Patents by Inventor Kazuhiko Ishihara

Kazuhiko Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120164210
    Abstract: The present invention relates to a cancer-cell-specific polymer compound containing a photosensitizer for photodynamic therapy and having a surface to which an antibody against a cancer-cell-specific antigen binds. An object of the present invention is to provide a photodynamic therapeutic agent that can reach the cancer tissue at a low concentration via active targeting and makes complications (e.g., sunlight hypersensitivity) associated with photodynamic therapy unlikely to occur.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 28, 2012
    Inventors: Masakazu Ueda, Kayoko Ueda, Tsunenori Arai, Sachiko Matsuda, Kazuhiko Ishihara
  • Publication number: 20120034488
    Abstract: A surface-treated steel sheet having a Co layer, wherein oxidation of the surface is prevented without deteriorating characteristics such as electrical conductivity. A surface-treated steel sheet which is provided with a Co layer on the surface is immersed in an antirust agent, which contains a fatty acid amine and uses water as a solvent, and then dried, thereby forming an antirust coating film on the surface of the surface-treated steel sheet. The antirust coating film containing the fatty acid amine has a thickness of 10-500 ? (in terms of SiO2) as determined by XPS depth analysis. Preferably, the fatty acid amine is benzenemethanamine or trimethylamine, and more preferably, the fatty acid amine additionally contains benzotriazole.
    Type: Application
    Filed: October 14, 2009
    Publication date: February 9, 2012
    Applicant: TOYO KOHAN CO., LTD.
    Inventors: Kazuhiko Ishihara, Tatsuo Tomomori, Eiji Yamane, Hideyuki Minagi
  • Publication number: 20120022665
    Abstract: Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility.
    Type: Application
    Filed: December 25, 2009
    Publication date: January 26, 2012
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara
  • Patent number: 8063238
    Abstract: Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: November 22, 2011
    Assignees: Tokai University Educational System, Tokyo Medical and Dental University
    Inventors: Yu Nagase, Naoya Shimoyamada, Yasuhiko Iwasaki, Kazuhiko Ishihara
  • Publication number: 20110274940
    Abstract: Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).
    Type: Application
    Filed: November 20, 2009
    Publication date: November 10, 2011
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara
  • Publication number: 20110178594
    Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
    Type: Application
    Filed: November 7, 2008
    Publication date: July 21, 2011
    Inventors: Hyung Il Kim, Kazuhiko Ishihara
  • Publication number: 20110059176
    Abstract: The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under mild conditions appropriate for body tissue components (i.e., at ordinary temperature and pressure) without conducting a chemical reaction or employing a physical procedure such as heating or light or radiation irradiation. This makes it possible to provide a tissue adhesion prevention material and a joint contracture prevention materials, which can effectively prevent postoperative adhesion of a tissue in the affected area to the surrounding tissue and contracture of the movable part of a joint.
    Type: Application
    Filed: November 14, 2008
    Publication date: March 10, 2011
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Toru Moro, Kozo Nakamura, Hiroshi Kawaguchi, Noriyuki Ishiyama, Kazuhiko Ishihara, Tomohiro Konno, Tadashi Ohyama, Mizuna Yoshikawa
  • Publication number: 20110027757
    Abstract: An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.
    Type: Application
    Filed: December 19, 2008
    Publication date: February 3, 2011
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Toru Moro
  • Publication number: 20100262237
    Abstract: The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
    Type: Application
    Filed: March 26, 2007
    Publication date: October 14, 2010
    Applicants: JAPAN MEDICAL MATERIALS CORPORATION, THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Masayuki Kyomoto, Kazuhiko Ishihara, Yasuhiko Iwasaki, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Noboru Yamawaki
  • Publication number: 20100222226
    Abstract: To provide an electronic component mounting system and an electronic component mounting method which can prevent a mounting failure due to positional error in a height direction of a substrate and ensure mounting quality. The electronic component mounting system includes a plurality of electronic component mounting devices connected to one another and mounts an electronic component on a substrate to manufacture a mounting substrate. A print test device for testing the substrate after solder printing measures a height position of a height measurement point set on the upper surface of the substrate 4 by a height measuring machine 22 and outputs a measurement result as substrate height data. In a component placing step using an electronic component placing device, a control parameter for controlling a component placing operation of the placing head 32 is updated.
    Type: Application
    Filed: September 17, 2004
    Publication date: September 2, 2010
    Inventors: Kazuhiko Ishihara, Sohei Funaoka, Kanehisa Yokoyama
  • Patent number: 7785372
    Abstract: An artificial joint member made of a polymeric material including a portion made of a polymeric substance has a sliding surface composed of a polymer having phosphoryl choline groups. With such an arrangement, the artificial joint member is provided with a sliding part capable of keeping a satisfactory lubricating state for a long time.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: August 31, 2010
    Assignees: Kabushiki Kaisha Kobe Seiko Sho
    Inventors: Kazuhiko Ishihara, Toru Moro, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Tomohiro Konno, Tomiharu Matsushita, Shuji Kusumoto
  • Publication number: 20100210458
    Abstract: A biomicromolecule-separating, monolithic silica column having a silica matrix and pores formed in the silica matrix, the silica matrix and pores have been modified at surfaces thereof with a polymer, which is obtainable by polymerization of a monomer composition including a phosphorylcholine-analogous-group-containing monomer represented by the following formula (1): R1, R2 and R3 are the same or different and each represent a hydrogen atom, C1-6 alkyl group or C1-6 hydroxyalkyl group, R4 represents a C1-6 alkylene group, R5 represents a hydrogen atom or methyl group, and n stands for an integer of from 1 to 4, such that the surface-modified pores are provided with a pore size comparable to a molecular size of biomicromolecules to be separated.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 19, 2010
    Applicant: SONY CORPORATION
    Inventors: Tomoko Katsuhara, Masahiro Matsumoto, Kazuhiko Ishihara
  • Publication number: 20100137133
    Abstract: The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
    Type: Application
    Filed: July 1, 2009
    Publication date: June 3, 2010
    Applicant: SHISEIDO COMPANY, LTD.
    Inventors: Katsuyuki Maeno, Kazuyuki Miyazawa, Akira Ishikubo, Kazuhiko Ishihara
  • Publication number: 20100036081
    Abstract: Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.
    Type: Application
    Filed: August 31, 2007
    Publication date: February 11, 2010
    Applicants: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Yu Nagase, Naoya Shimoyamada, Yasuhiko Iwasaki, Kazuhiko Ishihara
  • Publication number: 20090321357
    Abstract: The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
    Type: Application
    Filed: June 23, 2009
    Publication date: December 31, 2009
    Applicant: Shiseido Company, Ltd.
    Inventors: Katsuyuki Maeno, Kazuyuki Miyazawa, Akira Ishikubo, Kazuhiko Ishihara
  • Publication number: 20090306781
    Abstract: The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing material 10 for being used under a humid environment comprising: a base body 12 made of a polymer material having a methylene group; and a polymer layer 30 covering a bearing surface 16 of the substrate 12, the polymer layer 30 comprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface 16, wherein a phosphoric index of the sliding surface 16 which is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.
    Type: Application
    Filed: February 5, 2007
    Publication date: December 10, 2009
    Inventors: Masayuki Kyomoto, Toru Moro, Kazuhiko Ishihara, Tomohiro Konno, Kozo Nakamura, Yoshio Takatori, Hiroshi Kawaguchi, Hiroaki Takadama, Makoto Kondo, Noboru Yamawaki, Takeshi Nizuka, Masami Hashimoto
  • Publication number: 20080300375
    Abstract: The present invention is an eye lens material wherein phosphorylcholine groups of a specific structure are covalently bonded onto the material surface by means of an after-treatment in which a phosphorylcholine-containing chemical compound is reacted with an eye lens material. The object of the present invention is to provide a contact lens that prevents protein adsorption and a method of manufacturing thereof.
    Type: Application
    Filed: May 18, 2005
    Publication date: December 4, 2008
    Inventors: Yukimitsu Suda, Kazuyuki Miyazawa, Kazuhiko Ishihara
  • Publication number: 20080300369
    Abstract: The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded to the surface of an eye lens material having hydroxyl groups wherein the chemical compound represented by the following formula (2) is reacted and covalently bonded through ester-bonding to the eye lens material in an organic solvent. The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof.
    Type: Application
    Filed: May 18, 2005
    Publication date: December 4, 2008
    Inventors: Yukimitsu Suda, Kazuyuki Miyazawa, Kazuhiko Ishihara
  • Patent number: 7438860
    Abstract: It is an object of the present invention to provide a droplet discharging head suited to the discharge of a sample solution, and particularly one that contains a bio-related substance. This object is achieved by a droplet discharging head 1 for discharging a sample solution, wherein the portion of the inner walls of the droplet discharging head 1 that comes into contact with the sample solution is covered with a polymer composed of phosphorylcholine group-containing unsaturated compound units, or a copolymer including same. The droplet discharging head is preferably an electrostatic drive or piezoelectric drive type.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: October 21, 2008
    Assignees: Seiko Epson Corporation
    Inventors: Fumio Takagi, Kazuhiko Ishihara
  • Patent number: 7378538
    Abstract: A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating units with a phosphorylcholine group being represented by the formula (II): wherein A is a bond selected from a single bond, —O—, —COO—, —OOC—, —CONH—, —NH—, —NHCO—, —NR2— and —CH2O— where R2 is an alkyl group having 1 to 6 carbon atoms; and m is an integer of 1 to 12.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: May 27, 2008
    Assignee: Tokai University
    Inventors: Yu Nagase, Masataka Oku, Kazuhiko Ishihara, Yasuhiko Iwasaki