Patents by Inventor Kazuhiko Ishihara

Kazuhiko Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9138511
    Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: September 22, 2015
    Assignees: SUNTECH Co., Ltd
    Inventors: Hyung-Il Kim, Kazuhiko Ishihara
  • Patent number: 9044323
    Abstract: The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: June 2, 2015
    Assignee: KYOCERA MEDICAL CORPORATION
    Inventors: Masayuki Kyomoto, Toru Moro, Kazuhiko Ishihara, Tomohiro Konno, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Hiroaki Takadama, Makoto Kondo, Noboru Yamawaki, Takeshi Nizuka, Masami Hashimoto
  • Patent number: 9034414
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: May 19, 2015
    Assignees: KYOCERA MEDICAL CORPORATION, THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Yasuhiko Iwasaki, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Noboru Yamawaki
  • Publication number: 20150005180
    Abstract: A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.
    Type: Application
    Filed: September 17, 2004
    Publication date: January 1, 2015
    Inventors: Kazuhiko Ishihara, Sohei Funaoka, Kanehisa Yokoyama
  • Publication number: 20140371395
    Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
    Type: Application
    Filed: June 30, 2014
    Publication date: December 18, 2014
    Inventors: Hyung-Il Kim, Kazuhiko Ishihara
  • Patent number: 8795841
    Abstract: Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: August 5, 2014
    Assignees: Japan Medical Materials Corporation, The University of Tokyo
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara
  • Patent number: 8772368
    Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: July 8, 2014
    Assignees: Suntech Co., Ltd.
    Inventors: Hyung-Il Kim, Kazuhiko Ishihara
  • Patent number: 8765265
    Abstract: Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility.
    Type: Grant
    Filed: December 25, 2009
    Date of Patent: July 1, 2014
    Assignees: Kyocera Medical Corporation, The University of Tokyo
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara
  • Publication number: 20140170331
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Application
    Filed: February 21, 2014
    Publication date: June 19, 2014
    Applicants: KYOCERA Medical Corporation, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, THE UNIVERSITY OF TOKYO
    Inventors: Masayuki KYOMOTO, Kazuhiko ISHIHARA, Yasuhiko IWASAKI, Toru MORO, Kozo NAKAMURA, Yoshio TAKATORI, Hiroshi KAWAGUCHI, Tomohiro KONNO, Noboru YAMAWAKI
  • Patent number: 8697238
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: April 15, 2014
    Assignees: Kyocera Medical Corporation, The University of Tokyo, National University Corporation Tokyo Medical and Dental University
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Yasuhiko Iwasaki, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Noboru Yamawaki
  • Publication number: 20140011957
    Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
    Type: Application
    Filed: September 11, 2013
    Publication date: January 9, 2014
    Applicants: Suntech Co., Ltd.
    Inventors: Hyung-Il Kim, Kazuhiko Ishihara
  • Publication number: 20140011960
    Abstract: In analyzing, fractionating, and culturing cells alive, operations can be more simply made in real time and culture can be performed while removing unnecessary cells from cultured cells for purification. Desired cells are also analyzed and fractionated from the cultured cells to increase the purity, recovery rate, and viability of the cells. A cell-adhesive photocontrollable base material is used in which light irradiation causes the bond dissociation of a photolabile group comprising an O-nitrobenzyl skeleton to irreversibly change the surface of the irradiated portion thereof from that of the cell-adhesive material to that of a non-cell-adhesive material. Cell images are detected and analyzed to obtain the positional information of desired cells. Based on this information, areas among cells and a cell-adhesive photocontrollable material are cut by second light irradiation.
    Type: Application
    Filed: February 6, 2012
    Publication date: January 9, 2014
    Inventors: Tomohiro Konno, Kazuhiko Ishihara, Batzaya Byambaa, Hisashi Sugiyama, Satoshi Ozawa
  • Publication number: 20130344590
    Abstract: An object of the present invention is to provide, as a method for immobilizing a protein molecule, protein immobilization method and means in which orientation of a molecule to be immobilized can be controlled, the molecule can be stably immobilized without a complicated process and a chemical group used for immobilization does not affect the activity and the function of the protein. Specifically, the present invention relates to a method for immobilizing a molecule including the steps of forming a labeled molecule by attaching a label peptide sequence comprising a hydroxyl group-containing amino acid to a molecule; and bringing a molecule having a phenylboronic acid group into contact with the labeled molecule, to capture the labeled molecule by the molecule having a phenylboronic acid group.
    Type: Application
    Filed: January 30, 2012
    Publication date: December 26, 2013
    Inventors: Tomohiro Konno, Kazuhiko Ishihara, Hirokazu Nishida
  • Patent number: 8575229
    Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: November 5, 2013
    Assignees: Suntech Co., Ltd
    Inventors: Hyung Il Kim, Kazuhiko Ishihara
  • Patent number: 8551332
    Abstract: The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: October 8, 2013
    Assignees: Shiseido Company, Ltd.
    Inventors: Katsuyuki Maeno, Kazuyuki Miyazawa, Akira Ishikubo, Kazuhiko Ishihara
  • Patent number: 8318865
    Abstract: The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded to the surface of an eye lens material having hydroxyl groups wherein the chemical compound represented by the following formula (2) is reacted and covalently bonded through ester-bonding to the eye lens material in an organic solvent. The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: November 27, 2012
    Assignees: Shiseido Company, Ltd., Kazuhiko Ishihara
    Inventors: Yukimitsu Suda, Kazuyuki Miyazawa, Kazuhiko Ishihara
  • Patent number: 8277834
    Abstract: The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group. The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: October 2, 2012
    Assignees: Shiseido Company, Ltd.
    Inventors: Yukimitsu Suda, Kazuyuki Miyazawa, Kazuhiko Ishihara
  • Patent number: 8236873
    Abstract: An eye lens material preventing protein adsorption is manufactured by reacting in a reaction medium of either water, an organic solvent, or a water/organic solvent mixture an eye lens material having OH groups with a phosphorylcholine group-containing compound of formula (1), thereby forming an acetal bond according to formula (2) which covalently bonds the phosphorylcholine group-containing compound to a surface of the eye lens material.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: August 7, 2012
    Assignee: Shiseido Co., Ltd.
    Inventors: Yukimitsu Suda, Kazuyuki Miyazawa, Kazuhiko Ishihara
  • Publication number: 20120197413
    Abstract: The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
    Type: Application
    Filed: October 2, 2008
    Publication date: August 2, 2012
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Toru Moro
  • Publication number: 20120197407
    Abstract: Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm3 on at least a part of the surface of a polymer base (A) that has a ketone group on the surface. The sliding material can be obtained by immersing the polymer base (A) into a liquid of a monomer (C) that has a phosphorylcholine group, and causing surface graft polymerization by irradiation of light. Also specifically disclosed are an artificial joint member using the polymer sliding material, and an artificial joint.
    Type: Application
    Filed: August 18, 2010
    Publication date: August 2, 2012
    Applicants: THE UNIVERSITY OF TOKYO, Japan Medical Materials Corporation
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara