Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for rolling back protection processes. In one aspect, a method includes determining that a file is a malicious file, storing a duplicate of the file in a quarantine area, performing one or more protection processes on the file, if the determination that the file is a malicious file is a false positive determination, restoring the file by a pre-boot rollback process to a state prior to the one or more protection processes performed on the file, and booting the computer with the restored file, and if the determination that the file is a malicious file is not a false positive determination, not restoring the file to a state prior to the one or more protection processes performed on the file, and booting the computer.

Abstract: A device transmits a first advertisement to a client device of a user; updates an indicator, associated with the user, to indicate that the device transmitted the first advertisement to the client device; and receives a request from a user device of the user. The request includes an identifier associated with the user. The device further determines, based on the identifier, that the user of the user device is also the user of the client device; determines, based on the identifier and the indicator, that the device transmitted the first advertisement to the client device; selects a second advertisement for the user device based on the request; and transmits the second advertisement to the user device. The first advertisement and the second advertisement advertise a particular item.

Abstract: Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

Abstract: A time-interleaved sample-and-hold system includes a first sample-and-hold circuit and a second sample-and-hold circuit. The first sample-and-hold circuit and the second sample-and-hold circuit share a common sampling switch. A method of remediating a timing offset between a first sample-and-hold circuit and a second sample-and-hold circuit in a time-interleaved sample-and-hold system includes switching at least one shunt capacitor disposed between two logic gates in a timing circuit to adjust a delay between a timing signal for a common sampling switch electrically coupled to the first and second sample-and-hold circuits and a timing signal for at least one of the sample-and-hold circuits.

Abstract: A holder such as a portable document/notebook holder is provided for use with a portable computer such as a netbook or a laptop computer to locate a document or a notebook in a front space relative to a user by mounting the holder on to the portable computer and attaching the document or notebook to that holder. Connectors such as clips may be coupled to ends of two arms that are movably coupled to each other on the other ends. For example, a first arm may fold against a second arm in a closed position and the first arm may maintain an open position when the first arm is either partially folded or not folded. For reading hand written notes, instead of repetitive turning of the neck sideways only upward and downward movement of eyeballs is sufficient which avoids straining of neck or back, making the typing much faster and a comfortable task.

Abstract: The present invention provide processes for the preparation of Bendamustine hydrochloride monohydrate of formula (I) The present application also provides a process of purification of Bendamustine hydrochloride or monohydrate to get substantially pure Bendamustine hydrochloride monohydrate crystalline Form-SM. The said Bendamustine hydrochloride monohydrate crystalline Form-SM is characterized by X-ray powder diffraction pattern comprising at least 5 characteristic peaks selected from the XRPD 2 theta degrees peaks at 7.42, 10.60, 11.17, 16.43, 17.94, 22.89, 26.33, 28.77, 30.28, 31.92, 40.89±0.1 2?°. The present application also provides a process for the preparation of Bendamustine hydrochloride monohydrate crystalline Form-SM useful in making pharmaceutical composition for the treatment of cancer or similar proliferative disorders.

Abstract: A script including a plurality of actions to process in a session associated with a system is generated via a user interface, where the script includes both actions and metaactions. The actions correspond to commands associated with the session to be executed on the system, and the metaactions correspond to a selected plurality of the commands. The script is generated by receiving the actions and the metaactions to process on the system via the user interface associated with the session for interfacing with the system, capturing the actions and the metaactions, and saving the captured actions and metaactions to generate the script.

Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

Abstract: The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.

Abstract: A lithographic apparatus has an alignment system including a radiation source configured to convert narrow-band radiation into continuous, flat and broad-band radiation. An acoustically tunable narrow pass-band filter filters the broad-band radiation into narrow-band linearly polarized radiation. The narrow-band radiation may be focused on alignment targets of a wafer so as to enable alignment of the wafer. In an embodiment, the filter is configured to modulate an intensity and wavelength of radiation produced by the radiation source and to have multiple simultaneous pass-bands. The radiation source generates radiation that has high spatial coherence and low temporal coherence.

Abstract: A sensing system and method for detecting particles in an air volume includes a main airflow path including an inlet from the air volume. Also included is a collection site within the main airflow path. The collection site is for drawing an air sample from the main airflow path. Additionally the system includes a means to induce a localized increase in particle speed at the collection site relative to air speed along the remainder of the main airflow path. The means to induce a localized increase includes an auxiliary airflow path from the main airflow path. The auxiliary airflow path has an exit upstream of the collection site. In an alternative form of the invention, the means to induce the localized increase in particle speed at the collection site comprises a venturi in the main airflow path with the collection site being disposed along the venturi.

Abstract: Methods and arrangements for facilitating virtual appliance image delivery. Virtual appliance image templates are stored at a caching location, based on a historical request pattern. A request is received for a virtual appliance image and there is provided, to a second location, a virtual appliance image responsive to the received request. A difference is determined between the requested virtual appliance image and stored virtual appliance image templates.

Abstract: Methods and arrangements for facilitating virtual appliance image delivery. Virtual appliance image templates are stored at a caching location, based on a historical request pattern. A request is received for a virtual appliance image and there is provided, to a second location, a virtual appliance image responsive to the received request. A difference is determined between the requested virtual appliance image and stored virtual appliance image templates.

Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Abstract: Coherent optical receiver performance is optimized and made adaptable to changing optical channel conditions by providing feedback loops to adjust receiver parameters based on measured receiver performance.

Abstract: A computer system includes at least one processor and a computer-readable storage medium that includes instructions executable by the at least one processor. The instructions implement a table having a linear collection of multiple primary objects, where each of the primary objects occupies a single row in the table and a table control module to create virtual intermediate row-level objects from the linear collection of multiple primary objects. The virtual intermediate row-level objects include a first subset of the primary objects linked to one or more other subsets of the primary objects in a virtual hierarchy using a binding mechanism. The instructions are configured to implement a card view module configured to generate a card view from the virtual intermediate row-level objects and to render a display of the card view having multiple cards in a single row, where each of the cards represents one of the multiple primary objects.

Abstract: A hand-held, portable electronic device is provided with a retainer port that defines an accessory retaining structure formed in an exterior periphery of a device housing for removably retaining a retainable wireless accessory in a cavity of the accessory retaining structure. In one embodiment of the present invention, the hand-held, portable electronic device includes a first transceiver adapted to communicate with the retainable wireless accessory over a short-range wireless communication link. The retainable wireless accessory may include a second transceiver adapted to communicate with the hand-held, portable electronic device using the short-range wireless communication link.

Abstract: In one illustrative embodiment, a functional device hardware element of a mobile telecommunication device is provided externally by forming a dual geometric structure in an exterior surface of at least two device side edges of a device housing. The device housing has first and second grooves being substantially disposed from the front surface to the back surface across the side circumferential surface of first and second device edges of at least four device side edges, respectively, such that a combination of the first and second grooves is configured to jointly define at least one of a shape and a size of a predefined geometric structure that is selected to externally form a functional device hardware element of the mobile telecommunication device from the device housing of the device body.

Abstract: Ontology system providing enhanced search capability receives a search request specifying nodes and edges of interest and determines a set of matching ontologies stored in a knowledge store. The ontology system also generates a ranking for each of the matching ontologies based on the extent of matching. Data indicating the matching ontologies and corresponding rank is sent as a search result.