Abstract: Heart valve delivery systems and methods of delivering and implanting heart valves using delivery catheters are disclosed. The delivery systems can include a handle assembly which can include a first control mechanism, a second control mechanism, and a decoupling mechanism. The delivery systems can also include a delivery catheter extending from the handle assembly. The delivery catheter can include an outer shaft, which can be controlled by the first control mechanism; a prosthesis containing capsule comprising a proximal capsule portion connected to the outer shaft, and a distal capsule portion releasably coupled to the proximal capsule portion. After deploying a valve prosthesis, the capsule can be closed by activating the decoupling mechanism in the handle to rapidly close the distal and proximal capsule portions together. The delivery system can also include a centering element to guide the distal and proximal capsule portions together.

Abstract: A pharmaceutical combination comprising (a) a B-Raf inhibitor and (b) a histone deacetylase inhibitor; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: The invention features modular implantable ventricular assist devices configured to be, at least in part, assembled within a patient. The devices generally include a pump assembly and an expandable frame. The frame is configured to engage tissue of a patient when implanted. The pump assembly is configured to be operably coupled to the frame when the frame is implanted and in the expanded configuration.

Abstract: An improved drilling riser assembly including a male drilling riser assembly section and a female drilling riser assembly section that form a connection joint when mated. The drilling riser assembly sections having an internal stab type main drilling riser connector. The drilling riser assembly sections each have main drilling riser flanges that have helically threaded rings on an outer edge of the flange. A box and pin connector each have an inner helically threaded ring that mates with the outer helical flange ring of a drilling riser assembly section. The box and pin connectors extend towards each other and make up an enclosed compression joined mating section around the stab type connectors of the drilling riser assembly.

Abstract: A catheter assembly according to the present invention includes a handle assembly, an introducer sheath, and a distal tip assembly. The distal tip assembly can include first and second retaining sleeves and a slotted tip with a non-traumatic tip guard positioned at the proximal end of the slotted tip. The handle assembly can include a fixed main handle and two or more rotating handles that allow a user to control the distal tip assembly of the catheter. Each control knob on the handle assembly controls a portion of the components on the distal tip of the catheter by allowing for precise manipulation of various delivery shafts. Each delivery shaft extends from the handle assembly to respective positions towards the distal end of the catheter.

Abstract: The invention features modular implantable ventricular assist devices configured to be, at least in part, assembled within a patient. The devices generally include a pump assembly and an expandable frame. The frame is configured to engage tissue of a patient when implanted. The pump assembly is configured to be operably coupled to the frame when the frame is implanted and in the expanded configuration.

Abstract: A walled dispenser base for use with a removable bottle collar for delivering a liquid from a supply bottle has a hollow interior. A rim is formed at a top portion of the walled dispenser base. A foot is formed at a bottom portion of the walled dispenser base. A side opening is formed in a sidewall of the walled dispenser base. The side opening enables a valve coupled to a mouth of the supply bottle inverted and positioned within the removable collar to pass from an interior of the walled dispenser base to a location outside the walled dispenser base.

Abstract: In one illustrative embodiment, the ball inserter device comprises, among other things, a body having a ball insertion opening and a ball drop opening, wherein the ball drop opening intersects the ball insertion opening, a ball inserter piston that is attached to the body and an inserter cavity isolation valve coupled to the body wherein the valve element, when closed, blocks the ball insertion opening and partially defines an insertion cavity between the inserter cavity isolation valve and the ball inserter piston and a pressure relief valve coupled to the body that is in fluid communication with the insertion cavity. In this example, the device also comprises a ball input device coupled to the body that includes a plug, a removable cap and an opening that is axially aligned with the ball drop opening.

Abstract: A dispenser for delivering a liquid from a supply bottle is disclosed. The dispenser has a base with a base foot. A tubular support is attached to the base foot. The tubular support extends vertically from the base foot. A rim is attached to the tubular support. The rim extends horizontally from the tubular support at a location above the base foot. The rim is vertically aligned with the base foot. A removable bottle collar engages with the rim. The removable bottle collar is adapted to engage and support the supply bottle inverted and positioned within the rim. The removable bottle collar has a center aperture where a mouth of the supply bottle extends there through.

Abstract: A catheter assembly according to the present invention includes a handle assembly, an introducer sheath, and a distal tip assembly. The distal tip assembly can include first and second retaining sleeves and a slotted tip with a non-traumatic tip guard positioned at the proximal end of the slotted tip. The handle assembly can include a fixed main handle and two or more rotating handles that allow a user to control the distal tip assembly of the catheter. Each control knob on the handle assembly controls a portion of the components on the distal by of the catheter by allowing for precise manipulation of various delivery shafts. Each delivery shaft extends from the handle assembly to respective positions towards the distal end of the catheter.

Abstract: A computing machine creates a local certificate authority (CA) that has certificate signing authority, creates a certificate signing request (CSR) that includes data of a local service that is hosted by the computing machine, creates a service certificate for the local service using at least a portion of the data in the CSR, signs the service certificate using a private key of the local CA, and provides the service certificate to the local service. The private key is stored locally on the computing machine.

Abstract: A cat litter sieving system comprises a litter handler convertible between a flat configuration, an open container configuration, a transport configuration, and a disposal configuration, and sieve. The sieve comprises a riser to retain a frame at a selected distance above a litter box, said frame supporting a mesh member having a perimeter and defining a plurality of holes therethrough of sufficient size to permit granules of cat litter to pass through while retaining clumps of cat litter.

Abstract: A dispenser for delivering a liquid from an inverted supply bottle has a walled base. The walled base of the dispenser is coupled to the inverted supply bottle. The walled base has an interior reservoir. The interior reservoir is in liquid communication with the inverted supply bottle. The interior reservoir stores a predetermined quantity of the liquid transferred from the inverted supply bottle. A valve is attached to the bottom of the walled base. The valve is in liquid communication with the interior reservoir. The valve controls a flow of the liquid through the interior reservoir from the inverted supply bottle. The valve delivers the liquid from the interior reservoir to a location outside of the walled base.

Abstract: A computing machine creates a temporary certificate authority (CA) hosted locally by the computing machine, creates a service certificate for a local service being hosted by the computing machine, and signs the service certificate using a private key of the temporary CA. The private key is stored locally on the computing machine. The computing machine removes signing authority of the temporary CA, and provides the service certificate to the local service.

Abstract: A method for operating a material handling system including an overhead rack defining a plurality of storage positions, first and second side rails disposed above the overhead rack, a first cross rail movably coupled to the first and second side rails, and a first transport vehicle movably coupled to the first cross rail includes positioning the first transport vehicle above at least one interior window defined in the overhead rack. At least a portion of the first transport vehicle is descended through the interior window to interface with a first load port of a first tool disposed below the overhead rack. The first transport vehicle is positioned above at least one periphery window defined in the overhead rack. At least a portion of the first transport vehicle is descended through the periphery window to interface with a second load port of a second tool disposed below the overhead rack.

Abstract: A dispenser for delivering a liquid from a supply bottle has a base having a hollow interior. The base has a rim formed at a top portion of the base, a foot formed at a bottom portion of the base, and a window formed in the base. A removable bottle collar engages with the rim and is adapted to engage and support the supply bottle inverted and positioned within the rim. The removable bottle collar has a center aperture where a mouth of the supply bottle extends there through. The liquid from the supply bottle is delivered from the mouth of the supply bottle through the base window to a location outside the base.

Abstract: A dispenser for delivering a liquid from a supply bottle is disclosed. The dispenser has a base with a base foot. A tubular support is attached to the base foot. The tubular support extends vertically from the base foot. A rim is attached to the tubular support. The rim extends horizontally from the tubular support at a location above the base foot. The rim is vertically aligned with the base foot. A removable bottle collar engages with the rim. The removable bottle collar is adapted to engage and support the supply bottle inverted and positioned within the rim. The removable bottle collar has a center aperture where a mouth of the supply bottle extends there through.