Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.

Abstract: Provided is an electric cable driving mechanism having a self-return function. The electric cable driving mechanism includes a housing assembly, an electric motor, a three-stage transmission mechanism and a multifunctional nut, the three-stage transmission mechanism includes a coil spring assembly, the electric motor is fixed to the housing assembly, and the three-stage transmission mechanism and the multifunctional nut are mounted in the housing assembly; and the multifunctional nut includes two cable mounting grooves and is in transmission connection to the electric motor by means of the three-stage transmission mechanism. According to the electric cable driving mechanism having a self-return function of the present disclosure, the three-stage transmission mechanism is used, and outputs a larger force compared with two-stage transmission; and a split multifunctional screw rod is easy to mount, such that mounting of a coil spring during assembly is prevented from scratching the screw rod.

Abstract: A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S1: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S2: annotating and filtering the somatic mutations, and translating to obtain mutant peptide sequences of a patient; step S3: filtering the mutant peptide sequences to obtain neopeptide sequences based on a proteome of the normal sample; step S4, performing a human leukocyte antigen (HLA) typing analysis based on alignment data of the normal sample to obtain HLA genotypes of the sample; step S5, predicting binding affinities between the neopeptide sequences and the HLA genotypes to obtain specific neoantigens of the sample, and performing a weighted scoring on each of the specific neoantigens and calculating the TNB of the sample.

Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.

Abstract: Provided are a class of benzimidazole compounds and an application thereof as a 300/CBP inhibitor. Specifically, provided are a compound represented by formula (P) and a pharmaceutically acceptable salt thereof.

Abstract: Implementations of the present specification provide a method and an apparatus for managing a TLB cache in a virtualization platform, where the virtualization platform runs a plurality of virtual machines, each virtual machine is allocated with a unique VPID, and all virtual logical processors in the virtual machine share the VPID; and a guest process running in the virtual machine is allocated with a PCID. An identifier field of a TLB entry in the TLB cache includes a VPID and a PCID.

Abstract: A modified cutinase is disclosed. The cutinase has the modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of asparagine at position 181 with alanine, or substitutions of asparagine at position 181 with alanine and phenylalanine at position 235 with leucine. The modified enzyme has improved PET-hydrolytic activity, and thus, the high-activity PET hydrolase is obtained, and the industrial application value of the PET hydrolase is enhanced.

Abstract: This disclosure relates to anti-TNFRSF9 (tumor necrosis factor receptor superfamily member 9) antibodies, antigen-binding fragments, and the uses thereof.

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for performing mathematical operations on a processor. The method generally includes initializing at least a portion of weight data for a machine learning model in a first memory component associated with a processor. Input data is stored in a second memory component coupled with the processor. Operations using the machine learning model are executed, via a functional unit associated with the processor, based on the at least the portion of the weight data and the input data. A result of the operations using the machine learning model are stored in the second memory component.

Abstract: Certain aspects of the present disclosure provide techniques for desparsified convolution. A weight tensor having unstructured sparsity is accessed, and a densified weight tensor is generated based on the weight tensor by directionally squeezing the weight tensor to remove sparse values, and generating a sparsity map based on the directional squeezing. The densified weight tensor and sparsity map are output for use in a convolutional neural network.

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for surrogated federated learning. A set of intermediate activations is received at a trusted server from a node device, where the node device generated the set of intermediate activations using a first set of layers of a neural network. One or more weights associated with a second set of layers of the neural network are refined using the set of intermediate activations, and one or more weight updates corresponding to the refined one or more weights are transmitted to a federated learning system.

Abstract: A fuser driving device, a fusing device and an image forming device are provided. The fuser driving device includes: a front frame and a rear frame, where the front frame and the rear frame are fixedly connected to each other; a gear, where two ends of the gear are respectively mounted to the front frame and the rear frame through a bearing; a driving arm mounted in the gear, where the driving arm is movable axially along the gear to enter into or withdraw from the fuser, and when the driving arm enters into the fuser, the driving arm is driven to rotate through the gear, to drive a fusing roller of the fuser to rotate; and a withdrawing device including a pulling member and an operating member, where one end of the pulling member is connected to the driving arm and the other end is connected to the operating member, and the pulling member is moved by operating the operating member to pull the driving arm to withdraw from the fuser into the gear.

Abstract: The present invention provides a method for treating a used particulate filter, comprising: removing particulates from the particulate filter; and introducing simulated ash into inlet channels of the particulate filter after removing the particulates.

Abstract: Disclosed herein are polyurethane foams which can be used for reducing or preventing the corrosion of polymeric materials, which can be produced by mixing components (a) at least one polyisocyanate, (b) at least one compound having at least two groups reactive toward isocyanates, (c) optionally chain extender and/or crosslinking agent, (d) blowing agent, (e) catalyst, (f) optionally auxiliaries and additives, and (g) at least one anhydride to give a reaction mixture, and curing said reaction mixture to give the polyurethane foams, where the anhydride is added in an amount of 0.05-5 wt %, based on the weight of component (a). Also disclosed herein are a method of reducing or preventing the corrosion of polymeric materials by using such polyurethane foams and a method of using the polyurethane foams in certain applications, for example, in automotive interiors.

Abstract: A capacitor includes: a semiconductor substrate; at least one trench provided in the semiconductor substrate and formed downward from an upper surface of the semiconductor substrate; a first conductive layer provided above the semiconductor substrate and in the trench; a first insulating layer provided between the substrate and the first conductive layer to isolate the first conductive layer from the substrate; a second conductive layer provided above the r substrate and in the trench, the second conductive layer including a first and a second conductive region that are independent from each other, the first conductive region being electrically connected to the substrate, and the second conductive region being electrically connected to the first conductive layer; and a second insulating layer provided between the first and the second conductive layer to isolate the first conductive region from the first conductive layer and isolate the second conductive region from the substrate.

Abstract: Certain aspects of the present disclosure provide techniques for desparsified convolution. An activation tensor is received, and a convolution output is generated for the activation tensor, comprising: selecting a subset of weight elements, corresponding to a set of non-zero elements in the activation tensor, from a weight tensor, and multiplying the set of non-zero elements and the set of weight elements.

Abstract: A touch detection drive circuit in an electronic device inputs a touch excitation signal to a touch electrode, and receives a detection signal of the touch electrode. An isolation power supply circuit: receives the touch excitation signal and a primary power supply voltage; based on the touch excitation signal in a non-touch detection phase, short-circuits a first reference ground and a second reference ground, stores the primary power supply voltage, and transmits the primary power supply voltage to the touch detection drive circuit; and in a touch detection phase, disconnects the first reference ground from the second reference ground and discharges to the touch detection drive circuit.

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, a method for preparing the same and a use of the same. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof, and the nitrogen-containing heterocyclic compound is expected to treat and/or prevent various RAS-related diseases.

Abstract: The present application discloses an electric vehicle, and an electric heating device and a control system thereof. The electric heating device includes: n resistance heating units, independently electrically connected in parallel with each other; n switches, electrically connected in series with respective resistance heating units for independently controlling power-on or power-off of the respective resistance heating units; and a controller, configured to selectively turn on or turn off any at least one of the n switches according to a working condition of the electric vehicle, wherein n is a natural number equal to or greater than 2.

Abstract: The present invention provides a fusion polypeptide, comprising a carrier protein and a polypeptide of interest, wherein the carrier protein has a plurality of coil domains linked by a ring, the polypeptide of interest is inserted in the ring of the carrier protein, and the carrier protein masks a site of interest on the polypeptide of interest, thereby blocking the accessibility of the site. The present invention also provides a polypeptide dimer, comprising a first polypeptide and a second polypeptide, wherein the first polypeptide comprises a first dimerization domain and a polypeptide of interest, the second polypeptide comprises a second dimerization domain and a binding domain, and the binding domain can bind to a site of interest on the polypeptide of interest. The present invention also provides a polynucleotide and a vector encoding the fusion polypeptide and polypeptide dimer, and a host cell comprising the polynucleotide and/or vector.