Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

Abstract: A method for de-icing or anti-icing an aircraft portion having at least one piezoelectric element fastened on the inner face of the aircraft portion includes, during a design phase of the aircraft portion, placing the piezoelectric element on an area of the aircraft portion to determine frequencies of resonance and increased dynamic coupling, and during the de-icing or anti-icing of the aircraft portion, the same piezoelectric element is excited according to the natural frequencies of the area.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: An electronic circuit includes a plurality of processing elements, a register bank, and a control circuit. The processing elements consume power by processing a plurality of operands to generate a plurality of result values. The register bank has a plurality of registers. The control circuit is configured to determine one or more unused processing elements among the processing elements by snooping one or more incoming operands and an instruction type, control routing of one or more random operands from the register bank to the unused processing elements, and control routing of a random result value generated by one of the unused processing elements into a trash register of the registers. The power consumed by the unused processing elements in the generation of the random result value and a write of the random result value into the trash register temporally blurs a total power consumed by the electronic circuit.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: The present invention relates to compounds of formula (I) their salts and derivatives. Further object of the present invention are compositions, which comprise at least one compound of formula (I) or its pharmaceutically acceptable salts and derivatives and excipients and, optionally, a further active compound. Further object of the present invention are compounds of formula (I) or compositions which comprise them for use as antibacterial agents.

Abstract: A device including a support (4) comprising a support base defining a spherical base contact surface, extending along a virtual sphere (S) and a circular rim extending in a rim plane; a first and a second needle mobile on the support between extracted and inserted positions in which the first and second needles are outside and maximally inserted in said virtual sphere, respectively, via first and second intermediate piercing positions in which, respectively, the first and second needles extend along first and second insertion axis and their tips are located on first and second insertion points belonging respectively to first and second hemispheres of the virtual sphere separated by a “median radial plane of the rim”, an angle (?) between the median radial plane and any insertion axis being between 70° and 110°.

Abstract: The invention relates to a piezoelectric motor with bending travelling wave, comprising a rotary shaft (4) connected to a rotor (3), a piezoelectric element (2) attached to a vibrating stator (1), and a decoupling web (5) for attaching the vibrating stator to a mounting (7). The mounting (7) is mechanically connected to a base (9) by means of at least one deformable element (10) and at least one piezoelectric actuator (11), so that the support can be deformed angularly relative to the base in order to rotate the shaft when the vibrating stator is no longer electrically powered. The motor is particularly suitable for applications that require micrometre or nanometre accuracies, for example in positioning tools in industrial processes, precise medical robotics or optical applications.

Abstract: The present invention concerns a tryptophan metabolite chosen from kynurenic acid, anthranilic acid, quinolinic acid, picolinic acid, quinaldic acid and the mixtures of same or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt of same, for use as a drug intended for increasing and/or maintaining muscle mass and/or strength in a mammal, and in particular intended for treating and/or preventing muscle atrophy in mammals and/or for promoting muscle growth in mammals doing exercise and aiming to increase muscle mass and/or quality and/or strength, for preventing the appearance of symptoms of sarcopenia or for rehabilitation following muscle loss and/or for improving recovery time after an intense physical effort.

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable storage media for shared folder backed integrated workspaces. In some implementations, a content management system can provide a graphical user interface (GUI) that integrates communications and content management into a single user interface. The user interface can include mechanisms that allow a user to provide input to generate a new workspace. The user interface can provide a mechanism to allow a user to view conversations related to the workspace and/or content items associated with the workspace. The user interface can present representations of content items associated with the workspace and allow the user to provide input to generate, view, edit, and share content items associated with the workspace.

Abstract: An electronic circuit includes a plurality of processing elements, a register bank, and a control circuit. The processing elements consume power by processing a plurality of operands to generate a plurality of result values. The register bank has a plurality of registers. The control circuit is configured to determine one or more unused processing elements among the processing elements by snooping one or more incoming operands and an instruction type, control routing of one or more random operands from the register bank to the unused processing elements, and control routing of a random result value generated by one of the unused processing elements into a trash register of the registers. The power consumed by the unused processing elements in the generation of the random result value and a write of the random result value into the trash register temporally blurs a total power consumed by the electronic circuit.

Abstract: The present invention relates to a method for detecting and/or tracking and/or characterizing the formation of a biofilm. The present invention also relates to a device for detecting and/or characterizing the formation of a biofilm suitable for implementing the method. The present invention can be used in particular in the analytical fields, in biological and enzymological research, in the pharmaceutical field and/or in the medical field.

Abstract: The present invention relates to new compounds that act as inhibitors of metallo-beta-lactamases (MBL). The present invention also relates to pharmaceutical compositions comprising such MBL inhibitors, and uses thereof in the treatment of bacterial infections. More generally, the present invention finds applications in any field wherein bacteria producing MBL must be removed.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: A method and system for validating execution of a smart contract comprises storing the smart contract within a blockchain having at least one first order block. The smart contract has a set of electronically-defined contract clauses, each being defined by at least one satisfaction value, and the combination of the satisfaction values of the set of contract clauses having a satisfaction hash value for the contract. A set of one or more electronically-stored second order transactions each having a subset of one or more execution values is read and a subset of transactions corresponding to the contract clauses are selected. An execution hash value of the combination of execution values of the subset of transaction is determined. A smart contract is considered as fully executed if the execution hash value of the combination of execution values of the subset of transactions matches the satisfaction hash value of the smart contract.