Abstract: The present invention relates to the compound of formula (I) and to compositions comprising the same and to the use of the compound and to compositions of the compound in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compound.

Abstract: The present invention relates to compounds defined by formula I wherein the groups X, Y, W and R1 to R4 are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are agonists of the 5-HT2C receptor, and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this receptor, such as metabolic and CNS-related disorders.

Abstract: The present disclosure relates to a method of preparing exonuclease resistant molecules of block-decoys, use of the molecules in methods of modulating expression of recombinant proteins, particularly in vitro, for example by down regulation or inhibition of one or more transcription factors, and novel molecules of block-decoys, especially those obtained or obtainable from the methods herein. The disclosure also relates to use of said block decoys in vitro and in therapy. In one aspect there is provided a method for regulating recombinant gene expression in vitro comprising the steps of: a) providing a host cell encoding one or more recombinant genes for expression, b) contacting the cell with a exonuclease resistant block-decoy under condition suitable for the block-decoy to gain entry into the cell, and c) expressing the recombinant protein or protein.

Abstract: The present invention relates to the compound of formula (I) and to compositions comprising the same and to the use of the compound and to compositions of the compound in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the said compound.

Abstract: A method of aligning the radiation beam in a radiotherapy system comprising a source for producing a beam of radiation and an imaging device for imaging from the beam, both mounted so as to be rotatable about an axis using a fiducial phantom between the source and the imaging device, the method comprising: rotating the beam and imaging device in a trajectory about the axis while obtaining a plurality of images of the fiducial phantom from a plurality of different angles, wherein at least one image includes a feature of the imaging apparatus, adjusting the trajectory of the source relative to that feature so as to position the isocentre substantially centrally of the volume, determining from each image of the fiducial phantom the position of the source at the rotational position the image was obtained, and calculating the centre of rotation of the positions of the source to define the isocentre of the system.

Abstract: The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making said compounds.

Abstract: A rotary trimmer for trimming flash and the blow dome from a plastic bottle forming a portion of a plastic blow molded log discharged from a blow mold includes flash punching, a neck support plate, and a guillotine blade. The neck support plate is movable by a plate drive to move adjacent the neck of the plastic log to support the neck during cutting of the blow dome and cooperates with a log holder to essentially support the entire outer periphery of the neck. The guillotine blade is movable by a blade drive to pass through the plastic log and sever the blow dome from the neck of the log.

Abstract: Shrink film having a desirable balance of properties is manufactured from a polyethylene blend composition having a fractional melt index and a molecular weight distribution of from about 2.5 to about 7. The blend composition comprises a first blend component that is made with a single site catalyst and has a molecular weight of greater than about 140,000 and a first density, d1. The blend composition also contains a second blend component having a lower molecular weight and a second density, d2, that is greater than the density of d1 in an amount of from about 0.018 to about 0.032 g/cc. The films of this disclosure may be used, for example, as an overwrap or pallet wrap to protect goods during shipping and in food packaging applications (such as shrink wrap for frozen poultry).

Abstract: The present invention relates to cross-linked peptides that are associated with human eIF4G and bind to eIF4E, uses thereof and pharmaceutical compositions comprising the peptides.

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: Flying Car, roadable aircraft, amphibian, multimode, multifunctional, composite versatile personal transport vehicle with twin, parallel fuselages, hulls, each with inflatable pontoons and/or wheels below and a cabin. Combined, aircraft, airplane, aeroplane, flying, air, aerial, airborne vehicle with variable, folding wings which is convertible via automatic transformation to a land vehicle and to a sea vessel. Two wings are stored between the fuselages. They extend on a system of rails, pivots and counter-rotating, fuselage-mounted arms which then sink flush into the wings' undersides and lock for flight. Upon wing extension and retraction, controls for road transport and flight controls alternately emerge or are stowed inoperably, as needed. Engine power alternately drives a propeller for flight, wheels for road travel and a separate, submersible, marine propeller for water transport.

Abstract: A system for monitoring and displaying a plurality of telecommunication assets on at least one telecommunication structure by creating a customer profile and a library of survey set ups and storing information from independent survey set ups mounted on or proximate to the offshore asset on the administrative data storage. The system includes creating a library of tagged assets for the offshore asset using at least one independent survey set up, wherein each tagged asset has an icon with a hyperlink to a library of images. The system includes identifying placement locations on offshore assets and forming an executive dashboard for display on at least one client device, wherein a virtually positioned icon positioned on an image of the tagged assets presents a hyperlink to the library of survey set ups for that tagged asset, thereby enabling toggling from the image to the library of survey set ups.

Abstract: A method for monitoring a plurality of tagged assets on at least one offshore asset, by creating a customer profile and a library of survey set ups and storing information from independent survey set ups mounted on or proximate to the offshore asset on the administrative data storage. The method includes creating a library of tagged assets for the offshore asset using at least one independent survey set up, wherein each tagged asset has an icon with a hyperlink to a library of images. The method includes identifying placement locations on offshore assets and forming an executive dashboard for display on at least one client device, wherein a virtually positioned icon positioned on an image of the tagged assets presents a hyperlink to the library of survey set ups for that tagged asset, thereby enabling toggling from the image to the library of survey set ups.

Abstract: The present invention relates to modified eIF4G1 peptides, uses thereof and pharmaceutical compositions comprising the modified eIF4G1 peptides.

Abstract: The Ceiling Debris Collection Bin is a receptacle with a wide opening that facilitates the nearly complete collection of acoustic ceiling debris removed by the Popcorn Ceiling Scraper—U.S. Pat. No. 6,101,663. The makers this Scraper recommend use of a plastic trash bag for collection of debris but a trash bag is not efficient enough, being limited to an opening defined by the scraper's flexible band. The new Ceiling Debris Collection Bin is very efficient owing to the flared side design. Debris that flies all over and might escape collection by a trash bag would be captured by this uniquely designed Ceiling Debris Collection Bin with nearly three times the collection area. The collapsible wings of the bin accommodate the flexible metal band of the Popcorn Ceiling Scraper, so that the Scraper can be pushed up to where the ceiling meets the wall.

Abstract: A free-standing wall includes concrete base blocks adjacent to each other forming a base course; a first set of concrete wall blocks stacked on the base course and on each other to form a first wall face; and a second set of concrete wall blocks stacked on the base course and on each other to form a second wall face that faces the opposite direction from the first wall face and that has the same number of courses as the first plurality of wall blocks. Methods of constructing the wall arrangement include laying the base blocks next to each other end to end; stacking individual blocks of a first set of blocks on the base course and then on each other to form a first wall face; stacking individual blocks of the second set of blocks on the base course and then on each other to form a second wall face that faces a direction opposite of the first wall face.

Abstract: A method and system for establishing a wireless connection between a portable computer system and a wireless network, particularly when the portable computer system goes out of coverage and a wireless connection needs to be re-established. The portable computer system has a main processor and a digital signal processor (DSP). The main processor is placed in a low power mode, conserving battery power. When the portable computer system goes out of coverage, broadcast channels used by the wireless network are scanned by the DSP instead of the main processor to identify channels that have sufficient signal strength for the wireless connection. Thus, the main processor remains in the low power mode. When the DSP identifies acceptable channels, it wakes up the main processor and identifies the channels having sufficient signal strength. The main processor then establishes a wireless connection using one of the channels identified by the DSP.

Abstract: The invention refers to a method for provisioning of a network access for a mobile communication device having at least one communication interface. A mobile communication device comprising a secure payment application in a secure environment is provided. Network access from a network operator with the mobile communication device is requested. A payment to the network operator for the requested network access using the secure payment application is conducted. A network access application from the network operator is downloaded and the network access application in the secure environment of the mobile communication device is stored wherein the network access application is used for an authentication of the mobile communication device to the mobile network.

Abstract: An assembly and process for forming a two stage extruded pipe having a central inner sleeve and a pair of outer attached lobes. The central sleeve shaped (also termed a grout receiving tube) is produced in an initial extrusion operation, following which it enters a cross head operation where a pair of outer lobes are attached to cross sectional exterior surface locations according to a second stage extrusion operation so as to be integrally formed therewith. Other steps include cooling of the dual stage extruded pipe, as well as sectioning and stacking the pipe. Additional steps include forming elongated slots or apertures into the central sleeve portion of the finished extrusion, such in non-interfering fashion with the individual passageway defining and lobes.

Abstract: The present invention is a coated article containing at least two adjacent cooling holes that are substantially uncoated. In an embodiment, the coated article includes a base material, an outer surface and a coating on a portion of the outer surface. Here, the adjacent cooling holes are arranged along an axis on the outer surface and extend within the base material at an angle to the outer surface. The coating may include at least one unfinished edge oriented substantially parallel to the axis and set off at an oblique angle and a distance from the adjacent cooling holes.