Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: A person support apparatus includes one or more thermal image sensors whose outputs are analyzed to perform one or more functions. Such functions include automatically turning on a brake, automatically turning on one or more lights, detecting when a patient associated with the person support apparatus has fallen, enabling a propulsion system of the patient support apparatus to be used, automatically controlling one or more environmental controls, and/or automatically arming an exit detection system after entry of a patient onto the person support apparatus. Multiple thermal images may be generated from multiple sensors to generate stereoscopic thermal images of portions of the person support apparatus and its surroundings.

Abstract: A tile for attaching to a wall of a gas turbine engine. The tile has a main body. The tile also has a bridging structure that projects outwardly from the main body and has a hole configured to receive an elongate fastener so that the tile can be attached to the wall of the gas turbine engine by passing the elongate fastener through a hole in the wall of the gas turbine engine and the hole in the bridging structure.

Abstract: The present disclosure relates to the field of molecular biology and more specifically to microarrays and methods.

Abstract: A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: This invention relates to heterocyclic compounds, which are pyrimidinone derivatives having human neutrophil elastase inhibitory properties, and their use in therapy.

Abstract: Systems and methods for determining a passenger service parameter for flight disruption are provided. A method can include receiving, by one or more processors, data indicative of user selection of flight disruption criteria. The method can further include determining, by the one or more processors, at least one impacted passenger based at least upon the data indicative of the user selection. The method can further include determining, by the one or more processors, an alternate flight accommodation for the at least one impacted passenger. The method can further include determining, by the one or more processors, a flight delay for the at least one impacted passenger based at least upon the alternate flight accommodation. The method can further include determining, by the one or more processors, a passenger service parameter associated the at least one impacted passenger based at least upon the flight delay.

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated

Abstract: A location detection system for person support apparatuses includes multiple network wireless access points that communicate with a plurality of mobile transceivers positioned on board the person support apparatuses. Based upon signal strength data (e.g. RSSI or RCPI) of messages from the access points to the transceivers, the locations of the person support apparatuses are determined. In some embodiments, the person support apparatuses include an additional location detection system that utilizes fixed locators having short range transceivers to generate a second location determination of the person support apparatuses. In still other embodiments, the person support apparatuses utilize the second location detection system to determine the location of the wireless access points. The person support apparatuses may also broadcast their location to other devices that then utilize the received signal strengths of those messages to determine their own location.

Abstract: The present invention provides methods for creating an array of features on a surface based on content transferred from a plurality of beads to the surface. Nucleic acid content can be transferred using a method including the steps of (a) providing a surface having one or more primer oligonucleotides attached to the surface; (b) providing a pool of beads, wherein beads in the pool have a plurality of templates attached thereto, the plurality comprising multiple copies of a single nucleic acid template sequence; (c) arraying the beads onto the surface by hybridizing the templates to the primer oligonucleotides; and (d) extending the primers to produce copies of the templates attached to the surface.

Abstract: Pyrazolone derivatives of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of diseases or conditions in which HNE is implicated.

Abstract: Pyrimidone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and condition in which HNE is implicated.

Abstract: A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated.

Abstract: Systems and methods are disclosed for managing and storing electronic health records data. In an embodiment, a database module containing a plurality of databases stores a plurality of different types of patient medical data records. Each patient medical data record is composed of one or more categories of data which may be stored in different databases. A server module configured to respond to requests received from a client is connected to the database module. The server module includes a layer of application logic, a layer of composite services, a layer of domain services, and a layer of foundation services. A request received by the server module is first processed by the application logic, then by the appropriate composite services, domain services and foundation services. Domain services may communicate with the database module, generating a response that may be processed by the composite and application logic layers before sending back to the client.

Abstract: The present disclosure relates to a data storage system, and processes and computer programs for such data storage system, for example including processing of: managing one or more metadata tree structures for storing data to one or more storage devices of the data storage system in units of blocks, each metadata tree structure including a root node pointing directly and/or indirectly to blocks, and a leaf tree level having one or more direct nodes pointing to blocks, and optionally including one or more intermediate tree levels having one or more indirect nodes pointing to indirect nodes and/or direct nodes of the respective metadata tree structure; maintaining the root node and/or nodes of at least one tree level of each of at least one metadata structure in a cache memory; and managing I/O access to data based on the one or more metadata structures.

Abstract: A person support apparatus includes one or more thermal image sensors whose outputs are analyzed to perform one or more functions. Such functions include automatically turning on a brake, automatically turning on one or more lights, detecting when a patient associated with the person support apparatus has fallen, enabling a propulsion system of the patient support apparatus to be used, automatically controlling one or more environmental controls, and/or automatically arming an exit detection system after entry of a patient onto the person support apparatus. Multiple thermal images may be generated from multiple sensors to generate stereoscopic thermal images of portions of the person support apparatus and its surroundings.

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated.

Abstract: A device is provided that humidifies breathing gas. The device has a chamber with an inlet and an outlet. A chemical heater is positioned within the chamber and a trigger activates the heater. The chamber can be a conduit with an inner wall and an outer wall with a reservoir defined therebetween. The chemical heater can be positioned within the reservoir.

Abstract: The present invention relates to a sequencing method which allows for increased rates of sequencing and an increase in the density of sequencing data. The system may be based on next generation sequencing methods such as sequencing by synthesis (SBS) but uses multiple primers bound at different positions on the same nucleic acid strand.

Abstract: The present invention relates to the field of molecular biology, and more specifically to methods for reducing the complexity of a nucleic acid sample.