Abstract: The invention provides NSP4 inhibitors (such as anti-NSP4 antibodies) and methods of using the same.

Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Z2, Z3, and Z5 are as described herein, compositions thereof, and uses thereof.

Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Q, P1 and P2 are as defined in this disclosure.

Abstract: The present invention discloses a filter with an automatic control of flow, which contains a housing having a water inlet and a water outlet on one end, a bottom cover connecting to the other end of the housing and a filter material provided in the housing, comprising an outlet end fluidly connecting with the water outlet through a flow control unit. Based on the structure design of the flow control unit, the filter of the present invention can remind users to replace the filter materials in an easy and visible way at the time when the filter materials reach the end of working period.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

Abstract: The present disclosure provides methods of treating a subject suffering from or at risk of a BRAF V600 mutation or BRAF fusion mutation related disease or condition, without activating the MAPK pathway or inducing expression of MAPK pathway genes in cells harboring wild-type BRAF.

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract: Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Q, P1 and P2 are as defined in this disclosure.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, wherein the compounds are of Formula (I): Methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases are also described.

Abstract: Disclosed are compounds of Formula I(b): or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Ring A, Ring HD, J, each T, R3, R4, R5, each R7, and m are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

Abstract: The present invention provides a reverse osmosis filtration system without pressure tanks consisting of a filter element connecting member and external filter elements and having a raw water inlet, a pure water outlet and a wastewater outlet. In the reverse osmosis filtration system of the present invention, filter elements can be quickly and easily installed for avoiding leakage occurs during the installation or replacement of the filter elements, so that users can conveniently install or replace the filter elements by themselves and purposes of convenient operation and leakage prevention can be achieved. Meanwhile, water storage pressure tanks and pumps are omitted in the reverse osmosis filtration system of the present invention for reducing manufacturing costs and effectively avoiding secondary pollution.

Abstract: Heterocyclic compounds of formula (I), methods for their preparation, pharmaceutical compositions containing such a compound and their therapeutic uses.

Abstract: A combinative connector includes a connecting rod and a socket. The connecting rod sequentially includes a polygonal insert, a circular portion, a conical frustum and an external annular groove. The socket sequentially includes a polygonal bore, a circular bore, an internal annular groove and an annular flange. During insertion of the polygonal insert in the polygonal bore, the conical frustum is moved past the annular flange before the circular portion is inserted in the circular bore, the conical frustum is inserted in the internal annular groove and engaged with the annular flange, and the annular flange is inserted in the external annular groove. A gap between the circular portion and a wall of the circular bore is smaller than a gap between the polygonal insert and a wall of the polygonal bore to reduce rocking of the connecting rod relative to the socket.

Abstract: A multi-functional toolbox includes at least one storage unit and a connector detachably connected to the storage unit. The storage unit includes a box and a cover movable relative to the box between a first position and a second position. In the first position, the cover closes the box. In the second position, the cover opens the box.

Abstract: Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Z2, Z3, and Z5 are as described herein, compositions thereof, and uses thereof.

Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.