Abstract: A glucocerebroside compound, a pharmaceutical composition thereof, and the use of the glucocerebroside compound and the pharmaceutical composition thereof in the preparation of drugs for preventing or treating immune-related diseases.

Abstract: A prediction-type intelligent vehicle decision control method and apparatus, a vehicle, and a storage medium are provided.

Abstract: Provided herein are pharmaceutical compositions including compounds having Formula (I) in an effective amount to inhibit cysteine protease as well as methods of using thereof.

Abstract: An adjustable cavitator structure has a cavitator disposed at a head end of the underwater vehicle. The cavitator has a cavitator body, a center of which is connected to the head center of the underwater vehicle through a damper. The front end of the cavitator body is detachably connected with a head fairing device. The cavitator body is of a double-layer structure including a first layer and a second layer. A plurality of cavitator disc face retractable sheets are installed on the first layer and the second layer and are evenly distributed around the axis of the cavitator body, and are slidably connected with the corresponding first layer or second layer. A buffer driving mechanism for driving the cavitator disc face retractable sheets to slide in a radial direction of the cavitator body is installed at the head end of the underwater vehicle.

Abstract: A method is provided that includes receiving a data request from a requesting device requesting data from a data source, looking up, in a blockchain ledger, a transaction corresponding to the data request to validate the data request, forwarding the validated data request to a data server, receiving a data response from the data server in response to the data request, wherein the data response comprises the requested data from the data source, and forwarding the data response to the requesting device.

Abstract: Disclosed are a vacuum heat-preservation box lid and a vacuum heat-preservation lunch box. The vacuum heat-preservation box lid includes: a box lid body; a frame bracket, the frame bracket being connected to the box lid body, the frame bracket being provided with at least one rotatable fastening lug, the fastening lug being provided with an air release hole plug; and a seal ring, the seal ring being connected to the box lid body, the seal ring being provided with an air release hole for communicating an inside of a box body with the outside. When the fastening lug is snapped shut, the air release hole plug is in interference fit with the air release hole, thus blocking the air release hole. When the fastening lug is opened, the air release hole plug is separated from the air release hole, thus unblocking the air release hole.

Abstract: The present disclosure relates to the field of genetic engineering or enzyme engineering, and in particular to an application of MmBBK2 in preparation of trypsin and chymotrypsin inhibitors. The MmBBK2 has the amino acid sequence shown in SEQ ID NO.1 or SEQ ID NO.2. The present disclosure clarifies for the first time that MmBBK2 in mulberry leaves has both trypsin and chymotrypsin inhibitory activity, and reveals its physical and chemical properties. The MmBBK2 has good application prospects in preparing trypsin and chymotrypsin inhibitors. On the basis of knowing its physical and chemical properties, its activity may be accordingly eliminated, promoting the development and utilization of mulberry leaf resources in animal feed, providing new perspectives and ideas for the development and utilization of mulberry leaves in animal feed and health food, and improving economic benefits of mulberry resources.

Abstract: Provided are an electrode plate wrinkling detection apparatus and cell production equipment, pertaining to the field of battery technologies. The electrode plate wrinkling detection apparatus includes an image detection mechanism and a moving mechanism. The moving mechanism is configured to drive the image detection mechanism to move on a winding machine within a region directly facing a cell and adjust a shooting angle of the image detection mechanism. The image detection mechanism includes an image capture device and a detection module that are interconnected. The image capture device is configured to photograph a cell to obtain a picture of the cell and transmit the picture of the cell to the detection module. The detection module is configured to examine the picture of the cell to detect presence of electrode plate wrinkling using a grayscale algorithm and output a detection result.

Abstract: The present disclosure relates to the field of genetic engineering or enzyme engineering, and in particular to an application of MmPI in preparation of trypsin inhibitors. The amino acid sequence of the MmPI is shown in SEQ ID NO.1. The present disclosure clarifies for the first time that MmPI in mulberry leaves has trypsin inhibitory activity and reveals its physical and chemical properties. The MmPI has good application prospects in preparing trypsin inhibitors. On the basis of knowing the physical and chemical properties of the MmPI, its activity may be accordingly eliminated, thereby it promotes the development and utilization of mulberry leaf resources in animal feed, provides new perspectives and ideas for the development and utilization of mulberry leaves in animal feed and health food, and enhances the economic benefits of mulberry resources.

Abstract: The drive device of the lifting apparatus includes an electric actuator 91, a movable part 93 that is driven and moved by an electric actuator 91, a first link member 951L (951R), a second link member 953L (953R) rotatably coupled to the first link member 951L (951R) via a shaft member 952L (952R), and a guide member 97L (97R) having a guide hole 971L (971R) for guiding the shaft member 952L (952R) that moves with the movement of the movable part 93. The lifting platform 50 is raised and lowered by vertically extending and retracting a pair of lower right and left X-shaped arms 71L (71R) and a pair of upper right and left X-shaped arms 75L (75R) via the first link member 951L and second link member 953L along with movement of the movable part 93.

Abstract: The present invention provides anti-LRP5/6 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for treating diseases and disorders associated with Wnt pathway signaling.

Abstract: A method of selecting a group of multimode optical fibers, includes comparing a first effective modal bandwidth at a first wavelength of a multimode optical fiber with a first effective modal bandwidth threshold at the first wavelength, the multimode optical fiber being in a group of multimode optical fibers meeting a first OM standard, wherein the first wavelength is from 844 nm to 863 nm; and categorizing the multimode optical fiber as passing a transmission distance requirement if the first effective modal bandwidth of the first multimode optical fiber is greater than or equal to the first effective modal bandwidth threshold; wherein the transmission distance is defined in a transceiver specification, wherein the transceiver specification is one or more of: (a) an 800G bidirectional (BiDi) transceiver specification, or (b) a 100G/lane based MM VCSEL transceiver specification, or (c) a 25Gbaud based transceiver specification, or (d) 50G PAM4 based transceiver specification.

Abstract: The present disclosure provides engineered WNT agonists and methods of treating gastrointestinal disorders with modulators of the WNT signaling pathway.

Abstract: The present invention relates to an S-configuration-containing amino benzamide pyridazinone compound, a preparation method therefor, and a pharmaceutical composition and application thereof. Specifically, the present invention relates to a compound represented by the following general formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition and application thereof. The S-configuration compound of the present application has very strong binding activity on class I histone deacetylase (HDAC1), and shows inhibitory activity on in-vitro proliferation of various tumor cells.

Abstract: A process for smelting high-speed steel by using an intermediate frequency furnace-LF furnace-VD includes: firstly, melting a steel material in an intermediate frequency furnace, smelting until the steel material is melted, adjusting chemical components, and then performing deoxidation and slagging; performing electric heating for steel tapping, sending the steel tapping into an LF furnace for smelting, heating to 1470-1510° C., and adjusting the chemical components; and finally, sending these components into a VD furnace for vacuum treatment, and performing steel tapping after the components are qualified. A slagging process in the intermediate frequency furnace is used, then the coarse adjustment of chemical components, the primary deoxidation, and the slagging are performed in the intermediate frequency furnace. After the molten steel is sent to the LF furnace, the slag adjustment can be performed. A content of oxygen in the molten steel can be controlled within 10 ppm after the VD vacuum treatment.

Abstract: Provided are modulators of androgen receptor (AR) condensates, methods of modulating or inhibiting AR condensates, and methods of treating diseases and conditions using such modulators or inhibitors of AR condensates.

Abstract: A coated substrate for an electronic device can include a substrate, a basecoat layer on the substrate, and an anti-fingerprint topcoat layer on the basecoat layer. The substrate can include a metal or metal alloy. The basecoat layer can include pigment particles and a first one-part thermally cured polymeric resin. The anti-fingerprint topcoat layer can include a second one-part thermally cured polymeric resin and an anti-fingerprint material. The anti-fingerprint material can include a fluoropolymer, a silane, or a combination thereof. The basecoat layer can be cured before applying the anti-fingerprint topcoat layer on the basecoat layer.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided is a photocurable conductive black composition including: (a) at least one (meth)acrylate-functionalized urethane oligomer; (b) at least one photopolymerizable compound; (c) a photoinitiator; (d) a visible-light blocking system; (e) conductive fillers; and optionally (f) a thermal initiator. Also provided are a method for forming a cured product composed of the photocurable conductive black compositions, and an article comprising the cured product.

Abstract: or a salt (e.g., pharmaceutically acceptable salt) or stereoisomer thereof, wherein X, Y, R1a, R1b, R2, R3, R4s, R5, p, and n are as defined herein. Use of the compounds as a component of a pharmaceutical compositions and methods for their use are also provided.