Abstract: The disclosed technology is generally directed to code transparency. In one example of the technology, a claim associated with an application is received. The claim is a document that is signed with a claim signature and that includes evidence associated with a policy, and further includes an expected set of at least one binary measurement associated with the application. The evidence is cryptographically verifiable evidence associated with the application. A trusted execution environment (TEE) is used to provide a distributed ledger. The claim is verified. Verifying the claim includes verifying the expected set of at least one binary measurement associated with the application, verifying the claim signature, and, based at least on the evidence, verifying that the application meets the policy. Upon successful verification of the claim, the claim is appended to the distributed ledger. A ledger countersignature associated with the claim is generated.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: An actuator system for articulated mechanism may have a fluid actuator having a displaceable member operating an output configured to apply an output force to the articulated mechanism. A fluid system may be in fluid communication with the fluid actuator to supply the fluid actuator with motive fluid to contribute to the output force. The fluid system may include a pressure reservoir configured for storing fluid, a pumping device for controlling a pressure of the fluid in the reservoir, and a circuit for directing the fluid from the reservoir to the fluid actuator. An actuator device may be operatively connected to the fluid actuator to apply a variable force to the displaceable member to contribute to the output force.

Abstract: The disclosed technology is generally directed to code transparency. In one example of the technology, evidence associated with a policy is obtained. The evidence includes data that includes cryptographically verifiable evidence associated with initial source code in accordance with the policy. The initial source code is source code for a CTS. The initial binary is based on the initial source code is executed in a TEE such that a CTS instance begins operation. The CTS instance is configured to register guarantee(s) associated with code approved by the CTS instance. The TEE is used to provide a ledger. The evidence is stored on the ledger. Measurement(s) associated with the binary are provided. A service key associated with CTS instance is generated. TEE attestation of the measurement(s), the evidence, and the service key is provided.

Abstract: The present invention relates to a yeast cell producing a functional antibiotic-inactivating enzyme. The yeast cell of the invention comprises an exogenous nucleic acid encoding the antibiotic-inactivating enzyme, wherein the exogenous nucleic acid comprises an intron able to prevent the production of a functional antibiotic-inactivating enzyme in a bacterial host cell.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: Oral care compositions and methods of use thereof are disclosed herein. In accordance with some aspects, the oral care composition comprises from about 0.5 to about 9 wt. % of one or more surfactants; from about 0.3 to about 1 wt. % of one or more thickening agent; particles having a refractive index of from about 1.0 to about 2.5; a stannous ion source; a nitrate ion source; and a phosphate ion source, wherein the composition is substantially free of a titanium containing material, and all weight percentages are based on the total weight of the oral care composition.

Abstract: Aspects of the invention are directed to oral care compositions. In accordance with an aspect, provided is an oral care composition having a surfactant system comprising at least one of: (i) a non-sulfate based anionic surfactant and an amphoteric surfactant, or (ii) a nonionic surfactant and an amino acid surfactant; a stannous ion source; a nitrate ion source; and a phosphate source.

Abstract: Oral care compositions comprising a stannous ion source, tetrasodium pyrophosphate and an antioxidant, as well as to methods of using these compositions are disclosed herein. In some embodiments, the antioxidant is selected from ascorbyl phosphate and ascorbate.

Abstract: Described herein are oral care compositions comprising a surfactant system comprising an amino acid derived surfactant, and an amphoteric surfactant; a zinc salt; and a stannous ion source. Methods of making and using the same are also described.

Abstract: Described herein are oral care compositions having a surfactant system comprising four or more surfactants individually selected from a non-sulfate based anionic surfactant, an amphoteric surfactant, a nonionic surfactant, and an amino acid surfactant; a stannous ion source; a nitrate ion source; and a phosphate source. Methods of making and using these compositions are also described.

Abstract: Methods, systems, and computer program products for direct assignment of physical devices to confidential virtual machines (VMs). At a first guest privilege context of a guest partition, a direct assignment of a physical device associated with a host computer system to the guest partition is identified. The guest partition includes the first guest privilege context and a second guest privilege context, which is restricted from accessing memory associated with the first guest privilege context. The guest partition corresponds to a confidential VM, such that a memory region associated with the guest partition is inaccessible to a host operating system. It is determined, based on a policy, that the physical device is allowed to be directly assigned to the guest partition. Communication between the physical device and the second guest privilege context is permitted, such as by exposing the physical device on a virtual bus and/or forwarding an interrupt.

Abstract: A spectroscopy device including: an electron source arranged to emit a flux of electrons towards a sample, a pulsed photon source emitting photon pulses towards the sample, at least one spectrometer for receiving a flux of electrons originating from the sample, at least one electron detector; and at least one deflector, between the electron source and the at least one electron detector, synchronized with the pulsed photon source to allow or prevent the passage of electrons emitted by the electron source, towards the electron detector.

Abstract: The disclosed technology is generally directed to code transparency. In one example of the technology, a claim associated with an application is received. The claim is a document that is signed with a claim signature and that includes evidence associated with a policy, and further includes an expected set of at least one binary measurement associated with the application. The evidence is cryptographically verifiable evidence associated with the application. A trusted execution environment (TEE) is used to provide a distributed ledger. The claim is verified. Verifying the claim includes verifying the expected set of at least one binary measurement associated with the application, verifying the claim signature, and, based at least on the evidence, verifying that the application meets the policy. Upon successful verification of the claim, the claim is appended to the distributed ledger. A ledger countersignature associated with the claim is generated.

Abstract: The disclosed technology is generally directed to code transparency. In one example of the technology, evidence associated with a policy is obtained. The evidence includes data that includes cryptographically verifiable evidence associated with initial source code in accordance with the policy. The initial source code is source code for a CTS. The initial binary is based on the initial source code is executed in a TEE such that a CTS instance begins operation. The CTS instance is configured to register guarantee(s) associated with code approved by the CTS instance. The TEE is used to provide a ledger. The evidence is stored on the ledger. Measurement(s) associated with the binary are provided. A service key associated with CTS instance is generated. TEE attestation of the measurement(s), the evidence, and the service key is provided.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.