Patents by Inventor Karl J. Guegler

Karl J. Guegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Disease associated protein kinases
    Patent number: 6207148
    Abstract: The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: March 27, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Preeti Lal, Surya K. Goli, Purvi Shah
  • Human protease molecules
    Patent number: 6203979
    Abstract: The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: March 20, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Jennifer L. Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
  • Cytokine signal regulators
    Patent number: 6201106
    Abstract: The invention provides human cytokine signal regulators (CKSR) and polynucleotides which identify and encode CKSR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CKSR.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: March 13, 2001
    Assignee: Incyte Genomics, Inc.
    Inventors: Henry Yue, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn
  • Human MAP kinase homolog
    Patent number: 6190663
    Abstract: The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: February 20, 2001
    Assignee: Incyte Genomics, Inc.
    Inventors: Phillip R. Hawkins, Janice Au-Young, Karl J. Guegler, Craig G. Wilde
  • Composition for the detection of genes encoding receptors and proteins associated with cell proliferation
    Patent number: 6183968
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: February 6, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Preeti Lal, Jennifer L. Hillman, Henry Yue, Roopa Reddy, Karl J. Guegler, Mariah R. Baughn
  • Vacuolar proton ATPase subunits
    Patent number: 6180342
    Abstract: The invention provides human vacuolar proton ATPase subunits (VATPS) and polynucleotides which identify and encode VATPS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of VATPS.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: January 30, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Y. Tom Tang, Preeti Lal, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Human pinch protein homolog
    Patent number: 6174702
    Abstract: The invention provides a human PINCH protein homolog (PINCH-PH) and polynucleotides which identify and encode PINCH-PH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PINCH-PH.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: January 16, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Preeti Lal, Karl J. Guegler, Neil C. Corley
  • Human protease associated proteins
    Patent number: 6171790
    Abstract: The invention provides human protease associated proteins (HPRAP) and polynucleotides which identify and encode HPRAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HPRAP.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: January 9, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Y. Tom Tang, Preeti Lal, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Extracellular adhesive proteins
    Patent number: 6168920
    Abstract: The invention provides human extracellular adhesive proteins (EXADH) and polynucleotides which identify and encode EXADH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of EXADH.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: January 2, 2001
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Henry Yue, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Protein phosphatase-related molecules
    Patent number: 6165767
    Abstract: The invention provides human protein phosphatase-related molecules (PPRM) and polynucleotides which identify and encode PPRM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of PPRM.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: December 26, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Preeti Lal, Henry Yue, Neil C. Corley, Karl J. Guegler, Mariah Baughn
  • Serine/threonine protein kinase
    Patent number: 6162431
    Abstract: The present invention provides a human growth factor receptor binding protein (HSTPK) and polynucleotides which encode HSTPK. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing HSTPK and for treating disorders associated with expression of HSTPK.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: December 19, 2000
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Karl J. Guegler, Preeti Lal
  • Serine/threonine protein kinases
    Patent number: 6156523
    Abstract: The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: December 5, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Y. Tom Tang, Surya K. Goli, Neil C. Corley, Karl J. Guegler, Gina A. Gorgone, Jennifer L. Hillman
  • ATP-dependent RNA helicase protein
    Patent number: 6139837
    Abstract: The invention provides a human ATP-dependent RNA helicase (ADRH-1) and polynucleotides which identify and encode ADRH-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of ADRH-1.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: October 31, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Karl J. Guegler, Neil C. Corley, Purvi Shah
  • Human immune system associated molecules
    Patent number: 6135941
    Abstract: The invention provides human immune system associated proteins (HISAP) and polynucleotides which identify and encode HISAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HISAP.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: October 24, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Preeti Lal, Y. Tom Tang, Henry Yue, Janice Au-Young, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn
  • Human growth-associated methyltransferases
    Patent number: 6132714
    Abstract: The invention provides a human growth-associated methyltransferase (GAMT) and polynucleotides which identify and encode GAMT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of GAMT.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: October 17, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Y. Tom Tang, Henry Yue, Karl J. Guegler, Purvi Shah
  • Hydrolase enzymes
    Patent number: 6132964
    Abstract: The invention provides human hydrolase-like molecules (HHLM) and polynucleotides which identify and encode HHLM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HHLM.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: October 17, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Preeti Lal, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Purvi Shah
  • Human regulatory molecules
    Patent number: 6132973
    Abstract: The invention provides human regulatory molecules and polynucleotides (collectively designated HRM) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing, preventing, and treating disorders associated with expression of human regulatory molecules.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: October 17, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Preeti Lal, Jennifer L. Hillman, Olga Bandman, Purvi Shah, Janice Au-Young, Henry Yue, Karl J. Guegler, Neil C. Corley
  • Human cytochrome P450
    Patent number: 6130077
    Abstract: The invention provides a human cytochrome P450 (HUCYP) and polynucleotides which identify and encode HUCYP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HUCYP.
    Type: Grant
    Filed: October 1, 1998
    Date of Patent: October 10, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Henry Yue, Karl J. Guegler, Neil C. Corley, Janice Au-Young
  • Human SMN-like protein
    Patent number: 6130064
    Abstract: The invention provides a human SMN-like protein (HSLP) and polynucleotides which identify and encode HSLP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HSLP.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: October 10, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Y. Tom Tang, Neil C. Corley, Karl J. Guegler
  • Human fibrous protein
    Patent number: 6127146
    Abstract: The invention provides a human fibrous protein (FIBR) and polynucleotides which identify and encode FIBR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of FIBR.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: October 3, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Preeti Lal, Karl J. Guegler, Neil C. Corley