Abstract: The present disclosure relates to monoclonal antibodies anti-FGFR4 and their use as medicaments and diagnostic agents. In particular, it relates to an antibody which specifically binds to the acid box domain of FGFR4 and to specific portions thereof. Nucleic acids coding for said antibody, vectors and host cells for their expression and production, antibody-drug conjugates and pharmaceutical compositions comprising said antibody are also within the scope of the present disclosure. The present disclosure also relates to antibodies anti-FGFR4 for use for detecting, killing, affecting or inhibiting development and/or differentiation of colon cancer stem cells.

Abstract: Embodiments are directed to a computing system with permission control via data redundancy. The computing system includes a memory and a permission control circuit coupled to the memory. The permission control circuit encodes a first data vector by using a bit position register with a first permission control code for a first user, writes the encoded first data vector into the memory, and updates content of the bit position register from the first permission control code to a second permission control code for a second user. The encoded first data vector written into the memory is inaccessible for the second user based on the updated content of the bit position register.

Abstract: A breast pump system comprises at least one wearable milk collection hub connected via an air line to a combined external air pump and control unit. Each milk collection hub comprises: (a) a breast shield made up of a breast flange and a nipple tunnel; (b) a flexible diaphragm that is configured to prevent milk from reaching the external air pump; (c) an outer shell that is configured to removably attach to the breast shield, such that, when attached, the breast shield and outer shell form a vessel for collecting milk; and (d) a diaphragm cap that is configured to be secured over the diaphragm, forms part of the front face of the outer shell, and includes a port connected to the air line.

Abstract: The present disclosure provides novel solid sorbents synthesized by the reaction of polyamines with polyaldehyde phosphorus dendrimer (P-dendrimer) compounds for metal sequestration. The sorbents are highly stable and exhibit desirable thermodynamics and reaction kinetics with a wide variety of metals including heavy metals and rare earth elements. The sorbents can be easily regenerated for repeated use to extract metals from an aqueous solution. The materials are stable to aqueous and organic media, as well as strong acid and bases. The sorbents maintain full capacity over many cycles of use.

Abstract: A method for reducing the concentration of amines in a wash liquid stream exiting a wash section in an acid gas scrubbing process includes introducing the wash liquid stream exiting the wash section of the acid gas scrubbing process to an adsorbent material, wherein the wash liquid stream has a first concentration of amines. The wash liquid stream having the first concentration of amines is flowed through the adsorbent material, and the adsorbent material retains at least a portion of the amines thereby providing a wash liquid stream having a second, reduced concentration of amines. The wash stream with reduced concentration of amines is recycled back to the wash section to remove amines more effectively from the acid gas being scrubbed. The adsorbent material can be regenerated for reuse. Amine recovered from the regenerated adsorbent material can be recycled to the process for reuse.

Abstract: A handheld appliance having a body and an attachment, the body includes an attachment mechanism having a slot and an actuator, the attachment including a protrusion adapted to engage with the slot wherein the actuator has a first position and a second position and the actuator is moved from the first position towards the second position as the protrusion engages with the slot. In the first position the actuator may at least partially obscures the slot. The actuator includes a surface which may interact with the protrusion when the protrusion engages with the slot. The surface may be adapted to at least partially define the slot at or near the second position. When the protrusion is at a pre-determined position within the slot, the actuator may return towards the first position. The actuator may be biased into the first position.

Abstract: A system including an elongated catheter and an implant. The elongated catheter includes a proximal end configured for operative coupling to an electrical supply module, a distal end with a first electrical connector and a first conducting wire to electrically couple the electrical supply module with the first electrical connector. The implant includes a proximal connecting hub configured to detachably mount to the distal end of the elongated catheter, a second electrical connector configured to mate with the first electrical connector, and an active module electrically coupled to the second electrical connector. The first electrical connector is rotatably mounted to the distal end of the elongated catheter and the second electrical connector is non-rotatably attached to the proximal connecting hub of the implant and the elongated catheter can detach from the implant without rotation of the first electrical connector relative to the second electrical connector.

Abstract: A system includes an elongated catheter including a proximal end configured for operative coupling to an electrical power source, a distal end with a first electrical connector and a first conducting wire, an implant including a tissue energising module and a proximal connecting hub configured to detachably couple with the distal end of the elongated catheter. The proximal connecting hub includes a second electrical connector configured to mate with the first electrical connector and electrically couple the first electrical connector with the tissue energising module through a second conducting wire. A latch system to lock the distal end of the catheter to the proximal connecting hub arm includes an arm attached to the distal end of the catheter that is resiliently deformable such that the arm engages a sidewall of the proximal connecting hub and a locking element that is axially adjustable.

Abstract: A system measures, by executing a monitoring process, first metric data associated with trade data at a first time point after the trade data is output by a first process of an application and before the trade data is input to a second process of the application, identifies the trade data at a second time point after the trade data is output by the second process and before the trade data is output by the application, measures second metric data associated with the trade data identified at the second time point, and sends, in response to a latency value obtained based on the first metric data or the second metric data exceeding a latency threshold, a latency alert to a user computing device associated with the application. The monitoring process is not a process of the application and is not linked with the first process or the second process.

Abstract: A device to reduce left ventricle afterload in a target blood vessel in a mammal includes a cushion configured for positioning within a lumen of the target blood vessel and receipt of a fluid and configured to contract during systole and expand during diastole, a reservoir having a cavity for receiving the fluid, and a conduit extending between and fluidically coupling the cushion and the reservoir, whereby during use fluid in the cushion is transferred to the reservoir during systole and returned to the cushion during diastole. The cushion has an annular cross section defining a central lumen for blood flow and is configured for positioning in the lumen of the target vessel abutting an inner wall of the target vessel, whereby during use blood flow is directed through the central lumen of the cushion.

Abstract: The disclosure provides a synthetic standard which includes polynucleotides (e.g., DNA or RNA) containing multiple clinically important germline and somatic variants. These materials are utilized to calibrate, evaluate, and/or validate the performance of polynucleotide-based genetic analysis assays, such as NGS assays. In one aspect the disclosure provides a method for validating assay performance including generating synthetic variant DNA fragments comprising variants with known allele frequencies, wherein the fragments comprise a molecular tag; combining the synthetic variant DNA with wild-type DNA to create test samples; preparing one or more dilutions of the test samples; performing an assay of interest on the one or more dilutions of test samples; and comparing the outcome of the assay with the test samples with known allele frequencies of interest, thereby validating the performance of the assay.

Abstract: A liquid spraying system having an electrically operated pulse width modulation control for directing a modulated liquid discharge based upon frequency and duty cycle of a reciprocally operated liquid control valve. The spray nozzle assembly includes a nozzle body having an inwardly converging conical chamber communicating between an upstream liquid directing plate and a downstream liquid discharge passage. The liquid directing plate is formed with a one or more rings of circumferentially spaced liquid directing passages angularly oriented with respect to a central liquid flow axis of the nozzle body for directing liquid discharging from said nozzle body discharge passage into a predetermined conical spray pattern.

Abstract: The present invention relates to a rain and sun shield device for pet crates/cages that prevents rainwater from accumulating inside the crates. More specifically, the rain and sun shield device includes multiple lip structures designed to be mounted on the top surface of the crate, such that the lip structures deflect any rainwater pouring over the crate and prevent any rainwater from entering inside the crate. The rain and sun shield device can be retrofitted to existing animal crate/cage designs or incorporated into the manufacturing of new models to provide protection against rainwater and sunlight. The device protects pets from the elements while being kept in a crate or cage placed in outdoor settings or while being transported in the bed of a pickup truck. The device ensures that pets remain safe, shaded, and dry.

Abstract: An implantable shunting device configured to shunt blood from the left atrium of the heart to the azygous vein through an aperture in the atrial septal wall is provided. The device comprises a flexible tube configured for radial adjustment between a contracted delivery configuration suitable for delivery in a delivery catheter and a deployed radially expanded configuration, the tube having a through lumen, a distal end configured to anchor within the azygous vein, and a proximal end configured to span an aperture in an atrial septal wall and anchor to the wall to provide fluid communication between the left atrium and the azygous vein. Methods of treating heart disease by implanting a shunting device of the invention are also disclosed.

Abstract: A spray tip comprises a tip body, a tip piece, and a pre-orifice piece. The tip body has a fluid channel along a channel axis (AC). The tip piece is disposed within the fluid channel, and has a stepped, narrowing passage that terminates in an outlet orifice. The pre-orifice piece has an inlet passage, and is disposed within the fluid channel, abutting and immediately upstream of the tip piece. The pre-orifice piece and the tip piece together define a turbulating chamber therebetween.

Abstract: Embodiments are directed to a processor having a functional slice architecture. The processor is divided into tiles (or functional units) organized into a plurality of functional slices. The functional slices are configured to perform specific operations within the processor, which includes memory slices for storing operand data and arithmetic logic slices for performing operations on received operand data (e.g., vector processing, matrix manipulation). The processor includes a plurality of functional slices of a module type, each functional slice having a plurality of tiles. The processor further includes a plurality of data transport lanes for transporting data in a direction indicated in a corresponding instruction. The processor also includes a plurality of instruction queues, each instruction queue associated with a corresponding functional slice of the plurality of functional slices, wherein the instructions in the instruction queues comprise a functional slice specific operation code.

Abstract: A method of operating a radar apparatus comprises: (a) capturing a first chirp of data in the cycle and storing the data in a local storage memory; (b) processing the captured data to generate a set of range bin data, (c) transferring the range bin data from the local storage memory to a remote burst access memory, (d) repeating the steps (a) and (b) for each subsequent chirp, (e) repeating step (c) so as to transfer the range bin data from the local storage memory to the remote burst access memory, (f) transferring from the remote burst access memory into the local storage memory, (g) process the data transferred into the local storage memory to generate a set of velocity data, and repeating steps (f) and (g) until all of the data in the remote burst access memory block of data has been processed by the second FFT.

Abstract: A door handle sanitizer includes a housing that is mountable to a door and an access lid pivotally attached to the housing. An interior volume of the housing includes a dispensing mechanism having a connector disposed within the interior volume that is configured to removably receive a sanitizer refill container, and a nozzle configured to dispense a sanitizing material onto the door handle. A power supply is operably connected to a motion sensor, a timer, indicator lights, a dispensing mechanism actuator, and a control circuit. The control circuit includes control switches that allow for customization of the door handle sanitizer's spray frequency. If a timer switch is set to a timer interval, then the control circuit activates the dispenser in an interval corresponding to the selected interval. If a motion sensor switch is set to an on position, then the control circuit activates the dispensing mechanism actuator when the motion sensor detects motion.

Abstract: Several embodiments disclosed herein pertain to polymer compositions with optical enhancing agents. In some embodiments, the compositions are provided as polymer (layers including medical films), devices, or parts of devices. Some embodiments provide methods of making such compositions and articles of manufacture comprising them, as well as methods of using polymer compositions or the articles made therefrom. In several embodiments, the polymer formulation includes a base polymer and an optical enhancing additive. In some embodiments, surprisingly, the optical enhancing additive confers upon the polymer film improved stability, including thermal stability.

Abstract: A spray tip comprises a tip body, a tip piece, and a pre-orifice piece. The tip body has a fluid channel along a channel axis (AC). The tip piece is disposed within the fluid channel, and has a stepped, narrowing passage that terminates in an outlet orifice. The pre-orifice piece has an inlet passage, and is disposed within the fluid channel, abutting and immediately upstream of the tip piece. The pre-orifice piece and the tip piece together define a turbulating chamber therebetween.