Patents by Inventor Kazuhiko Ishihara

Kazuhiko Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7368252
    Abstract: An object of the present invention is to provide an immunoassay of PSA using an agglutination accelerator, which has an agglutination accelerating effect equal to or stronger than the known agglutination accelerator; hardly generates non-specific turbidity; and hardly generates salting out even in a solution with a high salt concentration.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: May 6, 2008
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Kyoichi Sumida, Koji Wada, Kazuhiko Ishihara
  • Publication number: 20080038221
    Abstract: The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group. The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption. n denotes a natural number 1-18.
    Type: Application
    Filed: May 18, 2005
    Publication date: February 14, 2008
    Inventors: Yukimitsu Suda, Kazuyuki Miyazawa, Kazuhiko Ishihara
  • Patent number: 7323224
    Abstract: A method for discharging a liquid containing a biological material includes adding as a dispense stabilizer a polymer composed of phosphorylcholine-group-containing unsaturated compound units or a copolymer including same to the liquid containing the biological material; and discharging the liquid containing the dispense stabilizer using an inkjet system.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: January 29, 2008
    Assignees: Seiko Epson Corporation, Kazuhiko Ishihara
    Inventors: Fumio Takagi, Kazuhiko Ishihara
  • Publication number: 20070181503
    Abstract: The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
    Type: Application
    Filed: May 18, 2005
    Publication date: August 9, 2007
    Inventors: Katsuyuki Maeno, Kazuyuki Miyazawa, Akira Ishikubo, Kazuhiko Ishihara
  • Publication number: 20060217276
    Abstract: Contact lens wetting solutions for reducing friction between the contact lens and ocular tissues, and maintaining such effect for a long time, are disclosed. The wetting solution is composed only of a particular ratio of a lubricant composed of copolymer (A) obtained by polymerizing a monomer composition comprising 2-(meth)acryloyloxyethyl phosphorylcholine and alkyl(meth)acrylate, a buffer, an inorganic chloride, a preservative, a chelating agent, and water. The copolymer (A) has a weight average molecular weight of 100,000 to 1,000,000, and satisfies the formula 80?N×R?240, provided that 4?N?18 and 10%?R?60%, wherein N stands for the carbon number of the alkyl group in monomer Y constituting copolymer (A), and R stands for a molar fraction of the unit derived from monomer Y with respect to the sum of the units derived from monomers X and Y.
    Type: Application
    Filed: June 8, 2006
    Publication date: September 28, 2006
    Applicants: NOF Corporation, Nobuo Nakabayashi, Kazuhiko Ishihara
    Inventors: Motohiro Mitani, Ryota Ando, Hirofumi Irie, Ken Suzuki, Nobuo Nakabayashi, Kazuhiko Ishihara
  • Patent number: 7108787
    Abstract: A modified hollow-fiber membrane which has improved surface hydrophilicity without increasing the amount of components released therefrom, is less apt to interact with living-body components, does not adsorb proteins, and is less apt to deteriorate in performance. The hollow-fiber membrane has a copolymer of 2-methacryloyloxyethylphosphorylcholine and other polymerizable vinyl monomer held on a surface of the membrane, the copolymer being present on the surface in a higher concentration than in other parts of the membrane. The modified hollow-fiber membrane is useful in medical applications such as hemodialysis and blood filtration and in the medical industry, food industry etc.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: September 19, 2006
    Assignee: NOF Corporation
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Shinji Miyazaki, Kazuo Imamura, Ken Suzuki, Koji Kamenosono
  • Publication number: 20060177585
    Abstract: A method for discharging a liquid containing a biological material includes adding as a dispense stabilizer a polymer composed of phosphorylcholine-group-containing unsaturated compound units or a copolymer including same to the liquid containing the biological material; and discharging the liquid containing the dispense stabilizer using an inkjet system.
    Type: Application
    Filed: December 14, 2005
    Publication date: August 10, 2006
    Inventors: Fumio Takagi, Kazuhiko Ishihara
  • Publication number: 20060160089
    Abstract: An agent for fixing (a) substance(s), which can fix various substances to be fixed on a substrate via covalent bonds and which has an excellent effect for the prevention of non-specific adsorption is disclosed. A polymer containing a plurality of phosphorylcholine groups and photoreactive groups in one molecule is used. The polymer binds to the substrate and to the substance to be fixed via the photoreactive groups, thereby the substance to be fixed is bound to the substrate via covalent bonds through the polymer, and non-specific adsorption is effectively prevented by the phosphorylcholine groups. Further, an agent for fixing (a) substance(s) for fixing the substance on a substrate, comprising a nonionic water-soluble macromolecule having at least 2 photoreactive groups in one molecule was also provided.
    Type: Application
    Filed: March 30, 2004
    Publication date: July 20, 2006
    Applicants: KANAGAWA ACADEMY OF SCIENCE AND TECHNOLOGY, TAIKO-DENKI CO., LTD.
    Inventors: Yoshihiro Ito, Hirokazu Hasuda, Tomohiro Konno, Kazuhiko Ishihara, Tetsuya Yamauchi
  • Publication number: 20060041160
    Abstract: A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, —O—, —COO—, —OOC—, —CONH—, —NH—, —NHCO—, —NR2— and —CH2O— where R2 is an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.
    Type: Application
    Filed: February 18, 2004
    Publication date: February 23, 2006
    Applicant: Tokai University
    Inventors: Yu Nagase, Masataka Oku, Kazuhiko Ishihara, Yasuhiko Iwasaki
  • Publication number: 20050008497
    Abstract: It is an object of the present invention to provide a droplet discharging head suited to the discharge of a sample solution, and particularly one that contains a bio-related substance. This object is achieved by a droplet discharging head 1 for discharging a sample solution, wherein the portion of the inner walls of the droplet discharging head 1 that comes into contact with the sample solution is covered with a polymer composed of phosphorylcholine group-containing unsaturated compound units, or a copolymer including same. The droplet discharging head is preferably an electrostatic drive or piezoelectric drive type.
    Type: Application
    Filed: May 20, 2004
    Publication date: January 13, 2005
    Inventors: Fumio Takagi, Kazuhiko Ishihara
  • Patent number: 6828028
    Abstract: A medical material having a surface which is safe and excellent in stability with the lapse of time and has a high durability as needed in establishing a long-lasting surface lubricity in a wet state and an excellent compatibility with blood, and a method for producing the same. These materials are obtained by forming a coating layer with a coating material containing a polymeric substance (A) having a heterocyclic group represented by the formula (1) on at least a part of a surface of a medical material base, and then ring-opening the heterocyclic group remaining in the coating layer by a nucleophilic compound (N): wherein X represents O, NH or S; and R1 represents H or CH3.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: December 7, 2004
    Assignee: NOF Corporation
    Inventors: Hiroki Fukui, Ken Suzuki, Kenshiro Shuto, Nobuyuki Yamamoto, Kazuhiko Ishihara, Nobuo Nakabayashi
  • Publication number: 20040243249
    Abstract: An artificial joint member made of a polymeric material including a portion made of a polymeric substance has a sliding surface composed of a polymer having phosphoryl choline groups. With such an arrangement, the artificial joint member is provided with a sliding part capable of keeping a satisfactory lubricating state for a long time.
    Type: Application
    Filed: March 10, 2004
    Publication date: December 2, 2004
    Inventors: Kazuhiko Ishihara, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Tomiharu Matsushita, Shuji Kusumoto
  • Publication number: 20040157276
    Abstract: An object of the present invention is to provide an immunoassay of PSA using an agglutination accelerator, which has an agglutination accelerating effect equal to or stronger than the known agglutination accelerator; hardly generates non-specific turbidity; and hardly generates salting out even in a solution with a high salt concentration.
    Type: Application
    Filed: March 4, 2004
    Publication date: August 12, 2004
    Applicant: WAKO PURE CHEMICALS INDUSTRIES, LTD.
    Inventors: Kyoichi Sumida, Koji Wada, Kazuhiko Ishihara
  • Patent number: 6706260
    Abstract: A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R1, R2 and R3 are the same or different and each represents hydrogen atom or C1-4 alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: March 16, 2004
    Assignees: NOF Corporation
    Inventors: Shinji Tanaka, Ken Suzuki, Kenshiro Shuto, Akio Hayashi, Nobuo Nakabayashi, Kazuhiko Ishihara
  • Publication number: 20040045897
    Abstract: A modified hollow-fiber membrane which has improved surface hydrophilicity without increasing the amount of components released therefrom, is less apt to interact with living-body components, does not adsorb proteins, and is less apt to deteriorate in performance. The hollow-fiber membrane has a copolymer of 2-methacryloyloxyethylphosphorylcholine and other polymerizable vinyl monomer held on a surface of the membrane, the copolymer being present on the surface in a higher concentration than in other parts of the membrane. The modified hollow-fiber membrane is useful in medical applications such as hemodialysis and blood filtration and in the medical industry, food industry etc.
    Type: Application
    Filed: June 2, 2003
    Publication date: March 11, 2004
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Shinji Miyazaki, Kazuo Imamura, Ken Suzuki, Koji Kamenosono
  • Publication number: 20030186825
    Abstract: Contact lens wetting solutions for reducing friction between the contact lens and ocular tissues, and maintaining such effect for a long time, are disclosed. The wetting solution is composed only of a particular ratio of a lubricant composed of copolymer (A) obtained by polymerizing a monomer composition comprising 2-(meth)acryloyloxyethyl phosphorylcholine and alkyl(meth)acrylate, a buffer, an inorganic chloride, a preservative, a chelating agent, and water. The copolymer (A) has a weight average molecular weight of 100,000 to 1,000,000, and satisfies the formula 80≦N×R≦240, provided that 4≦N≦18 and 10%≦R≦60%, wherein N stands for the carbon number of the alkyl group in monomer Y constituting copolymer (A), and R stands for a molar fraction of the unit derived from monomer Y with respect to the sum of the units derived from monomers X and Y.
    Type: Application
    Filed: February 21, 2003
    Publication date: October 2, 2003
    Inventors: Motohiro Mitani, Ryota Ando, Hirofumi Irie, Ken Suzuki, Nobuo Nakabayashi, Kazuhiko Ishihara
  • Publication number: 20030114785
    Abstract: A blood analyzing apparatus is provided, which includes a microcapillary fabricated on a substrate by a micromanufacturing technique and used for sampling, filtering, separating, and moving blood and a detector so as to conduct a process from sampling blood to analyzing it using the substrate. A blood analyzing method is also provided for conducting a process from sampling blood to analyzing it by using the blood analyzing apparatus.
    Type: Application
    Filed: December 31, 2002
    Publication date: June 19, 2003
    Inventors: Jun Kikuchi, Yasuhiro Horiike, Hiroki Ogawa, Yuzuru Takamura, Akio Oki, Sakuichiro Adachi, Takanori Ichiki, Kazuhiko Ishihara
  • Patent number: 6270788
    Abstract: A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: August 7, 2001
    Assignee: Medtronic INC
    Inventors: Edouard Koulik, Larik Vincent, Patrick Cahalan, Eric Fogt, Kazuhiko Ishihara, Nobuo Nakabayashi
  • Patent number: 6258371
    Abstract: A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: July 10, 2001
    Assignee: Medtronic Inc
    Inventors: Edouard Koulik, Larik Vincent, Patrick Cahalan, Eric Fogt, Kazuhiko Ishihara, Nobuo Nakabayashi
  • Patent number: 6214957
    Abstract: Solubilizers, emulsifiers and dispersing agents having the effects of moisturizing the skin when used as washing agents and having the character of elevating the concentration of a material to be solubilized, emulsified or dispersed in solvents including water as compared with the case where the material is employed alone, or elevating the apparent concentration of a material to be emulsified or dispersed in solvents by increasing homogeneity of the emulsion or dispersion which contain as the active ingredient polymers obtained by polymerizing monomer compositions containing at least one hydrophilic monomer (a) having a group represented by general formula (1) in the side chain, wherein R1, R2 and R3 represent each H or C1-4 alkyl.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: April 10, 2001
    Assignees: NOF Corporation, Japan Science Technology Corporation
    Inventors: Daijiro Shiino, Kazunori Waki, Nobuo Nakabayashi, Kazuhiko Ishihara