Patents by Inventor Kunio Harada

Kunio Harada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210190725
    Abstract: In order to provide a piston and a syringe with good sliding performance and pressure resistance performance, the piston contained in the syringe that pressurizes or decompresses an internal medium is configured such that a soft portion made of a soft material and a rigid portion made of a material having rigidity higher than rigidity of the soft portion, are connected in series, and arranged such that the soft portion is in contact with the medium and the rigid portion is not in contact with the medium. The soft portion includes a hollow on a surface in contact with the medium. The rigid portion has an end surface facing the soft portion, the end surface including at least an outer peripheral portion in contact with the soft portion. The outer diameter of the soft portion is larger than the outer diameter of the rigid portion, and the outer diameter of the rigid portion is slightly smaller than the inner diameter of an outer cylinder of the syringe.
    Type: Application
    Filed: October 9, 2018
    Publication date: June 24, 2021
    Inventors: Takashi ANAZAWA, Kunio HARADA, Motohiro YAMAZAKI
  • Publication number: 20210130877
    Abstract: The present invention addresses the problem of providing a novel digital PCR analysis method. One embodiment of the novel digital PCR analysis method is a DNA detection method including the steps of: partitioning a DNA solution containing a fluorescent-labeled probe or a DNA intercalator and a target DNA to be detected into a plurality of compartments; carrying out a nucleic acid amplification reaction in the compartments; measuring a fluorescence intensity in association with a temperature change; calculating a melting temperature of a DNA double strand based on a change in the fluorescence intensity in association with the temperature change; and calculating a ratio of a fluorescence intensity at a second temperature that is lower than a first temperature in association with the temperature change to that at the first temperature.
    Type: Application
    Filed: May 20, 2019
    Publication date: May 6, 2021
    Applicant: HITACHI, LTD.
    Inventors: Junko TANAKA, Tatsuo NAKAGAWA, Yuzuru SHIMAZAKI, Kunio HARADA
  • Publication number: 20210132096
    Abstract: An automated analyzer includes a plurality of measurement units including a measurement section which measures a sample, a suction container connected to the plurality of measurement units through a first path, a vacuum exhaust system connected to the suction container through a second path, a discharge section connected to the suction container through a third path, a pressure adjustment mechanism disposed in the second path, and a control section which performs control such that the suction container is vacuum-exhausted by the vacuum exhaust system.
    Type: Application
    Filed: October 6, 2017
    Publication date: May 6, 2021
    Inventors: Satoshi OZAWA, Kunio HARADA, Atsushi KISHIOKA, Haruyoshi YAMAMOTO, Yu ISHIGE, Yoshinobu KOHARA, Tetsuyoshi ONO
  • Publication number: 20190293625
    Abstract: A method includes a step of introducing a solution between a substrate with a membrane in which the membrane is provided so as to close an opening and a substrate provided with an independent electrode in which the independent electrode is provided, a step of pressure bonding the substrate with the membrane and the substrate with the independent electrode through a partition wall, and a step of forming a sealed liquid tank surrounded by at least the membrane and the partition wall by the pressure bonding, and arraying of a solid-state type nanopore sequencer is simply performed.
    Type: Application
    Filed: October 12, 2017
    Publication date: September 26, 2019
    Inventors: Mayu AOKI, Itaru YANAGI, Kunio HARADA, Kenichi TAKEDA
  • Publication number: 20190022647
    Abstract: A biological sample analysis chip including a first substrate, a membrane disposed on the first substrate, a first liquid tank which is provided with a first electrode, a plurality of second liquid tanks each of which is provided with at least one flow path and a second electrode; and a second substrate disposed below the first substrate, in which the plurality of second liquid tanks are substantially insulated from each other, the membrane disposed on the first substrate is disposed between the first liquid tank and the plurality of second liquid tanks so as to form a portion of the first liquid tank and a portion of the plurality of second liquid tanks, and the second substrate is provided with the at least one flow path and the second electrode so as to form a portion of the plurality of second liquid tanks.
    Type: Application
    Filed: February 22, 2016
    Publication date: January 24, 2019
    Applicant: HITACHI, LTD.,
    Inventors: Mayu AOKI, Kenichi TAKEDA, Kunio HARADA
  • Publication number: 20180298435
    Abstract: The present invention was made to provide novel methods for detecting DNA and devices therefor. Specifically, the present invention is a method of detecting DNA including the steps of: adding, to an oil, a fluorescently-labeled probe, a DNA intercalator, and a DNA solution containing a target DNA to produce droplets; performing PCR on the droplets; and measuring fluorescence from the fluorescently-labeled probe and fluorescence from the DNA intercalator, wherein the DNA solution has a concentration at which each droplet is produced so as to contain one or less target DNA molecule. In addition, the present invention is a DNA detection device including a droplet production unit, a thermal cycler unit, and a fluorescence detection unit which perform these steps.
    Type: Application
    Filed: July 5, 2016
    Publication date: October 18, 2018
    Inventors: Junko TANAKA, Yoshinobu KOHARA, Kunio HARADA, Yu ISHIGE
  • Patent number: 9921160
    Abstract: A laser beam 6 irradiated from a side face of a microchip 1 in which plural channels 2 fill ed with a member of a refractive index n2 in an inner portion of a member of a refractive index n1 (n2<n1) are arranged in parallel with the same plane, along the same plane is refracted in a direction of being directed from an upper base to a lower base in a case where a section of the channel 2 is configured by a trapezoidal shape of upper base>lower base, and is deviated swiftly from a channel array. Hence, the laser beam 6 is made to be deviated gradually from the channel array by irradiating the laser beam 6 from the side face of the microchip 1 by being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channels 2 can efficiently be subjected to laser beam irradiation.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: March 20, 2018
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Takashi Anazawa, Yoshitaka Kodama, Motohiro Yamazaki, Kunio Harada
  • Patent number: 9812288
    Abstract: The objective of the present invention is to simply perform image observation through transmitted charged particles. A sample irradiated by a charged particle beam is disposed directly or via a predetermined member on a light-emitting element (23) whereinto charged particles that have traversed or scattered inside the sample enter, causing a light to be emitted therefrom, which is collected and detected efficiently using a light transmission means (203) to generate a transmission charged particle image of the sample.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: November 7, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Minami Shouji, Takashi Ohshima, Yuusuke Oominami, Hideo Morishita, Kunio Harada
  • Publication number: 20170212052
    Abstract: A laser beam 6 irradiated from a side face of a microchip 1 in which plural channels 2 fill ed with a member of a refractive index n2 in an inner portion of a member of a refractive index n1 (n2<n1) are arranged in parallel with the same plane, along the same plane is refracted in a direction of being directed from an upper base to a lower base in a case where a section of the channel 2 is configured by a trapezoidal shape of upper base>lower base, and is deviated swiftly from a channel array. Hence, the laser beam 6 is made to be deviated gradually from the channel array by irradiating the laser beam 6 from the side face of the microchip 1 by being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channels 2 can efficiently be subjected to laser beam irradiation.
    Type: Application
    Filed: June 23, 2015
    Publication date: July 27, 2017
    Inventors: Takashi ANAZAWA, Yoshitaka KODAMA, Motohiro YAMAZAKI, Kunio HARADA
  • Publication number: 20170069458
    Abstract: The objective of the present invention is to simply perform image observation through transmitted charged particles. A sample irradiated by a charged particle beam is disposed directly or via a predetermined member on a light-emitting element (23) whereinto charged particles that have traversed or scattered inside the sample enter, causing a light to be emitted therefrom, which is collected and detected efficiently using a light transmission means (203) to generate a transmission charged particle image of the sample.
    Type: Application
    Filed: January 9, 2015
    Publication date: March 9, 2017
    Inventors: Minami SHOUJI, Takashi OHSHIMA, Yuusuke OOMINAMI, Hideo MORISHITA, Kunio HARADA
  • Patent number: 9360404
    Abstract: It has been difficult to conduct high-sensitivity, high-precision measurement due to externally generated contamination or cross-contamination. Thus, the invention includes (1) a filter unit having a filter at a bottom of a container for holding a liquid, the filter being adapted to filter a liquid, and (2) an attachment cover having a first opening and a second opening, the filter unit being attachable to and detachable from the attachment cover via the first opening, and the attachment cover being adapted to, when the filter unit is attached to the attachment cover, allow filtration by the filter in a state in which an inner face of the attachment cover is tightly in contact with an outer face of the filter unit, and discharge a resulting filtrate through the second opening.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: June 7, 2016
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Masahiro Okanojo, Hideyuki Noda, Shinichi Fukuzono, Kunio Harada
  • Patent number: 9319598
    Abstract: A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: April 19, 2016
    Assignee: HITACHI, LTD.
    Inventors: Miyuki Kono, Shin-ichiro Umemura, Takafumi Miyatake, Kunio Harada, Yoshitoshi Ito, Hironori Ueki
  • Patent number: 9194793
    Abstract: Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holder 30 detachable from the device as a unit holds a light emission unit 15 formed of an LED and a light receiving element 21, and the holder is placed inside a thermostatic chamber 18 which holds a constant temperature fluid 17. Thus, the photometric unit is reduced in size.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: November 24, 2015
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Sakuichiro Adachi, Kunio Harada, Isao Yamazaki, Masaharu Kiyama, Takeshi Fujita
  • Publication number: 20150324626
    Abstract: A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 12, 2015
    Inventors: Miyuki KONO, Shin-ichiro UMEMURA, Takafumi MIYATAKE, Kunio HARADA, Yoshitoshi ITO, Hironori UEKI
  • Patent number: 9118839
    Abstract: A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: August 25, 2015
    Assignee: HITACHI, LTD.
    Inventors: Miyuki Kono, Shin-ichiro Umemura, Takafumi Miyatake, Kunio Harada, Yoshitoshi Ito, Hironori Ueki
  • Publication number: 20150192505
    Abstract: It has been difficult to conduct high-sensitivity, high-precision measurement due to externally generated contamination or cross-contamination. Thus, the invention includes (1) a filter unit having a filter at a bottom of a container for holding a liquid, the filter being adapted to filter a liquid, and (2) an attachment cover having a first opening and a second opening, the filter unit being attachable to and detachable from the attachment cover via the first opening, and the attachment cover being adapted to, when the filter unit is attached to the attachment cover, allow filtration by the filter in a state in which an inner face of the attachment cover is tightly in contact with an outer face of the filter unit, and discharge a resulting filtrate through the second opening.
    Type: Application
    Filed: June 7, 2013
    Publication date: July 9, 2015
    Inventors: Masahiro Okanojo, Hideyuki Noda, Shinichi Fukuzono, Kunio Harada
  • Publication number: 20150068627
    Abstract: An actuator device includes a pin that performs translatory motion along a groove of a cam to which a three-way stopcock is connected, the cam that performs rotary motion, and a control unit that causes the pin to perform the translatory motion along an extending direction of the cam, and rotates the cam with respect to a central axis of rotation, thereby to divert a passage of the three-way stopcock. A first, second, third, and fourth grooves that form the groove have a linked shape. Directions of inclinations of the first inclination angle and the third inclination angle are opposite with respect to the central axis, and directions of inclinations of the second inclination angle and the fourth inclination angle are opposite with respect to the central axis.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 12, 2015
    Inventors: Kunio HARADA, Akihiro FURUKAWA, Masakazu SUGAYA, Norihito KUNO, Hisashi MURATA
  • Publication number: 20140240480
    Abstract: A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: HITACHI, LTD.
    Inventors: Miyuki KONO, Shin-ichiro Umemura, Takafumi Miyatake, Kunio Harada, Yoshitoshi Ito, Hironori Ueki
  • Patent number: 8767195
    Abstract: A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: July 1, 2014
    Assignee: Hitachi, Ltd.
    Inventors: Miyuki Kono, Shin-ichiro Umemura, Takahumi Miyatake, Kunio Harada, Yoshitoshi Ito, Hironori Ueki
  • Patent number: 8675187
    Abstract: In an analysis system for detecting amounts of components contained in samples, many samples can be measured simultaneously in the whole of the system by use of compact inexpensive photometers. An LED with low heat generation and a long life span is used as a light source. Compactness is achieved by bended optical axis instead of a straight one. Components for bending an optical axis and components for condensing light to ensure an amount of light are in common use to reduce the number of components. Compactness, reduction of the number of components, and integration achieve easy optical axis alignment and precise measurement.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: March 18, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kunio Harada, Sakuichiro Adachi, Isao Yamazaki