Abstract: The present invention relates generally to the field of pharmaceutical formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The formulations may further contain a histidine buffer, an inorganic salt, a sugar polyol, and a non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit low viscosity and a substantial degree of antibody stability after being subjected to thermal and other physical stress. Also provided are methods of making and methods of using such antibody formulations.

Abstract: A backlight module includes: a back plate; a first optical film disposed on the back plate; and a second optical film disposed on the first optical film. The first optical film includes a plurality of first protrusions that protrude toward the second optical film, and at least one of the plurality of first protrusions has a first height. The first height is greater than or equal to 4 ?m and smaller than or equal to 10 ?m.

Abstract: Systems and techniques are provided for coordinating multi-user experiences. For example, a process can include obtaining a plurality of settings associated with a plurality of multi-user experience participants. The plurality of settings includes one or more arbitrated settings and one or more non-arbitrated settings. The process can include arbitrating, by a settings arbitration engine, the one or more arbitrated settings to generate one or more adjusted settings for each arbitrated setting. The process can include generating, by an experience adaptation engine, an adapted multi-user experience, wherein the adapted multi-user experience is configured to enforce the one or more adjusted settings for each arbitrated setting.

Abstract: Systems and techniques are provided for conditioning virtual representatives. For example, a method can include obtaining, by a conditioning engine, a baseline model for a virtual representative; obtaining, by the conditioning engine, one or more conditioning inputs configured to condition an action in one or more multi-user experiences of the virtual representative; generating, based on the baseline model and the one or more conditioning inputs configured to condition an action in one or more multi-user experiences of the virtual representative, a conditioned model for the virtual representative; and outputting the conditioned model for the virtual representative.

Abstract: The present invention relates generally to the field of pharmaceutical formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The formulations may further contain a formulation buffer, a viscosity reducer, and a non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit low viscosity and a substantial degree of antibody stability after being subjected to thermal and other physical stress. Also provided are methods of making and methods of using such antibody formulations.

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical composition thereof and application thereof. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compounds as represented in Formula I in the present disclosure have good inhibitory effects on cells of various mutations such as KRAS G12C, KRAS G12D, KRAS G12V, KRAS Q61H and other mutations, as well as on KRAS-amplified wild-type cells, and are expected to treat and/or prevent a wide range of diseases associated with Ras.

Abstract: An optical sensor circuit is provided. In the optical sensor circuit, an output stage circuit transmits a voltage of first and second node to the output line according to a first driving signal. A first sensor is configured to generate a first photocurrent according to a first color light that senses an ambient light, and generate a second photocurrent according to a second color light. A second sensor is configured to generate a third photocurrent according to a third color light, and generate a fourth photocurrent according to the second color light. In a sensing phase, when the first sensor senses the first color light, and the second sensor senses the third color light, the first sensor adjusts a voltage level of the voltage according to the first photocurrent, and the second sensor adjusts the voltage level of the voltage according to the third photocurrent.

Abstract: A method includes a computer device that determines a first sensing central point of a second sensing area and a second sensing central point of a third sensing area based on sensing data on a hovering control panel at a reference moment, determines an area segmentation line of a first sensing area based on the first sensing central point and the second sensing central point, and segments, based on the area segmentation line, the first sensing area generated at a first moment to obtain a first sensing control area and a second sensing control area such that, a case in which sensing areas generated by two objects are combined or a weaker sensing area is covered when the two objects are in proximity or overlap can be effectively avoided.

Abstract: A touch detection drive circuit in an electronic device inputs a touch excitation signal to a touch electrode, and receives a detection signal of the touch electrode. An isolation power supply circuit: receives the touch excitation signal and a primary power supply voltage; based on the touch excitation signal in a non-touch detection phase, short-circuits a first reference ground and a second reference ground, stores the primary power supply voltage, and transmits the primary power supply voltage to the touch detection drive circuit; and in a touch detection phase, disconnects the first reference ground from the second reference ground and discharges to the touch detection drive circuit.

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for surrogated federated learning. A set of intermediate activations is received at a trusted server from a node device, where the node device generated the set of intermediate activations using a first set of layers of a neural network. One or more weights associated with a second set of layers of the neural network are refined using the set of intermediate activations, and one or more weight updates corresponding to the refined one or more weights are transmitted to a federated learning system.

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for performing mathematical operations on a processor. The method generally includes initializing at least a portion of weight data for a machine learning model in a first memory component associated with a processor. Input data is stored in a second memory component coupled with the processor. Operations using the machine learning model are executed, via a functional unit associated with the processor, based on the at least the portion of the weight data and the input data. A result of the operations using the machine learning model are stored in the second memory component.

Abstract: Certain aspects of the present disclosure provide techniques for desparsified convolution. A weight tensor having unstructured sparsity is accessed, and a densified weight tensor is generated based on the weight tensor by directionally squeezing the weight tensor to remove sparse values, and generating a sparsity map based on the directional squeezing. The densified weight tensor and sparsity map are output for use in a convolutional neural network.

Abstract: A fuser driving device, a fusing device and an image forming device are provided. The fuser driving device includes: a front frame and a rear frame, where the front frame and the rear frame are fixedly connected to each other; a gear, where two ends of the gear are respectively mounted to the front frame and the rear frame through a bearing; a driving arm mounted in the gear, where the driving arm is movable axially along the gear to enter into or withdraw from the fuser, and when the driving arm enters into the fuser, the driving arm is driven to rotate through the gear, to drive a fusing roller of the fuser to rotate; and a withdrawing device including a pulling member and an operating member, where one end of the pulling member is connected to the driving arm and the other end is connected to the operating member, and the pulling member is moved by operating the operating member to pull the driving arm to withdraw from the fuser into the gear.

Abstract: A capacitor includes: a semiconductor substrate; at least one trench provided in the semiconductor substrate and formed downward from an upper surface of the semiconductor substrate; a first conductive layer provided above the semiconductor substrate and in the trench; a first insulating layer provided between the substrate and the first conductive layer to isolate the first conductive layer from the substrate; a second conductive layer provided above the r substrate and in the trench, the second conductive layer including a first and a second conductive region that are independent from each other, the first conductive region being electrically connected to the substrate, and the second conductive region being electrically connected to the first conductive layer; and a second insulating layer provided between the first and the second conductive layer to isolate the first conductive region from the first conductive layer and isolate the second conductive region from the substrate.

Abstract: Certain aspects of the present disclosure provide techniques for desparsified convolution. An activation tensor is received, and a convolution output is generated for the activation tensor, comprising: selecting a subset of weight elements, corresponding to a set of non-zero elements in the activation tensor, from a weight tensor, and multiplying the set of non-zero elements and the set of weight elements.

Abstract: A touch detection drive circuit in an electronic device inputs a touch excitation signal to a touch electrode, and receives a detection signal of the touch electrode. An isolation power supply circuit: receives the touch excitation signal and a primary power supply voltage; based on the touch excitation signal in a non-touch detection phase, short-circuits a first reference ground and a second reference ground, stores the primary power supply voltage, and transmits the primary power supply voltage to the touch detection drive circuit; and in a touch detection phase, disconnects the first reference ground from the second reference ground and discharges to the touch detection drive circuit.

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, a method for preparing the same and a use of the same. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof, and the nitrogen-containing heterocyclic compound is expected to treat and/or prevent various RAS-related diseases.

Abstract: The present application discloses an electric vehicle, and an electric heating device and a control system thereof. The electric heating device includes: n resistance heating units, independently electrically connected in parallel with each other; n switches, electrically connected in series with respective resistance heating units for independently controlling power-on or power-off of the respective resistance heating units; and a controller, configured to selectively turn on or turn off any at least one of the n switches according to a working condition of the electric vehicle, wherein n is a natural number equal to or greater than 2.

Abstract: The present invention provides a fusion polypeptide, comprising a carrier protein and a polypeptide of interest, wherein the carrier protein has a plurality of coil domains linked by a ring, the polypeptide of interest is inserted in the ring of the carrier protein, and the carrier protein masks a site of interest on the polypeptide of interest, thereby blocking the accessibility of the site. The present invention also provides a polypeptide dimer, comprising a first polypeptide and a second polypeptide, wherein the first polypeptide comprises a first dimerization domain and a polypeptide of interest, the second polypeptide comprises a second dimerization domain and a binding domain, and the binding domain can bind to a site of interest on the polypeptide of interest. The present invention also provides a polynucleotide and a vector encoding the fusion polypeptide and polypeptide dimer, and a host cell comprising the polynucleotide and/or vector.