Abstract: Methods for amplifying nucleic acids are provided. The methods can be used to minimize sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimizing GC bias during amplification reactions with multiple templates of different sequence. The methods are suited to solid phase amplification, for example, utilizing flow cells.

Abstract: A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: A location detection system identifies the locations of medical devices such as patient support apparatuses and/or patient care devices within a medical facility. The devices communicate via a wired connection to one or more medical facility systems (e.g. nurse call system, computer network, etc.), and/or via a wireless connection to such systems. The location detection system automatically determines location information of the devices and communicates the location information so that the recipient of any outgoing alerts and/or other information sent from the devices is apprised of the location of the particular device sending the alert or other information. Caregivers are thereby able to respond to the correct location of an alert, and software systems such as EMR systems, admission discharge and transfer (ADT) systems, etc. are able to correlate transmitted device data with the location and/or patient assigned to that location.

Abstract: The present invention is directed to a combination of a deformable package (20) containing a cream product; and a tool (10) for dispensing the cream product from the deformable package (20) comprising a first member (12) which supports the deformable package (20), and a second member (14) connected to the first member (12) by a hinge (40), wherein the tool (10) is arranged so that, in use, when a user pushes the first and second members (12), (14) towards one another, the deformable package (20) is squeezed between the first and second members (12), (14) to dispense the cream product from the package (20).

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: The present invention relates to the creation of digital multimedia, in particular the creation of digital animation and or audio tracks by multiple participants. Specifically, the invention relates to a novel method to facilitate, through automation, custom tools and custom methods, the creation and maintenance of a collaboration of two or more individuals who generate incremental media elements, and a resultant accretive animation and or audio thereof.

Abstract: Disclosed herein are compositions and methods for sequencing nucleic acids.

Abstract: The subject disclosure is directed towards detecting malware or possible malware in an input file by allowing the input file to be opened, and by monitoring for one or more behaviors corresponding to the open file that likely indicate malware. Only certain executable files and/or file types opened thereby may be monitored, with various collected event data used for antimalware purposes when improper behavior is observed. Example behaviors include writing of a file to storage, generation of network traffic, injection of a process, running of script, and/or writing system registry data. Telemetry data and/or a sample of the file may be sent to an antimalware service, and malware remediation may be performed. Data (e.g., the collected events) may be distributed to other nodes for use in antimalware detection, e.g., to block execution of a similar file.

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HNE is implicated.

Abstract: Compounds of formula (I) described herein are imidazolone derivatives having human neutrophil elastase (HNE) inhibitory properties and are useful for the treatment of diseases and conditions in which HNE is implicated.

Abstract: A method, medium, and system to receive a baseline airline schedule including details associated with at least one flight; optimize the baseline airline schedule in accordance with at least one specified optimization objective to generate an optimized airline schedule; evaluate a robustness of the optimized airline schedule based on an execution of a simulation based process to generate a set of quantitative metrics; and generate a record of the set of quantitative metrics.

Abstract: The present disclosure provides methods and techniques for manufacturing proppant or lost circulation material from drilling cuttings. In an example embodiment, a method for manufacturing proppant or lost circulation material from drilling cuttings includes obtaining solid drilling cuttings from drilling fluid, removing any remaining hydrocarbon from the solid drilling cuttings, and rending the solid drilling cuttings into a powder form. The method further includes using the powdered drilling cuttings as raw material in a proppant or lost circulation material manufacturing process. In an example embodiment, the proppant or lost circulation material manufacturing process can be sintering or flame spheroidization.

Abstract: Compounds of formula (I) described herein are imidazolone derivatives having human neutrophil elastase (HNE) inhibitory properties and are useful for the treatment of diseases and conditions in which HNE is implicated.

Abstract: Pyrimidinone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HINE is implicated.

Abstract: A method for modeling power usage within a macrogrid uses data relating to the behavioral patterns and states (“BA”) of the users, data relating to external impacts on power usage and disaggregated power consumption data in at least one premises within the macrogrid (forming “power usage model data”) and thereafter a method of forecasting and predicting future power requirements within the macrogrid uses such power usage model data.

Abstract: A person support apparatus, such as a bed, stretcher, cot, recliner, or the like, includes an exit detection system having a plurality of force sensors that support the weight of an occupant positioned on a support surface. The force sensors are part of an exit detection system that issues an alarm when the occupant exits, or is about to exit, the person support apparatus. The distribution of weight applied to the force sensors is used to determine if the occupant is about to exit the person support apparatus. Compensation is made to the exit detection system for changes in the weight distribution that are not caused by movement of the occupant. Such changes may be due to siderail movement, support surface pivoting, and/or movement of other components of the person support apparatus.

Abstract: A method for validating data changes made to a database is disclosed. The changes are made in the context of a transaction, and validation is performed using a rules database storing a plurality of rules. The method includes identifying a set of data entities affected by one or more data changes made in the context of the transaction. In response to an instruction to commit the transaction, data entities in the set of affected data entities are validated using rules from the rules database. The transaction is committed in dependence on the outcome of the validation.

Abstract: A system for automatically analysing aircraft systems data is described. The system comprises a data acquisition module operable to acquire aircraft systems data, a data archiving module operable to store aircraft systems data and a data analysis module operable to analyse the aircraft systems data to identify non-predetermined troubleshooting procedures for fault rectification. Automated identification of improved maintenance techniques can thus be provided, with the added benefit that maintenance manuals and procedures may thereby be automatically adapted over time. A related method is also described.

Abstract: A person support apparatus, such as a bed, cot, stretcher, or the like, includes an exit detection system that utilizes an occupant motion parameter to determine whether to issue an alert or not. The motion parameter may be based on the weight and motion of the occupant. Successive positions of the occupant are determined in order to calculate a velocity of the occupant. In some embodiments, the kinetic energy of the occupant is used to determine if an alert should be issued. Objects positioned on the person support apparatus may also be detected and tracked. Auto-zeroing of a built-in scale, as well as automatic recognition of the removal, movement, and/or addition of objects is also provided.

Abstract: A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.