Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: The present disclosure discloses a compound 1,1,3,3-tetramethylguanidine (R)-(tert-butoxycarbonyl)(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dicarbonyl-3,6-dihydropyrimidine-1(2H)-yl)-1-phenylethyl) sulfamate (of structural formula I) and a preparation method thereof.

Abstract: A dummy optical signal generation apparatus includes a multi-longitudinal mode laser configured to provide a light source signal. The dummy optical signal generation also includes a comb optical bandpass filter. The light source signal provided by the multi-longitudinal mode laser outputs a dummy optical signal through the comb optical bandpass filter. The dummy optical signal is an optical signal that does not comprise service information.

Abstract: The present invention relates to an integrated package structure. The integrated package structure includes a main substrate, a first module, a second module, a cavity element and a large-size device, wherein the main substrate includes a first surface of the main substrate and a second surface of the main substrate opposite to each other; the first module and the second module are stacked; the first module and the second module which are stacked, the cavity element and the large-size device are horizontally arranged on the first surface of the main substrate, and are respectively electrically connected to the main substrate. Owing to this arrangement, the demand of a current integrated package structure for a further high-density, miniaturized, multi-dimensional and multi-demand layout design can be met.

Abstract: The present invention discloses an image enhancement system and an implementation method therefor. The system comprises a media signal processing apparatus, an image enhancement apparatus, a microscope body, and a binocular tube. The image enhancement apparatus comprises a housing, and a display device and a superposition lens group that are disposed in the housing, the display device is connected to the media signal processing apparatus, the superposition lens group is disposed on a main optical path of the microscope body, the binocular tube is disposed on the microscope body, the display device is configured to receive information data sent by the media signal processing apparatus and convert the received information data into an optical image, the optical image sent by the display device is superposed to the main optical path of the microscope body through the superposition lens group to form a superposed image, and the superposed image can be observed through the binocular tube.

Abstract: The present disclosure discloses a method for improving production of L-lactic acid (L-LA) by Saccharomyces cerevisiae based on regulation and control of ethanol metabolic flux, and belongs to the technical field of microorganisms. According to the present disclosure, acid-resistant Saccharomyces cerevisiae TJG16 is used as a production strain, an ethanol dehydrogenase gene adhA derived from Bacillus subtilis is introduced to promote conversion of ethanol into acetaldehyde, and a lactate aldolase gene BAL derived from Brucella sp. is introduced to promote synthesis of lactic acid from the acetaldehyde. Moreover, an acetaldehyde dehydrogenase gene ALD6 is knocked out to prevent synthesis of acetic acid from the acetaldehyde, a transcriptional regulatory factor encoding gene GAL80 for regulating and controlling galactose is knocked out, and lactate dehydrogenase LDH is integrated, so that the L-LA is finally increased.

Abstract: The invention discloses a recombinant Corynebacterium glutamicum for efficient synthesis of highly pure hyaluronic acid and oligosaccharides thereof, belonging to the technical field of bioengineering. The recombinant Corynebacterium glutamicum constructed in the present invention can produce hyaluronic acid with a yield up to 40 g/L, and a crude product purity of 95%. Addition of exogenous hyaluronic acid hydrolase and optimization of the fermentation conditions results in hyaluronic acid oligosaccharides with specific molecular weight, and can further improve the yield of hyaluronic acid to 72 g/L. The invention lays a solid foundation for the efficient synthesis of highly pure hyaluronic acid by microorganisms, and the constructed recombinant Corynebacterium glutamicum is suitable for industrial production and application.

Abstract: A method for electroporation of biological cells, comprising the steps of: providing a shock tube for cell electroporation; filling up the cavity with the cell sample comprising cells and materials to be injected into the cells, wherein a bulged liquid surface is formed; securing the stopple to a second end of the tube by a positioning structure, while generating a compressive deformation to the elastic piece between the stopple and the second electrode; connecting the first electrode and the second electrode with a pulse power supply to perform electroporation.

Abstract: This application discloses a battery tray and a battery formation and capacity-grading device. The battery tray includes a fixed frame; and a fixed component located in the fixed frame, the fixed component including a first limiting assembly and a second limiting assembly, the first limiting assembly including at least two first limiting members which extend along a first direction respectively and are spaced apart along a second direction which intersects the first direction, the second limiting assembly being connected to the first limiting assembly and including at least two second limiting members which are disposed along the first direction and are connected with the first limiting members to form a limiting space for accommodating a battery cell, and the second limiting members being movably disposed along the first limiting members in the first direction.

Abstract: A powertrain includes a motor, a reducer, and an elastic component. The reducer includes an input shaft, the motor includes an output shaft, the input shaft is coaxially coupled to the output shaft, a coupling end of the input shaft includes a first limiting platform and a first coupling surface, and a coupling end of the output shaft includes a second limiting platform and a second coupling surface. The first limiting platform and the second limiting platform are disposed opposite to each other along an axial direction of the input shaft. The elastic component is fastened between the first limiting platform and the second limiting platform. The elastic component allows the motor to move axially in an operation process. Compared with a manner in which inner and outer rings of a bearing of a fixed motor are completely fastened, this reduces an assembly requirement of the motor.

Abstract: The present disclosure provides a recombinant Bacillus subtilis for increasing the yield of menaquinone 7 (MK-7) and application thereof, and belongs to the field of genetic engineering. In the present disclosure, 14 recombinant strains BS1-BS14 are constructed through the modification of genes related to the biosynthetic pathway of MK-7 on a chromosome of Bacillus subtilis, wherein BS6-BS14 significantly increase the yield of the MK-7, reaching up to 33.5 mg/L, which is 3.53 times the yield of the original strain of wild-type Bacillus subtilis 168. The present disclosure further provides a method for modifying the MK-7 biosynthetic pathway in microorganisms to increase the yield of the MK-7, providing a theoretical basis for constructing a high-yielding strain of the MK-7.

Abstract: Rapid and accurate quality prediction of resistance spot welding (RSW) for the automotive and other transportation sectors. A machine learning system and method incorporates materials information, e.g., material classification, surface coating, dimensions, stack-up conditions, etc., welding schedule, e.g., current, voltage, force, electrode displacement, welding equipment conditions, e.g., electrode information, water cooling, etc., as well as in-process measurable signals, e.g., heat generation, acoustic emission, etc., and offline weld attribute measurements to determine weld quality metrics. The system and method can also determine a set of resistance spot welding input parameters to produce a desired weld quality.

Abstract: Provided herein are processes for the preparation of (S)-2-(2,6-dioxopipelidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl) methyl) benzyl)amino)isoindoline-1, 3-dione, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof, which is useful for treating, preventing, and managing various disorders. Also provided are solid forms of various intermediates and products obtained from the processes.

Abstract: A detection system for a suspension system of a maglev train, comprising a detection component and a controller. The detection component comprises: a driving unit, a first test coil unit and a second test coil unit. A first test coil group of the first test coil unit corresponds to a gap coil of a to-be-detected suspension sensor, and a second test coil group of the second test coil unit corresponds to a speed coil of the to-be-detected suspension sensor. The controller is communicatively connected with the driving unit and a suspension controller, the driving unit is configured to send a driving signal to at least one of the first test coil unit and the second test coil unit in response to a control command from the controller, and the controller is configured to acquire parameter information fed back by the suspension controller.

Abstract: An aneuploid Stevia cultivar from colchicine-induced polyploidy, designated ‘AP-1’. The plant parts of Stevia cultivar ‘AP-1’, the plants of stevia ‘AP-1’ and methods for producing a Stevia plant produced by crossing the cultivar ‘AP-1’ with itself or another Stevia variety, including methods using colchicine treatments for producing an aneuploidy Stevia plant. The disclosure further relates to hybrid Stevia seeds and plants produced by crossing the cultivar ‘AP-1’ with another Stevia cultivar. Ten highly polymorphic SNPs and the corresponding genomic sequences used to identify ‘AP-1’.

Abstract: In some implementations, an optical isolator core includes a Faraday rotator and a plurality of birefringent crystal plates. The plurality of birefringent crystal plates may include a first birefringent crystal plate to separate input light into light having a first polarization and light having a second polarization, and a second birefringent crystal plate to combine the light having the first polarization and the light having the second polarization in output light that is laterally displaced by the single stage optical isolator. The Faraday rotator may be provided between the first birefringent crystal plate and the second birefringent crystal plate. In some implementations, the plurality of birefringent crystal plates further include a third birefringent crystal plate provided between the Faraday rotator and the second birefringent crystal plate.

Abstract: This invention provides a low-temperature semen cryopreservation device, comprising: a box body for containing low-temperature cryoprotectant fluid; a tray, one end of which is pivotally connected to the inner side wall of the box body, and a limiting portion is provided on the tray for limiting the movement of the cryoprotectant tube. Two openings are sequentially arranged along the height direction on one side of the box body relative to the hinge end, with the height of one opening higher than that of the hinge end, and the height of the other opening lower than that of the hinge end; a limiting plate, which can be detachably inserted into either opening. When the limiting plate is switched from one opening to the other, the tray tilts to drive the cryopreservation tube to rotate 180 degrees, thereby ensuring the low-temperature cryoprotectant fluid to evenly fumigate the cryopreservation tube, improving the pre-cooling effect.

Abstract: A genetic testing device includes a safety cabinet, a gas flow control system, a first treatment module configured to treat an amplification reagent and a polymerase chain reaction (PCR) plate, a second treatment module configured to treat a reagent, a tip, and a gene sample, a sample injection module configured to inject an amplification reagent into a microwell of a PCR plate, a purification treatment module configured to treat a gene sample, an amplification detection module for gene amplification and detection, a heat sealer configured to seal a PCR plate, a material delivery module A, a material delivery module B, and a material delivery module C.

Abstract: A sensor package comprises an active element with a first region and an opposite second region. The first region includes a sensing structure. The second region comprises at least one contact pad. A moulding compound encapsulates the second region and not the first region. The active element comprises at least one conductive line for routing signals from the sensing structure to the contact pad. The projection of the conductive line over the active element corresponds to a portion of the external surface of the active element. The active element comprises at least one dummy track providing a protrusion thereby raising a portion of the surface of the active element to at least the same height as the portion corresponding to the conductive line. These protrusions can receive mechanical pressure from a moulding insert applied during manufacture, relieving pressure over the portion of the surface including the conductive lines.

Abstract: An ultra-low-voltage static random access memory (SRAM) cell for eliminating half-select-disturbance under a bit interleaving structure includes a cross-coupled inverter pair, two N-type write transistors NM1 and NM2, two P-type write transistors PM1 and PM2, and two N-type transistors NM3 and NM4, where the two N-type transistors NM3 and NM4 form a readout path. The present disclosure can be applied to applications with a storage requirement at an ultra-low voltage, especially applications with certain requirements for an access speed and reliability of an SRAM at a low voltage. Compared with other different SRAM cells, the ultra-low-voltage SRAM cell can achieve higher read and write working frequencies with similar energy consumptions.