Abstract: Embodiments of a method for forming a three-dimensional (3D) memory devices are disclosed. The method can comprise forming a device wafer including: forming a first channel hole penetrating a first alternating layer stack of a device wafer, forming an epitaxial layer on a bottom of the first channel hole, and forming a first channel layer on a sidewall of the first channel hole. The method can further comprise forming at least one connecting wafer, each connecting wafer including a second channel hole penetrating a second alternating layer stack without an epitaxial layer on a bottom of the second channel hole; and bonding the at least one connecting wafer and the device wafer, such that a second channel layer on a sidewall of the second channel hole in each connecting wafer is electrically connected with the first channel layer in the device wafer.

Abstract: A guide RNA comprising: a gRNA spacer sequence at the 5? end of the guide RNA, wherein the spacer sequence is complementary to a target gene, a scaffold sequence that binds to Cas9, and an RNA capture and sequencing domain comprising: a barcode sequence, and a primer binding sequence; nucleic acids and vectors encoding the guide RNA; cells expressing the guide RNA; and a library comprising a plurality of guide RNAs. Also disclosed are methods of introducing a genetic perturbation into a cell, methods of assessing an effect of at least one genetic perturbation on RNA expression in a cell, methods of identifying nucleic acid sequences associated with a disease state and a method of identifying candidate therapeutic agents.

Abstract: The present invention relates to a bispecific antibody that binds to human CD19 and CD3, wherein the bispecific antibody is composed of a Fab fragment which specifically recognizes a cell membrane antigen and a single-chain antibody which recognizes a CD3 molecule, where the single-chain antibody which recognizes the CD3 molecule is linked to the C-terminus of the CH1-region peptide fragment of the Fab fragment through a hydrophilic linker peptide-linker; and where the Fab fragment which specifically recognizes a cell membrane antigen contains a Fab structure which specifically recognizes a human CD19 antigen, and the bispecific antibody has the following structure: where the linker peptide-linker is composed of 8-20 hydrophilic amino acids.

Abstract: An apparatus and a method for configuring or updating a programmable logic device are provided. The apparatus includes a control module and a storage module connected to the control module. The control module includes: a JTAG interface for connecting the control module to a JTAG host, and a configuration interface compatible with a to-be-configured programmable logic device. The control module is configured to: after receiving a first control instruction including configuration information via the JTAG interface, store the configuration information into the storage module; and after receiving a configuration instruction, read the configuration information to configure the to-be-configured programmable logic device. A configuration clock used in a process that the control module configures the to-be-configured programmable logic device is generated from the to-be-configured programmable logic device, the control module or an external clock source.

Abstract: Method and systems for displaying content items on an information resource include identifying a supplemental content item to append to a DOM tree of the information resource and identifying a first content item displayed in a first container of the information resource. The methods also includes monitoring a position of a predetermined portion of the first content item relative to a viewport of the application and determining, responsive to monitoring the position of the predetermined portion of the first content item, that the first content item is visible within the viewport of the application. The method also includes appending the supplemental content item in a second container at a first position between the first container and an end of the information resource and displaying the supplemental content item within the viewport of the application responsive to detecting a scroll action towards the end of the information resource.

Abstract: A computer system assists in fixing issues. Ticket management logic receives an issue detected on a device. Diagnosing logic identifies the issue based on contextual information received from the device and stores issue data related to the issue into a data store. Routing logic receives an indication of a flagged component of the issue data, flagged by a developer, and initiates communication between a user and the developer based at least in part on the flagged component.

Abstract: Method and systems for displaying content items on an information resource include identifying a supplemental content item to append to a DOM tree of the information resource and identifying a first content item displayed in a first container of the information resource. The methods also includes monitoring a position of a predetermined portion of the first content item relative to a viewport of the application and determining, responsive to monitoring the position of the predetermined portion of the first content item, that the first content item is visible within the viewport of the application. The method also includes appending the supplemental content item in a second container at a first position between the first container and an end of the information resource and displaying the supplemental content item within the viewport of the application responsive to detecting a scroll action towards the end of the information resource.

Abstract: A computer system assists in fixing issues. Ticket management logic receives an issue detected on a device. Diagnosing logic identifies the issue based on contextual information received from the device and stores issue data related to the issue into a data store. Routing logic receives an indication of a flagged component of the issue data, flagged by a developer, and initiates communication between a user and the developer based at least in part on the flagged component.

Abstract: Provided are a novel method for manufacturing a stack of carbon nanotube and graphene that can improve a capacitor characteristic, an electrode material including the stack of carbon nanotube and graphene, and an electric double-layer capacitor using the same. A method for manufacturing a stack of graphene and carbon nanotube includes a step of dispersing the graphene in an aqueous MOH solution (M represents an element selected from a group consisting of Li, Na, and K) to adsorb MOH on the graphene, a step of heating the graphene with MOH adsorbed thereon that is obtained in the adsorption step in vacuum or in an inert atmosphere in a temperature range of 400° C. or more and 900° C. or less to form pores in the graphene, and a step of dispersing the carbon nanotube and the graphene with the pores that are obtained in the step of forming the pores in a dispersion medium to stack the carbon nanotube and the graphene with the pores.

Abstract: A lamination manufacturing method for large-sized metal components with complicated structures is provided, relating to a part manufacturing method to solve the problem that traditional machining, entire plastic forming and the existing additive manufacturing method are difficult to manufacture large-sized metal components with complicated special-shape structure and high-performance requirement. The manufacturing method includes the steps: step 1. obtaining a three-dimensional digital model of a large-sized metal component with complicated structure, and dividing the model into a plurality of slice layers; step 2. selecting the actually available metal sheet corresponding to the thickness of each slice layer divided in step 1, and machining each metal sheet to obtain a shaped sheet consistent with the model of each slice layer in step 1; step 3. stacking the shaped sheets obtained through machining of step 2 according to the order of the corresponding slice layers in step 1; and step 4.

Abstract: Embodiments of a method for forming a three-dimensional (3D) memory devices are disclosed. The method can comprise forming a device wafer including: forming a first channel hole penetrating a first alternating layer stack of a device wafer, forming an epitaxial layer on a bottom of the first channel hole, and forming a first channel layer on a sidewall of the first channel hole. The method can further comprise forming at least one connecting wafer, each connecting wafer including a second channel hole penetrating a second alternating layer stack without an epitaxial layer on a bottom of the second channel hole; and bonding the at least one connecting wafer and the device wafer, such that a second channel layer on a sidewall of the second channel hole in each connecting wafer is electrically connected with the first channel layer in the device wafer.

Abstract: A system for predicting and summarizing medical events from electronic health records includes a computer memory storing aggregated electronic health records from a multitude of patients of diverse age, health conditions, and demographics including medications, laboratory values, diagnoses, vital signs, and medical notes. The aggregated electronic health records are converted into a single standardized data structure format and ordered arrangement per patient, e.g., into a chronological order. A computer (or computer system) executes one or more deep learning models trained on the aggregated health records to predict one or more future clinical events and summarize pertinent past medical events related to the predicted events on an input electronic health record of a patient having the standardized data structure format and ordered into a chronological order.

Abstract: A system for predicting and summarizing medical events from electronic health records includes a computer memory storing aggregated electronic health records from a multitude of patients of diverse age, health conditions, and demographics including medications, laboratory values, diagnoses, vital signs, and medical notes. The aggregated electronic health records are converted into a single standardized data structure format and ordered arrangement per patient, e.g., into a chronological order. A computer (or computer system) executes one or more deep learning models trained on the aggregated health records to predict one or more future clinical events and summarize pertinent past medical events related to the predicted events on an input electronic health record of a patient having the standardized data structure format and ordered into a chronological order.

Abstract: A system for predicting and summarizing medical events from electronic health records includes a computer memory storing aggregated electronic health records from a multitude of patients of diverse age, health conditions, and demographics including medications, laboratory values, diagnoses, vital signs, and medical notes. The aggregated electronic health records are converted into a single standardized data structure format and ordered arrangement per patient, e.g., into a chronological order. A computer (or computer system) executes one or more deep learning models trained on the aggregated health records to predict one or more future clinical events and summarize pertinent past medical events related to the predicted events on an input electronic health record of a patient having the standardized data structure format and ordered into a chronological order.

Abstract: A structural design method of a product is provided. The method includes obtaining a preliminary design of a subsurface mesh structure by filling a body model of the product with spherical cells at preset positions of the body model and performing an finite element analysis and optimization; and optimizing, through a design method for optimizing functions, filling features of the spherical cells based on a simulation analysis so that the structure of the product satisfies a preset target.

Abstract: A dual-band antenna, a wireless local area network (WLAN) device, and a method for manufacturing a dual-band antenna, where the dual-band antenna includes a conductive plane, a smooth curved-surface assembly joined onto the conductive plane, and a feed pin connected to the smooth curved-surface assembly. The conductive plane is configured to function as a first antenna, for receiving and sending a radio frequency signal of a first frequency band, and the smooth curved-surface assembly is configured to function as a second antenna, for receiving and sending a radio frequency signal of a second frequency band. Hence, a curved surface of a surface of the curved-surface assembly that is used as the second antenna transits smoothly. Therefore, a current is distributed relatively evenly, and radiation efficiency is relatively high.

Abstract: Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided.

Abstract: Electronic design automation systems, methods, and computer readable media are presented for the generation of power-related connectivity data by an analog simulator (for example, by propagating the power supply data and/or ground data through the circuit components of the analog design schematic). In some embodiments, the verification module determines consistency between different versions of power-related connectivity data, such as: (i) power-related connectivity data from the analog design schematic and (ii) power-related connectivity data from the power-related data characterizing the mixed-signal design. Such verification determines whether the mixed-signal design satisfies the low power specification as expressed in the power-related data characterizing the mixed-signal design.

Abstract: A computer system assists in fixing issues. Ticket management logic receives an issue detected on a device. Diagnosing logic identifies the issue based on contextual information received from the device and stores issue data related to the issue into a data store. Routing logic receives an indication of a flagged component of the issue data, flagged by a developer, and initiates communication between a user and the developer based at least in part on the flagged component.

Abstract: Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenviroment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.