Abstract: The present invention provides process for preparation of crystalline Bortezomib (Ia) as its monohydrate which is designated as crystalline Form-SB and characterized by having water content ranging between 3.5-6.0% w/w; X-ray powder diffraction pattern comprising characteristic 2?° peaks selected from the XRPD peak set of 5.6, 7.5, 9.8, 10.2, 11.3, 15.1, 18.0, 20.5, 21.5 and 23.6±0.20 2?°, wherein peaks at 9.8 and 11.39±0.20 2?° are un-split and 100% intensity peak is present at 5.6±0.20 2?°, DSC isotherm comprising the endothermic peaks ranging between 45 to 60° C. (Peak-1) and 175 to 185° C. (Peak-2) and IR absorption characteristic peaks approximately at 3387 cm?1, 3304 cm?1, 2953 cm?1, 2927 cm?1, 2868 cm?1, 1627 cm?1, 1455 cm?1, 1400 cm?1, 1201 cm?1, 1150 cm?1, 1020 cm?1, 747 cm?1 and 702 cm?1 and Raman absorption spectra having characteristic peaks approximately at 3066 cm?1, 1583 cm?1, 1528 cm?1, 1281 cm?1, 1213 cm?1, 1035 cm?1, 1022 cm?1 and 1004 cm?1.

Abstract: A system and method of diagnosing and correcting errors in a server computer. A server computer is coupled by a communication path to a client computer. A storage device stores a diagnostic error detecting and correcting program and the server computer is programmed to implement the diagnostic error detecting and correcting program. The server computer detects several selected operating parameters during operation of the server process and determines if at least a first of the selected operating parameters are outside a pre-determined specification for the selected operating parameters. In response to the selected operating parameters being outside the pre-determined specification, the server computer notifies the client computer of an error with the server process. The server computer can also detect communication errors and attempt to restore communications by modifying communication parameter(s).

Abstract: An embodiment may have two rotary discs including a second disc (a cap) and a first disc; and a rotary ‘cam’ (having ports) placed in the central hole of the first disc. A cap is half the diameter of the first disc. Both face each other and maintain contour complementarity during both of two modes of operation The cap seals the cavity underneath, and without jeopardizing the sealing, permits entry and exit of the radial ridges and furrows of the first disc into it. The ridges sweep the floor (under surface) of the cap and divide the cavity into variable volume compartments that suck and expel fluid simultaneously through the ‘cam’. The machine is designed to work as rotary pump, compressor, turbine or internal combustion engine.

Abstract: Interlayer fabrication methods and interlayer structure are provided having reduced dielectric constants. The methods include, for example: providing a first uncured insulating layer with an evaporable material; and disposing a second uncured insulating layer having porogens above the first uncured insulating layer. The interlayer structure includes both the first and second insulating layers, and the methods further include curing the interlayer structure, leaving air gaps in the first insulating layer, and pores in the second insulating layer, where the air gaps are larger than the pores, and where the air gaps and pores reduce the dielectric constant of the interlayer structure.

Abstract: A file stored in a first portion of a computer memory of a computer is determined to be a malicious file. A duplicate of the file is stored in a quarantine area in the computer memory, the quarantine area being in a second portion of the computer memory that is different from the first portion of the computer memory. One or more protection processes are performed on the file. The determination that the file is a malicious file is determined to be a false positive and the file is restored, during a boot sequence, to a state prior to the one or more protection processes being performed on the file.

Abstract: Provisioning, managing and tracking of services provided by a cloud infrastructure system are described. A subscription request from a customer for one or more services provided by the cloud infrastructure system is received. Resources for the requested services are then provisioned. Resource usage information for the resources is collected and an overuse of the resources provisioned to the services in the subscription request, by a customer is determined. The overage information is provided to the customer.

Abstract: The treatment of endophthalmitis is challenging due to the emergence of MDR bacteria. We evaluated the therapeutic potential of Ply187AN-KSH3b, a chimeric phage endolysin derived from the Ply187 prophage in a mouse model of Staphylococcus aureus endophthalmitis. The endolysin was injected intravitreally in C57BL/6 mouse eyes at 6 h and 12 h post S. aureus infection. The disease progression was monitored by ophthalmoscopic, electroretinography, histological, cell death and microbiological parameters. Expression of cytokines/chemokines and cellular infiltration was assessed. Intravitreal injection of chimeric Ply187AN-KSH3b (both at 6 and 12 h post infection) significantly improved the outcome of staphylococcal endophthalmitis, preserved retinal structural integrity, and maintained visual function. Phage lysin treatment significantly reduced the bacterial burden and the levels of inflammatory cytokines and neutrophil infiltration in the eyes.

Abstract: The present invention provides saxagliptin bisulphate, saxagliptin acetate, saxagliptin oxalate, saxagliptin bicarbonate, and saxagliptin carbonate, their polymorphic forms, processes for their preparation, and pharmaceutical compositions thereof.

Abstract: Implementations of power management in a device are described. The device includes a power driver configured to manage power supply to one or more components in system-on-chip (SOC) hardware. The device further includes power subsystems configured as drivers for controlling the components of the SOC hardware and a user interface configured to receive a selected power mode as an input and identify profiles of one or more applications being executed in the device. Based on the selected power mode, the power driver directs the power subsystems to change a mode of operation of at least one component determined from the profiles of the one or more applications being executed.

Abstract: A system and method which dynamically generate proxy connections in a communication system. A client computer system has a processor that is coupled by a communications path including at least one proxy connection to a first target server. An algorithm for dynamically generating proxy connections is stored in machine readable storage. The algorithm is implemented by the processor causing the client computer system to execute generating an additional one of the proxy connections in response to receiving a request and to generate a program identifier which identifies the additional proxy connection. The processor determines if the program identifier is a unique program identifier. If the program identifier is not unique, the processor changes the identifier to render it a modified program identifier so that it is unique and stores the program identifier or the modified program identifier to a configuration file at the client computer system.

Abstract: A system, method and computer program product for dynamically changing access tokens in a communication system. A client computer system is communicatively coupled by a communication channel to at least one target server. The client computer system includes a processor connected to a storage device that has a non-transitory machine-readable storage medium. The storage device stores a connection failure recovery program. The client computer system is programmed to implement the connection failure recovery program. The client computer system initiates a session by transmitting a first request for a connection to the target server using a first token type such as a client security token and if the first request fails, transmits a second request for a connection to the target server using a different token type.

Abstract: A system for discovery and analysis of network data usage of users of a communication network may collect information related to data usage over a network. The system may determine network data usage patterns for users from the data usage information. The network usage data, usage patterns and additional information may be analyzed to create user segments, and to analyze network data usage for the user segments. Differentiated data services may be created and implemented based on the network data usage for the user segments.

Abstract: Provided is a method of address resolution in a software-defined network. An Address Resolution Protocol (ARP) request message is received on a network device. The Address Resolution Protocol (ARP) request message from the network device is forwarded to an OpenFlow controller. A determination is made whether the OpenFlow controller includes information to identify a Media Access Control (MAC) address corresponding to an IP address of a receiving device from the Address Resolution Protocol (ARP) request message. A response is generated depending on whether the OpenFlow controller includes said information.

Abstract: A method includes determining a plurality of configuration entries based on received provisioning requests and further based on provisioning system resource utilization data. Each configuration entry includes a corresponding virtual system template, and a corresponding number of virtual systems to be provisioned. The method also includes provisioning the corresponding number of virtual systems for a first configuration entry in the plurality of configuration entries. The corresponding number of virtual systems are provisioned based on the corresponding virtual system template for the first configuration entry. The method additionally includes storing the provisioned virtual systems in a resource pool and processing a provisioning request utilizing a pre-provisioned virtual system stored in the resource pool.

Abstract: A system and method for user activity and preference analysis in a multi-user, multi-location digital environment that analyzes each user's state at each location where the user is present. If the user is present at multiple locations, the system and method also identify users that have mixed states, i.e., active at one or more locations and inactive at one or more second locations. If a user does not have a system-acceptable exception for its inactive state, the system and method may take action with respect to the user, which action may include warning the user or removing the user from the location.

Abstract: Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts.

Abstract: A method and system for are provided for optimizing and distributing data processing and resources in a multi-user, multi-location digital environment. User activity and user states are compiled and analyzed for each location where the user is present. User event processing may include distributing event data to one or more user state processors, choosing the optimum target processor, and filtering user event data to eliminate duplicate or unnecessary transmissions between processors that are hosted on one or more servers. Process intensive tasks, such as analyzing and transmitting user events, generated by user activity and user state changes, may be implemented using threads in an asynchronous processing environment, wherein the processors are horizontally scalable.

Abstract: An FDSOI integrated circuit die supplies on an output node a regulated output voltage based on a reference voltage. A pass transistor that passes a first current to the output node. A feedback loop regulates the output voltage by generating a second current based on the first current and applying a control signal to the pass transistor based on the second current. A loop current adaptor adapts a ratio of the first and second currents by adjusting a back gate bias voltage applied to a back gate of loop transistor of the feedback loop.

Abstract: The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS?(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS? is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

Abstract: The present invention provides processes for the preparation of rivaroxaban and its intermediates.