Abstract: Provided is a method for determining a drug combination targeting different sites of a protein or a protein complex, including: identifying a first binding site and a second binding site of the protein or the protein complex based on a three-dimensional structure thereof, wherein the first binding site and the second binding site are different sites in the three-dimensional structure of the protein or the protein complex; identifying a first drug interacting with the first binding site; identifying a second drug interacting with the second binding site; and combining the first drug and the second drug to provide at least one of a synergistic effect and an additive effect in suppressing an activity of the protein or the protein complex. Also provided is a method for treating a ATG4B-related disease or a 3C-like protease-related disease by the drug combination.

Abstract: A method for generating a codebook based on a discrete cosine transform, suitable for an electronic device with a plurality of antennas is provided, including: generating an identity matrix, and the size of the identity matrix is related to the number of antennas of the electronic device; inputting a plurality of column vectors of the identity matrix into a discrete cosine transform formula to calculate a plurality of codeword elements corresponding to the column vectors; generating a plurality of codewords corresponding to the column vectors, the codewords corresponding to the column vectors comprise the codeword elements corresponding to the column vectors; multiplying the codewords by a coefficient related to the number of antennas; determining whether the calculation of all the codewords has been completed; and completing the codebook.

Abstract: A drug ranking method, a drug ranking system and a comparison method for drug ranking method are provided. The processing unit executes ranking a plurality of drugs according to a protein target, comparing a plurality of drug ranking methods, and correcting a drug ranking method.

Abstract: A document managing method for a printing device is provided. The document managing method includes the following steps. Firstly, a printing mechanism prints a document with plural papers, and transfers the plural papers to a paper collection platform. Then, a management module manages the plural papers from two lateral sides of the plural papers. Then, a paper ejection module ejects a first portion of the plural papers at a first speed, and then ejects a second portion of the plural papers at a second speed. Consequently, the plural papers are exited from the paper collection platform. Then, the management module is separated from the two lateral sides of the plural papers, so that the plural papers fall down to a supporting tray. The first speed is faster than the second speed.

Abstract: A pneumatic ball launcher includes a tube, a ball pathway unit, a push unit, a holding unit, an airway unit and a pneumatic unit. The ball pathway unit is used for connecting one end of the tube and wrapping part of a ball channel of the tube. The push unit includes a push bar, a slide base, a first driver and a second driver. The holding unit, detachably connected with the push unit, is used for holding the ball pushed by the push bar. The airway unit is connected with the holding unit. The pneumatic unit includes a valve mechanism, a pneumatic cylinder and a gas tank. When the valve mechanism opens to allow the gas tank to discharge into the holding unit via the airway unit, the ball held by the holding unit would be ejected out of the tube.

Abstract: The fuel economizer is series-connected between a fuel tank and a fuel vaporization device of an internal combustion engine, and includes a first piping element and an oil cup. A first end of the first piping element is connected to the fuel vaporization device, and a second end of the first piping element is connected to the fuel tank through the oil cup for filtering the fuel tank's fuel. A spirally threaded shaft is tightly housed inside the first piping element and the spirally threaded shaft's outer circumference is configured with spiral threads to speed, rotate, and disturb the fuel as the fuel flows through to disrupt the surface tension and density of the fuel.

Abstract: An optical module positioning method for an image processing device is provided. The image processing device includes a scanning platform and an optical module. The scanning platform includes a first region, a second region, a third region and a fourth region. The fourth region is arranged between the first region and the second region. The first region is arranged between the third region and the fourth region. The optical module positioning method includes the following steps. Firstly, the optical module is driven to perform a scanning operation to acquire a scanned image while the optical module is not moved. Then, by judging the color values of two ends of the scanned image, the region where the optical module is stayed can be recognized according to the associated color values.

Abstract: Disclosed is a screw compressor (100), comprising a screw compressor housing (101), a discharge cavity (113), at least one silencing channel, and at least one adjustment piston, wherein the discharge cavity (113) is defined by at least one part of the screw compressor housing (101); the at least one part of the screw compressor housing (101) defining the discharge cavity (113) forms a wall of the discharge cavity (113); at least one hole is provided in the wall of the discharge cavity (113); the at least one adjustment piston can be inserted into the at least one hole and move therein; the at least one silencing channel is formed by the at least one hole and the at least one adjustment piston, and the at least one silencing channel is in fluid communication with the discharge cavity (113); and the position of the at least one adjustment piston in the at least one hole determines the silencing length of the at least one silencing channel.

Abstract: An antenna structure includes a metal frame, a feeding portion, and a first ground portion. The metal frame is provided with a slot, a first gap, a second gap, and a third gap. The first gap, the second gap, and the third gap are coupled to the slot, and the slot, the first gap, the second gap, and the third gap divide the metal frame into a radiating portion and a first coupling portion. A portion of the metal frame between the first gap and the third gap form the radiating portion, and a portion of the metal frame between the second gap and the third gap form the first coupling portion. The feeding portion is electrically coupled to the radiating portion to feed an electric signal to the radiating portion. The first ground portion is electrically coupled to the radiating portion to provide ground to the radiating portion.

Abstract: Provided is a method for treating a SARS-CoV2 3CLpro-related disease in a subject in need thereof by blocking dimerization of 3C-like main protease (3CLpro) of the SARS-CoV2, including administering to the subject a first agent which binds to a first binding site of a SARS-CoV2 3CLpro complex and a second agent which binds to a second binding site of the SARS-CoV2 3CLpro complex, wherein the first binding site and the second binding site are functionally different sites in the three-dimensional structure of the SARS-CoV2 3CLpro complex. Also provided is a pharmaceutical combination including the first agent and the second agent for suppressing SARS-CoV2, thereby alleviating COVID-19.

Abstract: A toolkit includes a rotation member, a driving member and an engaging member. The driving member is assembled in one side of the rotation member. The engaging member is assembled in another side of the rotation member. Wherein the driving member is rotatable relative to the engaging member by rotating the rotation member.

Abstract: An apparatus is provided. The apparatus includes a stage and a plate disposed on the stage. The apparatus further includes a pressure film sensor that is formed on the plate and configured to detect a contact force between a plurality of needles on a probe head of a probe card and the pressure film sensor. The apparatus still includes a distance detector that is configured to detect a distance between the pressure film sensor and the needles. In addition, the apparatus includes an adjustment driver that is configured to adjust the probe card based on the detected contact force of the pressure film sensor.

Abstract: Coupled-cavity vertical cavity surface emitting lasers (VCSELs) are provided by the present disclosure. The coupled-cavity VCSEL can comprise a VCSEL having a first mirror, a gain medium disposed above the first mirror, and a second mirror disposed above the gain medium, wherein a first cavity is formed by the first mirror and the second mirror. A second cavity is optically coupled to the VCSEL and configured to reflect light emitted from the VCSEL back into the first cavity of the VCSEL. In some embodiments, the second cavity can be an external cavity optically coupled to the VCSEL through a coupling component. In some embodiments, the second cavity can be integrated with the VCSEL to form a monolithic coupled-cavity VCSEL. A feedback circuit can control operation of the coupled-cavity VCSEL so the output comprises a target high frequency signal.

Abstract: The present disclosure relates to a film having light transmittance and a manufacturing method thereof. The film includes a Polyurethane (PU) surface layer, and a thermoplastic elastomer layer. The thermoplastic elastomer layer is disposed under the PU surface layer. The thermoplastic elastomer layer includes color masterbatch material. The color masterbatch material is between 0.1-1% weight. By controlling the amount of color masterbatch material in the thermoplastic elastomer layer, the film of the present disclosure has real color appearance and good light transmittance.

Abstract: A method for enabling rehabilitation at home for a user to regain a physical ability by means of an apparatus for physical use collects user information of a user. A virtual object is created based on the user information. The virtual object representing the user is displayed on a displaying mechanism. The virtual object is trained to move and perform rehabilitation actions. Actions and movements performed by the user are collected while the rehabilitation actions are displayed. The copycat actions of the user are compared with the rehabilitation actions and the user is assisted to correctly copy the rehabilitation actions based on the comparison. The user can undergo physiotherapy at home without a physiotherapist being present. A VR rehabilitation system and a VR rehabilitation apparatus applying the method are also provided in addition to the physical apparatus.

Abstract: A control method and a time aware bridge device for a seamless Precision Time Protocol (PTP) are provided. The control method includes: utilizing the time aware bridge device to pre-configure a first control signal source as a master control signal source, and pre-configure a second control signal source as a backup control signal source; utilizing the time aware bridge device to determine whether one or more packets from the master control signal source conform to at least one predetermined rule to generate a determination result; and selectively configuring the second control signal source as the master control signal source according to the determination result.

Abstract: The invention relates to a method, a non-transitory computer-readable storage medium, and an apparatus for debugging a solid-state disk (SSD) device. The method is performed by a processing unit of a single-board personal computer (PC) to include: simulating to issue a first Joint Test Action Group (JTAG) command through a General-Purpose Input/Output (GPIO) interface (I/F) to the SSD device for stopping a running of a processing unit of a flash controller in the SSD device; simulating to issue a second JTAG command through the GPIO I/F to the SSD device for forcing the SSD device to exit a sleep mode; and simulating to issue a third JTAG command through the GPIO I/F to the SSD device for reading a designated length of data from a static random access memory (SRAM) in the SSD device.

Abstract: The invention relates to a method, an apparatus and a non-transitory computer-readable storage medium for debugging a solid-state disk (SSD) device. The method is performed by a processing unit of a single-board personal computer (PC) when loading and executing a function of a runtime library, to include: receiving a request to drive a General-Purpose Input/Output (GPIO) interface (I/F), which includes a parameter required for completing a Joint Test Action Group (JTAG) command; issuing a first hardware instruction to the GPIO I/F to set a register corresponding to a GPIO test data input (TDI) pin according to the parameter carried in the request for emulating to issue the JTAG command to a solid-state disk (SSD) device, wherein the single-board PC is coupled to the SSD device through the GPIO I/F; issuing a second hardware instruction to the GPIO I/F to read a value of the register corresponding to the GPIO TDI pin; and replying with a completion message in response to the request.

Abstract: The present invention relates to a composition or combination for the production of butanol and isopropanol, comprising an acetone-butanol-ethanol (ABE)-producing Clostridium strain and a genetically engineered B. subtilis strain, wherein said genetically engineered B. subtilis strain has been transformed by at least one polynucleotide molecule; the at least one polynucleotide molecule comprising a secondary alcohol dehydrogenase gene operably linked to at least one promoter. The invention also relates to methods of producing butanol and isopropanol in a co-culture, methods of producing butyrate, isopropanol and butanol in a co-culture and methods of producing esters.

Abstract: A miniaturized sensing probe and a manufacturing method thereof are provided. The miniaturized sensing probe includes: a probe substrate including a probe part and a circuit connection part; a sensor disposed on the probe part and electrically connected to the circuit connection part; and a needle unit used to accommodate the probe part of the probe substrate; wherein the sensor performs sensing when placed into an analyte through the needle unit and transmits a sensing signal through the circuit connection part. The miniaturized sensing probe of the present invention may be easily placed into the analyte without the use of other instrument or surgery. This means is of benefit to a clinician performing an early diagnosis on a patient with a peripheral vascular disease or monitoring the biological value of the muscle during surgery in real time.