Abstract: This invention relates to antisense oligonucleotides comprising at least one N3??P5? phosphorodiamidate linkage (NPN) in the backbone, useful for modulating gene expression involved in the pathogenesis of a disease. Compounds useful as building blocks of said antisense oligonucleotides and methods of preparing building block compounds including NPN linkages are provided.

Abstract: Various embodiments of the present invention are directed to methods, systems and computer program products for conducting an online transaction on a website involving sensitive information. Such embodiments provide methods, systems and computer program products to: (a) register at least one entity with a gate keeper module, the registering comprising associating the entity with a subscription level; (b) associate a sub-string of a character string with a unique token so that a direct link does not exist between the unique token and the character string; and (c) during processing of the online transaction: (i) using the unique token for intermediate steps during the processing of the online transaction; and (ii) only accessing the character string in storage memory to complete the online transaction after receiving a request from at least one registered entity associated with a subscription level associated with a privilege to receive the requested sensitive information.

Abstract: A collapsible structure is provided and includes a hub, an exterior skin surrounding the hub and a plurality of spokes extending outwardly from the hub to the exterior skin.

Abstract: Systems and methods are disclosed for brokering data exchanges between on-board and off-board systems of a vehicle. One method comprises receiving, at a data broker engine, one or more data requests from an origination system, wherein each of the one or more data requests specifies at least one or more of a request type and a target system. Then the data broker engine determines whether the request type is a one-time transmission, a periodic transmission, an event-triggered transmission, or a change-triggered transmission. Following the determination, the data broker engine retrieves data from the target system based on the determined request type and transmits the data to the origination system.

Abstract: Various embodiments of the present invention are directed to methods, systems and computer program products for conducting an online transaction on a website involving sensitive information. Such embodiments provide methods, systems and computer program products to: (a) register at least one entity with a gate keeper module, the registering comprising associating the entity with a subscription level; (b) associate a sub-string of a character string with a unique token so that a direct link does not exist between the unique token and the character string; and (c) during processing of the online transaction: (i) using the unique token for intermediate steps during the processing of the online transaction; and (ii) only accessing the character string in storage memory to complete the online transaction after receiving a request from at least one registered entity associated with a subscription level associated with a privilege to receive the requested sensitive information.

Abstract: The present disclosure includes apparatuses comprising replaceable memory. An example apparatus may include a controller and a memory package coupled to the controller and including a plurality of memory dies. At least one of the memory package and the controller may be a replaceable unit that is removable from the apparatus and replaceable with a different replaceable unit while maintaining operation of the apparatus.

Abstract: In one embodiment, a method includes receiving one or more deployment units for an application to be deployed. The method further includes receiving a selection of a deployment topology for the application. The deployment topology specifies one or more virtual machines (VMs). In addition, the method includes providing a list of VM templates. The list includes one or more VM templates for each of a plurality of cloud providers. Further, the method includes receiving a selection of at least one VM template from the list for each of the one or more VMs. The method additionally includes matching the one or more deployment units to the at least one VM template. The method also includes deploying the application on a computer system of a selected cloud provider from the plurality of cloud providers.

Abstract: A method for performing a rewind functional verification includes identifying state variables that model a number of registers on each edge of a retiming graph for an original design and a retimed design. Random variables are identified that model retiming labels representing a number and a direction of a register movement relative to a node on a retiming graph for the retimed design. A retiming constraint is identified for each edge on the retiming graph for the retimed design, wherein the retiming constraint reflects a relationship between the state variables and the random variables. A random variable that models a retiming label at a source of an edge is recursively substituted for a random variable that models a retiming label at a sink of the edge when a number of registers on the edge is unchanged after register retiming.

Abstract: Some aspects disclosed herein are directed to, for example, a system and method comprising a client device receiving an input of at least a portion of a message. The client device may transmit, to a server device, the at least the portion of the message for display via a second client device. The client device may determine an identifier for the at least the portion of the message. The client device may determine, based on a lexicon, a marker name for the at least the portion of the message. The client device may generate an association between the marker name for the at least the portion of the message and the identifier for the at least the portion of the message. The client device may store, at a storage location, the marker name for the at least the portion of the message, the identifier for the at least the portion of the message, and the association between the marker name for the at least the portion of the message and the identifier for the at least the portion of the message.

Abstract: A session-specific policy may be used to define specific configuration and operational characteristics of different types of sessions. One type of session may have one set of characteristics while a second type of session may have a different set of characteristics. The policy may be applied by a server or client, and may be propagated through an enterprise by a policy distribution management system to establish policies across multiple devices. Different session types include sessions from a local console, a remote user, a device-initiated session, a service-initiated session, and other types. Within each session type, policies may be defined for specific instances of each type. For example, different policies may be defined for different devices in a device-initiated policy.

Abstract: Particular embodiments provide a system for managing a virtualization environment, the system comprising a plurality of host machines, one or more virtual disks comprising a plurality of storage devices, and a virtualized file server (VFS) comprising a plurality of file server virtual machines (FSVMs), wherein each of the FSVMs is running on one of the host machines and conducts I/O transactions with the one or more virtual disks, and the host machines form a cluster. A health monitoring service may monitor the FSVMs to determine whether any of the FSVMs has failed or is having problems. If the health monitoring service detects a failure of one of the FSVMs on a first one of the host machines, for each resource lock associated with the first FSVM, the health monitoring service may reassign the resource lock to another one of the FSVMs.

Abstract: A camera system comprises an image capturing device, and connected to it are an object classification module and a calibration module. The object classification module is operable to determine whether or not an object in an image is a member of an object class, and the calibration module is operable to estimate representative sizes of the object. The object classification module may determine a confidence parameter that is used by the calibration module, or conversely, the calibration module may produce a size that is used by the classification module.

Abstract: A digital X-ray detector is provided. The detector includes a detector array configured to generate image data based on incident X-ray radiation. The detector also includes a housing in which the detector array is disposed. The detector is configured to be inductively charged and the detector lacks any external electrical connector.

Abstract: Described here are substantially pure (17-?)-3-Oxoandrost-4-en-17-yl tridecanoate compositions, methods of their preparation and uses thereof.

Abstract: A system for computer memory management that implements a memory pool table, the memory pool table including entries that describe a plurality of memory pools, each memory pool representing a group of memory pages related by common attributes; a per-page tracking table, each entry in the per-page tracking table used to related a memory page with a memory pool of the memory pool table; and processing circuitry to: scan each entry in the per-page tracking table and, for each entry: determine an amount of memory released if the memory page related with the entry is swapped; aggregate the amount of memory for the respective memory pool related with the memory page related with the entry in the per-page tracking table, to produce a per-pool memory aggregate; and output the per-pool memory aggregate for the memory pools related with the memory pages in the per-page tracking table.

Abstract: The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX, formula X, formula XI, formula XII, formula XIII, formula XIV and formula XV and the methods for the treatment of chronic pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic pain.

Abstract: Elasticity of a particular product is calculated based on product demand against various price points. Accurate product demand calculations are ensured by calculating the price journey of the product, with appropriate adjustments made for out of stock conditions and promotions and or discounts. The price journey data is then input into an impact estimation algorithm which allows calculation of demand elasticity accounting for various real-world factors impacting demand and elasticity, such as: price of a substitute or compliment, competitor price, weather, local events, calendar events, and other factors. This approach allows for superior price journey-based item-specific elasticity calculation, which allows for superior optimization of item price to maximize volume and profit.

Abstract: Systems and methods for allocating jobs in a distributed file system queue are provided. The system may receive a job request and intelligently divide the job request into one or more logical job stages. Each job stage may be assigned a stage weight based on historical data corresponding to each job stage, such as job stage computing requirements, job stage data outputs, and the like. The system may assign each job stage to a job queue n the distributed file system based on the stage weight and the current computing availability of each job queue. The system may execute each job stage in the assigned job queue to complete the job request.

Abstract: Various systems, methods, and apparatuses disclosed herein provide for receiving pressure data for an accumulator system, the pressure data providing an indication of a pressure in an accumulator tank of the accumulator system; receiving energy data, the energy data indicating an availability of free energy for use to charge the accumulator tank; and activating a charging source of the accumulator tank to charge the accumulator tank based on at least one of the pressure data and the energy data.