Abstract: A medical device delivery system can include a dilator including a tip having a taper in a distal direction, a coupler, and a flap that radially protrudes from the tip. The flap can be configured to bend against a body lumen to cover at least a portion of the delivery system when the dilator is tracked through the body lumen. A medical device delivery system can include a dilator including a tip having a lumen and a coupler having a lumen. The coupler can be configured to securely connect to the tip such that the lumen of the tip is aligned with the lumen of the coupler to allow a guide wire to pass therethrough. Methods for loading a medical device into a delivery catheter are also disclosed.

Abstract: Apparatuses and methods are disclosed for the analysing of non-Newtonian fluids and determining parameters to characterise the relationship between shear stresses and shear rates, i.e. the parameters of one or more rheological models of viscosity. A plurality of viscosity measurements are made in a fluid using one or more vibratory transducers operating at a plurality of frequencies. Parameters for the fluid are determined based on the measured viscosity values and the frequencies of vibration at which the viscosity measurements were obtained.

Abstract: Systems and techniques are described making use of a vibratory transducer and a reflector spaced from the vibratory transducer to form a cavity for receiving a fluid between the vibratory transducer and the reflector, wherein the vibratory transducer is vibrated to generate a wave in the cavity, which propagates through fluid in the cavity from a surface of the vibratory transducer and is being reflected by the reflector to generate a counter-propagating wave in the cavity. Based on the wave generated at the vibratory transducer and the counter-propagating wave generated at the reflector in combination, an indication of the energy returned to the vibratory transducer by the reflector is determined. One or more material properties of the fluid are determined based on the determined indication of the energy returned to the vibratory transducer.

Abstract: In some embodiments, a medical device delivery system includes a catheter and a retainer. The retainer can be engaged with the medical device to restrain relative movement of the medical device in one or more axial and/or radial directions. A variety of retainers and retainer systems are disclosed, many of which can reliably disengage the medical device from the retainer. Methods for using the medical device delivery system are also described.

Abstract: A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers. In a delivery state, a stent frame of the prosthesis is crimped over the inner shaft and maintained in a compressed condition by the outer sheath. The tethers are connected to the stent frame. In a partial deployment state, the outer sheath is at least partially withdrawn, allowing the stent frame to self-expand. Tension in the tethers prevents the stent frame from rapidly expanding and optionally allowing recapture. Upon completion of the stent frame expansion, the tethers are withdrawn.

Abstract: Valve delivery catheter assemblies including components that limit trauma to the expanded prosthetic valve and body channels as the distal tip of the catheter is withdrawn through the expanded valve and thereafter from the body. Catheter assemblies according to the present invention can include a handle assembly, an introducer sheath, and a distal tip assembly. The handle assembly can include a fixed main handle and two or more rotating handles that allow a user to control the distal tip assembly of the catheter. A safety button can be included on the handle assembly to allow for precise and consistent positioning of the prosthetic valve in the body. A valve retaining mechanism can be included to assist in retaining the prosthetic valve prior to deployment.

Abstract: A medical device delivery system can include a dilator including a tip having a taper in a distal direction, a coupler, and a flap that radially protrudes from the tip. The flap can be configured to bend against a body lumen to cover at least a portion of the delivery system when the dilator is tracked through the body lumen. A medical device delivery system can include a dilator including a tip having a lumen and a coupler having a lumen. The coupler can be configured to securely connect to the tip such that the lumen of the tip is aligned with the lumen of the coupler to allow a guide wire to pass therethrough. Methods for loading a medical device into a delivery catheter are also disclosed.

Abstract: A hydrodissector for hydrodissecting a vascular target, the hydrodissector comprising: a handle; a shaft extending from the handle at an angle and including a tip at a distal end thereof; at least one port provided at the tip and configured to be coupled to a fluid supply and to eject fluid from the at least one port into the space between the vascular target and surrounding tissues to dissect the vascular target from the surrounding tissues, the at least one port being sized to provide sufficient pressure and velocity to dissect the vascular target from the surrounding tissues, wherein the length of the shaft is configured for insertion into an incision to atraumatically hydrodissect the vascular target from the surrounding tissues, and wherein the shaft is configured to releasably couple with one or more hook-shaped attachments configured to lift the vascular target after the vascular target is dissected from the surrounding tissues.

Abstract: The Messaging Search and Management Apparatuses, Methods and Systems (“MSM”) transforms message, ranking request inputs via MSM components into work graphs, ML structure input data, ML structure, ranking response outputs. A work graph generation request that includes group level access control data may be obtained. A set of metadata access control carrying messages, a set of users, a set of channels, and a set of topics with access control data corresponding to the group level access control data may be determined. A user priority score for each of the other users, a channel priority score for each of the channels, and a topic priority score for each of the topics, from the perspective of each user, may be calculated. A work graph data structure may be generated that includes, for each user, data regarding the calculated user priority scores, channel priority scores, and topic priority scores.

Abstract: A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers. In a delivery state, a stent frame of the prosthesis is crimped over the inner shaft and maintained in a compressed condition by the outer sheath. The tethers are connected to the stent frame. In a partial deployment state, the outer sheath is at least partially withdrawn, allowing the stent frame to self-expand. Tension in the tethers prevents the stent frame from rapidly expanding and optionally allowing recapture. Upon completion of the stent frame expansion, the tethers are withdrawn.

Abstract: The Messaging Search and Management Apparatuses, Methods and Systems (“MSM”) transforms message, ranking request inputs via MSM components into work graphs, ML structure input data, ML structure, ranking response outputs. A work graph generation request that includes group level access control data may be obtained. A set of metadata access control carrying messages, a set of users, a set of channels, and a set of topics with access control data corresponding to the group level access control data may be determined. A user priority score for each of the other users, a channel priority score for each of the channels, and a topic priority score for each of the topics, from the perspective of each user, may be calculated. A work graph data structure may be generated that includes, for each user, data regarding the calculated user priority scores, channel priority scores, and topic priority scores.

Abstract: Valve delivery catheter assemblies including components that limit trauma to the expanded prosthetic valve and body channels as the distal tip of the catheter is withdrawn through the expanded valve and thereafter from the body. Catheter assemblies according to the present invention can include a handle assembly, an introducer sheath, and a distal tip assembly. The handle assembly can include a fixed main handle and two or more rotating handles that allow a user to control the distal tip assembly of the catheter. A safety button can be included on the handle assembly to allow for precise and consistent positioning of the prosthetic valve in the body. A valve retaining mechanism can be included to assist in retaining the prosthetic valve prior to deployment.

Abstract: A model of the viscoplastic boundary layer of a yield stress fluid is described and, based on which, there is provided a method of estimating the yield stress of a flowing yield stress fluid using one or more vibratory transducers having a vibratory surface in contact with the yield stress fluid, the method comprising: vibrating a vibratory surface of a vibratory transducer to transmit a wave from a vibrating surface into a viscoplastic boundary layer of the flowing yield stress fluid, the wave propagating a distance into the viscoplastic boundary layer; making, using the vibrations of the vibratory transducer, one or more measurements of the degree of damping of vibration; and estimating the yield stress of the flowing yield stress fluid based on the one or more measurements of the degree of damping of vibration. There are disclosed single-frequency, dual-frequency and triple-frequency modes of operation.

Abstract: A catheter assembly according to the present invention includes a handle assembly, an introducer sheath, and a distal tip assembly. The distal tip assembly can include first and second retaining sleeves and a slotted tip with a non-traumatic tip guard positioned at the proximal end of the slotted tip. The handle assembly can include a fixed main handle and two or more rotating handles that allow a user to control the distal tip assembly of the catheter. Each control knob on the handle assembly controls a portion of the components on the distal tip of the catheter by allowing for precise manipulation of various delivery shafts. Each delivery shaft extends from the handle assembly to respective positions towards the distal end of the catheter.

Abstract: In some examples, a medical device package may include a backing card that is configured to secure a medical device to a major surface of the backing card. The backing card is configured to be assembled from an open state into a closed state in which flaps on one or more ends of a central region of the backing card move over some of the central region and cover some of the secured medical device. The closed state defines a reduced footprint relative to the unfolded state. The backing card may be sealed in a pouch, which may then be housed in a carton. The carton includes exterior walls that enclose the sealed backing card and spacing elements that receive the sealed backing card at a relative location within the carton and holds the backing card a threshold distance from the exterior walls of the carton.

Abstract: A model of the viscoplastic boundary layer of a yield stress fluid is described and, based on which, there is provided a method comprises the steps of: vibrating a vibratory transducer at resonance at a first resonant mode in a yield stress fluid and making a first measurement of the resonant frequency; providing a vibration to liquefy at least a portion of the yield stress fluid around the one or more vibratory transducers; while said portion of the yield stress material is liquefied, vibrating a vibratory transducer at resonance at the first resonant mode in the yield stress fluid and making a second measurement of the resonant frequency; and estimating the yield stress of the yield stress fluid based on the first and second measurements. The vibration to liquefy yield stress fluid around the one or more transducers may be provided by the making of the second measurement at an increased amplitude of vibration relative to the first measurement.

Abstract: A hydrodissector for hydrodissecting a vein, the hydrodissector comprising a handle, a shaft extending from the handle at an angle and including a tip at a distal end thereof, at least one port configured to be coupled to a fluid supply for supplying fluid at a substantially constant pressure, and provided at the distal end of the shaft, and an image capturing assembly configured to provide direct visualization of the vein during hydrodissection. A minimally invasive method for dissecting a greater saphenous vein (GSV) from surrounding tissues using the hydrodissector is also described.

Abstract: A catheter assembly according to the present invention includes a handle assembly, an introducer sheath, and a distal tip assembly. The distal tip assembly can include first and second retaining sleeves and a slotted tip with a non-traumatic tip guard positioned at the proximal end of the slotted tip. The handle assembly can include a fixed main handle and two or more rotating handles that allow a user to control the distal tip assembly of the catheter. Each control knob on the handle assembly controls a portion of the components on the distal tip of the catheter by allowing for precise manipulation of various delivery shafts. Each delivery shaft extends from the handle assembly to respective positions towards the distal end of the catheter.

Abstract: Embodiments of the present disclosure provide methods, systems, apparatuses, and computer program products that are configured to generate a predicted channel add object in an improved system of networked computing devices. The embodiments disclose an apparatus and system that provide channel invite suggestions. The channel invite suggestions comprise recommendations of users to invite to group-based communication channels. To provide the channel-invite suggestions, the group-based communication system generates a user-channel data structure that stores a plurality of values that capture relationships between users and group-based communication channels. The values may capture information regarding membership of a user in a group-based communication channel, starring of a group-based communication channel by a user, a level of activity of a user in a group-based communication channel, and a user's word usage in a group-based communication channel.

Abstract: Example embodiments provided relates to a computing device of a group-based communication system configured to categorize multiple group-based communication messages in a workspace.