Abstract: Compounds of the formula II: wherein R1 and R2 are independently H, F or CH3 ; or R1 forms an ethynyl bond and R2 is H or C3-C6 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF3, OMe or halo; R3 is C1-C3 alkyl or C3-C6 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R3 is C3-C6 cycloalkyl it may alternatively be gem subsituted with fluoro; R4 is methyl or fluoro; m is 0, 1 or 2; E is a bond, or thiazolyl, optionally substituted with methyl or fluoro; A1 is CH or N, A2 is CR6R7 or NR6, provided at least one of A1 and A2 comprises N; R6 is H, C1-C4 alkyl, C1-C4 haloalkyl, C1-C3 alkyl-O—C1-C3 alkyl, or when A2 is C, R6 can also be C1-C4alkoxy or F; R7 is H, C1-C4 alkyl or F or a pharmaceutically acceptable salt, N-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteo

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.

Abstract: An exhaust treatment system comprising: a first oxidation catalyst to oxidize nitrogen compounds and/or hydrocarbon compounds in said exhaust stream; a first dosage device downstream of said first oxidation catalyst to supply a first additive into said exhaust stream; a first reduction catalyst device downstream of said first dosage device for reduction of nitrogen oxides in said exhaust stream using said first additive; a particulate filter, comprising a catalytically oxidizing coating downstream of said first reduction catalyst device to catch soot particles and oxidize one or several of nitrogen oxide and incompletely oxidized carbon compounds in said exhaust stream; a second dosage device downstream of said particulate filter to supply a second additive into said exhaust stream; and a second reduction catalyst device downstream of said second dosage device for a reduction of nitrogen oxides in said exhaust stream, using at least one of said first and second additive.

Abstract: A tunable inductor arrangeable on a chip or substrate comprises a first winding part connected at one end to a first input of the tunable inductor arrangement, a second winding part connected at one end to the other end of the first winding part, a third winding part connected at one end to a second input of the tunable inductor arrangement, a fourth winding part connected at one end to the other end of the third winding part, and a switch arrangement arranged. The switch arrangement tunes the tunable inductor by selectively connecting the first and fourth winding parts in parallel and the second and third winding parts in parallel, with the parallel couplings in series between the first and second inputs, or connecting the first, second, fourth and third winding parts in series between the first and second inputs. Corresponding transceivers, communication devices, methods and computer programs are disclosed.

Abstract: Provided are a method and a system for treatment of an exhaust stream, from a combustion engine comprising nitrogen oxides. An estimate of at least one future operating condition for the exhaust treatment system is determined based on a road section ahead of the vehicle. A first additive is input into the exhaust stream to cause a first reduction of nitrogen oxides in a first reduction catalyst device. A second additive is input into the exhaust stream to cause a second reduction of a second amount of nitrogen oxides in a second reduction catalyst device, arranged downstream of the first reduction catalyst device. The first supply of additive is controlled based on the estimated at least one future operating condition, such that the first reduction catalyst device is exposed, over time, to a substoichiometric condition, with respect to the first additive and the first amount of nitrogen oxides.

Abstract: Compounds of the formula II: wherein R1 and R2 are independently H, F or CH3; or R1 forms an ethynyl bond and R2 is H or C3-C6 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF3, OMe or halo; R3 is C1-C3 alkyl or C3-C6 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R3 is C3-C6 cycloalkyl it may alternatively be gem substituted with fluoro; R4 is methyl or fluoro; m is 0, 1 or 2; E is a bond, or thiazolyl, optionally substituted with methyl or fluoro; A1 is CH or N, A2 is CR6R7 or NR6, provided at least one of A1 and A2 comprises N; R6 is H, C1-C4 alkyl, C1-C4 haloalkyl, C1-C3 alkyl-O—C1-C3 alkyl, or when A2 is C, R6 can also be C1-C4 alkoxy or F; R7 is H, C1-C4 alkyl or F or a pharmaceutically acceptable salt, N-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as oste

Abstract: A radio receiver circuit configurable to operate in a carrier-aggregation (CA) mode and in a non-CA mode is disclosed. It comprises a first receive path arranged to be operatively connected to an antenna and a second receive path arranged to be operatively connected to the same antenna. It further comprises a control unit operatively connected to the first receive path and the second receive path. In the CA mode, the control unit controls the first receive path to receive a first component carrier (CC) and the second receive path to receive a second CC. In the non-CA mode, the control unit selectively controls the first receive path and the second receive path to both receive the same single CC.

Abstract: A tunable inductor arrangeable on a chip or substrate comprises a first winding part connected at one end to a first input of the tunable inductor arrangement, a second winding part connected at one end to the other end of the first winding part, a third winding part connected at one end to a second input of the tunable inductor arrangement, a fourth winding part connected at one end to the other end of the third winding part, and a switch arrangement arranged. The switch arrangement tunes the tunable inductor by selectively connecting the first and fourth winding parts in parallel and the second and third winding parts in parallel, with the parallel couplings in series between the first and second inputs, or connecting the first, second, fourth and third winding parts in series between the first and second inputs. Corresponding transceivers, communication devices, methods and computer programs are disclosed.

Abstract: A system and method for phase alignment of multiple PLLs are disclosed. The system comprises a plurality N of PLLs (PLL_1 . . . PLL_N) and a plurality N of phase detectors (DET_1 . . . DET_N). The plurality N of phase detectors and the plurality N of PLLs are connected in a loop such that an i-th phase detector (DET_i) is configured to receive an i-th feedback signal (FB_i) generated from the i-th PLL and an (i+1)-th feedback signal (FB_i+1) generated from the (i+1)-th PLL, and the N-th phase detector (DET_N) is configured to receive the first feedback signal (FB_1) generated from the first PLL and the N-th feedback signal (FB_N) generated from the N-th PLL. The an i-th phase detector (DET_i) is configured to generate an i-th adjustment signal indicating an i-th phase difference between the i-th and (i+1)-th feedback signals for adjusting a phase of the i-th or (i+1)-th PLL, wherein i=1, 2, 3, . . . N?1.

Abstract: An exhaust treatment system comprising: a first dosage device to supply a first additive into an exhaust stream; a first reduction catalyst device downstream of said first dosage device, including a slip-catalyst primarily for reduction of nitrogen oxides (NOx) through the use of the additive, and secondarily for oxidation of additive; an oxidation catalyst downstream of said first reduction catalyst device; a particulate filter downstream of said oxidation catalyst; a second dosage device downstream of said particulate filter to supply a second additive into said exhaust stream; a second reduction catalyst device downstream of said second dosage device for a reduction of nitrogen oxides in said exhaust stream using at least one of said first and said second additive.

Abstract: Methods and systems are provided for treatment of an exhaust stream that comprises nitrogen oxides NOx. The method comprises supplying a first additive to the exhaust stream as a first reduction of a first amount of nitrogen oxides NOx_1 reaching a first device, arranged to impact the first amount of nitrogen oxides NOx_1. The method also comprises supplying a second additive to the exhaust stream, which is used as a second reduction of a second amount of nitrogen oxides NOx_2 reaching a second device, arranged to reduce the second amount of nitrogen oxides NOx_2. At least one of the first supply and the second supply is controlled, based on a total ability for the first device to provide the first reduction, and for the second device to provide the second reduction, so that a required total reduction on the nitrogen oxides NOx in the exhaust stream is provided.

Abstract: An exhaust treatment system comprising: a first oxidation catalyst to oxidize nitrogen- and/or hydrocarbon compounds in an exhaust stream; a first dosage device downstream of said first oxidation catalyst to supply a first additive into said exhaust stream; a first reduction catalyst device, arranged downstream of said first dosage device, including a slip-catalyst primarily for reduction of nitrogen oxides (NOx), and secondarily for oxidation of additive; a second oxidation catalyst arranged downstream of said first reduction catalyst; a particulate filter arranged downstream of said oxidation catalyst; a second dosage device, arranged downstream of said particulate filter to supply a second additive into said exhaust stream; and a second reduction catalyst device, arranged downstream of said second dosage device for reduction of nitrogen oxides in said exhaust stream, with the use of at least one of said first and said second additive.

Abstract: A method and an exhaust treatment system are provided for treatment of an exhaust stream that comprises nitrogen oxides NOx. The method comprises using a first slip-catalyst SC1, arranged at a first device to create a first impact on a first amount of nitrogen oxides NOx_1 An NOx-storing catalyst may store nitrogen oxides NOx. The first slip-catalyst SC1 may reduce nitrogen oxides NOx, and/or oxidize potential additive in the exhaust stream. This first impact is actively controlled, based on the first amount of nitrogen oxides NOx_1 reaching the first device. The method also comprises a second impact on a second amount of nitrogen oxides NOx_2 reaching a second device. The active control of the first impact may be by active control of the dosage of additive at the first device, and/or through an active control of an exhaust environment, for example, a temperature for the exhaust stream.

Abstract: An exhaust treatment system comprising a first oxidation catalyst to oxidize nitrogen and/or carbon compounds in an exhaust stream and a first dosage device downstream of said first oxidation catalyst to supply a first additive. A first reduction catalyst device is arranged downstream of said first dosage device for reduction of nitrogen oxides using said first additive, and for the generation of heat, through at least one exothermal reaction with said exhaust stream. A particulate filter arranged downstream of said first reduction catalyst device to catch soot particles and a second dosage device, arranged downstream of said particulate filter to supply a second additive. A second reduction catalyst device is arranged downstream of said second dosage device for reduction of nitrogen oxides in said exhaust stream, through the use of at least one of said first and said second additive.

Abstract: An exhaust treatment system is provided for treatment of an exhaust stream, where the system comprises a first dosage device, arranged to supply a first additive into said exhaust stream and a first reduction catalyst device, arranged downstream for reduction of nitrogen oxides in said exhaust stream through the use of said first additive, and for the generation of heat through at least one exothermal reaction with said exhaust stream. A particulate filter arranged downstream of said first reduction catalyst device to catch soot particles. A second dosage device arranged downstream of said particulate filter to supply a second additive into said exhaust stream and a second reduction catalyst device, arranged downstream of said second dosage device for reduction of nitrogen oxides in said exhaust stream through the use of at least one of said first and said second additive.

Abstract: A treatment system for providing treatment of an exhaust stream comprising nitrogen oxides NOx, in which nitrogen monoxide NO and nitrogen dioxide NO2 are comprised. When the exhaust stream passes through the treatment system, oxidation occurs of compounds comprising nitrogen, carbon and/or hydrogen. An amount of nitrogen oxides NOx reaching a reduction catalyst device downstream of the oxidizing component in the exhaust treatment system is reduced. A ratio (NO2/NOx)det between an amount of nitrogen dioxide NO2 reaching a reduction catalyst device and the amount of nitrogen oxides NOx reaching the reduction catalyst device is determined. An active control of at least one parameter related to the combustion engine is carried out, based on the determined ratio, so that the amount of nitrogen oxides NOx reaching the reduction catalyst device is increased, if the determined ratio (NO2/NOx)det exceeds an upper threshold value (NO2/NOx)threshold_high.

Abstract: An exhaust treatment system comprising: a first dosage device, arranged to supply a first additive into said exhaust stream; a first reduction catalyst device, downstream of said first dosage device arranged for reduction of nitrogen oxides in said exhaust stream through the use of said first additive; a particulate filter, at least partly comprising a catalytically oxidizing coating, which is downstream of said first reduction catalyst device to catch soot particles, and to oxidize one or several of nitrogen oxide and incompletely oxidized carbon compounds in said exhaust stream; a second dosage device, downstream of said particulate filter to supply a second additive into said exhaust stream; and a second reduction catalyst device, downstream of said second dosage device for a reduction of nitrogen oxides in said exhaust stream, with the use of at least one of said first and said second additive.

Abstract: An amplification device (100) comprises an amplifier circuit (110) and a limiter (120). The amplifier circuit (110) comprises a signal input (111) for an input signal to be amplified and a first signal output (112) for a first output signal. The limiter (120) comprises a differential amplifier (125) comprising a first differential amplifier input (129) for a threshold control signal, a second differential amplifier input (113) for a feedback signal, and a differential amplifier output (124) for a threshold signal indicative of a difference between the threshold control signal and the feedback signal. The limiter (120) also comprises a first diode (121) having a first anode (122) coupled to the first signal output (112) and a first cathode (123) coupled to the differential amplifier output (124), and a feedback stage (128) coupled between the differential amplifier output (124) and the second differential amplifier input (113).

Abstract: Compounds of the formula II: wherein R1 and R2 are independently H, F or CH3; or R1 forms an ethynyl bond and R2 is H or C3-C6 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF3, OMe or halo; R3 is C1-C3 alkyl or C3-C6 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R3 is C3-C6 cycloalkyl it may alternatively be gem substituted with fluoro; R4 is methyl or fluoro; m is 0, 1 or 2; E is a bond, or thiazolyl, optionally substituted with methyl or fluoro; A1 is CH or N, A2 is CR6R7 or NR6, provided at least one of A1 and A2 comprises N; R6 is H, C1-C4 alkyl, C1-C4 haloalkyl, C1-C3 alkyl-O—C1-C3 alkyl, or when A2 is C, R6 can also be C1-C4 alkoxy or F; R7 is H, C1-C4 alkyl or F or a pharmaceutically acceptable salt, N-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteo

Abstract: An amplification device (100) comprises an amplifier circuit (110) and a limiter (120). The amplifier circuit (110) comprises a signal input (111) for an input signal to be amplified and a first signal output (112) for a first output signal. The limiter (120) comprises a differential amplifier (125) comprising a first differential amplifier input (129) for a threshold control signal, a second differential amplifier input (113) for a feedback signal, and a differential amplifier output (124) for a threshold signal indicative of a difference between the threshold control signal and the feedback signal. The limiter (120) also comprises a first diode (121) having a first anode (122) coupled to the first signal output (112) and a first cathode (123) coupled to the differential amplifier output (124), and a feedback stage (128) coupled between the differential amplifier output (124) and the second differential amplifier input (113).