Patents by Inventor Kazuhiko Ishihara

Kazuhiko Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6204324
    Abstract: A method for producing an aqueous solution of a polymer having a phosphorylcholine group in which a polymerizable composition containing a polymerizable monomer having the phosphorylcholine group represented by the formula (1) is polymerized in the presence of a non-metal polymerization initiator soluble in a water-containing medium, to obtain a crude polymer aqueous solution, and the crude polymer aqueous solution is purified with a separation membrane, and an aqueous solution of the polymer having the phosphorylcholine group obtained by the method and having not more than 2000 ppm of impurities.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: March 20, 2001
    Assignees: NOF Corporation, Japan Science and Technology Corporation
    Inventors: Kenshiro Shuto, Kazuo Matsuyama, Nobuo Nakabayashi, Kazuhiko Ishihara
  • Patent number: 5977257
    Abstract: A high molecular material and a medical material which is a mixed material containing a copolymer A produced by copolymerization of a monomer composition containing a monomer having a side chain represented by the formula (1) ##STR1## (R.sup.1, R.sup.2, R.sup.3 ; H or a C1-4 alkyl group) and a hydrophobic monomer, and one or more sorts of hydrophobic polymer B other than the copolymer A; wherein structure of said mixed material shows phase separation in which domains of several hundred micrometers or less in size consisting of the copolymer A are uniformly distributed in a phase consisting of said hydrophobic polymer B. A liquid high molecular composition in which the copolymer A and the hydrophobic polymer B are dissolved in a mixed solvent consisting of a halogenated hydrocarbon solvent and a lower alcohol solvent, which has turbidity of 60% or less.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: November 2, 1999
    Assignees: NOF Corporation, Japan Science and Technology Corporation
    Inventors: Kazunori Waki, Daijiro Shiino, Kazuo Matsuyama, Nobuo Nakabayashi, Kazuhiko Ishihara
  • Patent number: 5658561
    Abstract: A method of producing a material bearing zwitterionic groups, such as phosphoryl choline groups, which comprises treating at least the surface of a substrate with a solution or dispersion of a polymer grafter with zwitterionic groups, and material produced by the method. The method is suitable for producing materials for use in contact with blood and in particular a regenerated cellulose membrane.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: August 19, 1997
    Assignee: Biocompatibles Limited
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara
  • Patent number: 5629361
    Abstract: An emulsion of a polymer, in which the polymer comprises (a) a recurring unit derived from a (meth)acrylate and (b) a recurring unit derived from a vinyl compound having a group of --SO.sub.3 R in which R is a hydrogen atom, an alkali metal atom or ammonium ion. The emulsion forms a film on an adherend to decrease the infiltration into the adherend, exhibits an adhesion force to a hydroxyapatite structure, a cement, a metal or a mineral when it is applied thereto to form a film by only drying around room temperature without washing it with water, and exhibits excellent affinity to a radical-polymerizable acrylic resin composition.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 13, 1997
    Assignees: Mitsui Petrochemical Industries, Ltd., Nobuo Nakabayashi
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Yasukazu Saimi
  • Patent number: 5576182
    Abstract: An IgM class monoclonal antibody which specifically reacts with mucus glycoproteins produced by human gastric gland-type mucous cells is provided. By performing immunohistochemical staining using a labeled derivative of the monoclonal antibody, human gastric gland-type mucous cells as well as mucus secreted by these cells can be specifically stained. The monoclonal antibody can also be used for the analysis of gastric gland-type mucous cell-derived mucus glycoproteins in human body fluids as well as for the examination or diagnosis of cancer.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: November 19, 1996
    Assignee: Kanto Kagaku Kabushiki Kaisha
    Inventors: Makoto Kurihara, Kazuhiko Ishihara, Kyoko Hotta, Hiromi Tanaka, Shiro Shimauchi
  • Patent number: 5554669
    Abstract: An emulsion of a polymer, in which the polymer comprises (a) a recurring unit derived from a (meth)acrylate and (b) a recurring unit derived from a vinyl compound having a group of --SO.sub.3 R in which R is a hydrogen atom, an alkali metal atom or ammonium ion. The emulsion forms a film on an adherend to decrease the infiltration into the adherend, exhibits an adhesion force to a hydroxyapatite structure, a cement, a metal or a mineral when it is applied thereto to form a film by only drying around room temperature without washing it with water, and exhibits excellent affinity to a radical-polymerizable acrylic resin composition.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: September 10, 1996
    Assignees: Mitsui Petrochemical Industries, Ltd., Nobuo Nakabayashi
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Yasukazu Saimi
  • Patent number: 5466853
    Abstract: A diester monomer is represented by the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 represent a hadrogen atom, an alkoxy, alkenyloxy or hydroxyalkyloxy carbonyl group having 1 to 20 carbon atoms, or a phosphorylcholine derivative ##STR2## where Y denotes --(CH.sub.2)n, --(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 -- ##STR3## n denotes 1 to 8, m is an integer of 0 or 1, R.sub.4, R.sub.5 and R.sub.6 denote an alkyl or aryl group having 1 to 8 carbon atoms, or a hydroxyalkyl group having 2 to 20 carbon atoms; on the proviso that if R.sub.1 is a hydrogen atom, neither R.sub.2 nor R.sub.3 is a hydrogen atom and at least one of R.sub.2 and R.sub.3 denotes the aforesaid phosphorylcholine derivative group, and that if R.sub.2 is a hydrogen atom, neither R.sub.1 nor R.sub.3 is a hydrogen atom and at least one of R.sub.1 and R.sub.3 denotes the aforesaid phosphorycholine derivative group.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: November 14, 1995
    Assignee: NOF Corporation
    Inventors: Yasumi Koinuma, Takeo Matsumoto, Nobuharu Nakada, Nobuo Nakabayashi, Kazuhiko Ishihara
  • Patent number: 5461433
    Abstract: A highly hydrous soft contact lens comprising a copolymer which contains as an ingredient a monomer having constitution similar to that of phospholipid represented by the following general formula: ##STR1## n is an integer of 1-20, and, R.sub.2, R.sub.3 and R.sub.4 are the same or different groups and alkyl or hydroxyalkyl of 1-8 carbon atoms.Further, a treating solution for contact lenses which comprises a polymer containing as an ingredient the above monomer and a solvent which can dissolve the polymer.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: October 24, 1995
    Assignee: NOF Corporation
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Yoshishige Murata, Nobuharu Nakada, Takeo Matsumoto, Yasumi Koinuma
  • Patent number: 5368733
    Abstract: A water-soluble cellulose derivative which is obtained by subjecting a water-soluble cellulose to graft polymerization with 2-methacryloyloxyethyl phosphorylcholine and has a structural unit of the following formula (I): ##STR1## wherein n is an integer of 1-100, as well as a biocompatible material containing the water-soluble cellulose derivative as an effective component thereof. The water-soluble cellulose derivative having such specific structural unit is furnished with both of biocompatibility and affinity to cellulose and is thus utilizable as a biocompatible material, for example for hemocatharsis.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: November 29, 1994
    Assignee: NOF Corporation
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara
  • Patent number: 5264215
    Abstract: Disclosed is a bone cement composition comprising polyalkyl methacrylate derived from methacrylate having an alkyl group of 1-4 carbon atoms, hydroxyapatite, alkyl methacrylate having an alkyl group of 1-4 carbon atoms, 4-(2-methacryloyloxyethyl)trimellitic acid or anhydride thereof, and a polymerization initiator. Also disclosed are a cured product of the composition, an implant material using the composition and a process for the preparation of the implant material.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: November 23, 1993
    Assignees: Nobuo Nakabayashi, Mitsui Petrochemical Industries, Ltd., Asahi Kogaku Kogyo Kabushiki Kaisha
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Takashi Yamamoto
  • Patent number: 5243006
    Abstract: The acrylic copolymer of the present invention is an acrylic copolymer comprising recurring units derived from a (meth)acrylic ester compound and recurring units derived from a vinyl compound having --SO.sub.3 R (wherein R represents a hydrogen atom or a lower alkyl group) or having an acceptable salt thereof, wherein at least a part of ester groups of the (meth)acrylic ester compound is substituted by a group having recurring units derived from a (meth)acrylic ester. The present invention further provides a process for the preparation of the acrylic copolymer and use application of the acrylic copolymer utilizing its adhesion properties.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: September 7, 1993
    Assignees: Nobuo Nakabayashi, Mitsui Petrochemical Industries, Ltd.
    Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Takashi Yamamoto, Toru Kinoshita
  • Patent number: 5171588
    Abstract: The invention relates to a method for modulating the sedimentation rate of piscicultural dry pellets and to piscicultural dry pellets with a controlled sedimentation rate. The invention is characterized in that a defined surfactant is added to a piscicultural dry pellet material. In accordance with the invention, it is easy to modulate the floatation property or sedimentation rate of piscicultural dry pellets which has heretofore been difficult to control.
    Type: Grant
    Filed: May 13, 1991
    Date of Patent: December 15, 1992
    Assignee: Dai-Ichi Kogyo Seiyaku Co., Ltd.
    Inventors: Kazuhiko Ishihara, Jun Kawaguchi
  • Patent number: 5064446
    Abstract: A purified light gas consisting of hydrogen or helium and having a high purity of, for example, 99.99% or more is prepared from a feed gas containing at least 90 molar % or more of H.sub.2 or He and substantially no CO.sub.2 by gas-separating the feed gas through a plurality of gas-separating membrane modules each comprising at least one polymeric gas-separating membrane and having a gas-permeating ratio P.sub.A /P.sub.CH4 of 100 or more, wherein P.sub.A is a permeating rate of the light gas and P.sub.CH4 is a permeating rate of methane gas, in such a manner that each fraction of the feed gas permeated through and delivered from a preceding membrane module is fed to a next membrane module under the pressure, per se, of the delivered fraction of the feed gas without pressurizing the delivered fraction.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: November 12, 1991
    Assignee: Ube Industries, Ltd.
    Inventors: Yoshihiro Kusuki, Kazuhiko Ishihara
  • Patent number: 4933412
    Abstract: This invention relates to a flame retardant for synthetic fiber substrates and a method of imparting flame resistance to such substrates using the flame retardant. The flame retardant of this invention comprises 75 to 95 weight parts of a hexabromocyclododecane compound having a melting point not less than 195.degree. C. and 25 to 5 weight parts of a hexabromocyclododecane compound having a melting point less than 160.degree. C., which hexabromocyclododecane compounds are available on bromination of trans-trans-cis-cyclododecatriene. This flame retardant imparts excellent flame resistance to synthetic fiber substrates. Moreover, when a synthetic fiber substrate is dyed using a dye bath containing this flame retardant and a dye, the soiling of the substrate and dyeing equipment is kept at the minimum.
    Type: Grant
    Filed: February 10, 1989
    Date of Patent: June 12, 1990
    Assignee: Dai-Ichi Kogyo Seiyaku Co., Ltd.
    Inventors: Etsuo Ito, Masanari Matsumura, Kazuhiko Ishihara, Toshiaki Doyama
  • Patent number: 4758348
    Abstract: A method for separating a charge transfer interactive substance from a liquid mixture containing such a substance, wherein the separation is conducted by means of a separating membrane made of a copolymer having charge transfer interactive groups.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: July 19, 1988
    Assignee: Sagami Chemical Research Center
    Inventors: Kiyohide Matsui, Kazuhiko Ishihara, Isao Shinohara, Hiroyuki Nishide, Rieko Kogure
  • Patent number: 4666991
    Abstract: A graft copolymer consisting essentially of a main chain polymer having a glass transition temperature (Tg) of at least 30.degree. C. and a graft chain fluorine-containing polymer having a repreating unit of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group, and R.sup.2 is a polyfluoroalkyl group.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: May 19, 1987
    Assignee: Sagami Chemical Research Center
    Inventors: Kiyohide Matsui, Kazuhiko Ishihara
  • Patent number: 4039517
    Abstract: A hydrophilic and thermoreactive urethane composition having improved properties such as stability in solution, non-tackiness, water resistance and strength and useful in treating and finishing fibrous products prepared by forming a urethane prepolymer containing free isocyanate groups from (a) (1) a compound containing at least 2 active hydrogen atoms, containing an oxyethylene chain, and having a molecular weight of about 200 to 20,000, or (2) a compound containing at least 2 active hydrogen atoms, not containing an oxyethylene chain, and having a molecular weight of about 200 to 20,000 and a compound containing at least 2 active hydrogen atoms, containing an oxyethylene chain and having a molecular weight of about 200 to 200,000; and (b) an excess of a polyisocyanate; and if desired, (c) a chain extender containing at least 2 active hydrogen atoms; whereby the prepolymer has an oxyethylene chain content of 10 to 40% by weight, and then reacting the prepolymer or a solution thereof with not more than 3 time
    Type: Grant
    Filed: May 29, 1975
    Date of Patent: August 2, 1977
    Assignee: Dai-Ichi Kogyo Seiyaku Co., Ltd.
    Inventors: Tamotu Hamamura, Sumio Goto, Kazuhiko Ishihara