Abstract: The present invention relates generally to the field of pharmaceutical formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The formulations may further contain a histidine buffer, an inorganic salt, a sugar polyol, and a non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit low viscosity and a substantial degree of antibody stability after being subjected to thermal and other physical stress. Also provided are methods of making and methods of using such antibody formulations.

Abstract: Disclosed are a method and apparatus for compressing a topology recognition model, an electronic device, and a medium. The method includes: pruning a to-be-compressed model to obtain a pruned model, and training the pruned model to obtain a trained pruned model; quantifying a bit quantity of a weight parameter of each neural network layer in the trained pruned model from a first bit quantity to a second bit quantity to obtain a highly-quantified pruned model, and training the highly-quantified pruned model to obtain a trained highly-quantified pruned model; using the trained highly-quantified pruned model as the to-be-compressed model, continuously pruning and quantifying the to-be-compressed model until a compressed topology recognition model is obtained, and deploying the compressed topology recognition model on an Internet of Things in Power Systems (IOTIPS) terminal, to reduce a size of the topology recognition model while ensuring the topology recognition model meets an accuracy requirement.

Abstract: A utility vehicle for power emergency repair includes a cab, a carriage and a lighting device, including mounting bases, a wire pole, a rotary base and a lamp assembly. A rotary shaft is bridged between the mounting bases, and the rotary base is fixedly connected to the rotary shaft. First and second positioning units are provided on the top of the carriage. The rotary base has first and second positioning surfaces, the first positioning unit includes a first limiting platform, and the second positioning unit includes a rotation limiting plate and positioning plates. The positioning plates is supported on a lower end surface of the rotation limiting plate. The utility vehicle further includes a driving assembly and first and second contacts. A trigger signal is generated and the driving assembly is controlled to release braking on the rotary shaft when the first and second contacts contact each other.

Abstract: A power transmission and transformation project acceptance method based on building information modeling (BIM) and point cloud measurement includes: S1: constructing a BIM model based on a design drawing, where the BIM model includes standard parameters of key components of a power transmission and transformation project; S2: obtaining point cloud data, and constructing a point cloud data model based on the point cloud data, where the point cloud data model includes actual parameters of the key components of the power transmission and transformation project; S3: comparing the BIM model with the point cloud data model to obtain construction acceptance data; and S4: visualizing the construction acceptance data and outputting an acceptance report to complete acceptance of the power transmission and transformation project. The BIM model and the point cloud data model are compared to implement rapid and efficient acceptance of the power transmission and transformation project.

Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.

Abstract: Systems and techniques are provided for conditioning virtual representatives. For example, a method can include obtaining, by a conditioning engine, a baseline model for a virtual representative; obtaining, by the conditioning engine, one or more conditioning inputs configured to condition an action in one or more multi-user experiences of the virtual representative; generating, based on the baseline model and the one or more conditioning inputs configured to condition an action in one or more multi-user experiences of the virtual representative, a conditioned model for the virtual representative; and outputting the conditioned model for the virtual representative.

Abstract: A backlight module includes: a back plate; a first optical film disposed on the back plate; and a second optical film disposed on the first optical film. The first optical film includes a plurality of first protrusions that protrude toward the second optical film, and at least one of the plurality of first protrusions has a first height. The first height is greater than or equal to 4 ?m and smaller than or equal to 10 ?m.

Abstract: Systems and techniques are provided for coordinating multi-user experiences. For example, a process can include obtaining a plurality of settings associated with a plurality of multi-user experience participants. The plurality of settings includes one or more arbitrated settings and one or more non-arbitrated settings. The process can include arbitrating, by a settings arbitration engine, the one or more arbitrated settings to generate one or more adjusted settings for each arbitrated setting. The process can include generating, by an experience adaptation engine, an adapted multi-user experience, wherein the adapted multi-user experience is configured to enforce the one or more adjusted settings for each arbitrated setting.

Abstract: This application relates to the field of wireless communications technologies, and discloses an encoding method and apparatus, to improve accuracy of reliability calculation and ordering for polarized channels. The method includes: obtaining a first sequence used to encode K to-be-encoded bits, where the first sequence includes sequence numbers of N polarized channels, the first sequence is same as a second sequence or a subset of the second sequence, the second sequence comprises sequence numbers of Nmax polarized channels, and the second sequence is the sequence shown in Sequence Q11 or Table Q11, K is a positive integer, N is a positive integer power of 2, n is equal to or greater than 5, K?N, Nmax=1024; selecting sequence numbers of K polarized channels from the first sequence; and performing polar code encoding on K the to-be-encoded bits based on the selected sequence numbers of the K polarized channels.

Abstract: A cryogenic storage tank includes an inner tank, a shell and two support assemblies supported between the inner tank and the shell. The two support assemblies are provided on two opposite ends of the inner tank along the axis of the inner tank. The support assemblies all include a plurality of support members, and the plurality of support members of each support assembly are symmetrically provided with respect to the vertical centre axis plane of the inner tank, and each of the upper side and the lower side of the horizontal centre axis plane of the inner tank is provided with support members; each support member includes an inner end connected to the outer end of the inner tank and an outer end connected to the inner wall of the shell, and the support member is located in a different plane from the axis of the inner tank.

Abstract: The present invention relates generally to the field of pharmaceutical formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The formulations may further contain a formulation buffer, a viscosity reducer, and a non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit low viscosity and a substantial degree of antibody stability after being subjected to thermal and other physical stress. Also provided are methods of making and methods of using such antibody formulations.

Abstract: This disclosure relates to anti-CD40 (TNF Receptor Superfamily Member 5) antibodies, antigen-binding fragments, and the uses thereof.

Abstract: This disclosure relates to anti-PD-1 (Programmed Cell Death Protein 1) antibodies, antigen-binding fragments, and the uses thereof.

Abstract: A high-temperature tube furnace comprises: a process tube (1) with a top cover (101) arranged on the top end thereof, the top cover (101) being provided with through holes (1011); a gas supply pipe (2) communicating with the through holes (1011) of the top cover (101) of the process tube (1), process gas being introduced into the process tube (1) through the gas supply pipe (2) and the through holes (1011) of the top cover (101) of the process tube (1); a wafer boat (3) arranged in the process tube (1), and comprising a supporting frame (301) and supporting plates (302), the supporting plates (302) being distributed in multiple layers along the length direction of the supporting frame (301) and used for supporting multiple substrates (w), each substrate (w) being placed on one supporting plate and each supporting plate supporting the entire bottom of the substrate (w).

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical composition thereof and application thereof. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compounds as represented in Formula I in the present disclosure have good inhibitory effects on cells of various mutations such as KRAS G12C, KRAS G12D, KRAS G12V, KRAS Q61H and other mutations, as well as on KRAS-amplified wild-type cells, and are expected to treat and/or prevent a wide range of diseases associated with Ras.

Abstract: An optical sensor circuit is provided. In the optical sensor circuit, an output stage circuit transmits a voltage of first and second node to the output line according to a first driving signal. A first sensor is configured to generate a first photocurrent according to a first color light that senses an ambient light, and generate a second photocurrent according to a second color light. A second sensor is configured to generate a third photocurrent according to a third color light, and generate a fourth photocurrent according to the second color light. In a sensing phase, when the first sensor senses the first color light, and the second sensor senses the third color light, the first sensor adjusts a voltage level of the voltage according to the first photocurrent, and the second sensor adjusts the voltage level of the voltage according to the third photocurrent.

Abstract: A method includes a computer device that determines a first sensing central point of a second sensing area and a second sensing central point of a third sensing area based on sensing data on a hovering control panel at a reference moment, determines an area segmentation line of a first sensing area based on the first sensing central point and the second sensing central point, and segments, based on the area segmentation line, the first sensing area generated at a first moment to obtain a first sensing control area and a second sensing control area such that, a case in which sensing areas generated by two objects are combined or a weaker sensing area is covered when the two objects are in proximity or overlap can be effectively avoided.

Abstract: A touch detection drive circuit in an electronic device inputs a touch excitation signal to a touch electrode, and receives a detection signal of the touch electrode. An isolation power supply circuit: receives the touch excitation signal and a primary power supply voltage; based on the touch excitation signal in a non-touch detection phase, short-circuits a first reference ground and a second reference ground, stores the primary power supply voltage, and transmits the primary power supply voltage to the touch detection drive circuit; and in a touch detection phase, disconnects the first reference ground from the second reference ground and discharges to the touch detection drive circuit.

Abstract: Certain aspects of the present disclosure provide techniques for desparsified convolution. A weight tensor having unstructured sparsity is accessed, and a densified weight tensor is generated based on the weight tensor by directionally squeezing the weight tensor to remove sparse values, and generating a sparsity map based on the directional squeezing. The densified weight tensor and sparsity map are output for use in a convolutional neural network.