereon. The shelf is formed with two toothed blocks for elastic engagement with the racks so that the shelf can be moved relative to the shell along the racks and kept in a desired position relative to the shell.

Abstract: A tool includes a chuck connected to a handle. The chuck includes a mandrel including a non-circular cavity defined therein, a slit in communication with the non-circular cavity, a first bore in communication with the non-circular cavity, and a second bore in communication with the slit. A bit with a non-circular profile can be inserted in the non-circular cavity. A flat bit can be inserted in the slit. A ball is located in the first bore. A pin is located in the second bore. A movable sleeve is located around and movable along the mandrel and formed with a thread. A rotary sleeve is rotationally located around the mandrel and formed with a thread engaged with the thread of the movable sleeve. By rotating the rotary sleeve, the movable sleeve pushes the ball into the non-circular cavity and the pin into the slit.

Abstract: A chuck includes a shaft, a ring, a ball and an elastic helical ferrule. The shaft includes a cavity defined therein and an aperture in communication with the cavity. The aperture includes a large open end and a small open end. The ring includes a tunnel for receiving the shaft. The ball includes a first portion for insertion in the tunnel via the large open end of the aperture and a second portion for insertion in the cavity via the small open end of the aperture. The elastic helical ferrule includes sections for contact with the ball and sections in contact with the shaft.

Abstract: Disclosed is a chuck including a body, at least one ball and a helical spring. The body includes an axial space defined therein and at least one radial bore with a small open end near the axial space and a large open end in an external side thereof. The ball includes a first section movably placed in the radial bore, a second section movable into the axial space, and a third section movably placed outside the radial bore. The helical spring is placed around the body and in contact with the third section of the ball for biasing the second section of the ball into a recess defined in a bit inserted in the axial space.

Abstract: A screwdriver-used torque transmission apparatus includes a frame including a slot, an aperture and four cavities. The slot is in communication with the aperture and cavities. A gear includes a non-circular aperture axially defined therein, teeth formed on a side thereof, and teeth formed on an opposite end thereof. The gear is located in the slot. A pawl formed with at least one tooth and a block is located in each of the cavities. A shell includes two pushers formed on an internal side thereof. The shell is rotationally provided around the frame between two one-way modes in each of which a related one of the pushers pushes the blocks of two related ones of the pawls to disengage the teeth of the two pawls from the teeth of the gear.

Abstract: A screwdriver includes a handle, a shaft, a torque-transmitting unit and a torque-adjusting unit. The shaft is partially inserted in the handle. The torque-transmitting unit is located in the handle and operable to transmit an adjustable maximum value of torque to the shaft from the handle. The torque-adjusting unit is partially located in the handle, connected to the torque-transmitting unit, and operable to adjust the adjustable maximum value of torque.

Abstract: A hand tool includes a handle, a shank pivotally connected to the handle, and a locking unit operable for retaining the shank in a selected one of first and second angles relative to the handle. The first angle is about 175° to 185°, wherein the second angle is about 115° to 145°.

Abstract: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

Abstract: An illuminated keyboard includes optical sensors and units each comprising an optically transmissive key member; a scissors-shaped structure having a top secured to the key member; a light guide diaphragm under the scissors-shaped structure; an insulating diaphragm under the light guide diaphragm and including a light source on a top surface, a positive conductor connected to a positive terminal of the light source and on the top surface, a negative conductor connected to a negative terminal of the light source and on a bottom surface, and a bus having one end interconnecting the positive and negative conductors, and the other end connected to the sensor; a film circuit board under the insulating diaphragm and including a holed rubber dome with the key member positioned therein; and a base board with the scissors-shaped structure retained thereon. Brightness is adjusted in response to light condition as sensed by the sensor.

Abstract: Disclosed is a chuck including a rod, a ball, two spring-loaded pushers, and a spring-loaded sleeve. The rod includes a hexagonal pocket axially defined therein, a circular pocket axially defined therein so that it is in communication with the hexagonal pocket, and an aperture transversely defined therein so that it is in communication with the hexagonal pocket. The ball is movably located in the aperture so that the ball can be partially inserted in the hexagonal pocket. The first spring-loaded pusher is movably located in the circular pocket for pushing a bit. The spring-loaded sleeve is movably located on the rod for pushing the ball in a direction. The second spring-loaded pusher is movably located between the rod and the sleeve for pushing the ball in an opposite direction.

Abstract: A chuck includes a cylinder, a ball, two spring-loaded pushers and a spring-loaded sleeve. The cylinder includes a hexagonal pocket axially defined therein, a circular pocket axially defined therein, and an aperture transversely defined therein. The ball is movably located in the aperture so that the ball can be inserted partially in the hexagonal pocket. The first pusher is movably located in the circular pocket for pushing a bit. The second pusher is movably located around the cylinder and abutted against the ball. The sleeve is movably located on the cylinder and formed with first and second annular ribs on an internal side thereof. The first rib is abutted against the second pusher while the second rib is abutted against the ball so that the ball is kept in the aperture while the second pusher is retained around the cylinder.