Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: A drug coated balloon includes a balloon body and a drug loaded coating layer. The drug loaded coating layer includes a first drug loaded coating component having at least two controllable sustained release drugs with different drug release kinetics, and a second drug loaded coating component including an active drug. The second drug loaded coating component is dispersed among the controllable sustained release drugs and couples the controllable sustained release drugs on the balloon body. The first and second drug loaded coating components are both non-hydrophilic compositions. The drug coated balloon provides sufficient initial drug loading dosage to the lesion site, and has adjustable drug release rate, thereby allowing the drug coated balloon to provide bioactive drugs to the treatment site at different stages of the cascade reaction of vascular restenosis, providing the controllable long-acting therapeutic drugs, and improving the overall vascular drug release efficacy.

Abstract: Disclosed is a method of preparing black tea extract with high theaflavin content, which utilizes an enzyme solution prepared by extracting polyphenol oxidase and laccase from bergamot yam (Dioscorea opposita foshou) or Chinese yam (Dioscoreae Rhizoma). Also disclosed is a method of treating liver fibrosis or kidney injury or atherosclerosis in a subject.

Abstract: A seat bracket includes a base mechanism, an electric motor, a transmission mechanism, and a telescopic mechanism, where the transmission mechanism includes a transmission piece, a transmission rod, and a link, the transmission piece and the transmission rod are rotatably connected through the link, the transmission piece is rotatably connected to the telescopic mechanism, the transmission rod is rotatably connected to the base mechanism, the electric motor, an output end of the electric motor is connected to the transmission rod, and the electric motor is configured to drive the transmission rod to cause the transmission rod to drive the transmission piece and the link to rotate so that the telescopic mechanism extends or retracts.

Abstract: Provided herein are compositions and methods related to compositions comprising an Ig protease fusion protein. Also provided herein are compositions and methods for therapeutic treatment, such as of autoimmune diseases, allergies, or other immunological disorders, or in combination with the administration of another therapeutic, with such Ig protease fusion protein.

Abstract: The present disclosure relates to the field of smart home technologies and provides a base station and a cleaning robot system. The base station is configured to clean a cleaning system of a cleaning robot and includes a base station body and a cleaning assembly. The cleaning assembly may be movably disposed on the base station body, and includes a first cleaning member and a second cleaning member different from the first cleaning member. The first cleaning member and the second cleaning member remove debris from the cleaning system by interfering with the cleaning system. The first cleaning member and the second cleaning member come into contact with a cleaning mechanism of the cleaning robot through relative movement between the cleaning assembly and the cleaning mechanism after the cleaning assembly faces the cleaning mechanism, such that the debris on the cleaning mechanism may be removed.

Abstract: The present disclosure provides an N protein epitope mutation marker for preparing an epitope deletion-marked vaccine strain of type II porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof, belonging to the technical field of biological products. In the mutation marker, one or more amino acids are mutated based on an epitope sequence at positions 92 to 103 of a C-terminal of an N protein of the type II PRRSV; and the epitope mutation marker has an amino acid sequence shown in SEQ ID NO: 1, where X1 is selected from the group consisting of T, P, and A; and X2 is selected from the group consisting of V and A.

Abstract: Methods, apparatuses, electronic devices for MRI scanning are provided, in which in each scanning plane segment, original k-space data of a current scanning plane is obtained, and a first plane image of the current scanning plane is generated based on the original k-space data, the type of the current scanning plane is determined, and the second plane image of the current scanning plane is generated based on the first plane image of the current scanning plane with a prediction mode corresponding to the type of the current scanning plane.

Abstract: Provided is a dual recombinant viral vector system for expressing, in a cell, a polypeptide molecule which is composed of two different peptide chains and has an antigen binding activity, wherein the first chain is expressed using a first viral vector, the second chain is expressed using a second viral vector, and the first and second chains can be assembled, after being expressed in a cell, into the polypeptide molecule which has an antigen binding activity. Further provided are a dual plasmid system for the production of the dual recombinant viral vector system, a host cell containing the dual recombinant viral vector system, a pharmaceutical composition, and the use of and the method for delivering the polypeptide molecule to a subject by using the dual recombinant viral vector system.

Abstract: Disclosed are a brake apparatus, a wheel body assembly, and a rollator. The brake apparatus comprises a shaft body, a housing, a magnetic induction mechanism and an adjustment mechanism. The housing rotates relative to the shaft body; the magnetic induction mechanism is arranged in the housing to generate resisting force opposite to a rotation direction of the housing or the shaft body to the housing or the shaft body by a magnetic field reaction when the housing rotating relative to the shaft body. The adjustment mechanism is connected to the magnetic induction mechanism for adjusting a magnitude of the resisting force. The magnetic induction mechanism is capable of playing a braking role on the wheel body integrated or connected with the brake apparatus, because its braking force is related to the rotation of the housing or shaft body, rather than friction braking, it will not produce an emergency stop effect.

Abstract: A combined bio-artificial liver support system, includes branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end of which is set as a blood input end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end.

Abstract: The technical field of active substance preparations is belonged to, and provided are astaxanthin pickering emulsion with colon targeted delivery function, and a preparation method and application method thereof. The preparation method includes the following steps: S1, reparation of deacetylated-oxidized chitin nanofiber (DE-TO-ChNF)/carboxymethyl konjac glucomannan (CMKGM) nanogel; S2, preparation of astaxanthin oil phase; and S3, preparation astaxanthin pickering emulsion. Natural polysaccharide derivatives DE-TO-ChNF and CMKGM are used as raw materials, and stable crosslinking between covalent bonds and non-covalent bonds are formed between molecules in a composite system through the NHS/EDC, so as to form a stable nanogel. Then the nanogel is used as emulsifier and flaxseed oil rich in astaxanthin is used as oil phase to prepare the astaxanthin pickering emulsion by homogenization.

Abstract: Applications of different configurations of novel glucagon peptide 1 with fatty acid modification or nonmodification in the treatment of T2D or the pancreas protection are provided. The dimer of the present disclosure is formed by two identical cysteine-containing GLP-1 monomers through a disulfide bond. The H-like GLP-1 homodimer (disulfide bond is inside chains) showed remarkable increase in hypoglycemic duration without reducing specific activity. The GLP-1 dimer provided has an in-vivo effective duration of up to 19 days, which significantly prolonged compared with that of the positive control drug Liraglutide with 3 days of effective duration, or thereby greatly promoting the technical advancement in long-acting GLP-1 drugs and facilitating their clinical applications and business. Meanwhile the U-like homodimer (disulfide bond is at the C-terminus) does not affect blood glucose, but can obviously protect pancreatic exocrine cells such as acini and ducts, and improve pancreas function.

Abstract: A personal pet carrier according to an embodiment may include a bag portion to house the lower body of a pet. The sides of the bag may include open slits to facilitate scooping the pet's hind quarters and lower body into the bag. Side straps are provided near the top of the slits. A molle harness system enables the side straps to be positioned at different heights to accommodate the size of the pet. A collar strap and choke prevention strap connected between the collar strap and the front side of the bag may be provided to further secure the pet.

Abstract: A thermal management system, a vehicle, and a thermal management method. The thermal management system includes a tank assembly and a valve unit, the tank assembly includes a shell body and a cover plate, the shell body covers the cover plate and forms an accommodation chamber together with the cover plate, and the valve unit is installed on the shell body; the accommodation chamber is internally provided with a plurality of pipelines for liquid circulation, the shell body has a plurality of connection ports communicating with the accommodation chamber, a first end of the pipeline is correspondingly in communication with the connection port, and a second end of the pipeline and a portion of the pipeline are located outside of the accommodation chamber; and the valve unit has a plurality of valve ports correspondingly in communication with the connection ports.

Abstract: Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

Abstract: The present invention provides a fast-curing molding process for epoxy resin. The method includes the following steps: S1, mixing epoxy resin A glue and a protein-grafted manganese-zinc-iron oxide nanomaterial well into a colloidal state, and grounding the mixture for 10 to 30 min; S2, adding epoxy resin B glue to the mixed colloid in S1, and performing ultrasonic dispersion at 20 to 30° C. for 10 to 30 min; and S3, placing the mixture obtained after ultrasonic dispersion in S2 in a vacuum environment for 20 to 40 min, then taking the mixture out and injecting the mixture into a mold, placing the mold and the mixed colloid into an electromagnetic induction heater, placing the electromagnetic induction heater in a magnetic field environment with a magnetic field intensity of 1 to 1.5 mT for 2 to 3 h, cooling and then taking them out to obtain the cured epoxy resin.

Abstract: This document relates to materials and methods for the production of protein. For example, proteins having a low flavor or low color profile and food products comprising the same.

Abstract: The present application discloses a robot control method, a robot and a control terminal, which relate to the field of robot technology and can be used to improve the stability of the robot when there is a deviation between a desired posture and an actual posture of the robot. The robot control method includes calculating a first deviation between a current posture and the desired posture of the robot; updating dynamic parameters of the robot according to the first deviation; and obtaining a driving instruction of at least one joint module according to selected dynamic parameters to control the posture of the robot reaches or is close to the desired posture.

Abstract: Methods of binding ingredients of a meat alternative product are disclosed. One method comprises mixing a first hydrocolloid and a second hydrocolloid with a protein, thus producing the meat alternative product and forming the meat alternative product to a desired shape. Another method includes mixing a first hydrocolloid, a second hydrocolloid, and a protein, thus producing the meat alternative product and hydrating the meat alternative product. Products produced by the methods are also disclosed.